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PODCAST

Clinical Chemistry Podcast

Association for Diagnostics and Laboratory Medicine

This free monthly podcast is offered by Clinical Chemistry. Clinical Chemistry is the leading forum for peer-reviewed, original research on innovative practices in today"s clinical laboratory.

science chemistry

All Episodes

09:04

Interferon γ–Release Assays for Diagnosis of Latent...

Clinical Chemistry Podcast ·

2014/05/12

In well-resourced countries with a low incidence of tuberculosis, a major focus of TB control efforts is the detection and treatment of latent TB infection to prevent reactivation to active TB disease. This approach is particularly relevant for healthcare workers. Interferon Gamma Release Assays are used to detect the release of interferon from T cells stimulated by tuberculosis specific antigens. However, these tests differ in cost and complexity than the conventional tuberculin skin test.

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07:01

Posttransplantation Bone Marrow Assessment by...

Clinical Chemistry Podcast ·

2014/05/07

Recent studies have demonstrated that a variety of cells release exosomes or microvesicles into nearby biological fluids such as blood and saliva. During the exocytic process various proteins' messenger RNA and micro RNA are included in these exosomes.

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07:06

Sandwich Assay for Tacrolimus Using 2 Antitacrolimus...

Clinical Chemistry Podcast ·

2014/04/29

Tacrolimus or FK506 is a macrocyclic lactone that is commonly used along with other immunosuppressant drugs to reduce graft rejection in organ transplantation by suppressing the immune system. Because of its narrow therapeutic window, it is critical to accurately monitor blood concentrations of this drug for optimal efficacy.

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19:28

Novel Uses for Platelet Function Testing in the...

Clinical Chemistry Podcast ·

2014/04/21

Platelet function testing has traditionally been used to diagnose inherited qualitative and quantitative defects in platelet function, such as Von Willebrand disease, but with the increased use of anti-platelet agents to prevent arterial thrombosis and the interest in identifying patients at risk for thrombosis despite anti-platelet therapy, the use of platelet function testing to monitory response to anti-platelet therapy, for example, aspirin, has become a hot topic.

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11:07

Publication and Reporting of Test Accuracy Studies...

Clinical Chemistry Podcast ·

2014/04/14

Over the past several years, investigations have shown that many clinical studies remain unpublished and even among published studies the results are often presented selectively.

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08:36

Screening Method to Evaluate Point-of-Care Human...

Clinical Chemistry Podcast ·

2014/04/07

Pregnancy tests such as the ones used to test urine in hospitals have been shown to give false-negative results in certain patients.

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11:58

Influence of PCR Reagents on DNA Polymerase Extension...

Clinical Chemistry Podcast ·

2014/04/02

In the February 2014 issue of Clinical Chemistry, the influence of PCR reagents on DNA polymerase extension rates were studied by examining nucleotide incorporation with DNA dyes. We are joined by one of the authors of that study, Dr. Carl Wittwer. He is Professor of Pathology at the University of Utah Health Sciences Center and is also affiliated with ARUP Laboratories, BioFire Diagnostics, and is an Associate Editor of Clinical Chemistry.

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09:35

FullIssueSummary April2014

Clinical Chemistry Podcast ·

2014/04/01

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06:45

Islet autoantibodies and type 1 diabetes: does the evide...

Clinical Chemistry Podcast ·

2014/03/24

Type 1 diabetes is a chronic progressive autoimmune disorder with complex, polygenic susceptibility. Environmental factors which are poorly defined also contribute to the pathogenesis. This disease is characterized by lymphocyte infiltration into the islets of Langerhans in the pancreas, leading to inflammation and selective destruction of the insulin-producing beta cells resulting in hyperglycemia.

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17:28

Digital PCR as a Novel Technology and Its Potential...

Clinical Chemistry Podcast ·

2014/03/17

The latest incarnation of polymerase chain reaction, Digital PCR, takes three decades of development in enzyme chemistry and assay design and applies them with formidable precision and sensitivity.

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17:07

Diagnosis of Gestational Diabetes Mellitus: it is...

Clinical Chemistry Podcast ·

2014/03/10

Hemoglobin A1C is one of the analytes most commonly measured in clinical laboratories in patients with diabetes mellitus. Physicians use Hemoglobin A1C to monitor long-term glycemic control, adjust therapy, and predict complications of diabetes. It was recently added as a criterion for diagnosis of diabetes.

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13:23

Invention and Validation of an Automated Camera...

Clinical Chemistry Podcast ·

2014/03/06

Although standardization of barcodes and label formats has lowered the number of mislabeled specimens in clinical laboratories, it remains a potential source of pre-analytical error. Published error rates of mislabeled specimens range up to as high as just over 1 percent.

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07:17

FullIssueSummary May2014

Clinical Chemistry Podcast ·

2014/03/01

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11:16

FullIssueSummary March2014

Clinical Chemistry Podcast ·

2014/03/01

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15:54

Diagnosis of Gestational Diabetes Mellitus: It Is...

Clinical Chemistry Podcast ·

2014/02/25

Gestational diabetes mellitus is often defined as any degree of glucose intolerance during pregnancy. Fetal complications and adverse outcomes for both the fetus and the mother are important concerns in gestational diabetes.

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14:07

Genomic Test Validation for Incidental Findings

Clinical Chemistry Podcast ·

2014/02/18

Acute kidney injury is an important health problem. Patients who develop acute kidney injury have increased in-hospital mortality, and if they do survive, they still suffer long-term increased morbidity and mortality. For that reason there has been great interest in the development of biomarkers that could identify kidney injury in its earliest stages, at a time when interventions might be more successful.

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08:35

Biomarkers for Acute Kidney Injury: Where Are We...

Clinical Chemistry Podcast ·

2014/02/18

Acute kidney injury is an important health problem. Patients who develop acute kidney injury have increased in-hospital mortality, and if they do survive, they still suffer long-term increased morbidity and mortality. For that reason there has been great interest in the development of biomarkers that could identify kidney injury in its earliest stages, at a time when interventions might be more successful.

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07:32

As if Biomarker Discovery wasnt Hard Enough

Clinical Chemistry Podcast ·

2014/02/04

The discovery phase of proteomics is essential for the identification of suitable markers for exploration and validation of promising new clinical tests. But can researchers be certain if what they believe they are measuring is in fact what they are actually measuring?

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09:48

FullIssueSummary February2014

Clinical Chemistry Podcast ·

2014/02/01

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11:29

The Ethical Implications of Preimplantation Genetic...

Clinical Chemistry Podcast ·

2014/01/03

The development of in vitro fertilization in the 1970s has revolutionized the treatment of infertility. The ability to culture embryos has allowed for the development of the preimplantation genetic diagnosis. This involves removing a cell from the developing embryos for genetic testing before choosing one to implant. Just like prenatal diagnosis, it is used to screen for various genetic diseases before birth. For women of advanced maternal age or couples with known genetic mutations, the ability to

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1,086 results

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