In today’s show, Theral is joined by Chris Petersen, Chief Technology Officer at Scientist.com, a company sometimes called the "Amazon for science"—though with a great deal more complexity. Chris pulls back the curtain on how AI is transforming the research services marketplace and offers a rare look into how AI is already reshaping the infrastructure of pharma and biotech.Calling this the "tinkering phase" of AI, Chris likens the current moment to the early days of the web—when best practices were

In today’s program, we continue our series on disease subtyping with Dr. Jeffery Klco, a pediatric pathologist and researcher at St. Jude Children’s Research Hospital. Dr. Klco joins us to discuss groundbreaking work recently published in Nature Genetics, which redefines the genomic landscape of childhood acute myeloid leukemia (AML).Klco and his team have identified twelve novel molecular subtypes of pediatric AML—some driven by genetic alterations that had long gone undetected by standard

In this episode, we're talking about a strange phenomenon where the immune systemseems to intentionally shuttle certain microbes from the gut to lymph nodes and the spleen.

Dr. Aaron Viny, oncologist and researcher at Columbia University, begins today’s conversation with a personal milestone—he’s now been leukemia-free for 21 years. This experience gives his work on cancer a powerful human dimension that comes through in his interview with Theral today—not only in his dedication to patient care, but in his boundary-pushing research on the epigenetic roots of cancer.Dr. Viny’s research focuses on the epigenetic architecture of hematologic malignancies, exploring how

Ūdens aprites cikls ir viens no ķēdes posmiem, kas ietekmē un faktiski rada laikapstākļus. Redzamākais šī aprites posms, protams, ir lietus, kuru šovasar esam redzējuši vairāk nekā gribētos. Bet neredzamā daļa ir mitrums gaisā - ar aci nesaskatāms, bet ļoti nozīmīgs. Cilvēki bieži nemaz nesaprot, ka to sajūt, un nezina, kādu ietekmi tas atstāj uz mūsu pašsajūtu, veselību. Skaidrojam, kā gaiss mijiedarbojas ar ūdeni. Ja to saprot un patur prātā, daudzas lietas top skaidras un ir daudz vieglāk

We’re happy to welcome back Ben Busby, Principal Scientist at DNAnexus, to dive deeper into the evolving world of disease subtyping and multi-omic data sets. Building on our previous conversation with Busby about the genomic data ecosystem, we explore the shift from single-cause disease models to multifaceted approaches that incorporate genomics, proteomics, imaging, and more."We’re no longer in a world where we’re doing genomics or imaging or proteomics," he explains. "These things are all coming

本期《老板请坐》聚焦创业者和运营者的真实困境：为什么客户反馈不错，自己却总觉得比同行 “弱一截”？为什么用 3 个月、6 个月的标准流程套项目，结果往往 “死得快”？为什么明明做了很多赛道、拿过结果，却始终找不到核心竞争力？对话中，我们拆解了创业中最容易被忽视的 “隐形杀手”—— 自我效能不足（即 “心力资本” 匮乏）：从 “一跟同行比就觉得优势蒸发” 的自我怀疑，到 “只盯 KPI、忽视过程价值” 的焦虑循环；从 “靠量迭代陷入内卷” 的困局，到 “找不到愿力、方向迷茫” 的挣扎。 我们聊透了如何跳出 “标准化陷阱”，如何在过程中积累心理资本，以及为什么 “愿力” 比技术、资源更能决定项目的生死。无论你是正在硬扛的老板，还是陪跑项目的运营者，都能在这里找到共鸣：原来那些 “做得还行却依然不安” 的时刻，都是突破自我的起点。 01:00 警惕 “标准周期” 陷阱：3 个月、6 个月的止损逻辑若忽视行业特性，容易导致项目 “被杀死”，需结合行业特性灵活调整监测指标。 09:00

Join the hosts of EAST: In the Arena and Careercast in this special Combocast! as they talk with Dr. Alison Wilson, Chief of Trauma and Acute Care Surgery at West Virginia University, about how she is leveraging the resources and expertise in trauma and critical care at her home shop to empower local and regional hospitals to care for their communities. EAST In The Arena - https://www.east.org/education-resources/inthearena EAST Careercasts - https://www.east.org/career-development/care...

John Cumbers, founder of SynBioBeta, joins Theral for our annual look ahead at the field of synthetic biology and the upcoming SynBioBeta 2025 conference, happening May 6–9 in San Jose. It's obviously a big year for AI, and synthetic biology is no exception. As John puts it, “Biology and AI coming together represents a huge opportunity for us to be able to understand biology and then ultimately engineer biology.” This year’s conference features a strong emphasis on AI's role in scaling and

Today Theral is joined by returning guests Chris Mason of Weill Cornell Medicine and Simon Fredriksson, CEO of Pixelgen Technologies, for a deep dive into the emerging field of cell surface proteomics and its power to illuminate both space biology and cancer research.Chris Mason shares new insights from his work on the Space Omics and Medical Atlas (SOMA), the largest collection of astronaut health data to date. His latest findings confirm that space is more than a hostile environment—it’s a

We're back with part 2 of our interview with Dr. Eleanor Janega to discuss Demons in Medieval Europe - and a lot of that has to do with sexy sex.  So… another EXPLICIT tag! Eleanor's Blog Going-MedievalEleanor's book The Once and Future SexThe Apocalypse Tapestry of Angers (The Guardian)The Apocalypse Tapestry (Wikipedia)YouTube videos with Eleanor Monty Summers translation of the Malleus Maleficarum  (AMZ affiliate link)Become a supporter of this podcast:

In this episode, we're talking about the OAS-RNaseL virus-sensing pathway,and the passage of its product, 2,5-oligoadenylate, through gap junctions.

In our last episode, we explored the growing shift from genomics to multi-omics. But for Pacific Biosciences CEO Christian Henry, the foundation of discovery remains clear: “DNA is still where it’s at.” PacBio is doubling down on long-read sequencing, committed to delivering on its promise of accuracy and completeness.2024 marks a “watershed year” for PacBio, with the launch of the Vega system—a benchtop long-read sequencer at an unprecedented $169,000 price point—alongside major advancements in

业失败后重回职场，但内心那颗躁动的心从未平息？明明有专业能力、有技术，却在市场上总感觉「差那么一点」？是自我认知不清、能力不足，还是市场定位偏差？本期播客，我们邀请到资深商业性格心理学专家，与两位有过创业经历的实践者展开深度对话，直击创业者的核心痛点： 01:00 「准备中」陷阱：为什么总在准备资源、能力、风口，却迟迟不敢/不能真正开始？完美主义背后的恐惧是什么？ 04:00 「核心竞争力」迷思：能力≠优势≠天赋！如何区分？为什么「什么都懂点」反而让人找不到方向？你的「非标」特质在哪里？ 24:00 「心力成本」与「不配得感」：不敢开始、害怕失败、担心面子…这些阻碍行动的心理根源是什么？ 37:00 创业三要素匹配：专家提出关键模型——自我认知、项目特性、价值观匹配。三者如何共振才能避免「努力白费」？ 49:00 向内探索是起点：商业的本质是人。不了解自己（天赋、性格、热爱、能量来源），如何定位项目、服务客户？创业是你性格的自然延伸。 01:00:01 实操方法论：每日「自我觉察三问」复盘法（开心/成就/懊恼+能量状态），如何帮你精准定位？为什么「嫌弃」你的人可能藏着你的天赋密码？

#228: Veterinary behaviorists are called "psychiatrists" in France, where Dr Claude Beata is one of a very small number of these doctors who are helping treat emotional issues in pets, including the use of psycho-pharmaceuticals.

How does "rewilding" mice change their immune system? Also, an interview with an organizer of the Atlanta Stand Up for Science march!

Ja mēs pret sienu mestu trīs bumbas, tās, visticamāk, atsistos un katra aizripotu uz savu pusi, bet daļiņu fizikā pastāv kolektīvisms un elektroni pārvietojas saskaņoti. Kāpēc?Kolektīvi elektroni kaudzītēs. Zem šāda īpatnēja vārdu salikuma slēpjas svaigs Latvijas Universitātes fiziķu un matemātiķu atklājums kopā ar kolēģiem no Nēla Universitātes Francijā, kuri ar eksperimentu un jaunu universālu matemātisko metodi izpētījuši elektronu uzvedību un noskaidroja, cik elektroni ir nepieciešami, lai tie

Latvijas četras sezonas sniedz lielu laikapstākļu daudzveidību un dažādību, kur no saules pielietas tveices vasarā nonākam līdz tumšiem aukstiem ziemas mēnešiem. Un vēl pa vidu tik dažādas dabas norises varam redzēt! Vējam, lietum, sniegam un citām dabas parādībām latviešu valodā ir daudz apzīmējumu un apvidvārdu. Ko tie stāsta par vietu, kurā dzīvojam un kā valodas dažādība stāsta par mūsu klimata daudzveidību? Kāpēc cilvēki jau izsenis cenšas izskaidrot dabas norises un laikapstākļus un saista tos

Kad mazs bērns savā likstā vaino kādu citu, pārlieku asi reaģē stresa situācijā vai ir centrēts uz sevi un savām vēlmēm - to mēs itin viegli saprotam un skaidrojam ar vecuma īpatnībām, bet, ko darīt, ja šādas reakcijas rada pieaugušais? Pasē pilngadību sasniedzam līdz ar 18. dzimšanas dienu, bet, kad par pieaugušo ir uzskatāms cilvēks no bioloģijas skatu punkta? Vai cilvēka smadzenēs emocionālais briedums tiek sasniegts līdz ar kādu gada skaitli, bioķīmisku procesu vai smagu iekšēju darbu ar savām

This month Stuart talks to Dr Craig Lyons about his recent article on Jet Ventilation. Related Article.