Someone made an AI-based "virtual lab" to engineer nanobodies -is this a paradigm shift in how we do science, or a transpararent and cynical effort to slurp up all of the citations for being first? Por que no los dos?

Welches Organ ist meine Schwachstelle? Wie jung ist mein Körper? Wie können wir gesund alt werden? Das biologische Alter beschäftigt uns je länger, je mehr. Genau da setzt der Schweizer Forscher Tony Wyss Coray an. Er kann mit einem neuen Verfahren das Alter der einzelnen Organe feststellen.Der Bluttest Als erste Person in der Schweiz macht Tobias Müller einen Test, welcher das Alter seiner Organe bestimmt. Dabei wird untersucht, welche organspezifischen Proteine im Blut aktiv sind und welche

In this special tribute episode, Mendelspod honors the life and legacy of Dr. Atul Butte (1969-2025), a towering figure in big data and precision medicine who passed away earlier this year. Atul was more than a pioneer in translational bioinformatics—he was a mentor, a builder, and a boundless source of ideas. He sought to “lift all boats in the harbor.”Joining the conversation are three scientists who worked closely with him and continue to carry forward his vision:* Dr. Marina Sirota, UCSF

Planētas, zvaigznes, galaktikas un asteroīdi - kā dažādi debess ķermeņi tiek pie saviem nosaukumiem? Kāpēc dažus rotā garas ciparu un burtu rindas, bet citi dēvēti mītiskos tēlos? Atbildes meklēsim kopā ar Latvijas Universitātes Eksakto un tehnoloģijas fakultātes Astronomijas institūta pētnieku Ilgoni Vilku un Latvijas Astronomijas biedrības pārstāvi Mārtiņu Gillu.

Studijā Toms Bricis ar stāstiem par Atlantijas okeāna viesuļvētrām, par rudens sezonas laikapstākļu aktualitātēm un arī kāds patīkams dārza stāsts.

In this podcast, Pooja Shah speaks to Jun Hiu and Caroline Larkin about the management of intracranial aneurysms, drawing on key insights from the August 2025 article in BJA Education. The discussion explores management techniques, perioperative considerations, and anaesthetic strategies in both elective and emergency settings. With a focus on multidisciplinary collaboration and evidence-based practice, this episode offers a comprehensive overview for anaesthetists involved in the care of pat...

Bacteria have immune systems? Even adaptive immune systems? And autoimmunity?Well... sort of

In this episode of Mendelspod, we’re joined by Raju Rayavarapu, bioinformatician at DNAnexus and former FDA data specialist, to discuss how regulatory science is adapting to the age of AI, big data, and cloud platforms.* 0:00 How has AI changed regulatory informatics?* 4:15 KISS* 12:50 On standards* 25:00 So nothing new about AI? The juicy question of the interview* 32:45 Raju’s life: good days and bad nightsDespite the buzz around AI, Raju insists the fundamentals haven’t changed much. “It still

Ūdens aprites cikls ir viens no ķēdes posmiem, kas ietekmē un faktiski rada laikapstākļus. Redzamākais šī aprites posms, protams, ir lietus, kuru šovasar esam redzējuši vairāk nekā gribētos. Bet neredzamā daļa ir mitrums gaisā - ar aci nesaskatāms, bet ļoti nozīmīgs. Cilvēki bieži nemaz nesaprot, ka to sajūt, un nezina, kādu ietekmi tas atstāj uz mūsu pašsajūtu, veselību. Skaidrojam, kā gaiss mijiedarbojas ar ūdeni. Ja to saprot un patur prātā, daudzas lietas top skaidras un ir daudz vieglāk

Illumina’s new interpretation software, Illumina Connected Insights, signals a turning point in oncology genomics—where sequencing power meets end-to-end clinical utility. On this episode of Mendelspod, host Theral Timpson sits down with Jing Gao, VP of Software Engineering at Illumina, to explore how the company is extending its leadership from sequencers to software.“We’ve moved from offering modular tools to building full-stack solutions,” Jing explains. “Connected Insights is about taking raw

This month Alex speaks to Dr Alex James about the recent two articles on anaesthesia for pancreatic resection surgery Anaesthesia for pancreatic resection surgery: part 1 Anaesthesia for pancreatic resection surgery: part 2

本期《老板请坐》聚焦创业者和运营者的真实困境：为什么客户反馈不错，自己却总觉得比同行 “弱一截”？为什么用 3 个月、6 个月的标准流程套项目，结果往往 “死得快”？为什么明明做了很多赛道、拿过结果，却始终找不到核心竞争力？对话中，我们拆解了创业中最容易被忽视的 “隐形杀手”—— 自我效能不足（即 “心力资本” 匮乏）：从 “一跟同行比就觉得优势蒸发” 的自我怀疑，到 “只盯 KPI、忽视过程价值” 的焦虑循环；从 “靠量迭代陷入内卷” 的困局，到 “找不到愿力、方向迷茫” 的挣扎。 我们聊透了如何跳出 “标准化陷阱”，如何在过程中积累心理资本，以及为什么 “愿力” 比技术、资源更能决定项目的生死。无论你是正在硬扛的老板，还是陪跑项目的运营者，都能在这里找到共鸣：原来那些 “做得还行却依然不安” 的时刻，都是突破自我的起点。 01:00 警惕 “标准周期” 陷阱：3 个月、6 个月的止损逻辑若忽视行业特性，容易导致项目 “被杀死”，需结合行业特性灵活调整监测指标。 09:00

In this episode of Mendelspod, Theral welcomes Dr. Rita Shaknovich, Chief Medical Officer in Agilent’s Life Sciences and Diagnostics group, for a high-level and deeply insightful look at where liquid biopsy technology stands today.With her background in hematopathology and molecular diagnostics, Rita brings clarity to a field that has long promised transformation—and is now delivering. “It’s not the future anymore. It’s actually here,” she says. Liquid biopsy has moved beyond the buzzword phase and

#261: The feline veterinarian whose name is on the bag of America's favorite litter talks about removing all scents from his litters because of the harm they do cats — and Tracie explains why Dr. Elsey's CleanProtein is the only dry cat food she can recommend.

Matt and Kevin discuss a new paper about the "subfornical organ"which (once again) undermines the idea of immune privilage, and also points to an interesting evolutionary question: why would T-cells migrating from fat to the brain affect hunger response?

In this episode of Mendelspod, Theral speaks with Frédéric Debode, Scientific Director at CRA-W in Wallonia, Belgium, about the evolving landscape of GMO detection in the age of gene editing. From early work in real-time PCR to the latest in next-gen sequencing and target enrichment, Debode has been on the front lines of tracking genetically modified organisms—often when the modifications leave almost no trace.What’s at stake? In Europe, labeling GMOs is not just a policy—it’s the law. Debode

#259: Travel writer and cat lover Jeff Bogle talks about his book “Street Cats & Where to Find Them: the Most Feline-Friendly Cities and Attractions Around the World,” which could serve as a road map for anyone wanting to give a feline theme to their travel planning.

业失败后重回职场，但内心那颗躁动的心从未平息？明明有专业能力、有技术，却在市场上总感觉「差那么一点」？是自我认知不清、能力不足，还是市场定位偏差？本期播客，我们邀请到资深商业性格心理学专家，与两位有过创业经历的实践者展开深度对话，直击创业者的核心痛点： 01:00 「准备中」陷阱：为什么总在准备资源、能力、风口，却迟迟不敢/不能真正开始？完美主义背后的恐惧是什么？ 04:00 「核心竞争力」迷思：能力≠优势≠天赋！如何区分？为什么「什么都懂点」反而让人找不到方向？你的「非标」特质在哪里？ 24:00 「心力成本」与「不配得感」：不敢开始、害怕失败、担心面子…这些阻碍行动的心理根源是什么？ 37:00 创业三要素匹配：专家提出关键模型——自我认知、项目特性、价值观匹配。三者如何共振才能避免「努力白费」？ 49:00 向内探索是起点：商业的本质是人。不了解自己（天赋、性格、热爱、能量来源），如何定位项目、服务客户？创业是你性格的自然延伸。 01:00:01 实操方法论：每日「自我觉察三问」复盘法（开心/成就/懊恼+能量状态），如何帮你精准定位？为什么「嫌弃」你的人可能藏着你的天赋密码？

“We’re going to be rewriting the textbooks on how tissues work.”In this compelling reunion with spatial biology pioneer Joe Beechem and a first-time visit from Oliver Braubach, we explore the rapid evolution of spatial technologies at Bruker, a legacy instrumentation company newly resurgent in the spatial space. Following Bruker’s acquisition of Nanostring and Canopy, the company has emerged as a unifying platform where whole-transcriptome discovery meets translational assay development—under one

Ja mēs pret sienu mestu trīs bumbas, tās, visticamāk, atsistos un katra aizripotu uz savu pusi, bet daļiņu fizikā pastāv kolektīvisms un elektroni pārvietojas saskaņoti. Kāpēc?Kolektīvi elektroni kaudzītēs. Zem šāda īpatnēja vārdu salikuma slēpjas svaigs Latvijas Universitātes fiziķu un matemātiķu atklājums kopā ar kolēģiem no Nēla Universitātes Francijā, kuri ar eksperimentu un jaunu universālu matemātisko metodi izpētījuši elektronu uzvedību un noskaidroja, cik elektroni ir nepieciešami, lai tie