This episode explores how different cultures around the world understand and interpret dreams. While modern science views dreams as brain activity, many ancient and traditional societies see them as messages from gods, ancestors, or spiritual realms.Aboriginal Australians connect dreams to Dreamtime, a sacred realm of creation. Native American tribes treat dreams as guides, using symbols like dreamcatchers for protection. African cultures such as the Zulu view dreams as communication from

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Trends in pharmacological sciences》(IF:13.9)上的重要综述"Reprogramming SUMO-primed ubiquitylation: opportunities in oncology and neurology"。该研究探讨了靶向细胞泛素-蛋白酶体系统的新型药物开发策略，聚焦于SUMO靶向泛素连接酶(StUbLs)系统在疾病治疗中的应用。研究发现，通过SUMO化-泛素级联反应可有效失活致癌融合蛋白，如抗癌药物三氧化二砷和氟维司群所展示的机制。更有前景的是，proximity-inducing技术可将易聚集蛋白招募至StUbL系统，有望减轻神经毒性包涵物形成。这项研究为肿瘤学和神经退行性疾病的治疗开辟了新途径，展示了重新编程SUMO-StUbL信号的巨大临床潜力。

Psicología de educativa

★毎週土曜日、夜10：30に配信！ ★ 「#ドリームハート 」の番外編番組 「#茂木健一郎のポジティブ脳教室 」 ここでは リスナーの皆様から寄せられたお悩みやご質問に 茂木健一郎さんが #脳科学 的にお答えし「ポジティブな考え方」を伝授していきます！ 今夜は 山口県の「ラジオネーム けんちゃん」さんからのメッセージ。 =========================================== 茂木さん こんばんは。 自分は情報を集めるのが 好きですが 集めすぎて 以前はパニックになっていました。 今は 大分うまくなりましたが たまに 疲れ果てます。 これも経験を積み重ねないと 駄目なんですかね？ 忌憚ないアドバイス、宜しくお願いいたします。 =========================================== 今週は こちらのご質問にお答えしていきます。 茂木さんに聞いて欲しい疑問・質問、お悩みやご相談など… 全てのメッセージは 毎週土曜日の夜10時から 全国38局で放送している 【#DreamHeart

The third Connecticut Genetic Counselors' Association (CTGCA) Annual Educational Conference was held last Friday (September 25th, 2025) at the gorgeous Jackson Laboratory for Genomic Medicine in Farmington, Connecticut. Our host Kira Dineen resides in Connecticut and has been lucky enough to present every year. This time moderating a panel about the economics of genetic counseling, which is now shared as this podcast episode. This panel conversation explores the economics of genetic

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在影响因子高达21.7的《Journal of the American College of Cardiology》上的重要论文"Fibrinolytic Therapy for Thromboembolic Diseases: Approved Indications and Future Directions"。这项全面综述探讨了纤维蛋白溶解疗法在血栓栓塞性疾病中的应用历程与未来发展。研究详细介绍了从1933年链激酶发现至今，各种纤维蛋白溶解剂的演变，包括阿替普酶及其改良型替奈普酶和瑞替普酶。文章重点分析了这些药物在ST段抬高型心肌梗死、急性缺血性卒中、肺栓塞等疾病中的治疗价值，同时强调了出血风险的平衡。研究还探讨了导管导向纤维蛋白溶解在中低风险血栓疾病中的应用前景，为临床医生提供了宝贵的治疗参考。

This week’s tHEORetically Speaking News Roundup covers nirsevimab’s real-world success in reducing RSV hospitalizations among infants, Boehringer Ingelheim’s FDA approval of Jascayd for idiopathic pulmonary fibrosis, and Arthrosi Therapeutics’ $153 million raise to advance a next-generation gout drug. We also highlight this year’s Nobel Prize in Medicine, honoring discoveries in immune tolerance that continue to shape today’s biggest breakthroughs. Tune in for this concise recap of these pivo...

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注最新研究"Artificial Intelligence and Novel Trial Designs for Acute Ischemic Stroke: Opportunities and Challenges"，发表于Stroke期刊(影响因子7.8)。这项重要研讨探讨了AI和创新试验设计在急性缺血性卒中治疗中的潜力与挑战。研究发现，AI已在卒中影像中发挥关键作用，未来将在临床护理和研究试验中产生更大影响。研究强调"人类在回路"的重要性，以及平台试验和务实、以患者为中心的设计如何加速新疗法开发。这些工具有望彻底改变卒中临床试验，但需充分理解其优势和局限性，以推动更有效的卒中治疗策略。

Introduction to the Amoeba After Dark podcast

In today’s Pharmaceutical Executive Daily, we cover Bristol Myers Squibb’s $1.5 billion acquisition of Orbital Therapeutics, ongoing legal and market implications of the Most Favored Nation drug pricing proposal, and the FDA’s approval of Libtayo as an adjuvant therapy for cutaneous squamous cell carcinoma.

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们关注发表在《Stroke》(IF:7.8)上的重要研究"Artificial Intelligence and Novel Trial Designs for Acute Ischemic Stroke: Opportunities and Challenges"。这项由卒中治疗学术产业圆桌会议组织的研究探讨了AI和创新临床试验设计在急性卒中领域的应用前景与挑战。研究发现，AI在影像学治疗中已发挥重要作用，未来几年将在临床护理和临床试验中产生更大影响。研究强调，高质量训练数据和"人工循环"元素对AI成功至关重要。同时，平台试验通过共享对照提高效率，而务实和以患者为中心的试验设计将加速新疗法的开发。这些创新工具有望彻底改变卒中治疗的未来！

In today’s Pharmaceutical Executive Daily, we cover the FDA’s approval of Johnson & Johnson’s Simponi for pediatric ulcerative colitis, why DSCSA compliance is only the beginning of pharma supply chain modernization, and the agency’s approval of Jascayd for idiopathic pulmonary fibrosis.

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们关注发表在《Annals of neurology》(影响因子8.1)上的重要研究"Skeletal Muscle Biomarkers of Amyotrophic Lateral Sclerosis: A Large-Scale, Multi-Cohort Proteomic Study"。这项突破性研究通过大规模蛋白质组学分析，在ALS患者血浆中鉴定出329种显著差异表达的蛋白质，其中PDLIM3、TNNT2和MYL11大幅升高，而ANTXR2和ART3显著降低。更令人振奋的是，这些生物标志物不仅可用于ALS诊断，还能反映疾病进展，并有望成为评估治疗效果的重要工具。研究首次证实了肌肉作为ALS生物标志物的主要来源，为开发新型治疗策略提供了关键方向。

Send us a text Compounding Pharmacies – are you prepared for increased scrutiny? With select grace periods now behind us, FDA's focus has shifted to active enforcement. Inspections and warning letters are becoming more frequent as FDA hones in on compliance with both agency registration requirements and USP compounding standards. Today's Quality Grind Short will help you strengthen your operations, stay inspection-ready, and protect both your patients and your business. At Medvacon, our exper...

Andres Leschziner presents his paper "Structure of LRRK1 and mechanisms of autoinhibition and activation". Reimer, J. M. et al., Nat. Struct. Mol. Biol. 30, 1735–1745 (2023).