In today’s Pharmaceutical Executive Daily, we cover the White House’s push for a Most Favored Nation drug pricing model, the FDA’s approval of Eli Lilly’s Inluriyo for ESR1-mutated metastatic breast cancer, and President Trump’s call for steep tariffs on branded pharmaceuticals

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Journal of the American Academy of Dermatology》(IF:12.8)上的重要研究"Impact of Immunosuppression on Cutaneous Squamous Cell Carcinoma Outcomes"。这项涉及11,930名患者的国际多中心研究发现，免疫抑制不仅是皮肤鳞状细胞癌的危险因素，更是独立预测不良预后的关键指标。免疫抑制患者表现出更高风险肿瘤特征和更差疾病结局，包括局部复发、远处转移和疾病特异性死亡。研究特别指出，器官移植和慢性淋巴细胞白血病患者面临不同风险模式。这一发现为临床风险评估提供了重要依据，建议将免疫抑制状态纳入皮肤鳞状细胞癌的风险预测模型，以指导个体化治疗和随访策略。

Moving from bright summer days, to crisper fall days, from deep greens into oranges and reds in fall. This is a turbulent period of transition, restlessness, and melancholia: fall.Lots of us feel restless, more anxious, up in their heads a lot. September is a typical month where everyone goes back to school. Childhood memories of our returning to school appear, making us anxious and unconsciously competitive. If you have children of your own; you might get triggered by them, reenact, and relive

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们要关注发表在《Nature Genetics》(影响因子31.7)上的重要论文"Advancing biological understanding of cellular senescence with computational multiomics"。这项研究深入探讨了细胞衰老这一复杂生物学过程，为理解和治疗衰老及相关疾病提供了新视角。研究团队全面概述了多组学方法在表征细胞衰老方面的应用，讨论了各种技术的能力与挑战，并提供了识别和空间定位衰老细胞的实用指南。这项突破性工作强调了计算分析在理解衰老细胞与微环境相互作用中的关键作用，为未来开发针对性抗衰老疗法奠定了重要基础。

Send us a text The FDA is cracking down — hard — on misleading drug advertising across TV, social media, and digital platforms. Why? Too many ads are pushing benefits while burying risks — or skipping fair balance entirely. Influencer campaigns, compounded drug promos, and telehealth ads are under the microscope. As a result, we’ve seen hundreds of warning letters and cease-and-desist letters having already been issued. In this Quality Grind Short, Mike talks about ways to prevent your produc...

In today’s Pharmaceutical Executive Daily, we cover Glenmark’s billion-dollar exclusive licensing deal with Hengrui, Harmony Biosciences’ trial setback for Zygel, and the CDC’s unanimous vote to broaden COVID-19 vaccine recommendations.

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们要介绍的是发表在《Trends in molecular medicine》(影响因子12.8)上的重要论文《AAV vectors: an emerging strategy for chronic pain management.》。这项研究系统总结了腺相关病毒(AAV)载体作为慢性疼痛管理基因治疗工具的前沿进展。全球有数百万人受慢性疼痛困扰，已成为重要的公共健康问题。研究表明，AAV载体通过靶向神经元和非神经元细胞中的分子疼痛通路，能够提供精确且持久的疼痛缓解。研究团队概述了神经病理性、炎症性和癌症相关疼痛的临床前创新，并提供了骨关节炎患者中AAV疼痛调节的临床数据。同时，论文全面分析了AAV治疗的关键问题，包括潜在免疫反应、毒性和不良反应。这项研究为慢性疼痛治疗开辟了新方向，可能改变未来疼痛管理的方式。

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们关注一项发表在影响因子高达9.3的《Acta neuropathologica》上的重要研究，题为"Differences and overlaps in TDP-43 pathology of 'pure' LATE-NC compared to LATE-NC coexisting with Alzheimer's disease."。研究发现，单纯的边缘优势型年龄相关TDP-43脑病与阿尔茨海默病共存的病例在病理特征上存在显著差异。纯LATE-NC患者年龄更大，认知障碍较轻，海马体中主要呈现网状神经突TDP-43模式，而与AD共存的病例中这种模式较少见。这些发现对理解痴呆的病理基础和开发针对性治疗具有重要意义，可能影响未来临床试验的设计方向。

In today’s Pharmaceutical Executive Daily, we cover the market reaction to Trump’s Tylenol–autism claim, the FDA’s complete response letter to Scholar Rock for its spinal muscular atrophy treatment, and a closer look at the state of evidence linking Tylenol use and autism risk.

In one of the largest recent Medicare fraud cases, Peter Roussonicolos, a Florida durable medical equipment (DME) company owner, was sentenced to 12 years in federal prison for orchestrating a scheme that defrauded Medicare of more than $61 million. Here’s how the scheme worked: Hidden Ownership: Roussonicolos used straw owners to disguise his true role in several DME companies, evading disclosure requirements and regulatory oversight. Illegal Kickbacks: He arranged payments to marketers and...

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。 本期关注发表在《Pharmacological research》(IF: 9.1)上的重要研究《The potential of CDK4/6 inhibitors in advancing the treatment of cutaneous melanoma》。这项研究揭示了CDK4/6抑制剂在皮肤黑色素瘤治疗中的巨大潜力。研究指出，CDK4/6抑制剂不仅能诱导肿瘤衰老，还能调节肿瘤微环境并增强免疫反应。尤其重要的是，这些药物与现有疗法（如MAPK抑制剂和免疫检查点抑制剂）联合使用，可能有效克服治疗抵抗，提高治疗效果，为晚期黑色素瘤患者提供新的治疗策略。这一发现为黑色素瘤治疗开辟了新方向，有望改善患者预后。

Quando uma família recebe a notícia de que uma criança pode estar com câncer, cada dia de espera por um diagnóstico parece uma eternidade. Este episódio traz reflexões sobre o câncer infantil, cuidado, esperança e como ciência e saúde pública podem caminhar juntas.Conversamos com Carol, gerente de Oncologia Pediátrica do Instituto Desiderata, sobre o primeiro Fórum de Oncologia Pediátrica, organizado em Brasília com apoio do Inca e da Opas. O encontro busca sensibilizar gestores para que priorizem

【科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载】本期关注发表在Clinical Psychology Review (IF: 13.7)的重要研究"The association between subjective and objective cognitive functioning from a transdiagnostic perspective: An umbrella review and meta-analysis"。这项伞状综述分析了50篇综述，涵盖20多种神经精神疾病，发现主观和客观认知之间的关系极不一致，效应量从无到弱不等。令人惊讶的是，心理健康因素如抑郁和焦虑比客观认知测试更能预测主观认知体验。研究强调，主观和客观认知 largely 是不重叠的构念，即使存在简单差异也不具诊断价值。这一发现对临床医生评估患者认知状况具有重要启示，提醒我们不应期望自我报告与测试结果完全一致。

Send us a text Hi! I am Dr. Akshata Almad, a neuroscientist with over 15 years of experience in understanding neurological diseases including Amyotrophic Lateral Sclerosis, Alzheimer's and Parkinsons disease. I received my PhD in neuroscience from the Ohio State University and have completed her post-doctoral training at Johns Hopkins University. I am currently dedicated to developing innovative therapeutics in drug discovery. In this episode, I share the personal story of my father, w...

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在Blood reviews（IF:6.9）上的重要综述"Metabolomics in sickle cell disease: Current knowledge and gaps - A scoping review"。这项范围综述揭示了代谢组学在镰状细胞病中的突破性发现，表明代谢谱分析能有效区分不同基因型和并发症患者。研究确定了与溶血、血管闭塞事件和肾病等关键临床结果相关的代谢物，涉及精氨酸、色氨酸和糖酵解等多条代谢通路。尽管取得进展，作者仍强调需要标准化的大规模代谢组学研究来填补现有知识空白，最终推动镰状细胞病的精准医疗发展。这项研究为理解疾病异质性和治疗反应提供了新视角。

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。《The association between subjective and objective cognitive functioning from a transdiagnostic perspective: An umbrella review and meta-analysis》这项发表在Clinical psychology review（IF=13.7）的重要研究发现，主观认知与客观认知之间仅存在微弱关联（r=0.14）。研究分析了50篇综述，涵盖超过20种神经精神疾病，发现抑郁和焦虑等精神健康因素与主观认知的相关性远强于客观测试结果。这一发现挑战了传统认知评估方法，提示临床医生不应期望患者自我报告的认知表现与神经心理学测试结果一致，二者反映的是认知功能的不同维度而非同一现象。这一发现对认知障碍的准确诊断具有重要意义。

In today’s Pharmaceutical Executive Daily, we cover GSK’s supplemental application to update the label for Leucovorin, the FDA’s complete response letter to Otsuka and Lundbeck’s sNDA for Rexulti, and the medical community’s response to former President Trump’s claims linking Tylenol use to autism risk.