科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在Neurosurgery(影响因子3.9)上的重要研究《Hypofractionation of Gamma Knife Radiosurgery for Intracranial Meningiomas: A Retrospective Multicenter Study and Systematic Review of Literature》。这项多中心研究评估了分割式伽马刀放射手术治疗颅内脑膜瘤的长期效果，发现低级别肿瘤5年控制率高达91.6%，而高级别肿瘤为37.9。研究还显示35%患者症状改善，分割方案(3次vs 5次)与肿瘤控制无显著差异。这一发现为临床医生提供了重要参考，证实分割式伽马刀放射手术对低级别脑膜瘤是安全有效的治疗选择，尤其适用于大型或靠近关键结构的肿瘤。

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注的是发表在《Intensive care medicine》(影响因子27.1)上的重要论文"European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2025: post-resuscitation care"。由Nolan JP教授领导的国际团队发布了最新的成人心肺复苏后护理指南，这些基于国际共识的更新涵盖了从心脏骤停后综合征管理到长期康复的全过程。指南特别强调了氧合控制、冠状动脉再灌注、血流动力学管理、体温控制以及预后评估等关键环节。这一里程碑式的更新为全球医疗专业人员提供了复苏后护理的最佳实践建议，有望显著提高心脏骤停患者的生存率和生活质量。

Under the Modernization of Cosmetics Regulation Act (MoCRA), reporting serious adverse events to the FDA is now mandatory. Companies must report serious incidents—such as hospitalizations, infections, disfigurement, or medically treated allergic reactions—within 15 business days. They must also maintain records of all adverse events for six years (or three years for small businesses). Practically, this requires setting up a system to capture and assess customer complaints, determine seriousne...

In today’s Pharmaceutical Executive Daily, we cover Novo Nordisk’s unsolicited proposal to acquire Metsera, renewed legal action against Tylenol’s manufacturer following statements from Robert F. Kennedy Jr., and AbbVie’s stronger 2025 profit outlook driven by immunology demand.

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【科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载】 欢迎收听今日医学前沿！最新发表在《Cancer treatment reviews》(影响因子9.6)上的研究"Precision oncology in gastric cancer: Shaping the future of personalized treatment"为胃癌治疗带来新希望。胃癌作为全球第三大癌症死因，因晚期诊断和高度异质性而预后极差。研究团队回顾了近年来开发的预临床模型，包括患者来源异种移植物、类器官和基因工程小鼠模型，这些工具有助于阐明疾病机制和药物测试。文章还强调了免疫疗法、抗体药物偶联物和合成致死等创新策略，有望克服当前治疗的耐药机制。这些突破性进展为胃癌患者带来了更精准、更有效的个性化治疗选择，有望显著改善临床预后。

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注一篇发表在影响因子8.1的《Annals of neurology》上的重要研究，题为"Disruption of the Blood-Brain Barrier Predicts Progression of Cerebral Small Vessel Disease White Matter Hyperintensities"。这项针对50名脑小血管病患者的突破性研究发现，血脑屏障破坏程度能准确预测白质高信号的进展。研究通过MRI成像显示，白质高信号区域及其周围半暗带的血脑屏障破坏与病变进展显著相关，每增加0.1%的破坏程度，病变进展风险就增加2倍。这一发现为早期干预和监测脑小血管病提供了重要生物标志物，可能改变临床管理策略。

In today’s Pharmaceutical Executive Daily, we cover Thermo Fisher’s $8 billion agreement to acquire Clario Holdings, Eli Lilly’s partnership with Walmart to launch retail pickup for its direct-to-consumer Zepbound program, and the FDA’s new draft guidance aimed at streamlining biosimilar development.

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们关注一项发表在《Computers in Biology and Medicine》(影响因子7.0)上的重要研究，标题为"Artificial Intelligence and radiomics models for the diagnosis and prognosis of peritoneal metastases on imaging: a systematic review and meta-analysis"。这项系统性回顾和荟萃分析评估了AI和放射组学模型在腹膜转移(PM)影像学诊断和预后中的性能。研究显示，13项研究的荟萃分析得出PM检测的综合AUC为0.84，敏感性0.75，特异性0.80。2D和3D影像数据表现相当，而将临床因素纳入模型可显著提高性能。这项发现为AI辅助癌症诊断开辟了新途径，有望改善腹膜转移患者的早期检测和个性化治疗决策。

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们关注发表在《European journal of nuclear medicine and molecular imaging》(影响因子8.6)上的重要研究《Comparing and combining TSPO-PET tracers in tauopathies》。 剑桥大学团队首次直接比较了tauopathies中常用的TSPO-PET示踪剂，发现标准化流程可有效统一不同示踪剂在神经炎症量化中的表现。在PSP患者中，[(11)C]PK11195和[(18)F]GE-180的结合模式高度相似；而在阿尔茨海默病患者中，示踪剂间可比性较弱，其中[(11)C]PK11195与[(18)F]GE-180最为接近。 这项研究为未来多中心神经炎症影像研究提供了重要标准化方法，有助于加速神经退行性疾病药物开发进程。

In today’s Pharmaceutical Executive Daily, we cover Eli Lilly’s partnership with NVIDIA to develop an AI supercomputer for drug discovery, a surge in biotech funding rounds and public offerings, and the FDA approval of Merck’s Winrevair for pulmonary arterial hypertension.

Darshan Kulkarni highlights that to stay compliant with the FDA, companies don’t need an exhaustive set of SOPs—just the essential ones. Inspectors primarily focus on SOPs covering informed consent, adverse event reporting, drug/device accountability, source documentation, PI oversight, protocol deviations, and record retention. He emphasizes keeping SOPs concise, practical, and enforceable, training staff consistently, and expanding them only as operational needs grow. Support the show

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注最新发表在《Cancer》(影响因子6.1)上的重要研究"A tour of leukemia progress in 2025, viewed through the MD Anderson leukemia research lens"。这项回顾性研究揭示了白血病治疗的革命性进展，过去20年靶向治疗彻底改变了治疗格局。从blinatumomab等抗体药物到BCR::ABL1抑制剂等小分子靶向药，不仅提高了患者生存率，还减少了对传统化疗的依赖。研究显示，更多白血病类型现被归类为"有利型"，包括慢性淋巴细胞白血病和特定急性淋巴细胞白血病亚型。然而，对于TP53突变等高风险患者群体，仍需开发更有效的治疗方案。这项进展为临床医生提供了宝贵的治疗参考，也为未来研究指明了方向。

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Ageing research reviews》(IF: 12.5)上的重要论文"From Pathogenesis to Precision Medicine: Targeting Immune Imbalance in Multiple Sclerosis"。这项研究揭示了多发性硬化症(MS)作为年轻人非创伤性残疾主要原因的严峻挑战，强调全球发病率和患病率持续上升的现状。研究指出，尽管FDA已批准改变复发型MS进程的治疗方法，但进展性疾病的治疗缺口仍是一个紧迫问题。最令人振奋的是，神经影像学、数字生物标志物与AI技术的融合，正在开创精准医疗的新时代，有望实现从常规监测向预测性和适应性护理的转变，为MS患者带来个性化治疗的新希望。

In today’s Pharmaceutical Executive Daily, we cover the resignation of Organon CEO Kevin Ali following an internal investigation tied to Nexplanon sales, GSK’s $357 million agreement with Syndivia to expand its antibody-drug conjugate portfolio, and new guidance from the American College of Surgeons classifying obesity as a treatable condition.

Get a look at the latest September/October issue of MEDSURG Nursing! For over 30 years, MEDSURG Nursing has been the trusted resource for advancing evidence-based practice, clinical research, and professional development in medical-surgical nursing.With 3.8 NCPD contact hours available, this issue is packed with opportunities to advance your practice and deliver exceptional care. Visit www.medsurgnursing.net to subscribe or access individual articles. Don’t forget to follow us on social media for