We’re back with a brand new season of Raincoast Radio! In the upcoming episodes, we’ll focus on the icon of the west coast, an essential life force that has spawned entire cultures and reminds us just how interconnected everything is: pacific salmon. Hosted by Raincoast salmon habitat biologist Auston Chhor, More than a fish plunges into questions surrounding this complex species, speaking with people from a variety of backgrounds working towards a better future for them. Whether you’re an

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Trends in immunology》(影响因子13.1)上的重要论文"Mitochondrial lipid metabolism in tumor immunosurveillance and evasion"。这项研究揭示了线粒体脂质代谢在肿瘤免疫监视和逃逸中的关键作用，探讨了线粒体如何调节肿瘤微环境中的免疫细胞代谢。研究发现，线粒体驱动的免疫反应具有抗肿瘤效果，而线粒体功能受损则会削弱免疫细胞的细胞毒性。该研究还指出，线粒体脂质代谢可能是癌症免疫治疗的一个有前景的治疗靶点，为开发新型免疫疗法提供了新思路。

Zellalterung im Weltall untersucht; Wichtige Planktonart gefährdet; Farbwahrnehmung entschlüsseltSendung vom 9. September

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们关注发表在《Cancer research》(影响因子12.5)上的重要研究"The Microbial Bile Acid Metabolite 3-oxo-LCA Inhibits Colorectal Cancer Progression"。这项突破性发现揭示了一种由肠道微生物产生的胆汁酸代谢物3-oxo-LCA能有效抑制结直肠癌进展。研究显示，3-oxo-LCA作为FXR受体激动剂，能恢复信号传导，减少癌细胞生长并促进肿瘤细胞凋亡。在小鼠模型中，它还增强了肠屏障功能，降低肿瘤负担。这一发现为开发基于肠道微生物代谢物的结直肠癌新疗法提供了重要方向，可能开辟癌症治疗的新途径。

Klimaanpassung: Gletscher als Frühwarnsystem; Klimawandel: Taranteln im VormarschSendung vom 8.9.2025

With everything going on in the world, I wanted to take a few minutes to address something that has been weighing on my heart. If anyone cares to hear my opinions on the state of the world, please listen. Thank you & much love for you all,-Shayn JonesBecome a supporter of this podcast: https://www.spreaker.com/podcast/inquiries-of-our-reality-with-shayn-jones--6312542/support.

Companhia de Desenvolvimento dos Vales do São Francisco e do Parnaíba (Codevasf) reforça  o compromisso com o fortalecimento da agricultura familiar e a geração de renda em Minas Gerais. O superintendente regional da Codevasf no Estado, Romeu Souto Filho, acompanhado do chefe da Unidade de Desenvolvimento Territorial, Alex Demier, participou de reuniões em Rio Pardo de Minas, município que se consolidou como um dos maiores polos produtores de mandioca e polvilho em território mineiro.

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们关注发表在Circulation（影响因子35.5）上的重要研究："Intensity, Duration, and Context Dependency of the Responses to Nutrient Surplus and Deprivation Signaling in the Heart: Insights Into the Complexities of Cardioprotection"。这项突破性研究揭示了心脏对营养信号反应的复杂性——同样的信号通路，在不同强度、持续时间和上下文条件下可能产生完全相反的效果。研究发现，短暂的PI3K信号可保护心脏免受急性应激，而持续激活则加速肥胖和衰老相关的病理性肥大；同样，SIRT1/AMPK通路在慢性条件下有益，却可能损害心脏对急性应激的反应。这一发现彻底改变了我们对心脏保护机制的理解，强调了精准医疗和个体化治疗的重要性，为心血管疾病的新疗法开辟了道路。

Yes, even we get hit with the "tech devil bug". we offer our apology and focus on the future!

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们要关注的是发表在《American journal of obstetrics and gynecology》(影响因子8.7)上的重要研究："Impact of exercise training during pregnancy on maternal biomarkers: A systematic review."这项系统综述分析了11项随机对照试验，发现孕期进行12周或以上的中等至高强度锻炼(每周2-3次)，能显著改善多种生物标志物。研究显示，运动可降低促炎因子TNF-α和IL-6，增加抗炎IL-10，改善血脂和葡萄糖调节，并对瘦素和BDNF等激素产生积极影响。更令人惊喜的是，运动还优化了脐带血成分、母乳免疫特性和胎盘矿物质含量。这项研究为孕期锻炼提供了科学依据，证明结合抗阻和有氧运动的方案能显著促进母婴健康。

Fierce windstorms in the Gobi Desert force scientists to think fast and run faster.Learn more about your ad choices. Visit megaphone.fm/adchoices

The Bureau of Reclamation has lowered Navajo Dam releases from 650 to 500 cfs to support endangered fish habitat along the San Juan River. Flows will remain within recovery program targets, with adjustments possible based on conditions.

Sendungshinweis: FM4 bis 1, 6.9.2025, 10 Uhr

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注一篇发表在《Comprehensive reviews in food science and food safety》(IF: 12.0)上的重要研究："Microbial Community Associations With Listeria monocytogenes in Food Processing Environments: A Systematic Review and Meta-Analysis"。这项颠覆性研究发现，李斯特菌的存活与整体微生物多样性无关，而是与特定细菌伙伴密切相关——假单胞菌、嗜冷杆菌和不动杆菌。这些能形成生物膜的细菌在冷藏温度下仍能生长，为李斯特菌创造了有利生存条件。研究结果挑战了传统认知，为食品加工环境中的李斯特菌防控提供了新思路，可能引导我们开发针对特定微生物伙伴的靶向控制策略，从而更有效地保障食品安全。

【科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载】 各位听众，今天我们关注一篇发表在影响因子8.7的《Molecular aspects of medicine》上的重要研究："Research advancements on sumoylation in gastrointestinal cancers"。这项研究揭示了SUMOylation这一关键翻译后修饰在多种胃肠道癌症中的核心作用。SUMOylation通过调节蛋白质功能，影响肿瘤细胞的迁移、侵袭和上皮间质转化，驱动胃癌、肝癌、结直肠癌等多种消化系统恶性肿瘤的生长和转移。更令人关注的是，SUMOylation还与化疗和放疗的抵抗性密切相关。这一发现不仅深化了我们对癌症分子机制的理解，更为开发针对SUMO通路的创新抗癌疗法提供了重要理论基础，有望为胃肠道癌症患者带来新的治疗希望。

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在影响因子8.7的《Molecular aspects of medicine》上的研究"Research advancements on sumoylation in gastrointestinal cancers"。这项突破性研究揭示了SUMO化修饰在胃肠道癌症中的关键作用。科学家发现SUMO化酶失调通过增强肿瘤细胞侵袭性和上皮间质转化促进癌症发生，并在胃癌、肝癌等消化道肿瘤中驱动肿瘤生长、转移和治疗抵抗。这一发现不仅深化了我们对癌症分子机制的理解，更为开发针对SUMO化通路的精准抗癌疗法提供了新方向，有望克服现有治疗中的耐药性问题。

Nagel statt Kralle: Daumen hilft Eichhörnchen beim Nüsseknacken; Braun statt blau: Algenplage in der KaribikSendung vom 5.9.2025

Os queijos finalistas do 18º Concurso Estadual dos Queijos Artesanais de Minas Gerais foram avaliados por 32 jurados, em Itanhandu, no Sul de Minas. Agora as notas serão contabilizadas e a divulgação dos vencedores vai ocorrer, no dia 13 de setembro, também em Itanhandu, município que faz parte da região produtora do Queijo Artesanal Mantiqueira de Minas.Este ano, o concurso, promovido pelo Governo de Minas por meio da Emater-MG, tem como novidade a criação da categoria Queijo Minas

Southwest Colorado and the Four Corners begin the week mostly dry with sunshine and near-normal temps. Northern mountains may see isolated showers today, with more storms possible Tuesday as a cold front moves in.

In this month's installment of Field Notes, Scott Bowe of Kemp Station discusses Ruffed Grouse – a hallmark species in the Northwoods.