Variants in genes tied to both conditions derail the formation of cilia, the tiny hair-like structure found on almost every cell in the body, a new study finds.

The findings from Charles Zuker’s lab put the taste system on the map, revealing that some fundamental principles of behavior are hardwired.

On this episode of Soundbites of the Annual Meeting, we talked to Stephen Kaminsky, PhD, professor of research in genetic medicine at Weill Cornell Medical College, and lead author of a phase 1 clinical trial of a new vaccine for cocaine addiction. In his conversation with ASGCT's Communications Committee Chair, Lynnea Olivarez, Dr. Kaminsky discusses: How the vaccine works and how its approach is different from other treatments Safety results from the unblinded data Implications this vaccine could

Introducing Quite Curious and your host: Dr. Ariel K. Frame, PhD

Send us a text In this Quality Grind Short, Mike examines the latest trends in FDA agency communications, including the use of LinkedIn and other media to reach out to regulated life science companies. He then suggests ways that companies can stay on top of these communications without the need for a full-time Regulatory Surveillance team. Contact MEDVACON: Message us at @MedvaconLifeSciences on LinkedIn Visit our website at www.medvacon.com/contact Email us at qualitygrind@medvacon.com Th...

In Alvarez v. Lincare, the Eleventh Circuit highlighted a growing risk for pharma marketers and legal teams running Direct-to-Patient (DTP) campaigns. Lincare and Optigen were accused of defrauding the government by: Routinely waiving co-pays without documenting financial hardship, Shipping unrequested supplies, Allegedly paying kickbacks to boost business. While most claims were dismissed—not because they weren’t serious, but due to insufficient specifics—the upcoding charges remained. Wh...

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们要分享发表在影响因子高达8.6的《European journal of nuclear medicine and molecular imaging》上的重要研究："Hybrid Tau-PET/MRI study: Quantitative susceptibility mapping in progressive supranuclear palsy and its correlation with Tau-PET"。这项突破性研究发现，通过结合tau-PET和定量磁化率映射(QSM)技术，能够更早地诊断进行性核上性麻痹(PSP)，这种疾病常被误诊。研究首次揭示了PSP患者特定脑区域铁积累的独特模式，并证实了铁与tau蛋白病理变化之间存在显著关联。这一发现为开发新型诊断生物标志物开辟了新途径，有望改变PSP的临床诊断和治疗前景。

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Cancer letters》(影响因子9.1)上的重要研究："Obese adipose tissue-derived extracellular vesicles enriched with glycolytic cargo promote colorectal cancer tumorigenesis." 这项突破性研究揭示了肥胖如何通过脂肪细胞释放的细胞外囊泡促进结直肠癌发展。科学家发现，肥胖患者脂肪组织释放的囊泡富含糖酵解酶，这些"分子信使"进入癌细胞后，不仅增强糖酵解活性，还提高癌细胞干性，加速肿瘤生长。更令人惊讶的是，通过阻断特定蛋白，研究人员成功阻断了这一过程，为肥胖相关结直肠癌提供了全新治疗靶点。这一发现不仅阐明了肥胖与癌症之间的分子联系，也为开发针对性疗法开辟了新途径。

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在影响因子5.8的《Journal of Medical Internet Research》上的研究"Evaluating Web Retrieval-Assisted Large Language Models With and Without Whitelisting for Evidence-Based Neurology: Comparative Study"。这项神经学领域的重要研究发现，当大型语言模型的网络检索限制在权威神经学网站时，回答准确率显著提升—Sonar模型从60%跃升至78%，专业版模型更达到88-89%。研究证实，使用专业医学来源可使模型表现媲美专业文献检索系统，为临床决策提供可靠支持。这一发现为AI医疗应用的安全边界提供了重要参考，表明简单的内容过滤就能显著提升AI在循证医学中的实用价值。

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Neurology》(影响因子7.7)上的重要文章："Target Trial Emulation: A Primer on Improving Observational Research in Neurology."这项研究探讨了一种创新方法，当随机对照试验因伦理、后勤或财务限制不可行时，如何通过"目标试验模拟"框架提高神经病学观察性研究的质量。研究团队详细介绍了如何模拟理想RCT的各个组件，包括资格标准、干预措施、治疗分配和结果分析，从而减少传统观察性研究中的偏差。这种方法虽无法完全解决数据集限制，但能显著改善研究设计，更精确地定义研究问题，为神经科医生提供更可靠的证据，特别是在RCT难以实施的临床情境中。

How can the biopharmaceutical industry improve? Join Bioprocess Online's Tyler Menichiello as he explores this question through a series of interviews with experts and leaders from across the space. Subscribe for biweekly, in-depth conversations with the brightest minds in biotech to learn how they're moving the needle to make better medicines and optimize manufacturing. Follow Tyler Menichiello on LinkedIn: https://www.linkedin.com/in/tmenichiello/ Keep up with everything biomanufacturing a...

Send us a text “if you don’t know what (the disease) is, then you can’t manage what you’re trying to treat or to prevent. “ For cattle producers and veterinarians, Diagnostics is the science that drives hitting the bullseye vs simply hitting the target. In this episode, Dr. Robert "Bob" Gentry explains how disease diagnostics work and their practical application for the modern cattleperson. Recorded February, 2025 - 4:47 minutes #veterinarian #cattle #vaccines #vaccinescience ©VST Labs for Me...

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在Stroke杂志(影响因子7.8)上的重要论文《Futile and Harmful Reperfusion and the Balance Between Treatment Effect and Overall Outcomes in Stroke》。这项研究挑战了中风治疗中"一刀切"的再灌注理念，提出了两个关键警告：无效再灌注现象——再灌注不一定转化为患者实际获益；以及有害再灌注——在某些情况下再灌注反而会恶化患者结局。研究强调，我们需要超越单纯关注血管开通的治疗模式，开发更精准的患者选择策略，利用先进影像和大数据预测治疗效果，实现个体化治疗，真正践行"首先不伤害"的医学伦理原则。

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。 本期关注发表在《Annals of Neurology》(IF: 8.1)上的重要研究"Endogenous Repair in Vanishing White Matter"。这项突破性研究揭示了消散性白质病中不同脑区修复能力的差异机制。研究团队发现，脑桥区域能够实现自发修复，而大脑和小脑白质却持续退化。关键在于胶质细胞功能状态：脑桥区域胶质细胞功能完好且有有效炎症反应，而大脑白质中胶质细胞功能异常，导致不可逆损伤。这一发现为开发针对这种目前无法治愈疾病的新疗法提供了关键方向，特别是通过保护和增强胶质细胞功能来促进修复。

Pharmaceutical speaker programs come in two forms: one aimed at promoting a product, and another focused purely on education. Both must be compliant, but many companies blur the lines—leading to billion-dollar fines. Government bodies like the OIG consider these programs “inherently suspect” unless strict criteria are met. To stay compliant, speakers must have relevant expertise (not just high prescription rates), and every presentation is vetted by a Medical-Legal-Regulatory (MLR) team. Desp...

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《International Journal of Epidemiology》(IF:6.4)上的重要研究"Using Mendelian randomization to investigate etiologic heterogeneity across renal cell carcinoma subtypes"。这项创新性研究利用孟德尔随机化方法，揭示了肾细胞癌不同亚型的独特病因模式。研究发现，肥胖、血压和吸烟等因素与透明细胞肾癌关联更强，而慢性肾病、肾功能指标和端粒长度则与乳头状肾癌关联更显著。这一发现强调了在肾癌研究和临床实践中区分组织学亚型的重要性，为个性化预防和精准治疗提供了关键依据。

A 2022 paper was retracted after an independent team of researchers reanalyzed the data and questioned its validity.

⚡️GLP-1 medications like semaglutide are best known for helping with weight loss and blood sugar—but could they also reduce inflammation and chronic pain?In this episode of the Rare Wellness Podcast, Dr. Jamie Lewis breaks down the science behind how GLP-1 receptor agonists may impact systemic inflammation, joint pain, and long-term disease risk. Whether you're managing autoimmune issues, metabolic dysfunction, or just looking to improve recovery, this episode connects the dots between GLP-1,

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们关注发表在《Neuro-oncology》(IF: 16.4)上的重要研究"Associations of supramaximal resection with outcome in glioblastoma across age groups: a report of the RANO resect group"。这项国际研究分析了1260例胶质母细胞瘤患者，发现手术切除效果存在年龄差异。虽然完全切除对比增强肿瘤对所有患者都有益，但超最大切除仅在65岁以下初发患者中显著延长生存期(40 vs 20个月)。在复发病例中，最大切除对年轻患者更有利。研究结果支持根据年龄采取分层手术策略，为胶质母细胞瘤的个体化治疗提供了重要依据。