Sendungshinweis: Riem Higazi bis 1, 31.5.2025, 10 Uhr

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在Circulation research（IF:16.5）上的重要研究"GP130 Antagonism Enhances Porcine RV Function"。这项突破性研究发现，GP130抑制剂SC144能显著改善猪右心室功能，射血分数从22%提升至37%。研究揭示了SC144通过多重机制发挥作用：减少免疫细胞浸润、抑制炎症反应、恢复脂肪酸代谢、改善线粒体功能，并恢复内皮细胞稳态。这一发现为右心室功能障碍这一多种心血管疾病的死亡风险因素提供了潜在治疗策略，填补了右心室增强治疗的空白，为临床转化带来新希望。

Phil came into Morning Edition live to talk about outdoor recreation conditions here in the 4 Corners.

Bauernkrieg: Die Rolle der Frauen; Haiforschung: Touristenbeobachtung hilft Forschern - Sendung vom 30.05.2025

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们介绍发表在影响因子高达16.5的《Circulation research》上的重要研究"GP130 Antagonism Enhances Porcine RV Function"。这项研究在大型动物模型中发现，GP130抑制剂SC144能显著改善右心室功能，使射血分数从22%提升至37%。更令人惊喜的是，这种药物通过多重机制发挥作用：减少免疫细胞浸润、平衡自噬过程、保护心肌细胞脂肪酸代谢，并恢复血管内皮细胞稳态。这一突破性发现为治疗右心室功能障碍这一心血管疾病死亡风险因素提供了全新的治疗策略，未来可能惠及众多心力衰竭患者。

On the trail of the world's most sought-after mushroom.Learn more about your ad choices. Visit megaphone.fm/adchoices

Highs run 10° above normal today and Friday before a weekend storm brings widespread rain, cooler temps, and mountain snow.

O Instituto UbyAgro acaba de completar um ano de atuação, reafirmando o compromisso de ampliar o impacto social e ambiental do agronegócio. Criado pelo Grupo UbyAgro, multinacional brasileira que, há 40 anos, transforma o agro com excelência em nutrição e defensivos agrícolas, a instituição atua como ponte entre o setor e as comunidades, desenvolvendo projetos de sustentabilidade, inclusão social, educação, cultura e inovação.

Что это за космическое веретено? Галактика NGC 2685 — настоящая астрономическая загадка. Её кольца вращаются в одной плоскости, а диск — в другой, словно гигантский межгалактический гироскоп. Это так называемая галактика с полярным кольцом — редкий и странный тип, возможно, результат поглощения другой галактики. Или… быть может, это нечто большее? Следы мегаструктур цивилизации III типа по Кардашеву? Пора включать воображение. Открой глаза, солдатик! Музыка: purple-planet.com

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们来关注发表在《Nucleic acids research》(影响因子16.6)上的重要研究："Translational and clinical development of therapeutic siRNA and ASOs: current industry practices, perspectives, and recommendations."这项研究探讨了RNA疗法，特别是小干扰RNA(siRNA)和反义寡核苷酸(ASOs)的临床转化开发现状。这些革命性疗法能够靶向传统上"不可成药"的蛋白质，为精准医疗开辟新途径。研究强调了生物偶联策略对提高药物稳定性和靶向性的关键作用，以及计算建模和临床药理学在优化这些复杂分子治疗中的重要性。这项行业共识为siRNA和ASO疗法的安全有效开发提供了宝贵指导，标志着精准医疗领域的重大进步。

University of Montana Climate Office launches regional project to strengthen drought resilience while the Four Corners shifts its focus to snowpack

Pflanzen retten – und dabei mithelfen, 20.000 Jahre alte Werkzeuge aus Walknochen, Tag der Leichten Sprache: Wie sie gelingt - Sendung vom 28.5.2025

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Nucleic acids research》(影响因子16.6)上的重要论文《Translational and clinical development of therapeutic siRNA and ASOs: current industry practices, perspectives, and recommendations.》。这篇由IQ联盟核酸工作组撰写的白皮书，深入探讨了RNA疗法的开发前景，特别是siRNA和ASO如何靶向传统"不可成药"的蛋白质，推动精准医疗发展。研究强调了生物偶联策略、组织分布分析和计算建模等关键因素对提升疗效的重要性。这些整合的行业见解将为siRNA和ASO疗法的最佳实践和监管指南提供宝贵参考，加速这一革命性治疗领域的安全高效发展。

A quick-moving trough brings breezy winds and isolated mountain showers today, with sunshine midweek and cooler, wetter weather returning this weekend.

Universum: Dokumentarfilmer erforschen Gänsegeier; Semaglutid: Wirksamkeit bei Diabetes - Sendung vom 27.05.2025

Preparar o solo para uma nova safra é uma etapa importante para um bom desenvolvimento das plantas e para uma excelente colheita. Pensando nisso, a Cibra, uma das maiores e mais inovadoras empresas de fertilizantes do Brasil, preparou um checklist para colocar em prática sempre que for iniciar o plantio de uma nova safra. Valter Asami, gerente de produtos agronomicos da Cibra, explica que o principal item é a qualidade do solo.

In any forest, there's a complex interdependent web of life underground.Learn more about your ad choices. Visit megaphone.fm/adchoices

Empathie: Was die Forschung darüber weiß; Megalodon: Neue Erkenntnisse zum Urzeit-Hai - Sendung vom 26.05.2025

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。《Obesity in reproduction: Mechanisms from fertilization to post-uterine development (Review)》这篇发表在影响因子5.7的《International journal of molecular medicine》上的综述，揭示了肥胖如何从受精到产后发育影响生殖健康的复杂机制。研究发现肥胖通过氧化应激和代谢内毒素血症损害男女双方的生殖功能：在男性中导致睾丸炎症和精子质量下降，在女性中引发卵巢功能障碍和卵子质量问题。更值得关注的是，父母肥胖还会影响后代发育，增加子代代谢和生殖疾病风险。研究指出，生活方式干预和抗氧化治疗可能部分逆转这些损害，为临床管理提供了重要方向。