Send us a text In this educational segment of Ask Your Eye Doctor, we take a deep dive into the fascinating structures of the human eye. We walk listeners through key anatomical components—like the cornea, retina, lens, and optic nerve—explaining each part's role in vision. Along the way, we break down commonly used ophthalmology terms such as "myopia," "astigmatism," "macula," and "intraocular pressure,"and many more, ensuring listeners can better understand their eye health and communicate ...

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们关注一项发表在影响因子高达9.3的《Acta neuropathologica》上的重要研究，题为"Differences and overlaps in TDP-43 pathology of 'pure' LATE-NC compared to LATE-NC coexisting with Alzheimer's disease."。研究发现，单纯的边缘优势型年龄相关TDP-43脑病与阿尔茨海默病共存的病例在病理特征上存在显著差异。纯LATE-NC患者年龄更大，认知障碍较轻，海马体中主要呈现网状神经突TDP-43模式，而与AD共存的病例中这种模式较少见。这些发现对理解痴呆的病理基础和开发针对性治疗具有重要意义，可能影响未来临床试验的设计方向。

Speakers: Khadijah Ahmed, Fayrouz Tamer, Karima WaleedGuest:

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。 本期关注发表在《Pharmacological research》(IF: 9.1)上的重要研究《The potential of CDK4/6 inhibitors in advancing the treatment of cutaneous melanoma》。这项研究揭示了CDK4/6抑制剂在皮肤黑色素瘤治疗中的巨大潜力。研究指出，CDK4/6抑制剂不仅能诱导肿瘤衰老，还能调节肿瘤微环境并增强免疫反应。尤其重要的是，这些药物与现有疗法（如MAPK抑制剂和免疫检查点抑制剂）联合使用，可能有效克服治疗抵抗，提高治疗效果，为晚期黑色素瘤患者提供新的治疗策略。这一发现为黑色素瘤治疗开辟了新方向，有望改善患者预后。

Quando uma família recebe a notícia de que uma criança pode estar com câncer, cada dia de espera por um diagnóstico parece uma eternidade. Este episódio traz reflexões sobre o câncer infantil, cuidado, esperança e como ciência e saúde pública podem caminhar juntas.Conversamos com Carol, gerente de Oncologia Pediátrica do Instituto Desiderata, sobre o primeiro Fórum de Oncologia Pediátrica, organizado em Brasília com apoio do Inca e da Opas. O encontro busca sensibilizar gestores para que priorizem

At first glance, responding to site-level findings seems simple—but when Edye and Darshan dug into the details, it became clear that the lines of responsibility blur fast. Here's how each side sees it: Site Perspective: Sites know the boots-on-the-ground reality. When a finding is made—especially during an external inspection like the FDA—they’re often the ones best positioned to analyze what went wrong. The site team (usually led by QA or compliance professionals) needs to: Conduct a r...

【科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载】本期关注发表在Clinical Psychology Review (IF: 13.7)的重要研究"The association between subjective and objective cognitive functioning from a transdiagnostic perspective: An umbrella review and meta-analysis"。这项伞状综述分析了50篇综述，涵盖20多种神经精神疾病，发现主观和客观认知之间的关系极不一致，效应量从无到弱不等。令人惊讶的是，心理健康因素如抑郁和焦虑比客观认知测试更能预测主观认知体验。研究强调，主观和客观认知 largely 是不重叠的构念，即使存在简单差异也不具诊断价值。这一发现对临床医生评估患者认知状况具有重要启示，提醒我们不应期望自我报告与测试结果完全一致。

In this episode of STBYM’s The Monstrefact, Robert discusses the legendary Kaiju Mothra…See omnystudio.com/listener for privacy information.

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在Blood reviews（IF:6.9）上的重要综述"Metabolomics in sickle cell disease: Current knowledge and gaps - A scoping review"。这项范围综述揭示了代谢组学在镰状细胞病中的突破性发现，表明代谢谱分析能有效区分不同基因型和并发症患者。研究确定了与溶血、血管闭塞事件和肾病等关键临床结果相关的代谢物，涉及精氨酸、色氨酸和糖酵解等多条代谢通路。尽管取得进展，作者仍强调需要标准化的大规模代谢组学研究来填补现有知识空白，最终推动镰状细胞病的精准医疗发展。这项研究为理解疾病异质性和治疗反应提供了新视角。

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。《The association between subjective and objective cognitive functioning from a transdiagnostic perspective: An umbrella review and meta-analysis》这项发表在Clinical psychology review（IF=13.7）的重要研究发现，主观认知与客观认知之间仅存在微弱关联（r=0.14）。研究分析了50篇综述，涵盖超过20种神经精神疾病，发现抑郁和焦虑等精神健康因素与主观认知的相关性远强于客观测试结果。这一发现挑战了传统认知评估方法，提示临床医生不应期望患者自我报告的认知表现与神经心理学测试结果一致，二者反映的是认知功能的不同维度而非同一现象。这一发现对认知障碍的准确诊断具有重要意义。

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在Pathologica(影响因子4.4)上的重要研究"Part III - Post-analytical phase"。这项研究聚焦精准肿瘤学中分子检测结果的标准化报告问题，为下一代测序(NGS)技术的变异注释、解释和报告提供了最新指导。研究强调结构化报告和临床适用性的重要性，同时关注组织和液体活检样本的标准化，旨在简化分子报告生成，改善多学科沟通，并促进NGS技术更好地融入日常肿瘤学实践。这项工作对提高肿瘤治疗的精准性和效率具有重要意义，为全球临床实验室提供了宝贵的参考标准。

Welcome to the Leap Together podcast, where we highlight top leaders driving breakthroughs in clinical research and life sciences.

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注《European journal of nuclear medicine and molecular imaging》(影响因子8.6)上发表的重要综述"Advances in PET imaging of oxidative stress: tracer innovation, mechanistic insight, and translational potential."。这项研究探讨了氧化应激作为多种疾病（包括神经退行性疾病、癌症、心血管损伤和炎症）的关键驱动因素。文章重点介绍了新型PET示踪剂如何实现对活性氧和氮物种的选择性成像，为无创监测氧化应激提供了革命性工具。这一突破性技术有望彻底改变我们对氧化应激相关疾病的早期诊断、治疗反应监测和个性化医疗的实践，为临床医生提供前所未有的疾病可视化能力。

Medical communications teams must exercise caution when using websites dedicated to medical affairs, as legal risks go beyond overt sales promotion. Drug and device manufacturers face compliance challenges, particularly when these platforms are accessed by broader audiences, including non-scientists. Key risks include: Off-Label Promotion: The Facteau case highlights how communications implying off-label use can lead to violations under the Food, Drug, and Cosmetic Act, even for FDA-cleared d...

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Molecular Psychiatry》(IF: 9.6)上的重要研究"The China Brain Multi-omics Atlas Project (CBMAP)"。这一开创性项目构建了首个覆盖千名中国人大脑的多组学图谱，填补了东亚人群在脑研究中的空白。通过整合基因组、表观基因组、转录组、蛋白质组和代谢组数据，CBMAP为理解衰老相关脑表型和神经精神疾病提供了宝贵资源。研究采用的空间转录组学和单核3D染色质结构分析等先进技术，不仅揭示了疾病机制，还增强了全基因组关联研究的实用性。这一突破性成果将显著加速脑障碍的药物发现和精准医疗发展，为全球脑科学研究注入新动力。

Maslow's Hierarchy of Needs, a cornerstone of psychological understanding, provides a framework for comprehending human motivation and behavior. This theory, often depicted as a pyramid, posits that individuals are driven by a hierarchy of needs, progressing from basic physiological requirements to self-actualization. Understanding this hierarchy is crucial for various fields, including business, education, and personal development.At the base of the pyramid lie the physiological needs, the

No one is thinking about you as much as you imagine, so quit obsessing over outside validation. A select few will care, so cherish them and build your life around them, as they are true wealth. Choose your tribe carefully, prioritizing realness over manufactured connection. Money is useful but ultimately phony, so don't build your identity on it; instead, be generous and avoid debt that limits your choices.Master rhetoric to understand how ideas move people and to navigate the world more

Smart Talks with IBM returns Tuesday, May 20th, and this season, we’re really shaking things up. Host Malcolm Gladwell will visit various companies to tell stories of how IBM clients are using artificial intelligence and data to transform the way they do business. This is a paid advertisement from IBM. Visit us at ibm.com/smarttalksSee omnystudio.com/listener for privacy information.

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Advanced drug delivery reviews》(影响因子：15.2)上的重要研究"Tumor microenvironment subtyping in pancreatic ductal adenocarcinoma: New avenues for personalized therapeutic strategies"。这项研究揭示了胰腺导管腺癌的复杂异质性，展示了特定基因改变如何塑造独特的肿瘤微环境，影响成纤维细胞编程和免疫细胞组成。作者提出了多细胞亚型分类和空间组织对患者预后的重要影响，为精准医疗提供了新视角。研究不仅阐明了肿瘤-基质网络的复杂相互作用，还探讨了针对肿瘤和基质双重弱点的创新治疗策略，为这一难治性癌症的个体化治疗开辟了新途径。

Were we sleeping when everything changed? Seems like the technologically driven future is already here. On kill switch, we explain the right NOW of our supercharged technological lives. Ask ourselves who is in control? Can we beat the computer or are we going to need to throw the kill switch? New host Dexter Thomas, Jr answers questions big and small – like who made Shrimp Jesus and why? To how and why you very well could get arrested by a computer. And we’ll be bringing the DIY back to