This week’s tHEORetically Speaking News Roundup covers the FDA’s new boxed warning for J&J’s CAR-T therapy Carvykti, a major study linking post-Dobbs abortion restrictions to rising intimate partner violence, and Pelage Pharmaceuticals’ $120M funding to advance a next-generation hair loss treatment. We also spotlight Ōura’s $900M investment to expand its AI-driven health tech platform. Tune in for this concise recap of these pivotal industry updates!

Darshan discusses the potential role of AI in medicine. He believes fears of AI replacing doctors for diagnosis are currently overblown, as trust in physicians remains crucial. However, he suggests AI could assist with preliminary research tasks, such as reviewing inclusion/exclusion criteria and conducting initial screening. Have you seen AI being used in this manner? Support the show

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Pharmacological research》(IF:9.1)上的重要研究"Vascular endothelial cells and angiogenesis"。该研究深入解析了血管内皮细胞在生理和病理状态下的分裂机制，揭示了肿瘤生长依赖血管生成的关键过程。论文详细阐述了VEGF家族、Semaphorins、Angiopoietins和Ephrins等多重信号通路在血管生成中的复杂调控网络。特别重要的是，研究强调了靶向血管生成信号作为癌症治疗策略的潜力，并介绍了Ponatinib等FDA批准的血管生成抑制剂在多种恶性肿瘤中的应用。此外，研究还指出异常血管生成与糖尿病视网膜病变和年龄相关性黄斑变性等疾病密切相关，为这些疾病的治疗提供了新思路。

In this episode of STBYM’s The Monstrefact, Robert discusses the Walrus Ghost from the spooky 1932 Fleischer Studios Betty Boop animated short "Minnie the Moocher."See omnystudio.com/listener for privacy information.

In today’s Pharmaceutical Executive Daily, we explore how antibody-drug conjugate collaborations are moving beyond oncology into autoimmune diseases, EMD Serono’s agreement with the Trump administration to expand access to in vitro fertilization therapies, and how the obesity treatment market is evolving after GLP-1 dominance.

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在Journal of nanobiotechnology(影响因子10.6)上的重要论文"Lipid-based nanoparticles external triggered release strategies in cancer nanomedicine"。研究指出，近半数人一生中将患癌症，而传统化疗药物面临递送挑战——不到0.1%的药物能到达肿瘤部位。脂质基纳米颗粒(LBNPs)虽能延长药物循环时间并利用EPR效应，但过于稳定的特性限制了药效释放。本文综述了热、超声、辐射、磁和光等外部触发策略的最新进展，这些技术可实现肿瘤部位的精准药物释放，大幅提高治疗效果并减少副作用，为癌症纳米医学开辟了新路径。

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This month, we’re starting a new webinar mini-series. Over the next 5 months, we have 4 expert speakers lined up for live talks on a variety of bioinformatics-related topics. Our first event is Wednesday, October 22nd, and guest speaker Dr. Nick Wisniewski will deliver a talk on AI-First Drug Discovery Pipelines. Nick was a guest on episode 57 of this podcast in January. Find out more about this month’s talk, and the other 3 events, on our LinkedIn

In today’s Pharmaceutical Executive Daily, we explore how pharma leaders are rethinking workforce development at the executive level, the industry’s growing investment in rare disease therapies, and emerging opportunities and challenges in psychiatric drug development.

Direct-to-Patient (DTP) models are transforming how medications reach patients, moving beyond clinical research into commercial distribution. Originally developed to help rare disease trial participants avoid long travel to research sites, DTP has become a standard solution for improving patient access and convenience. Today, patients can receive small molecules, complex biologics, and even medical devices directly at home, making what was once exceptional now routine. Despite the benefits, D...

Send us a text It doesn't take a great imagination to see that Bovine Papillomavirus (BPV) is not pretty. And, in terms of cost to the animal producer - both Beef and Dairy - BPV is downright ugly. In this brief, to-the-point podcast, topical expert (and industry pro) Dr Bob Gentry explains BPV's startling affect on animal and herd health. Edited May, 2025 - 03:07 minutes #papillomavirus #cattlefarm #dairyfarm #animalhealth #veterinary #veterinarian ©VST Labs for Medgene www.MedgeneLabs.com ...

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。欢迎收听今天的医学播客！我们关注发表在《American Journal of Obstetrics and Gynecology》(影响因子8.7)上的重要研究：《Assessment of Probiotic and Prebiotic Use in Gynecologic Cancer Patients: A Systematic Review》。 这项系统评价分析了9项随机对照试验，发现益生菌补充剂显著降低了妇科癌症患者放疗引起的腹泻发生率和严重程度，改善了大便一致性，并减少了止泻药的使用。相比之下，单独使用益生元效果有限。研究还发现益生菌可能加速肠道恢复并减少术后并发症。尽管如此，目前尚缺乏益生菌对化疗、免疫治疗及生存率影响的数据。这项研究为妇科癌症患者的辅助治疗提供了重要参考，但未来需要更多标准化菌株的试验来优化临床应用。

It’s back — the same conversations you loved, with a new name.Vigilance Unplugged explores the real stories behind careers in safety and risk management — and asks what’s next for the world of vigilance and life sciences.

In today’s Pharmaceutical Executive Daily, we explore Johnson & Johnson’s plan to separate its orthopaedics division into a standalone company, the global implications of the Most Favored Nation drug pricing proposal, and strategies helping small biotechs reach market faster.

In today’s Pharmaceutical Executive Daily, we cover Takeda’s new multi-year research collaboration with Nabla Bio, how tariff and pricing pressures are driving pharma toward direct-to-consumer strategies, and reports of AstraZeneca reaching an agreement with the Trump administration.