Eye On The Night Sky For Thursday, October 1

In this episode, I revisit Kodiak Sciences’ DAYBREAK readout for Zenkuda after getting the trade wrong. I break down what the 54% Q24 result really means, how the trial design and loading regimen may have shaped the durability headline, why payer step therapy could change the real-world patient population, and what I missed going into the catalyst. I also compare Zenkuda with Eylea HD and discuss what the data do—and don’t—tell us about the commercial opportunity for $KOD. #KodiakSciences #Biotech

In this episode, editor in chief Joseph E. Safdieh, MD, FAAN, highlights articles about the pros and cons of wearable devices, new data for thrombectomy use in medium-vessel occlusion strokes, and a new treatment for limb-girdle muscular dystrophy type 2I/R9.

Guest: Alice T. Shaw, MD, PhD Despite advances in ALK inhibition, resistance remains an important challenge in metastatic ALK+ non-small cell lung cancer (NSCLC). Dr. Alice Shaw, Chair of the Department of Medical Oncology at Dana-Farber Cancer Institute and Professor of Medicine at Harvard Medical School, explores patterns of disease progression, emerging on- and off-target resistance mechanisms, and the potential role of combination approaches in overcoming resistance.

Guest: Alice T. Shaw, MD, PhD In metastatic non-small cell lung cancer (mNSCLC), resistance to ALK TKIs can differ depending on which therapies a patient has previously received, with important implications for next steps in treatment. Dr. Alice Shaw explains how treatment history and molecular testing at progression can help identify ALK-dependent and other actionable resistance mechanisms to help inform next-line therapy. She's the Chair of the Department of Medical Oncology at

Guest: Alice T. Shaw, MD, PhD Despite major advances in targeted therapy for ALK+ metastatic non-small cell lung cancer (mNSCLC), challenges remain in achieving durable responses and preventing treatment resistance. Hear from Dr. Alice Shaw as she explores key unanswered questions and emerging research aimed at addressing gaps in care for these patients. Dr. Shaw is the Chair of the Department of Medical Oncology at Dana-Farber Cancer Institute and a Professor of Medicine at Harvard

Guest: Laura Chiavaroli, PhD How might diet and exercise influence metabolic outcomes among patients taking GLP-1 medicines? To find out, we recently spoke with Dr. Laura Chiavaroli, who discussed this topic at the 2026 European Association for the Study of Diabetes Annual Meeting. She shares emerging evidence on combining lifestyle interventions with GLP-1 therapy and highlights where gaps in research still remain. Dr. Chiavaroli is an Assistant Professor in the Department of

Guest: Edward Phelps, PhD Residual beta cells may persist after a type 1 diabetes (T1D) diagnosis, but how well do they continue to function? Tune in to hear Dr. Edward Phelps discuss research he presented at the 2026 European Association for the Study of Diabetes Annual Meeting that examined glucose-stimulated calcium responses in living pancreatic tissue from donors with recent-onset T1D. He explains how residual beta cells showed impaired responses to glucose regardless of the local

Guest: Vira Kravets, PhD Cellular interactions within pancreatic islets may provide important insights into the early stages and pathogenesis of type 1 diabetes (T1D). Tune in to hear Dr. Vira Kravets share research she presented at the 2026 European Association for the Study of Diabetes Annual Meeting, which focused on how alpha-beta cell proximity influences GLP-1R-mediated communication as well as the spatial association between alpha cells and T cells in human islets. Dr. Kravets

Guest: Edward Phelps, PhD Despite advances in type 1 diabetes (T1D) research, key questions remain about disease progression, immune mechanisms, and the optimal timing of intervention. Here to explore how immunology and islet research could help address these knowledge gaps is Dr. Edward Phelps. He’s an Associate Professor in the J. Crayton Pruitt Family Department of Biomedical Engineering at the University of Florida.

Starfish anatomy. If you want to know the parts, according to Dutch Wikipedia, they are: Legend 1 Arm 2 Ampullae 3 Radial canal 4 Gonads [...]The post Science Art: Dissection of Asterias rubens, by Hans Hillewaert. first appeared on The Guild of Scientific Troubadours.

In this podcast, we summarise the reviews and original articles in Volume 68, Issue 10 of Developmental Medicine & Child Neurology. The issue is available here: https://onlinelibrary.wiley.com/toc/14698749/2026/68/10 Generated by Gauff speech synthesis using MS Edge TTS licensed under MIT License. Follow DMCN on Podbean for more:  https://dmcn.podbean.com/ ___ Watch DMCN Podcasts on YouTube: https://bit.ly/2ONCYiC __ DMCN Journal: Developmental Medicine & Child Neurology (DMCN) has defined

In this podcast, Russell Dale discusses his paper 'Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism'. The paper is available here: https://doi.org/10.1111/dmcn.70467 Follow DMCN on Podbean for more:  https://dmcn.podbean.com/ ___ Watch DMCN Podcasts on YouTube: https://bit.ly/2ONCYiC __ DMCN Journal: Developmental Medicine & Child Neurology (DMCN) has defined the field of paediatric neurology and

In this podcast, Emma Glisson discusses her paper 'Dysphagia in paediatric acquired brain injury: Prevalence, outcomes, and impact of lesion sites on recovery'. The paper is available here: https://doi.org/10.1111/dmcn.70382 Follow DMCN on Podbean for more:  https://dmcn.podbean.com/ ___ Watch DMCN Podcasts on YouTube: https://bit.ly/2ONCYiC __ DMCN Journal: Developmental Medicine & Child Neurology (DMCN) has defined the field of paediatric neurology and childhood-onset neurodisability for

Founded in 1958, COSPAR organises Scientific Assemblies and Symposia in different countries where thousands of scientists, engineers and researchers gather over several days to share their latest work.This interview was recorded on 8 August 2026, on the final day of the 46th Scientific Assembly in Florence, Italy. Dr Pascale Ehrenfreund, a former president of the International Astronautical Federation who has led COSPAR as its president since 2022 — and was re-elected to that role just hours after

HeapsMOREnergy-nz - Solar Made Simple is a Renewable Energy/Climate focused show that will cover three Critical components in any Energy focused discussion, Energy Efficiency, Climate Change and What’s do-able Daily.

Guest: Darilyn Moyer, MD, MACP, FRCP, FIDSA, FAMWA, FEFIM With vaccination rates at historic lows and trust in public health institutions declining, primary care clinicians remain one of the most trusted sources of guidance for patients. Hear from Dr. Darilyn Moyer, Executive Vice President and Chief Executive Officer of the American College of Physicians, as she shares strategies for navigating difficult conversations about vaccines and preventive care.

Host: Diego Maselli, MD, FCCP Living with severe asthma can mean hospital stays, repeated oral steroid courses, and a long search for the right care, with many eligible patients still facing delays in starting advanced therapies or struggling to stay on them. In this episode of Deep Breaths: Updates from CHEST, Dr. Diego Maselli talks with patient advocate Stephanie Fuller about her journey from uncontrolled asthma to starting biologic therapy. Together, they explore why having ongoing

An extended Climate Matters Interview with Eliza Prestidge-Oldfield

Host: Shelina Ramnarine, PhD Guest: Firas George Hougeir, MD, FAAD Chronic hand eczema can be difficult to characterize and manage. Subtypes may overlap, triggers can take time to identify, and different inflammatory pathways may be at play, all while patients continue to experience burdensome symptoms. Join Dr. Shelina Ramnarine and Dr. Firas George Hougeir as they examine how recognizing chronic hand eczema as as a distinct inflammatory disease can inform timely treatment, guide