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PODCAST

Sharp Waves: ILAE"s epilepsy podcast

Epilepsy affects more than 50 million people. Every day. Sharp Waves brings you stories about people with epilepsy, physicians treating epilepsy, and researchers studying the condition. We"ll cover the latest research, challenges to diagnosis and treatment, and issues from around the world.

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All Episodes

18:48

A novel patient-reported outcome measure for...

Sharp Waves: ILAE"s epilepsy podcast ·

2025/10/27

Send comments and feedback Is there a fast, simple way to measure whether someone with epilepsy is doing "better" or "worse" compared with a past clinic visit? Not really. Seizure count is often considered a standard, but multiple small seizures may have less impact on someone's life than a single generalized tonic-clonic seizure. In this episode, we talk with authors of a study on an outcome measure that factors the impact of seizures as well as the impact of treatments. The study: Validat...

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30:50

Social work in epilepsy: Closing the treatment gap...

Sharp Waves: ILAE"s epilepsy podcast ·

2025/10/13

Send comments and feedback Closing the epilepsy treatment gap relies heavily on social and cultural acceptance of epilepsy as a brain disorder that can be managed with medication or other therapies. Dr. Rugare Mugumbate discusses the five disadvantages faced by people with epilepsy, as well as the important role of social workers and the need to focus on lessons learned from previous pilot projects and awareness campaigns. Dr. Mugumbate's book - Epilepsy in Resource Limited Settings: Managing...

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31:31

Somatic genetic epilepsies: Dr. Christian Bosselmann

Sharp Waves: ILAE"s epilepsy podcast ·

2025/09/29

Send comments and feedback Somatic genetic epilepsies arise from mutations that occur early in fetal development. They are usually only detectable by genetic sequencing of tissue. For these epilepsies, the timing of the mutation is key: For example, research has shown that focal cortical dysplasia type IIB and hemimegaloencephaly are genetically the same disease, but arise from somatic mutations at different developmental time points. This relatively new area of research is discussed by Dr. A...

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12:54

Research recap: Empiric immunotherapy for highly...

Sharp Waves: ILAE"s epilepsy podcast ·

2025/09/08

Send comments and feedback In a retrospective study of 31 patients with highly refractory epilepsy, 29% had more than a 50% reduction in seizures for at least 12 months after being treated with immunotherapy. Three of these patients became seizure free. Other than a trend toward a diagnosis of focal epilepsy, researchers did not identify any specific features predictive of treatment response. Sharp Waves spoke with the first author about the study and its implications. The study was published...

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34:22

Genetic testing: Variants of uncertain significance...

Sharp Waves: ILAE"s epilepsy podcast ·

2025/08/18

Send comments and feedback What are variants of uncertain significance (VUS) in epilepsy genetic testing? How are they defined, and can those definitions change over time? Sharp Waves talks with Dr. Gemma Carvill as part of our genetic testing series. RESOURCES Standards for interpreting variants (American College of Medical Genetics) Gene Reviews ClinVar GeneMatcher Gnomad ClinGen ILAE genetic literacy series EpiPred website for STXBP1 (developed by EpiMVP project - will be final by end of J...

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46:49

What's new in status epilepticus: Dr. Eugen Trinka

Sharp Waves: ILAE"s epilepsy podcast ·

2025/08/04

Send comments and feedback This episode covers a wide scope of issues, including treatment options, treatment response, prognosis and the role of seizures versus the underlying etiology, most common etiologies for different age groups, new-onset refractory status (NORSE), and the prevalence and special considerations of non-convulsive status epilepticus. ILAE's International Epilepsy Congress will be held in Lisbon, Portugal, from 30 August to 3 September 2025. We welcome you to join us! Sh...

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22:28

Valproate and reproductive risks in women and men...

Sharp Waves: ILAE"s epilepsy podcast ·

2025/07/21

Send comments and feedback In use since the 1970s, valproate is highly effective for genetic generalized epilepsies and some forms of pediatric epilepsy. The medication also is associated with a 10% risk of birth defects in children exposed to it in utero, as well as a 30% to 40% risk of neurodevelopmental issues, including autism. Sharp Waves spoke with Dr. Tony Marson about the reproductive risks for women and men taking valproate, discussing UK policies meant to ensure appropriate prescrip...

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13:01

ILAE Updated seizure classification: Dr. Sandor Beniczky

Sharp Waves: ILAE"s epilepsy podcast ·

2025/07/07

Send comments and feedback ILAE's updated seizure classification position paper was published in Epilepsia in April 2025. Sharp Waves talked with Dr. Sandor Beniczky about the updates and how they will impact research and clinical care. The position paper is open access and available online. Sharp Waves episodes are meant for informational purposes only, and not as clinical or medical advice. Let us know how we're doing: podcast@ilae.org. The International League Against Epilepsy is the wo...

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15:03

Documentary filmmaker confronts epilepsy in a new...

Sharp Waves: ILAE"s epilepsy podcast ·

2025/06/23

Send comments and feedback Seizures cost Stacia Kalinoski her career in broadcast journalism and forced her to give up running. In her new memoir, Kalinoski recounts her journey from first seizure in college to epilepsy surgery years later, describing her seizures, struggles with medication, and challenges coming to terms with her epilepsy. Kalinoski's book, Racing Uphill, is available July 1, 2025 and can be ordered or pre-ordered online. Stacia Kalinoski is an Emmy Award–winning TV news jou...

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22:21

Work-life balance: Dr. Sheryl Haut

Sharp Waves: ILAE"s epilepsy podcast ·

2025/06/09

Work-related stress and burnout are common in physicians, with rates of burnout estimated between 25% and 60%. These stresses impact physician health, patient care, and health care systems as a whole. Sharp Waves spoke with Dr. Sheryl Haut about strategies to identify work stress and mitigate burnout. Sharp Waves episodes are meant for informational purposes only, and not as clinical or medical advice. Let us know how we're doing: podcast@ilae.org. The International League Against Epilepsy...

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19:03

The role of microglia in epilepsy: Hero, villain, or...

Sharp Waves: ILAE"s epilepsy podcast ·

2025/05/27

Microglia can have protective and also potentially harmful effects in the brain. They seem to be involved in dampening the nervous system during acute seizures – but also appear to play a role in neuronal loss and cortical thinning. Dr. Cecilie Nome spoke with Dr. Amy Brewster about the many faces of microglia and the current understanding of their role in epilepsy and seizures. Sharp Waves episodes are meant for informational purposes only, and not as clinical or medical advice. Let us...

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31:59

Language models reveal concerns of people with...

Sharp Waves: ILAE"s epilepsy podcast ·

2025/05/12

Many of the most common concerns of people with epilepsy are topics they don't usually talk about with physicians. This is one of many findings of a study using AI to analyze more than 55,000 posts about epilepsy on Reddit. Sharp Waves spoke with the study's first author and two epilepsy advocates about the results and how they could help initiate important patient-provider conversations. PLEASE NOTE: This episode includes discussion of suicidal ideation. If you are in crisis, call your...

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26:36

Music, epilepsy, and the brain: Dr. Phillip Pearl &...

Sharp Waves: ILAE"s epilepsy podcast ·

2025/04/28

Music can affect emotions, spark memories, and influence mood. In cases of musicogenic epilepsy, music can trigger seizures. In other cases, music may reduce seizure frequency. Dr. Cecilie Nome talks with Dr. Phillip Pearl and Prof. Nigel Osborne about the power of music and its effects on the brain. Links: Nigel Osborne - Wikipedia Personalised music as a treatment for epilepsy - Epilepsy & Behavior Neuroscience and “real world” practice: music as a therapeutic resource for children in z...

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24:59

Genetic testing for epilepsy in low-resource regions

Sharp Waves: ILAE"s epilepsy podcast ·

2025/04/14

In lower- and middle-income countries, raising awareness of genetic etiologies in epilepsy and genetic testing options may ultimately shift national priorities toward making genetic testing part of the standard of care. Dr. Parthvi Ravat spoke with Dr. Jo Wilmshurst and Dr. Alina Esterhuizen about initiatives to increase awareness of genetics and genetic testing in epilepsy, including a decision tree model for epilepsy care in resource-restricted settings that has been implemented in Africa. ...

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29:15

Emergency diagnosis and treatment of status epilepticus

Sharp Waves: ILAE"s epilepsy podcast ·

2025/03/31

As a neurological emergency, status epilepticus (SE) requires timely diagnosis and treatment. A US study found that 10% of people with SE were not diagnosed by emergency services. Among those who were diagnosed in an ambulance, 20% did not receive any first-line treatment, while others received lower-than-recommended doses. Sharp Waves spoke to senior author Dr. Elan Guterman about the study. Publications mentioned during the conversation: Status Epilepticus Identification and Treatment Amo...

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21:50

Folic acid supplementation in women with epilepsy

Sharp Waves: ILAE"s epilepsy podcast ·

2025/03/17

Folic acid supplementation is recommended for all women with epilepsy who may become pregnant. However, there is no agreed-upon dose for women with epilepsy taking antiseizure medication, and there may be risks of high-dose (>1 mg/day) folic acid supplementation. Dr. Bruna Nucera spoke with Dr. Marte Helene Bjørk about the risks and benefits of folic acid supplementation and what this means for pregnant women with epilepsy. Sharp Waves episodes are meant for informational purposes only, a...

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25:24

High-frequency oscillations and epilepsy: Clinical...

Sharp Waves: ILAE"s epilepsy podcast ·

2025/03/03

High-frequency oscillations (80 to 500 Hz) are being studied as biomarkers of epileptogenic areas in the brain, as well as markers to be used in epilepsy surgery. Dr. Cecilie Nome leads a discussion about clinical research on HFOs and areas of uncertainty, as well as the importance of basic research in helping to understand this phenomenon. Publications mentioned during the episode: Roehri Eng N, et al. High-frequency oscillations are not better biomarkers of epileptogenic tissues than ...

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14:58

Finding epilepsy genes: Dr. Allan Bayat

Sharp Waves: ILAE"s epilepsy podcast ·

2025/02/17

There are potentially hundreds of "epilepsy genes" - but what is an epilepsy gene? How do researchers discover these genes and associate them with epilepsy? Sharp Waves spoke with Dr. Allan Bayat, a pediatric neurologist in Denmark focused on rare monogenic neurodevelopmental disorders and epilepsy. Sharp Waves episodes are meant for informational purposes only, and not as clinical or medical advice. Let us know how we're doing: podcast@ilae.org. The International League Against Epilepsy i...

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23:38

Genetic testing for epilepsy surgery: Dr. Pat Moloney

Sharp Waves: ILAE"s epilepsy podcast ·

2025/02/03

In the second episode of our genetics and epilepsy series, Sharp Waves explores how genetic insights can inform considerations and outcomes of epilepsy surgery. Dr. Alina Ivaniuk interviews Dr. Patrick Moloney, currently an epilepsy genomics fellow at the Chalfont Center for Epilepsy at University College London. Selected publications: Do germline genetic variants influence surgical outcomes in drug-resistant epilepsy? Epilepsy Res 2024 Genomics in the presurgical epilepsy evaluation. Epile...

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16:39

Genetic testing in epilepsy: Who, how, and why? Dr....

Sharp Waves: ILAE"s epilepsy podcast ·

2025/01/20

This first episode in a multipart series on genetics in epilepsy covers the basics of genetic testing. Dr. Alina Ivaniuk interviews Dr. Ilona Krey, a physician and researcher at the Institute of Human Genetics at Leipzig University Medical Center. Sharp Waves episodes are meant for informational purposes only, and not as clinical or medical advice.Let us know how we're doing: podcast@ilae.org.The International League Against Epilepsy is the world's preeminent association of health professiona...

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92 results

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