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PODCAST

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade,Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee -has redefined what’s possible for the human mind and body. After more than a thousand episodes ofBulletproof Radio, he’s taking it to the next level withThe Human Upgrade™- a masterclass inbiohacking, longevity, and performance optimization.Each episode explorescutting-edge science, advanced technology, and proven biohacksto help youupgrade your energy, focus, metabolism, and resilience.You’ll

health & fitness self-improvement

All Episodes

00:58:02

You've Been Getting Dumber Every Day Since You Turned...

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/23

Neuroscientist Dr. Tommy Wood breaks down the science of brain aging, cognitive decline, and the biohacking strategies you can use to build a sharper, more resilient mind at any age.

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01:00:39

Jason Fung: 3 Rules to Lose 50 Pounds Without Ever...

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/21

You are not eating because you are hungry. You are eating because you have been trained to, and the food industry designed it that way. This episode dismantles everything you thought you knew about hunger, weight loss, and metabolism, and gives you a science-backed framework to finally stop fighting your own biology.-Watch this episode on YouTube:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Dr. Jason Fung, a New York Times bestselling author, practicing

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00:17:38

1 Cup Every Morning Helped Me Lose 100 Pounds (Drink...

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/19

Everything you've been told about diet and exercise is wrong — here's how eating more fat, skipping breakfast, and ditching the gym helped one biohacker lose 100 pounds and turn back his biological clock by 20 years.

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00:11:04

Flouride and IQ, Sardinemaxxing, At Home Cancer Cure,...

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/17

5:17 PMA virologist who cured her own terminal cancer, the molecule that makes fasting actually work, a hair loss treatment that makes minoxidil obsolete, the sardine stack that beats your supplement shelf, and a 70-year study that should embarrass half the country's health policy — this week, the gap between what's known and what you're doing about it has never been more expensive to ignore.

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00:36:57

Why I'm Putting 100x Bleach on My Face : 1450

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/16

Your body already makes the most powerful wound-healing molecule on the planet, and now you can use it at home. This episode breaks down hypochlorous acid (HOCl), the compound your white blood cells produce naturally, and why it outperforms Neosporin, hydrogen peroxide, and synthetic antibiotics for everything from cuts and burns to eczema, rosacea, and chronic wounds.-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPR-Grab a generous discount

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00:36:35

CDC Director Jim O'Neill on Fixing America's Broken...

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/14

A sitting government health official and lifelong longevity insider joins Host Dave Asprey to reveal how the U.S. is finally overhauling its approach to diet, aging, AI, and chronic disease from the inside out.

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00:30:40

What Doctor's DON'T Tell You About Megadosing...

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/12

1:25 PMCreatine is not just a bodybuilding supplement anymore, and Host Dave Asprey breaks down the full science of why this cheap, safe, and massively underrated compound may be the single most versatile biohack available for boosting brain power, protecting mitochondria, building muscle, and extending longevity in both men and women.

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00:09:47

Superhuman Contact Lenses, Motivation Supplement...

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/10

A stealth bacterial infection hiding in cat scratches, a common amino acid quietly cutting men's lifespans, contact lenses that upgrade your vision beyond normal, a supplement stack that actually moves motivation, and a 30-second nervous system reset you can do for free — Dave breaks down five under-the-radar findings that are changing how serious biohackers think about daily health.

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01:12:26

Why Doctors Can't Fix Women in 2026 : 1446

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/09

Most women are suffering for years from anxiety, gut problems, low libido, and brain fog because no one is treating the real cause: their hormones. This episode is a masterclass in women's hormone optimization, covering everything from vaginal delivery of bioidentical hormones to why low estrogen destroys your gut, your sex drive, your mitochondria, and your marriage.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down

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00:54:21

The Underground World of Frog Venom Ceremonies : 1445

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/07

Frog venom burns your skin, makes you purge, and might be the most powerful healing tool you havenevertried. In this episode, Host Dave Asprey sits down with Kambo researcher and practitioner Caitlin Thompson to break down how intentional suffering through this ancient Amazonian medicine is producing dramatic results for people with autoimmune conditions, chronic illness, Lyme disease, addiction, and metabolic dysfunction. From thepeptidescience behind the purge to the biohacking case for

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00:18:10

Fix Mitochondria With NASA’s Secret Anti-Aging...

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/05

Dave Asprey breaks down why aging is driven by oxidative stress at the cellular level, and reveals how NASA-researched algae, specifically spirulina and chlorella, can activate your body's built-in antioxidant defenses to slow the process from the inside out.

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00:54:21

Your AC Is Making You Dumber : 1444

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/03

Toxic mold is silently destroying your health, relationships, and home — and Dave Asprey and Superstratum founder Seth Jones break down exactly what it costs you and how to finally fix it for good.

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00:55:15

Your Doctor Is Wrong About Autism (Here's How To...

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/02

Autism is reversible, and the science to prove it already exists. This episode delivers a master class on the biological roots of autism, whatactually triggersit, and the protocols that have helped real families recover their children, including one mom who sold everything she owned to make it happen.Host Dave Asprey sits down with TracySlepcevic, bestselling author of Warrior Mom: A Mother's Journey in Healing Her Son with Autism, certified integrative health practitioner, Air Force

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01:02:24

Your Organic Protein Powder Is Slowly Killing You :...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/31

Most people buying "clean" supplements are unknowingly loading their bodies with heavy metals, rancid fish oil, and glyphosate, even inside products labeled organic and healthy. This episode breaks down exactly what the supplement industry refuses to tellyou andgives you the tools to stop poisoning yourself every morning.-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPR-Grab a discount onPuoriProducts by

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00:15:26

This Legal Sleep Powder Beats Melatonin Every Time :...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/29

A step-by-step breakdown of the exact brain states, amino acids, and light environment changes that separate people who fall asleep easily from people who lie awake staring at the ceiling.

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00:31:10

I Injected Stem Cells Into My Penis (Here's What...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/27

The most advanced stem cell clinic on the planet just figured out how to upgrade your brain like hardware, and Dave went to Costa Rica to be one of the first to try it.

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00:57:31

Arthur Brooks | Why Your Life Has No Meaning : 1438

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/26

The neuroscience of why optimizing your body means nothing if you're starving the half of your brain responsible for meaning, consciousness, and everything that makes life worth living.

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00:55:36

This Popular Fat Loss Shortcut Destroys Your Youth :...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/24

Your gut microbiome controls your brain chemistry, your stress response, your sleep, your metabolism, and your ability to lose weight, and most people have no idea how broken theirs actuallyis.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRGet 20% off your next purchase ofOMNi-BiOTiCwith code ‘Dave20’ at:https://omnibioticlife.com/In this episode, Host Dave Asprey and microbiome expert Hannah Kleinfeld break down the hidden gut science

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00:21:08

Give Me 21 Minutes And I'll Give You Perfect Vision...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/22

Your eyes have a built-in nightly repair cycle that most people unknowingly disrupt, and by adopting seven simple daily habits — including red light therapy, blueberries, cold exposure, grounding, distance viewing, deliberate blinking, and aligning with natural light cycles — you can reactivate that self-healing switch and restore or preserve your vision naturally.

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00:12:36

SNL Roasts MAHA, Pistachios Slap, ChatGPT Doctor...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/20

SNL, pistachios, AI doctors, your microbiome's architecture, colon cancer under 50, and a measles comeback — this week's news is a masterclass in why the assumptions you haven't questioned yet are the most dangerous ones.

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320 results

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