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PODCAST

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade,Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee -has redefined what’s possible for the human mind and body. After more than a thousand episodes ofBulletproof Radio, he’s taking it to the next level withThe Human Upgrade™- a masterclass inbiohacking, longevity, and performance optimization.Each episode explorescutting-edge science, advanced technology, and proven biohacksto help youupgrade your energy, focus, metabolism, and resilience.You’ll

health & fitness self-improvement

All Episodes

00:12:36

SNL Roasts MAHA, Pistachios Slap, ChatGPT Doctor...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/20

SNL, pistachios, AI doctors, your microbiome's architecture, colon cancer under 50, and a measles comeback — this week's news is a masterclass in why the assumptions you haven't questioned yet are the most dangerous ones.

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01:01:20

Here's Why You Still Feel Like Sh*t After Doing...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/19

Your thyroid controls your energy, your metabolism, your testosterone, your mood, and your ability to think clearly. Most doctors are testing it wrong and treating it wrong, and this episode tells you exactly what to do instead.-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with McCall McPherson, a physician associate, TEDx speaker, and founder of Modern Thyroid Clinic, Modern Weight Loss, and the advocacy

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00:58:56

Hair Regrowth, Pain Relief, and Altered States — The...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/17

What if a glowing pyramid sitting in your living room could restructure your biology, compress decades of meditation into minutes, and shift your brain into an altered state without drugs, breathwork, or effort? This episode reveals the science and experience behind one of the most unusual biohacking technologies Host Dave Asprey has everencountered.-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPR-Get $250 off from The Light System by using

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00:16:47

This Nobel Prize Discovery Reverses Aging In 72 Hours...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/15

A Nobel Prize-winning discovery reveals that triggering autophagy — your body's built-in cellular repair switch — through strategic 72-hour fasting can reverse biological aging, sharpen the brain, and regenerate tissues from the inside out.

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00:12:34

Your Telomeres Are a Lie, Bats Beat Aging, Sleep Meds...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/13

Your sleep tracker might be lying to you, bats are breaking the telomere model, a cheap kitchen seed is flattening glucose spikes, the first real longevity supplement trial just dropped hard data, carbon monoxide is quietly spiking in homes across the country, and fat plus carbs around your workout might actually be the move.

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01:03:19

Your Penis Is a Longevity Organ (Here's How to Hack...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/12

Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it.-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Dr. Justin Houman, a nationally recognizedurologistand Assistant Professor of Urology at Cedars-Sinai Medical Center. Fellowship-trained and specializing in men's health, male fertility, and sexual medicine, Dr. Houman

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00:57:57

AI Expert Says: Humans Are Just Mystical Meat Robots...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/10

What if understanding how AI thinks could reveal uncomfortable truths about how your own brain works, and give you powerful tools to make smarter decisions, resist manipulation, and upgrade your cognition at the root level?-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Tom Griffiths, the Henry R. Luce Professor of Information Technology, Consciousness, and Culture in the Departments of Psychology and

en

00:09:42

How I Finally FIXED My Terrible Sleep After 18 Years ...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/08

In this video, I break down why light exposure, not just sleep duration, controls your circadian rhythm, energy, and recovery.

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00:11:31

WW3 Doomscrolling, 5 Minute Sleep Hack, Diet Wars,...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/06

Your genes don't decide your fate — this week Dave breaks down five research-backed stories on how diet, daily habits, amino acid biology, and even your news feed are quietly shaping how fast you age.

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00:56:09

Your Brain Is 0.5% Plastic (Here’s How to Flush It) :...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/05

Microplastics are everywhere from teabags to synthetic clothing, accumulating in your brain and disrupting hormones, but simple detox strategies and Josephine Musco's innovative tea strips can help you reduce exposure and remove what's already in your body.

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00:53:16

Why Are Hackers Microdosing “Sex Drugs” Now? : 1425

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/03

Most doctors treat the average patient. But you are not average, and this episode gives you the precision medicine blueprint to treat yourself like the individual you are, using multi-omictesting, biohacking technology, and longevity science tooptimizeevery layer of your biology.-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Dr. Anil Bajnath, a Board-Certified Family Physician, author of The Longevity

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00:14:50

A-List Celebrities' Anti-Aging Hack to Look 30 At 50...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/01

Scientists have discovered a remarkable connection between an ancient practice and our cellular aging process - one that celebrities and longevity researchers are quietly using to their advantage. It involves an enzyme in your body that most people don't even know exists, yet it plays a crucial role in how fast (or slow) you age.

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00:09:22

Mexican Cartel Biohacking, Google Anti-Aging...

The Human Upgrade: Biohacking for Longevity &... ·

2026/02/27

This week, Host Dave Asprey breaks down the first real human age reversal trials, DeepMind’s closed-door AI drug engine, the global gray market peptide boom, the return of measles, and how 2026 health policy shifts could quietly shape access to the next generation of longevity tools.

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01:00:34

The Secret to Staying DANGEROUS After 50 : 1422

The Human Upgrade: Biohacking for Longevity &... ·

2026/02/26

Peptides can change how you heal, lean out, build muscle, and age, but only if you stop taking influencer advice and start thinking like a scientist.-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPR-Get a discount fromBIOLONGEVITY LABS by using code ‘Dave’ at:https://biolongevitylabs.com/Host Dave Asprey sits down with Josh Felber and Jay Campbell for a deep, practical conversation on what peptidesactually are, how they work in the body, and

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00:57:02

The Home Laser That Reverses Skin Age By 20 Years : 1421

The Human Upgrade: Biohacking for Longevity &... ·

2026/02/24

Your skin is not just a cosmetic surface.It’sa living organ that responds to signals, and the right light signal can flip your biology into repair mode.-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPR-Get a discount from LYMA by using code ‘DAVE10’ at:https://lyma.life/ -Offer not valid on LYMA Laser PRO or LYMA Youth SystemIn this episode, Host Dave Asprey goes to London to meet Lucy Goff, founder of LYMA, at the LYMA headquarters. Lucy

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00:11:57

I Tested The Most Dangerous Viral Brain Hack : 1420

The Human Upgrade: Biohacking for Longevity &... ·

2026/02/22

This video explains that brain fog begins when the brain’s energy system—its mitochondria—starts to fail, long before any obvious signs of aging appear.

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00:11:06

Plastic in Your Testicles, AI Sleep Scans, The 29%...

The Human Upgrade: Biohacking for Longevity &... ·

2026/02/20

This week’s episode explores how microplastics, aging mindset, next-gen weight-loss drugs, AI-driven sleep diagnostics, altitude-linked glucose metabolism, and shifting supplement laws are reshaping the future of longevity and human performance.

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01:12:44

Change Your Morning, Change Your Life – Hal Elrod : 1418

The Human Upgrade: Biohacking for Longevity &... ·

2026/02/19

Hal Elrod shares how the updated Miracle Morning SAVERS routine and evening practices helped him survive cancer, optimize daily performance, and create lasting transformation through flexible, personalized morning and evening rituals.

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01:06:53

The Secret to Looking Younger is in Mushrooms (And...

The Human Upgrade: Biohacking for Longevity &... ·

2026/02/17

Your gray hair, thinning lashes, brain fog, and that low energy feeling after 30 might all trace back to one thing: falling NAD and stressed mitochondria. This episode breaks down what actually happens inside your cells as NAD declines, and what you can do about it using specific compounds from mushrooms, olive oil, and even chocolate. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Wonderfeel is gifting a 7-day Youngr™ supply (mini pouch)

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00:14:14

Low Testosterone Starts In Your Eyes (Avoid This...

The Human Upgrade: Biohacking for Longevity &... ·

2026/02/15

Testosterone decline is driven less by age and lifestyle than by disrupted sleep architecture, and this episode explains how deep sleep controls hormone production and how to restore it to rebuild healthy testosterone rhythms.

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