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PODCAST

Live Well Be Well with Sarah Ann Macklin | Health, Lifestyle, Nutrition

Sarah Ann Macklin

Health shouldn’t feel this hard. I’ve lived it, studied it, and now I’m here to help make it make sense. A smarter, more human way to live well. Subscribe now, and start living well, for real. Instagram: @sarahannmacklin Newsletter: https://substack.com/@sarahannmacklin Website: sarahannmacklin.com #LiveWellBeWell

health & fitness alternative health

All Episodes

00:10:03

This One Gut Microbe Could Decide If Cancer Treatment...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2026/02/06

Watch the FULL podcast here: https://youtu.be/yZDzsfNjG_MCurious what Akkermansia actually does for your health? It’s discussed here as a keystone gut microbe linked to improved insulin sensitivity, lower A1C in clinical studies, GLP-1 release and healthier blood vessels, with associations to cancer immunotherapy response. This clip explores the gut brain circulation connection, how metabolism and energy relate to this microbe, and why people considering immunotherapy might also focus on gut health

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01:38:59

Why Compatibility is Overrated: Alain de Botton’s...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2026/02/04

We spend so much of our lives trying to be impressive. We polish our edges and hide our cracks because we’re terrified that being "real" means being weak. But what if the very things we are hiding are actually the only bridges to real connection? It is a scary thought, but one that completely changes how we show up in the world.Here’s what we explore together:- Why being "invulnerable" is sometimes just as important as being open and how to know the difference.- How accepting

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00:11:17

How much social connection do we actually need?...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2026/02/02

Watch the FULL podcast here: https://youtu.be/HHvG8HEYdjAAre we built to manage only about 150 meaningful relationships, and what does that mean for our health? It matters because small, real-world connections help lower loneliness-driven stress that can worsen heart disease prognosis and raise some cancer risk. This clip explores the 150-person social limit, why in-person cues beat screens, a call-based study that eased loneliness, concerns about AI companions and hyper-independence, and lessons

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00:07:18

Can gut bacteria influence brain disease? The...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2026/01/30

Can specific gut and mouth bacteria influence brain health and conditions like Parkinson's or Alzheimer's? We look at early clinical work on Lactobacillus plantarum PS128 and its potential to slow Parkinson's progression, links between gum disease and dementia, and how Lactobacillus reuteri may stimulate oxytocin. This clip explores the gut-brain and oral-brain connections, the idea of a brain microbiome, and emerging views on brain regeneration and healthy aging. ***This episode is

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01:34:33

Why Women Feel Like TWO DIFFERENT PEOPLE Every Month...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2026/01/28

Ever feel like you’re waking up as two different people depending on the week of the month? One week you’re taking on the world with total confidence, and the next, you’re second-guessing every decision you’ve ever made. It turns out, that isn’t just "you being emotional", it’s actually a sign of your brain responding to a very specific biological rhythm.This week on Live Well Be Well, I’m sitting down with the brilliant Dr. Sarah Hill. She’s an evolutionary psychologist and the author of This Is

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00:07:19

Is Your Phone Killing Your Creativity? 3 Ways to...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2026/01/26

Can boredom and daydreaming actually boost creativity and calm? Here, I’m discussing how a solo writing sprint in nature left my HRV higher and my mind clearer, then we examine the default mode and executive networks, task switching, and screen-free habits. This clip explores the Meals, Bedroom, Bathroom rule for no phones, the value of nature time, and reframing boredom as daydreaming to restore the brain. We talk practical steps for dopamine-heavy habits, why reflection improves decisions, and how

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00:04:23

Longevity Doctor: Alzheimer’s Is Preventable If You...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2026/01/22

Watch the FULL podcast here: https://youtu.be/qHFymGgsYyEWorried about Alzheimer’s and what you can do now? You’ll hear practical, testable steps to lower risk by targeting metabolism, inflammation and toxins, plus daily habits for brain rest and sleep. This clip explores the idea that Alzheimer’s can have different drivers, the importance of early testing (continuous glucose monitors, hs-CRP, urine toxin tests), and simple changes like meditation, less phone time, better sleep, air purifiers,

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01:20:56

We Weren't Designed to be Happy: The Scientific...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2026/01/21

This week on Live Well Be Well, I’m joined by Dr Anders Hansen, psychiatrist, neuroscientist, and bestselling author of The Real Happy Pill and Brain Blues, to explore how modern life is reshaping our mental health, focus, and emotional resilience.In this conversation, Anders explains why anxiety, low mood, and restlessness are not failures of the mind, but evolutionary responses that no longer fit our current environment. We discuss how movement, boredom, attention, and social connection shape

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00:07:05

Why Women Face Higher Alzheimer’s Risk (And The One...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2026/01/19

Watch the FULL podcast here: https://youtu.be/QeNdkCVYquUAre women at higher risk of Alzheimer’s, and can life roles influence dementia risk? This clip explores why two-thirds of Alzheimer’s cases are in women, how vascular dementia differs, and how age-specific dementia risk has fallen over recent decades. We discuss factors like improved nutrition, better heart health care, and environmental complexity, jobs, education, and social engagement, linked to maintaining cognition into our 80s. A

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00:05:45

The Brain Has Bacteria? What the Brain Microbiome...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2026/01/16

Watch the FULL podcast here: https://youtu.be/yZDzsfNjG_MCould your brain host healthy bacteria? This clip explores how parts once taught as sterile, such as breast milk, the bladder, and the brain, contain beneficial microbes, and what they might be doing. We touch on gut and brain communication through the vagus nerve, the idea of dysbiosis versus infection, and why modern findings ask for humility in medicine. Here, I’m discussing practical takeaways like paying attention to how your body feels

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00:23:30

The Hardest Thing I’ve Learned About Self-Talk — and...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2026/01/14

A quick note before we beginThis year, I’m doing something I’ve wanted to do for a long time.I want to start this year by sharing something a little different.After four years of Live Well Be Well, I’m introducing regular solo episodes. It’s taken me a long time to get here. Not because I didn’t have things to say, but because it’s taken a lot of belief in myself to sit here and share my own thoughts, reflections, and opinions, alongside the voices of the people I speak to on the show.These episodes

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00:05:41

The Three S Model: Stimulus, Supply and Support for...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2026/01/12

Watch the FULL podcast here: https://youtu.be/QeNdkCVYquUCan nutrition and supplements meaningfully lower dementia risk or mainly boost day-to-day focus? They matter within a broader Three S model that links stimulus, supply, and support for brain adaptation. This clip explores why cognitive challenge is the primary stimulus, how supply depends on blood flow, oxygen, and fuel, and how support includes sleep and less chronic stress. We discuss omega-3s, B vitamins, choline, vitamin D, magnesium,

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00:05:15

Human Performance Scientist: Are GLP-1 weight loss...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2026/01/09

Are GLP-1 weight loss drugs a smart first step for obesity? They’re helping many people lose significant weight, yet concerns remain about side effects, muscle loss, cost, and regaining weight after stopping. This clip explores the promise and limits of GLP-1s, the call for long term data, and the need to pair medication with nutrition education, counseling, and strength training. It also considers real world access and whether short term success can translate into lasting health. ***This episode is

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01:07:55

Akkermansia, Cancer & GLP-1: How Your Gut Microbiome...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2026/01/07

In this episode of Live Well Be Well, I’m joined by Dr. William Li, physician scientist, bestselling author, and president of the Angiogenesis Foundation. William is one of the world’s leading voices on food as medicine, and together we explore how nutrition, immunity, and brain health are deeply connected, often in ways we underestimate.In this conversation, Dr. William Li shares how the body’s defence systems are constantly communicating with the brain, influencing inflammation, cognition, mood,

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00:06:04

Neuroscience Explains: Can You Prevent Alzheimer’s If...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2026/01/05

👉 Practical beats perfect.Here’s a free 5-recipe PDF I use to support energy and stress during busy weeks.https://sarahannmacklin.com/5_free_recipes👉 If this resonates, you can join the thousands who readThe Compassionate Cure each week.https://sarahmacklin.substack.com/Watch the FULL podcast here: https://youtu.be/QeNdkCVYquUDoes having APOE4 mean Alzheimer’s is inevitable? It doesn’t, and I explain how genes interact with lifestyle and environment to shape risk. This clip explores early-onset

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00:14:32

Why Do You Wake Up at 2–3am? The Real Sleep...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2026/01/02

Watch the FULL podcast here: https://youtu.be/ZXLWY5HcPXEIn this conversation, I sit down with Andy Galpin to talk about sleep, and why so many of us are still struggling with it despite doing “all the right things”.We unpack why sleep is getting worse globally, even as awareness and spending on sleep continue to rise. Andy explains why focusing on sleep duration alone misses the bigger picture, and why exhaustion is not the same as being physiologically ready for sleep. We also explore why waking

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00:47:19

What We Learned About the Brain in 2025 | Stress,...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2025/12/31

What if the qualities you’ve been taught to override are actually the ones keeping you well?To round of 2025, I’m joined by world-leading thinkers including Simon Sinek, Dr. Rick Doblin, Robin Sharma, Professor Nicolau, and Dr. Sarah McKay to explore what truly shapes our wellbeing when the noise fades and the signal becomes clearer.This episode weaves together some of the most powerful moments from conversations across the year. From introversion and energy boundaries, to trauma, inflammation,

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00:07:07

How Do You Know You’re in Zone 2? Finding the Right...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2025/12/29

Watch the FULL podcast here: https://youtu.be/7kfykswH6IoThis clip explores how to identify zone two intensity without relying on a wearable. I discuss the link between breathing rate, conversation ability and the underlying metabolic changes that define this training zone. We take a closer look at why many people unintentionally drift into higher intensities, suppress fat oxidation and struggle to lose weight despite working hard. The conversation also touches on fat max, mitochondrial function and

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01:01:23

The Biology of Health & Longevity | Top Expert...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2025/12/28

👉 Practical beats perfect.Here’s a free 5-recipe PDF I use to support energy and stress during busy weeks.https://sarahannmacklin.com/5_free_recipes👉 If this resonates, you can join the thousands who readThe Compassionate Cure each week.https://sarahmacklin.substack.com/👉 Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. https://sarahmacklin.substack.com/As we wrap up another incredible year of Live Well Be Well, I found myself asking one

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00:05:29

Are You Recovering Enough? Stress,Sleep, and Daily...

Live Well Be Well with Sarah Ann Macklin | Health,... ·

2025/12/26

Watch the FULL podcast here: https://youtu.be/IIenBH9xAEkThis segment explores how stress affects the body and why recovery matters just as much as the stress itself. The discussion makes clear that stress is normal, but what truly impacts health is how quickly we return to homeostasis once the moment has passed.Here, we examine the difference between ongoing strain and healthy regulation, the role of sleep in stress resilience, and why two people with the same workload can experience completely

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