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PODCAST

a16z Podcast

Andreessen Horowitz

The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

technology entrepreneurship

All Episodes

00:32:11

Geopolitics of AI: Why Nations Are Building Their Own...

a16z Podcast ·

2025/05/24

What happens when AI stops being just infrastructure—and becomes a matter of national identity and global power?In this episode, a16z’s Anjney Midha and Guido Appenzeller explore the rise of sovereign AI—the idea that countries must own their own AI models, data centers, and value systems.From Saudi Arabia’s $100B+ AI ambitions to the cultural stakes of model alignment, we examine:Why nations are building local “AI factories” instead of relying on U.S. cloud providersHow foundation models are

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00:36:19

What Is an AI Agent?

a16z Podcast ·

2025/05/22

What exactly is an AI agent — and does anyone actually agree?In this episode, taken from of AI + a16z, General Partner Guido Appenzeller and partners Matt Bornstein and Yoko Li break down one of the most hyped- and most hotly debated 0 concepts in AI right now: agents.Are agents just clever wrappers around LLMs? Tools that can reason and act? Or simply a fresh label for familiar tech?Whether you're building, investing, or just trying to make sense of the buzz, this episode is for you.Resources:Find

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00:33:14

The Evolution of the Firm — with Ben and Marc

a16z Podcast ·

2025/05/20

Recorded live at the 2025 a16z LP Summit, this episode is a candid conversation between a16z cofounders Marc Andreessen and Ben Horowitz—hosted by general partner Erik Torenberg.They cover the evolution of a16z from startup firm to multi-practice platform, how the media landscape is shaped by meme-speed narratives, why reorgs—not just returns—determine who wins, and what it takes to build an enduring venture franchise.They also share thoughts on the changing policy landscape for AI and crypto, the

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00:17:06

Unbundling the BPO: How AI Is Disrupting Outsourced Work

a16z Podcast ·

2025/05/17

Business Process Outsourcing (BPO) is a $300 billion industry powering the back- and front-office operations of the world’s largest companies.In her article, "Unbundling the BPO: How AI Will Disrupt Outsourced Work," Kimberly Tan (Partner, a16z) explores how the rise of AI is challenging the status quo. In this episode, Kimberly unpacks the shift—from call centers and invoice processing to cross-system automation and coding agents. They explore how AI is redefining the economics of scale, unlocking

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00:28:22

Marc Andreessen: Deep Vs. Broad Founders, AI in...

a16z Podcast ·

2025/05/16

Today on the a16z Podcast, we’re sharing Marc Andreessen’s recent appearance on TBPN.Marc—cofounder and general partner at a16z—joins hosts John Coogan and Jordi Hays for a wide-ranging conversation, recorded live at the a16z’s 2025 LP Conference in Las Vegas.They cover the rise of AI, the future of open source models, and how tech is transforming every corner of the economy—from education and defense to healthcare and housing.Marc also shares his thoughts on the evolution of venture capital, the

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00:42:16

What Super Agers Reveal About Preventing Disease

a16z Podcast ·

2025/05/14

American healthcare is in crisis—but what if we could change the system by preventing disease before it starts?In this episode of the a16z Podcast, general partner Vijay Pande sits down with Dr. Eric Topol, founder and director of the Scripps Research Translational Institute and one of the most cited researchers in medicine, to explore the cutting edge of preventive healthcare and longevity science.Drawing from his new book Super Agers: An Evidence-Based Path to Longevity, Topol breaks down why

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00:33:20

Startups & Defense: Katherine Boyle on TBPN

a16z Podcast ·

2025/05/07

In this episode of th a16z Podcast, we’re sharing Katherine Boyle’s recent interview on TBPN.Katherine—General Partner at a16z and the architect of the American Dynamism thesis—joins hosts John Coogan and Jordi Hays to discuss the state of the movement today. They cover the Department of Defense’s sweeping reform efforts, the role of startups in national security, and why American Dynamism is just getting started.From procurement reform to reindustrialization, this wide-ranging conversation explores

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00:35:55

Do You Really Know Your ICP? Why It Matters and How...

a16z Podcast ·

2025/05/07

Your ideal customer profile (ICP) is the north star for your entire company: it determines who you’re building for and selling to. Though most growth-stage founders think they know who their ICP is, very few know how to update and refine it to keep the company focused as they grow—which can lead to a lot of headaches down the road.In this debut episode of a16z Growth’s new company scaling podcast, the a16z Guide to Growth, a16z's Joe Morrissey (General Partner, a16z Growth), Michael King (Partner,

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00:40:56

The Software Crisis Behind America's Infrastructure

a16z Podcast ·

2025/04/30

Today’s critical infrastructure—air traffic, logistics, defense—is powered by legacy software. And that’s a problem.In this episode, recorded live at the a16z American Dynamism Summit, a16z partner Leila Hay sits down with Phillip Buckendorf, CEO of Air Space Intelligence, and Lt. Gen. Leonard J. Kosinski (Ret.), ASI’s Chief Strategy Officer and former Director for Logistics on the Joint Staff for the Pentagon. They explore why software is now a weapon system, how dual-use tech can harden both

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00:32:30

What Comes After Mobile? Meta’s Andrew Bosworth on AI...

a16z Podcast ·

2025/04/24

Are we nearing the end of the smartphone era?In this episode, a16z Growth General Partner David George talks with Meta CTO Andrew “Boz” Bosworth about what comes after apps and touchscreens. From smart glasses to AR headsets, Boz shares how AI is powering a new wave of computing—one that’s ambient, agentic, and driven by human intent.They explore what it takes to build for this future, the risks of changing interaction models, and why the next big platform shift may already be in motion.This episode

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00:37:51

The Dual-Use Founder: Vets Now Building For America

a16z Podcast ·

2025/04/16

In today’s world, the battlefield extends far beyond war zones—it’s embedded in our tech stacks, supply chains, and airspace security systems. So who better to solve these modern challenges than those who’ve served on the front lines?Recorded live at the third annual American Dynamism Summit in Washington D.C., this episode features a16z’s Matt Shortal—a veteran himself—moderating a conversation with three founders who transitioned from military service to building cutting-edge defense startups:John

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00:40:31

The Future of Drone Warfare

a16z Podcast ·

2025/04/09

War has always been shaped by technology—from steel and gunpowder to GPS and nuclear weapons. But the decisive technologies of tomorrow aren’t coming—they’re already here.In this episode, recorded live at our third annual American Dynamism Summit, a16z’s Senior National Security Advisor Matt Cronin sits down with Ryan Tseng (cofounder & CEO, Shield AI) and Adam Bry (cofounder & CEO, Skydio) to discuss the rise of autonomous drones, AI-driven warfare, and the escalating great power competition with

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00:51:18

How to Build with the Department of Defense

a16z Podcast ·

2025/04/02

When people think about startups working with the government, the phrase “black box” often comes up. But what if that box is finally being pried open?In this episode—recorded live at the American Dynamism Summit in DC—we talk with two Chief Technology Officers at the heart of American defense: Alex Miller, CTO for the Chief of Staff of the Army, and Justin Fanelli, CTO at the Department of the Navy. Along with a16z partner Leila Hay, they break down how the Department of Defense is shifting from

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00:38:14

The Top 100 GenAI Products, Ranked and Explained

a16z Podcast ·

2025/03/26

This month, a16z’s Consumer team released the fourth edition of the GenAI 100 — a data-driven ranking of the top 50 AI-first web products and mobile apps, based on unique monthly visits and active users.In just six months, the consumer AI landscape has shifted dramatically. Some products surged ahead, others plateaued, and a few unexpected players reshaped the leaderboard entirely.In this episode, a16z General Partner Anish Acharya and Partner Olivia Moore join us to unpack the latest rankings and

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00:55:03

Jensen Huang and Arthur Mensch on Winning the Global...

a16z Podcast ·

2025/03/21

The global race for AI leadership is no longer just about companies—it’s about nations. AI isn’t just computing infrastructure; it’s cultural infrastructure, economic strategy, and national security all rolled into one.In this episode, Jensen Huang, founder and CEO of NVIDIA, and Arthur Mensch, cofounder and CEO of Mistral, sit down to discuss sovereign AI, national AI strategies, and why every country must take ownership of its digital intelligence.How AI will reshape global economies and GDPThe

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00:43:19

Why AI Voice Feels More Human Than Ever

a16z Podcast ·

2025/03/18

AI voice technology has been around for years — think Siri or Alexa — but the magic has been missing. That’s changing, and quickly!In this episode, Anish Acharya, General Partner at a16z, and Olivia Moore, Partner at a16z, explore why AI voice is reaching a breakthrough moment, how today’s models feel more human than ever, and why voice is poised to become the primary way people interact with AI.With businesses already making tens of thousands of AI-driven phone calls daily, AI-powered conversations

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00:42:38

From Thesis to Meme to Fund: Building American Dynamism

a16z Podcast ·

2025/03/11

For over a century, the United States has been the birthplace of world-changing innovation – from the Wright brothers’ first flight to the invention of the transistor, the moon landing, and the birth of the internet. But in recent years, belief in American progress has wavered.Three years ago, a16z General Partner Katherine Boyle wrote a bold thesis called Building American Dynamism, challenging this apathy and calling for startups to tackle the country’s biggest problems. The idea spread fast –

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00:40:37

What Founders Get Wrong About Scaling – With Carta’s CEO

a16z Podcast ·

2025/03/07

Henry Ward, cofounder and CEO of Carta, has spent over a decade scaling his company from an early-stage startup to a 2,000-person industry leader. In this a16z Speedrun conversation with Games partner Josh Lu, Henry shares hard-earned lessons on:Hiring missionaries vs. mercenaries — and how to keep company culture intact as you scaleThe reality of product-market fit and why many founders try to sell too soonThe evolution of a CEO — from building a product to building a system around youInputs vs

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00:42:22

Creativity vs Control: Where AI Fits in the Creative...

a16z Podcast ·

2025/02/25

Being a creator in 2025 is tough—but building for creators is even harder. Perhaps no one understands this conundrum better than Scott Belsky. As the founder of Behance, a longtime executive at Adobe, and an advisor to companies like Pinterest and Atlassian, Scott has spent his career at the intersection of technology, design, and creativity.In this speedrun episode, recorded live in San Francisco during the fourth iteration of our a16z Games Speedrun program, we dive into:How AI can actually enable

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00:32:55

Who Will Own the Internet? a16z’s Chris Dixon on AI...

a16z Podcast ·

2025/02/20

Technology doesn’t grow in isolation—it evolves in waves. Just as mobile, cloud, and SaaS shaped the internet of the past 20 years, so too could crypto, AI, and new hardware usher in an era of the internet that’s pro-innovation, pro-startup, and pro-creator. Speaking with a16z Growth General Partner David George, a16z crypto Founder and Managing Partner Chris Dixon breaks down his vision for a new internet, from using crypto to decentralize AI infrastructure and kickstart network effects, to why AI

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