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PODCAST

The a16z Show

Andreessen Horowitz

The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

technology entrepreneurship

All Episodes

00:48:47

Martin Shkreli on AI, Pharma, and What Actually Matters

The a16z Show ·

2026/04/23

Erik Torenberg speaks with Martin Shkreli, American investor and businessman, about how he sees the AI landscape, from OpenAI to Anthropic, and what actually matters beyond the hype. They also talk through the future of computing, the limits of “vibe coding,” and why biotech and pharma remain some of the toughest industries to get right.Resources: Follow Martin on X: https://x.com/MartinShkreli Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show

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02:01:33

Balaji Srinivasan: Prove Correct, Not Just Go Direct

The a16z Show ·

2026/04/22

Erik Torenberg and Theo Jaffee speak with Balaji Srinivasan, angel investor, entrepreneur, and author of The Network State, about how AI is transforming media, eroding trust, and reshaping how information is created and verified. They discuss why systems like hiring, journalism, and online communication are breaking under synthetic content, and what replaces them. The conversation also examines the role of cryptography, on-chain data, and new models of proof in rebuilding trust

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01:07:18

Marc Andreessen: Monitoring the Situation and the...

The a16z Show ·

2026/04/21

Erik Torenberg and Theo Jaffee speak with Marc Andreessen, cofounder and general partner at a16z, about the launch of Monitoring the Situation (MTS), a new, always-on media network on X. They discuss the rise of the “current thing,” how narratives spread in real time, and why internet-native media is reshaping politics, culture, and attention.Resources: Follow Marc X: https://x.com/pmarca Follow Eric on X: https://x.com/eriktorenberg Follow Theo on X: https://x.com/theojaffee Follow MTS on X:

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00:47:05

Rethinking Git for the Age of Coding Agents with...

The a16z Show ·

2026/04/20

Matt Bornstein speaks with Scott Chacon, cofounder of GitHub and CEO of GitButler, about why Git's user interface has barely changed since 2005, how GitButler is rethinking version control for both humans and AI agents, and what the "next GitHub" might actually look like. They cover parallel branches, agent-optimized CLI design, the future of code review, and why the best engineers of the future will be the best writers. Resources: Follow Scott Chacon on X: https://twitter.com/chacon Follow Matt

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00:58:45

Network Effects, AI Costs, and the Future of Consumer...

The a16z Show ·

2026/04/19

This episode originally aired on The Kevin Rose Show. Kevin Rose speaks with Anish Acharya, general partner at a16z, about how AI is rewriting the rules of consumer software, the defensibility of network effects in a world where anyone can spin up an app in 48 hours, and why the real threat to consumer founders may be the cost of inference, not competition. They also discuss model pricing, the future of the four-day work week, and peptides. Resources: Follow Anish on X:

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01:04:01

The System Behind Self-Driving: Waymo’s Dmitri Dolgov

The a16z Show ·

2026/04/17

Waymo is now delivering hundreds of thousands of fully autonomous rides each week — but getting there required more than better models. It meant building a complete system for training, evaluating, and deploying a driver in the real world. In this episode — originally aired on the Cheeky Pint podcast — Waymo Co-CEO Dmitri Dolgov joins John Collison to break down how self-driving actually works today: from sensor fusion across LiDAR, radar, and cameras, to simulation, “critic” models, and the role of

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00:34:12

Technology, Culture, and the Next AI Interface with...

The a16z Show ·

2026/04/16

Erik Torenberg and Anish Acharya, general partners at a16z, speak with signüll about how technology reshapes culture, relationships, and the products we build. The conversation covers tacit knowledge versus intellectual knowledge, dating apps and their effect on human connection, AI relationships, why Claude feels artisan while other models feel utilitarian, and what consumer founders should actually care about.Resources: Follow signüll on X: https://twitter.com/signulll Follow Anish Acharya on

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01:39:18

Replit's CEO on Vibe Coding, Wealth Building, and...

The a16z Show ·

2026/04/15

Jack Neel speaks with Amjad Masad, CEO at Replit, about how AI is making it easier than ever to build and ship software without a technical background. They discuss Replit's rise from a browser-based coding tool to a platform generating $250 million in annual revenue, why Masad turned down a $1 billion acquisition offer, and his case for why AI represents empowerment rather than existential risk. This episode originally aired on The Jack Neel Podcast.Follow Amjad Masad on X:

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00:29:43

Ben Horowitz on AI Infrastructure, Economics and The...

The a16z Show ·

2026/04/14

Recorded live at the a16z Fintech Connect conference in Deer Valley, Alex Rampell speaks with Ben Horowitz, cofounder and general partner at a16z, about how AI has rewritten the fundamental rules of software competition, why crypto infrastructure will become essential in an AI-dominated world, and what the future holds for venture capital. Resources: Follow Alex Rampell on X: https://twitter.com/arampell Follow Ben Horowitz on X: https://twitter.com/bhorowitz Stay Updated:Find a16z on YouTube:

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00:54:39

Building Agents at Home: Parenting, Work, and...

The a16z Show ·

2026/04/13

Katherine Boyle and Sarah Wang speak with Jesse Genet, a startup founder and family builder, about building 11 AI agents while homeschooling four young children. Jesse runs agents across roles ranging from coding to curriculum planning to household management, and she shares how agent architecture, logging systems, and “benevolent neglect” parenting have changed her life as both a founder and a mother. Resources: Follow Jesse Genet on X: https://twitter.com/jessegenet Follow Katherine Boyle on X:

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00:31:23

What Running Windows at Microsoft Taught Steven...

The a16z Show ·

2026/04/10

Theo Jaffee speaks with Steven Sinofsky, board partner at a16z and former president of the Windows division at Microsoft, about Apple's 50th anniversary, the cultural differences that separated Apple and Microsoft, why the MacBook Neo puts Windows laptops in a difficult position, and what the history of computing design reveals about where hardware and software are headed.Resources: Follow Steven Sinofsky on X: https://twitter.com/stevesi Follow Theo Jaffee on X:

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01:39:00

Who Controls AI Acceleration? Vitalik Buterin and...

The a16z Show ·

2026/04/09

Eddy Lazzarin speaks with Vitalik Buterin, founder of Ethereum, and Guillaume Verdon, founder and CEO of Extropic, about whether AI progress can or should be steered, the risks of concentrated power, and what open source and decentralization mean for who benefits from increasingly powerful systems. This episode originally aired on the a16z crypto podcast. Resources: Follow Vitalik Buterin on X: https://twitter.com/VitalikButerin Follow Guillaume Verdon on X: https://twitter.com/GillVerd Follow

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00:59:37

The Agent Era: Building Software Beyond Chat with Box...

The a16z Show ·

2026/04/08

Erik Torenberg, Steve Sinofsky, and Martin Casado speak to Aaron Levie, CEO at Box, about what happens to enterprise software when agents become the primary users. They discuss why coding agents succeed where other knowledge work agents struggle, what abstraction layers mean for the workforce, and how data access and systems of record must change in an agent-first world.Resources: Follow Aaron Levie on X: https://twitter.com/levie Follow Steve Sinofsky on X: https://twitter.com/stevesi Follow

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01:07:07

Balaji on Why AI Raises the Cost of Verification

The a16z Show ·

2026/04/07

a16z general partner Erik Torenberg speaks with Balaji Srinivasan, angel investor and entrepreneur, about why AI simultaneously reduces the cost of creation and increases the cost of verification, and what that tension means for the shape of the AI economy. They discuss why AI drives companies toward the "trusted tribe" model of the Chinese internet, why physical world tasks are easier to automate than digital ones, why shortcuts only work for experts, and why AI makes everyone a CEO rather than

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00:28:37

Peter Yang on Small Teams, Coding Agents, and Why...

The a16z Show ·

2026/04/06

Anish Acharya speaks with Peter Yang, creator and product lead at Roblox, about how personal AI agents are replacing the apps we open every day, why coding agents feel like slot machines, and what happens when the cost of building software drops to near zero. They discuss why future companies will stay radically small, how the IDE is becoming a thinking tool rather than a making tool, and why human ambition will always create more jobs than AI eliminates.Follow Peter Yang on X:

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01:17:28

Marc Andreessen on AI Winters and Agent Breakthroughs

The a16z Show ·

2026/04/03

This episode originally aired on the Latent Space Podcast. swyx and Alessio Fanelli speak with Marc Andreessen about the arc of AI from its origins in 1943 to today's breakthroughs in reasoning, coding agents, and self-improvement. They cover the parallels between AI scaling laws and Moore's Law, the architectural insight behind Claude Code and the Unix shell, the coming supply crunch in compute, and why the messy reality of 8 billion people means both AI utopians and doomers are too optimistic

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00:42:27

Alex Blania on Proof of Human and Building World's...

The a16z Show ·

2026/04/02

a16z's Ben Horowitz and Erik Torenberg speak with Alex Blania, cofounder and CEO of Tools for Humanity, World, and cofounder of Merge Labs. World is building the largest real human network, a proof-of-human layer for the AI era. They cover the technical challenge of proving human uniqueness at scale using iris biometrics, the privacy architecture behind World ID, and why platforms from social networks to dating apps to video conferencing will soon require proof of human

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00:27:51

What Happens When a Public Company Goes All In on AI

The a16z Show ·

2026/04/01

David Haber speaks with Owen Jennings, executive officer and business lead at Block, about how the company rebuilt itself around AI agents, small squads, and internal tools like Goose and Builder Bot after restructuring more than 40% of its workforce. They discuss what it took to execute a major restructuring, how teams of three are now doing what teams of 14 used to, and how Block is shipping AI-native products like Money Bot and Manager Bot that generate custom interfaces on the fly for tens of

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00:49:01

How Radiant and Heron Are Rethinking Power Generation...

The a16z Show ·

2026/03/31

a16z general partners Erin Price-Wright and Erik Torenberg speak with Doug Bernauer, founder and CEO of Radiant, and Drew Baglino, founder and CEO of Heron, about rebuilding American energy infrastructure. They discuss portable micro nuclear reactors, solid state power electronics, why delivery rather than generation is the real bottleneck, the case for modular manufacturing, and whether data centers are actually good for the grid.Resources: Follow Doug Bernauer on X:

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01:07:40

Marc Andreessen on Evaluating Founders and AI's...

The a16z Show ·

2026/03/30

This episode originally aired on The Twenty Minute VC with Harry Stebbings. Marc Andreessen explains why learning from past investment mistakes can be a trap, shares his framework for evaluating founder greatness through IQ, courage, and drive, and makes the case that venture investors should back the person over the business plan. They also discuss why AI is reconcentrating the tech industry in Silicon Valley, the concept of consumer surplus and where 99% of AI's value will actually go, and why the

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1,071 results

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