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PODCAST

The a16z Show

Andreessen Horowitz

The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

technology entrepreneurship

All Episodes

00:36:42

Ben Thompson: Anthropic, the Pentagon, and the Limits...

The a16z Show ·

2026/03/05

In this conversation, previously aired on TBPN, John Coogan and Jordi Hays speak with Ben Thompson, founder of Stratechery, about his essay "Anthropic and Alignment" and the broader collision between AI power and state power that the Anthropic–Department of War standoff revealed.Resources: Follow Ben Thompson on X: https://twitter.com/benthompson Follow John Coogan on X: https://twitter.com/johncoogan Follow Jordi Hays on X: https://twitter.com/jordihays Follow TBPN on X:

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00:49:10

Deploying AI in Healthcare

The a16z Show ·

2026/03/04

a16z general partner Julie Yoo talks with Nikhil Buduma, CEO and cofounder of Ambience Healthcare, to discuss how AI is transforming clinical workflows. They cover the early days of deep learning, why Ambience started by running a medical practice before building a platform company, and what it takes to achieve high clinician adoption rates at major academic medical centers. They also dig into the challenge of building products when AI capabilities change every few months, the real ROI that's

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00:50:57

Ben Horowitz On What Makes a Great Founder

The a16z Show ·

2026/03/03

On the show Long Strange Trip, Sequoia Capital partner Brian Halligan speaks with a16z’s Ben Horowitz about what separates great founder CEOs from everyone else. Ben explains why first-time founders lose confidence, defer too much to senior hires, and let decision debt paralyze their companies. They discuss where founder mode works and where people are taking it too far, why the VP of Sales is the hire founders mess up more than any other, and why Andy Grove's "constructive confrontation" matters

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00:59:33

Chris Dixon: From Quant Trading to Building a16z Crypto

The a16z Show ·

2026/03/02

In this feed drop from the Internet History Podcast, host Brian McCullough speaks with Chris Dixon, general partner at a16z, about his path from 1980s hobbyist programmer to one of the most prominent venture capitalists in tech. Chris traces his career from quantitative finance to founding SiteAdvisor, cofounding Founder Collective, starting an early machine learning company, and eventually building a16z's crypto practice from the ground up. They also discuss his framework for spotting

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00:48:28

a16z's New Media Playbook

The a16z Show ·

2026/02/27

Erik Torenberg, Ben Horowitz, and Marc Andreessen discuss how the media landscape has fundamentally changed and what a16z is doing about it. They cover why offense beats defense, why individuals now matter more than corporate brands, why speed wins in the new media landscape, and the difference between oral and written culture on the internet.Resources: Follow Erik Torenberg on X: https://twitter.com/eriktorenberg Follow Ben Horowitz on X: https://twitter.com/bhorowitz Follow Marc Andreessen on

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00:47:01

When Giants Don’t Go Public: Inside the $5 Trillion...

The a16z Show ·

2026/02/26

Bloomberg's Odd Lots hosts Joe Weisenthal and Tracy Alloway speak with David George, general partner at a16z and head of the firm's growth fund, about why $5 trillion in tech market cap now sits in the private markets, how that figure has grown 10x in a decade, and what it means for founders, employees, and investors. They also cover SPVs, tender offers, the collapse of legacy software valuations, and why AI companies may be speed-running the path to public markets. This episode originally aired on

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01:48:00

Ben Horowitz: RSI, Crypto as AI Money, & Classified...

The a16z Show ·

2026/02/23

Moonshots host Peter Diamandis speaks with Ben Horowitz, cofounder and general partner at a16z, alongside regular cohosts Salim Ismail, Dave Blundin, and Dr. Alexander Wissner-Gross, about whether AI can or should be paused, what happened when Horowitz told a Biden administration official that regulating AI means regulating math, why crypto is the natural money for AI agents, and why the gap between AI capability and societal adoption may be wider than people think. This episode originally aired on

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00:52:53

Patrick Collison on Stripe’s Early Choices,...

The a16z Show ·

2026/02/20

Michael Truell, CEO of Cursor, sits down with Patrick Collison, CEO of Stripe and an investor in Anysphere, to talk about Collison's history with Smalltalk and Lisp, the MongoDB and Ruby decisions Stripe still lives with 15 years later, why he'd spend even more time on API design if he could do it over, and whether AI is actually showing up in economic productivity data. This episode originally aired on Cursor's podcast.Resources: Follow Patrick Collison on X:

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00:57:52

AI’s Capital Flywheel: Models, Money, and the Future...

The a16z Show ·

2026/02/19

a16z's Martin Casado and Sarah Wang join Latent Space hosts Alessio Fanelli and Swyx to discuss what makes this AI investment cycle unlike anything in the history of venture capital. They cover why the lines between venture and growth, apps and infrastructure are blurring, how frontier model companies can raise more than the aggregate of everyone built on top of them, and why the industry-wide gap between perception and reality has never been wider.Follow Alessio Fanelli on X:

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00:59:53

From Copilots to Agents: Rebuilding the Company...

The a16z Show ·

2026/02/18

a16z's Angela Strange and Gabriel Vasquez speak with Carlos García Ottati, founder and CEO of Kavak, about building Latin America's largest online used car marketplace across Mexico, Brazil, Chile, Argentina, and the Middle East. They discuss why building in emerging markets means constructing four businesses underneath your business, how Kavak replaced copilot tools with AI agents handling 90 to 95% of customer interactions, and what it took to go flat for a year during the transition before

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00:30:33

WSJ x a16z: The Next 25 Years of Defense Innovation

The a16z Show ·

2026/02/17

In this episode from WSJ Invest Live, Andy Serwer speaks with Katherine Boyle, general partner at a16z, about the American Dynamism practice she helped launch four years ago. They discuss why saying "America" out loud stunned Silicon Valley in 2022, how Russia's invasion of Ukraine changed everything, and what it means to invest in companies that support the national interest. Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show on SpotifyListen to

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00:58:12

Novartis CEO Vasant Narasimhan on Transforming a...

The a16z Show ·

2026/02/16

a16z general partner Jorge Conde talks with Vasant Narasimhan, CEO of Novartis International, about transforming a 250-year-old conglomerate into a pure play medicines company and unlocking $180 billion of value in the process. They cover Novartis's platform technologies: cell and gene therapies, RNA medicines, and radioligand therapies. They also discuss AI in drug discovery, the rise of China as a biotech competitor, and what Vasant looks for when evaluating startup partnerships, including his

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01:03:46

Balaji and Dan Wang: The Engineering State vs...

The a16z Show ·

2026/02/13

Balaji Srinivasan speaks with Dan Wang, author of Breakneck, about China's industrial rise, America's competing strengths in software and finance, and what happens when an engineering state and a lawyerly state collide. The conversation covers manufacturing dominance, the future of the dollar, why both superpowers keep making costly mistakes, and where builders fit into what comes next. Resources:Follow Dan Wang on X: https://twitter.com/danwwangFollow Balaji on X:

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01:21:34

Anish Acharya: Is SaaS Dead in a World of AI?

The a16z Show ·

2026/02/12

In this episode from 20VC, Harry Stebbings talks with Anish Acharya, general partner at a16z, about the future of SaaS in an AI world. Anish argues that software is completely oversold and that the general story about vibe coding everything is flat wrong. They discuss why SaaS switching costs are actually going down thanks to coding agents, where startups versus incumbents will win, and whether the apps layer or foundation models will capture more value. They also cover agent overhype, the changing

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01:05:35

How Magic Johnson Built a Billion-Dollar Portfolio in...

The a16z Show ·

2026/02/11

a16z’s Chris Lyons speaks with Earvin "Magic" Johnson about his 30-year journey from athlete to billionaire businessman. They cover the art of deal-making, lessons from mentors Michael Ovitz and Dr. Jerry Buss, why boring businesses often make the best investments, and Magic's sports ownership portfolio, from the Dodgers to the Commanders to the Sparks. They also discuss what the next generation of athletes and entertainers should know about equity, building teams, and taking risks. Resources:Follow

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00:26:24

Marc Andreessen: Who Runs the World’s AI?

The a16z Show ·

2026/02/10

Cisco president and CPO Jeetu Patel speaks with a16z cofounder Marc Andreessen about why AI may finally break a 50-year productivity slump—and what's at stake if America doesn't win the race. They discuss where value will accrue in the AI stack, why open source complicates the US-China competition, and what's blowing Andreessen's mind right now. Resources:Follow Marc Andreessen on X: https://twitter.com/pmarcaFollow Jeetu Patel on X: https://twitter.com/jpatel41 Stay Updated:If you enjoyed this

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00:47:59

The State of Markets

The a16z Show ·

2026/02/09

a16z Head of Investor Relations Jen Kha speaks with general partner David George about the state of AI and private technology markets. David shares data on why AI companies are growing 2.5x faster than traditional software while spending significantly less on sales and marketing, driven by massive market pull and record-breaking ARR per employee. They discuss the rise of Model Busters, which are companies that grow faster and longer than anyone would have modeled, like the iPhone. They also

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02:06:23

Balaji & Benedict Evans: When Tech Breaks Industries

The a16z Show ·

2026/02/06

This episode originally appeared on the Network State Podcast. Balaji Srinivasan and Benedict Evans sit down in Singapore for a wide-ranging conversation on the mechanics of disruption. Evans, a former Andreessen Horowitz partner who now writes one of tech's most-read newsletters, argues that the conversation about any technology peaks during the transition—not at 0% or 100% adoption. They cover AI's real capabilities and limits, the politics of technological disruption, why crypto's killer metric

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00:29:29

Why This Isn't the Dot-Com Bubble | Martin Casado on...

The a16z Show ·

2026/02/05

Christopher Mims and Tim Higgins of the Wall Street Journal sit down with a16z General Partner Martin Casado on WSJ’s Bold Names to ask whether the AI spending boom is a bubble waiting to burst. Martin explains why the fundamentals differ dramatically from the dot-com era—when WorldCom had $40 billion in debt versus today's tech giants with hundreds of billions on their balance sheets—and why a speculative valuation correction shouldn't be confused with systemic collapse. They also discuss where

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00:41:58

Why America’s Health Crisis Is an Incentive Problem

The a16z Show ·

2026/02/04

a16z general partner Erik Torenberg speaks with Justin Mares, founder and CEO of TrueMed. They discuss why American health outcomes are so poor compared to the rest of the developed world, how crop subsidies created a food system that "systematically outputs unhealthy people," and what it would take to treat the chronic disease crisis as a national security issue. Mares explains how TrueMed allows people to spend tax-free HSA and FSA dollars on lifestyle interventions like gym memberships, sleep

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1,034 results

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