PODCAST

Immune

Vincent Racaniello

A podcast about the body"s defenders against disease.

science life sciences

All Episodes

01:28:11

Immune 20: In defense of death

Immune ·

2019/05/29

The Immune trio explains how activation of the inflammasome by a bacterial protein causes blood clotting through a programmed cell death process called pyroptosis. Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Inflammasome activation triggers blood clotting (Immunity) Rotavirus and Nlrp9b inflammasome (Nature) Societal Amnesia and vaccines by Cindy Leifer Image credit Letters read on Immune 20 Time stamps by Jolene. Thanks! Weekly

01:16:33

Immune 19: Mom's the word

Immune ·

2019/04/17

The Immune team discusses immunization of pregnant mice to protect offspring from neonatal herpes simplex virus disease. Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Maternal immunization protects offspring (Sci Trans Med) Diversity of herpesvirus in neonates (TWiV 540) Mariana Mazzucato on Freakonomics Letters read on Immune 19 Time stamps by Jolene. Thanks! Weekly Science Picks Steph- iNaturalist Cindy- Taking a break is also hard

01:20:35

Immune 18: Biting off more TCR than you can chew

Immune ·

2019/03/27

The immunophiles discuss T cell antigen discovery by trogocytosis - the transfer of membrane patches among cells in close contact. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Trogocytosis for T cell antigen discovery (Nat Methods) Trogocytosis (J Immunol) Orphan T cell receptors (Cell) Letters read on Immune 18 Time stamps by Jolene. Thanks! Weekly Science Picks Steph-

01:08:23

Immune 17: Feed a macrophage, starve a tumor

Immune ·

2019/02/13

The immunophiles explain how metabolic rewiring of macrophages by CpG promotes clearance of cancer cells. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Darwin Day Metabolic rewiring of macrophages by CpG (Nat Immunol) Letters read on Immune 17 Time stamps by Jolene. Thanks! Weekly Science Picks Steph- Pregnant Scholar Cindy- Anti-vaxxers vaccinating against measles Vincent- Center for Science in the Public Interest Music by Steve

01:12:43

Immune 16: B is for Bursa

Immune ·

2019/01/19

The Immune team turns to chickens, which have been important in understanding the immune system, to show that infection of mature B cells is not required for the pathogenesis of Marek's disease herpesvirus. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Role of B cells in Marek's disease pathogenesis (PNAS) In ovo vaccination (YouTube) First chickens lacking B cells (PNAS)

01:26:27

Immune 15: Happy neu-trophil year

Immune ·

2018/12/22

Stephanie takes the Immune team on a tour of neutrophils, the most abundant leukocytes in mammals, including tethers and slings, neutrophil rolling, and neutrophil nets. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Slings enable neutrophil rolling (Nature) Sling video (La Jolla Inst Allergy Immunol) Neutrophil extracellular traps kill bacteria (Science) Neutrophil review

01:20:17

Immune 14: Braking bad

Immune ·

2018/11/14

The Immune team explains the science behind the 2018 Nobel Prizes awarded to Allison and Honjo: checkpoint immunotherapy. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode 2018 Nobel Prize in Medicine 2018 Nobel Prize in Medicine (pdf) What's in a name?(Can Res Inst) Checkpoint inhibitor failures(Nature) Image credit Time stamps by Jolene. Thanks! Weekly Science Picks Steph-

01:17:01

Immune 13: Do no harm

Immune ·

2018/10/20

The ImmuNerds discuss how a cellular long non-coding RNA binds to an innate RNA sensor and regulates virus-induced interferon production to prevent damage to the host. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Host lncRNA binds RIG-I (Cell) Microbe Art at virology blog Letters read on Immune 13 Time stamps by Jolene. Thanks! Weekly Science Picks Steph- That's Pediatrics

01:11:39

Immune 12: Systems immunology

Immune ·

2018/09/19

The Immune trifecta explores systems immunology, and its use in a study of immune system development in newborn children. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Immune system development in newborns (Cell) Dead parrots and live wildcats (TWiV 185) Pathogenesis card game (JAMA) Letters read on Immune 12 Weekly Science Picks Steph- Kaleidoscopean Cindy- 500 women scientists Vincent- NIH budget increase 2019 Music by Steve

01:08:33

Immune 11: Immunomimetic designer cells

Immune ·

2018/08/18

Cindy and Vincent describe the construction of a gene network that programs mammalian cells to detect and eliminate bacterial infections. Hosts: Vincent Racaniello and Cynthia Leifer Become a patron of Immune! Links for this episode Immunomimetic designer cells (Cell) Antimicrobial drug resistance (NIH) Image credit Letters read on Immune 11 Science Picks Cindy - No Tdap link to autism Vincent- Unpaywall Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology

01:15:39

Immune 10: Immune goes viral

Immune ·

2018/07/21

The Immune team travels to the University of Maryland for ASV 2018, where they meet up with Rebecca Lynch to explore her work on broadly neutralizing antibodies against HIV-1. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Rebecca Lynch Become a patron of Immune! Links for this episode Lynch Laboratory Immune merchandise Image credit Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to immune@microbe.tv

01:35:11

Immune 9: Neither mice nor lamprey lie

Immune ·

2018/06/20

The Immune team explores the variable lymphocyte receptors of jawless vertebrates, a system of immunity that parallels the structurally unrelated antibodies of jawed vertebrates. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Lamprey VLR responseto influenza virus (eLife) VLR-basedimmunity (Ann Rev Immunol) How the Immune System Works A Commotion in the Blood Immune merchandise Image credit Letters readon Immune 9 Weekly Science

01:19:29

Immune 8: Staying warm with γδ T cells

Immune ·

2018/05/25

The Immune team reveals how γδ T cells that synthesize interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode γδ17 T cells, T cell homeostasis and thermoregulation (Nat Immunol) γδ17 T cells cells at epithelial barriers(Nat Rev Immunol) Image credit Letters readon Immune 8 Weekly Science Picks Steph- Polycystic ovary syndrome and anti-Mullerian hormone

01:13:05

Immune 7: Contradictory complements in Alzheimer's...

Immune ·

2018/04/18

The Immune hosts discuss how the complement system functions, and its role in early synapse loss in a mouse model of Alzheimer's disease. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Complement and microglia cause synapse loss in Alzheimer's(Science) Superresolution structured illumination microscopy Image credit Weekly Science Picks Steph- Social Media for Social Change in Scienceand Structured Illumination Microscopy video

01:29:03

Immune 6: Potent antiviral antibodies without somatic...

Immune ·

2018/03/16

The Immune hosts explain how antibody molecules mature, then discuss the finding in infants of potent neutralizing antibodies against respiratory syncytial virus without somatic hypermutation. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Potent anti-RSV antibodies without somatic hypermutation (Immunity) History of vaccine enhanced RSV disease (Clin Vacc Immunol) Image credit Letters read on Immune #6 Weekly Science Picks

01:40:57

Immune 5: Mother knows best about food allergies

Immune ·

2018/02/22

The ImmuoModulators provide a primer on mucosal defenses, and explain how sensitizing female mice to food allergens prevents allergic reactions in their offspring. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Food Allergy(Nat Rev Dis Prim) Maternal allergen sensitization(J Exp Med) Image credit Letters readon Immune #5 Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and comments to

01:23:15

Immune 4: Putting the immunotherapy CAR T before the...

Immune ·

2018/01/23

The immu-knowledge-ists deconstruct the holy grail of oncologists, cancer immunotherapy, and the exciting development of CAR T cells and how they work. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Synthetic Immunoreceptors for Cancer Therapy (Trend Mol Med) Engineering immune cells to treat cancer (Cell) Engineering T cells for fungal infections (PNAS) CAR T cells for AIDS (PLoS Path) CAR T cells (NIH) Image credit Letters read

01:19:15

Immune 3: Two epitopes, four serotypes, and a...

Immune ·

2017/12/16

Cindy, Steph, and Vincent discuss recent problems with dengue virus vaccine, and a bi-specific monoclonal antibody against Zika virus. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Model for dengue ADE (Scitable) Dengue ADE in humans (Science) Dengvaxia discussion (TWiV 471) Bi-specific antibody to Zika virus (Cell) Building Zika Virus Letters read on Immune #3 Weekly Science Picks Cindy - Questions answered about starving

01:26:55

Immune 2: Lymphocytes after dark

Immune ·

2017/11/25

Cindy, Steph, and Vincent reveal that lymphocyte trafficking through lymph nodes and lymph are circadian - it is dependent on the time of day. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Circadian clocks control lymphocyte trafficking (Immunity) Lymph node image credit Letters read on Immune #2 Weekly Science Picks Cindy - Men ask more questions than women at a scientific conference (PLoS One) Steph - House just voted to

01:05:31

Immune 1: Some like it hot

Immune ·

2017/10/31

Cindy, Steph, and Vincent launch a new podcast, Immune, and reveal how warm temperature protects against atherosclerosis by regulating monocyte migration into the blood. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Become a patron of Immune! Links for this episode Leifer Lab at Cornell Stephanie Langel Thermoneutrality suppresses monocyte egress from bone marrow (Circ Res) Fever regulates immunity (Nat Rev Immunol) Macrophage image by Blausen Medical Weekly Science Picks Cindy -

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Immune

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