Immune

01:22:58

Immune 108: B cells go broad and live long

Immune ·

2026/09/30

Immune tackles papers on the breadth of human B cell responses following mRNA vaccination and on the role of mitochondria and reactive oxygen species in plasma B cell maintenance. Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server mRNA flu vaccine expands B cell breadth (Nat Immunol, 2026) Mitochondrial ROS and plasma cells (Nat Commun, 2026) Time

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35:55

Immune Booster 37: Secret lives of neutrophils with...

Immune ·

2026/09/22

Tanya Mayadas joins Immune to talk about her road to study neutrophils and her research findings on neutrophil antigen presentation and novel neutrophil targeting therapies. Host: Cindy Leifer Guest: Tanya Mayadas Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Tanya recently appointed department chair and director Neutrophils, von Willebrand factor and P-selectin (Cell, 1991) P-selectin knockout mouse (Cell, 1993)

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41:29

Immune Booster 35: Human immunology and Dengue virus...

Immune ·

2026/09/08

Adam Waickman discusses the unusual reason he got into studying immunology just in humans, his important studies on Dengue virus vaccine antibodies, and the problematic phenomenon of antibody dependent enhancement. Host: Cindy Leifer Guest: Adam Waickman Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Waickman Lab Website Dengue virus human infection model (Sci Trans Med, 2022) mRNA vectored antibody against Dengue (Antiviral

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01:23:38

Immune 107: Breakfast of champions

Immune ·

2026/08/25

Immune reviews new research that shows a boost in T cell function after eating and the potential for the cGAS-STING pathway to be a new lupus therapeutic target. Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server T cell immunity boosted after eating (Nature, 2026) Inhibiting autoimmunity through TLR7-cGAS (Nat Comm, 2026) Time stamps by Jolene Ramsey

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38:57

Immune Booster 34: Decoding antiviral signaling...

Immune ·

2026/08/19

Stacy Horner discusses her work on innate detection of viruses, viral countermeasures, and the role of m(6)A RNA modifications in regulating antiviral immunity. Host: Cindy Leifer Guest: Stacy Horner Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Hepatitis virus proteases block host response (J Virol, 2012) Host RNA binds to MAVS (Science, 2024) m6A modifications modify innate response to viruses (Cell Chem Biol, 2024)

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57:55

Immune Booster 33: Immunity to pesky parasites and...

Immune ·

2026/08/04

Scott Smith talks about his research on cloned individual antibodies and how those studies have shifted his thoughts on the role of IgE in parasite defense and food allergy. Host: Cindy Leifer Guest: Scott Smith Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Complement control proteins in poxvirus evasion (J Virol, 2000) Complement control protein reduces xenotransplant rejection (Transpl Proc, 2002) Engineering

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01:03:02

Immune 106: Science and podcasting with Kathryn Knoop...

Immune ·

2026/07/28

Kathryn Knoop and Marion Brunck join the Immune team to talk about their research and their podcast "Mucosal Immunology". Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker Guests: Kathryn Knoop and Marion Brunck Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Knoop: Oral tolerance in early life review Knoop: Gamma delta T cells in neonatal sepsis Knoop: EGF and IgA in breastmilk Brunck: FcGR's in

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42:38

Immune Booster 32: Natural infection versus vaccine...

Immune ·

2026/07/21

Jenna Guthmiller talks about how she became interested in immunology and her exciting research on how different responses to vaccines and infection shape future responses to infection. Host: Cindy Leifer Guest: Jenna Guthmiller Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Broadly neutralizing flu antibodies (Nature, 2022) First exposure antibodies to H1N1 flu (Sci Transl Med, 2021) Long lasting B cells to chimeric flu

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01:01:36

Immune 105: Tumor bacteria undermine immunotherapy

Immune ·

2026/06/30

Immune discusses a snippet on how EBV infection alters the immunopeptidome and promotes multiple sclerosis, and a paper on head and neck cancers harboring bacteria that create an immunosuppressive environment and promote immunotherapy resistance. Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server EBV, Golli-MBP presentation and multiple sclerosis (Cell,

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40:35

Immune Booster 31: NOD-like receptor discovery with...

Immune ·

2026/06/23

Gabriel Nunez discusses the discovery of NOD-like receptors, NOD1 and NOD2, in inflammatory bowel disease and how travel and taking a moment to enjoy local culture and art influences his creativity. Host: Cindy Leifer Guest: Gabriel Nuñez Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server HLA and antigen presentation (Hum Immunol, 1987) Bcl2, cell death, and B cells (Nature, 1991) Discovery of NOD1 (J Biol Chem, 1999) Discovery

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49:16

Immune Booster 30: Infant Immunology with Martha...

Immune ·

2026/06/09

Martha Alexander-Miller discusses why newborn and infant immune responses to vaccines are generally less effective and how we can make vaccines safer and more effective. Host: Cindy Leifer Guest: Martha Alexander-Miller Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Flu HA nanoparticle vaccine (Nat Comm, 2025) Sex-dependent adjuvant activity in newborns (Vaccines, 2024) Flu vaccine with R848 adjuvant (Vaccines, 2023) Time

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01:20:32

Immune 104: All about allergies

Immune ·

2026/05/26

The Immune team talks about two papers on the effect of sleep and environment on seasonal allergies. Hosts: Vincent Racaniello, Cindy Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Sleep is needed for condition dependent allergic responses (PNAS, 2020) Original paper on allergy to artificial rose (Am. J. Med. Sci. 181, 45–56 (1886)) One of multiple personalities allergic (Am J Clin Hypn, 1983)

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01:03:25

Matters Microbial #130: The Holobiont — Animals,...

Immune ·

2026/05/20

Matters Microbial #130: The Holobiont — Animals, Microbes, and Ecology May 19, 2026 Today Dr. Kevin Kohl, Associate Professor of Biological Sciences at the University of Pittsburgh, joins the #QualityQuorum to discuss how he and his colleagues study the interplay between animals, their resident gut microbes, and the overarching concept of the holobiont. Host: Mark O. Martin Guest: Kevin Kohl Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode The One

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31:56

Immune Booster 29: Immune regulation and science...

Immune ·

2026/05/19

Nicholas Jackson, AKA Nick the Immunologist, talks about being a graduate student, social media creator, and his research on cytokine tools to investigate regulatory T cells. Host: Cindy Leifer Guest: Nicholas Jackson (Nick the Immunologist) Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Richard DiPaolo lab IL-2, TGFb and Tregs preprint Nick the Immunologist on TikTok Nick the Immunologist on Instagram Time stamps

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44:56

Immune Booster 28: Immunometabolism, Inflammation,...

Immune ·

2026/05/05

Luke O'Neill recounts his role in discovering key components of the TLR signaling pathway, explains how pursuing unexpected research questions keeps him motivated, and reflects on his experiences as an entrepreneur founding biotech companies. Host: Cindy Leifer Guest: Luke O'Neill Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server O'Neill lab Identification of MAL in the TLR signaling pathway (Nature, 2001) GDF 15,

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37:44

Immune Booster 27: Interferons, JAKs, and STATs with...

Immune ·

2026/04/28

George Stark from the Cleveland Clinic reflects on his early training in biochemistry and how several sabbatical leaves sparked pivotal changes in his research trajectory, eventually drawing him to interferon signaling where he helped establish the core principles of the JAK–STAT pathway and uncovered interesting roles for interferon signaling in cancer. Host: Cindy Leifer Guest: George Stark Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV

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01:22:13

Immune 103: Cytokines 101

Immune ·

2026/04/21

The Immune team talks all about cytokines, from what they are to immunotherapies against them to treat diseases. Hosts: Vincent Racaniello, Cindy Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Non-specific virus neutralization by IgM and complement (mBio 2026) Natural antibodies against viruses (Virology blog, 2009) Biologics against inflammatory cytokines (Int J Cell Bio, 2016) Biologics against

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34:49

Immune Booster 26: Immune defense against parasitic...

Immune ·

2026/04/07

Irah King from McGill University talks about his passion to understand how our immune system detects and responds to helminthic worm infections, how the worms can reprogram those responses, and how these pathways might be exploited to develop new treatments for inflammatory diseases. Host: Cindy Leifer Guest: Irah King Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server King lab at McGill Stromal cells and disease

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01:13:52

Immune102: Living longer without B cells

Immune ·

2026/03/31

The Immune team discusses a paper describing the negative effects of old B cells on T cells and longevity and a snippet on an interesting vaccine approach to promote competition between gut commensals. Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server Vaccine enhanced competition of gut bacteria (Science 2025) B cells drive immunosenescence and

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01:07:04

Immune Booster 25: Out of the anti-vax woods with...

Immune ·

2026/03/17

A former anti-vax mom talks about going down the rabbit hole, her mindset shift, the importance of doctors who are willing to talk with patients about vaccines, and why she is now a vaccine advocate. Host: Cindy Leifer Guest: Ellen Mary Woods Subscribe (free): Apple Podcasts, RSS, email Become a patron of Immune! Links for this episode MicrobeTV Discord Server A shot at life foundation Voices for Vaccines information and advocacy What the iPhone bendgate can teach us about vaccine hesitancy Tips

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