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PODCAST

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade,Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee -has redefined what’s possible for the human mind and body. After more than a thousand episodes ofBulletproof Radio, he’s taking it to the next level withThe Human Upgrade™- a masterclass inbiohacking, longevity, and performance optimization.Each episode explorescutting-edge science, advanced technology, and proven biohacksto help youupgrade your energy, focus, metabolism, and resilience.You’ll

health & fitness self-improvement

All Episodes

00:51:24

Why Gen Z Can’t Handle the Real World (and How We Can...

The Human Upgrade: Biohacking for Longevity &... ·

2025/04/03

You think you’re helping your kid. You clear the path. You smooth the bumps. You make sure they never feel too sad, too bored, too uncomfortable.It feels like love.But what if it’s making them weak?In this episode, Dave Asprey sits down with bestselling author, TED speaker, and resilience expertJennifer Cohento reveal how today’s parenting norms are quietly producing the most anxious, dependent, and emotionally fragile generation in history—Gen Z.Whether you’re raising kids, managing young

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01:13:03

The Dirty Secret Behind Ozempic: How It Wrecks Your...

The Human Upgrade: Biohacking for Longevity &... ·

2025/04/01

For decades, gut health was reduced to yogurt commercials and vague promises from probiotics that barely worked. But what if we’ve been targeting the wrong bugs, using the wrong delivery, and ignoring the true source of chronic inflammation and accelerated aging?In this thought-provoking episode, Dave sits down with Hannah Kleinfeld, a leader in microbiome innovation, to expose why most probiotics fail—and how one company’s scientifically validated approach could redefine your gut, brain,

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01:18:05

Scientists Just Discovered the Essential Nutrient...

The Human Upgrade: Biohacking for Longevity &... ·

2025/03/27

For nearly a century, scientists believed we had discovered ALL of the essential fatty acids the human body needs. But what if they were wrong?Stephanie Venn-Watson, a veterinary epidemiologist and longevity researcher, joins Dave to reveal a groundbreaking discovery—a newly identified essential fatty acid, C15,that may hold the key to healthier aging and even longer lifespans. Originally uncovered in an unlikely place—U.S. Navy dolphins that were outliving their wild counterparts by

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01:11:07

This Is Your Brain on 2025: The Biohacker’s Guide to...

The Human Upgrade: Biohacking for Longevity &... ·

2025/03/25

You think you’re optimizing your brain—but what if the real culprit behind your brain fog, anxiety, and burnout is the modern world itself?In this episode,Columbia University psychiatrist and nutritional neuroscience pioneerDr. Drew Ramsey joins Dave Asprey to decode the biological chaos hijacking your mind—and how to fight back. From inflammation and gut dysbiosis to screen-induced disconnection and hidden trauma, this is the ultimate roadmap for healing the modern brain.You’ll explore the

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01:27:52

The Science of Consciousness: What’s Beyond the...

The Human Upgrade: Biohacking for Longevity &... ·

2025/03/20

You think, you feel, youare—but what if your consciousness isn’t just in your brain? What if reality itself is shaped by something beyond the physical?In this episode,Mark Gober—author, consciousness researcher, and former Silicon Valley banker—joins Dave Aspreyto challenge everything you think you know about the mind, reality, and human potential. He explores groundbreaking research on near-death experiences, psychic phenomena, and why some scientists believe consciousness may exist beyond

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01:14:46

The Hidden Cost of Being Too Nice: Why...

The Human Upgrade: Biohacking for Longevity &... ·

2025/03/18

You hold the door open. You say yes when you mean no. You put others first—always. It feels like the right thing to do… but is it costing you more than you realize?In this episode, Scott Barry Kaufman, Ph.D.—Columbia professor, psychologist, and author of Rise Above—joins Dave Asprey to expose the psychology of victim vs. empowerment mindsets. He reveals how toxic altruism, external validation, and emotional fragility keep people stuck—and how you can reclaim your confidence, set

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00:58:25

MDMA Therapy Without the Drugs? How Vibration Hacks...

The Human Upgrade: Biohacking for Longevity &... ·

2025/03/14

What do vibrations and the psychedelic experience have in common?MDMA therapy is revolutionizing mental health treatment, helping people overcome PTSD, anxiety, and emotional trauma with unprecedented success. But what if you could tap into those same powerful benefits—without taking a single drug?It turns out your brain responds to more than just chemistry. Vibration, frequency, and rhythm have been shaping human consciousness for millennia—from ancient chanting rituals to modern

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01:09:58

Brain Hacking 101: The Science of Self-Sabotage &...

The Human Upgrade: Biohacking for Longevity &... ·

2025/03/13

Your Brain is Lying to You—Here’s How to Take Back ControlEvery day, your brain is running subconscious scripts—hidden mental loops that shape your decisions, habits, and even your self-worth. But what if those loops are sabotaging you?In this episode,Bizzie Gold, mind architect and creator ofThe Break Method, joins Dave Asprey to expose theself-deception patterns controlling your thoughts—and how toreprogram your brain for true transformation.Bizzie’s method isn’t just another self-help

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01:11:50

How Learning a New Language Rewires Your...

The Human Upgrade: Biohacking for Longevity &... ·

2025/03/11

Is the Way You Speak Limiting How You Think?For years, scientists debated how language shapes the brain, but new research reveals it goes far beyond communication. Some languages lack numbers, grammar, or even complex sentences—yet their speakers navigate reality in ways that defy expectations.In this mind-bending episode, linguist Daniel Everett, known for challenging Noam Chomsky’s theories, shares how his time with the Pirahã people reshaped our understanding of language, cognition, and

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01:18:33

Your Genes AREN’T Your Fate—The NEW Science of DNA...

The Human Upgrade: Biohacking for Longevity &... ·

2025/03/06

For decades, we’ve been told that our DNA is a fixed blueprint—an unchangeable code that dictates our health and lifespan. But what if that’s only half the story?Sharon Hausman-Cohen, a physician, researcher, and genomics expert at IntellxxDNA, joins Dave to reveal the cutting-edge science ofgenetic optimization—how understanding your DNA can unlocklonger life, better brain function, and even protection from chronic disease.Forget the old-school genetic reports that left you with useless

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00:27:39

How to Build New Habits and KEEP Them! BJ Fogg &...

The Human Upgrade: Biohacking for Longevity &... ·

2025/03/05

In this all-time classic episode, Dave brings together two of the world’s top habit experts—BJ Fogg, PhD, and James Clear—to break down the real science of behavior change.

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00:55:28

Hacking Oxytocin, How to Use Rapamycin, Level Up Your...

The Human Upgrade: Biohacking for Longevity &... ·

2025/02/27

In this first-ever AMA episode, Davetackles your biggest biohacking questions—straight fromThe Upgrade Collective! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you’d like to have your questions answered on the next AMA, click the link below for details on The Upgrade Collective membership, and get all sorts of extra biohacking add-ons for your life!In today’s episode: What if you could

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01:06:55

The New Fasting Protocol to Increase Lifespan by 96%...

The Human Upgrade: Biohacking for Longevity &... ·

2025/02/25

Can You Mimic Fasting—Without Actually Fasting?Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveala groundbreaking fasting mimeticthat could revolutionize how we approach aging, metabolism, and health.Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sacrifices? Scientists have identified key compounds that mimic fasting at the cellular level—offering a way to extend

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01:24:01

The Secret Molecule for Endless Energy | Dr. Andrew...

The Human Upgrade: Biohacking for Longevity &... ·

2025/02/21

Could a single molecule be the difference between vibrant longevity and early decline?Dr. Andrew Salzman—Harvard-trained physician, scientist, and creator of the first PARP1 inhibitor, Chief Medical Officer of Wonderfeel—joins Dave to reveal therealkey to living longer, fighting disease, and maximizing your energy:NAD.This master molecule fuels yourmitochondria, DNA repair, and cellular resilience, but here’s the catch—it plummets as you age.That means more fatigue, brain fog, inflammation,

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01:20:08

Fix Your Blood Sugar: The FASTEST Way to Burn Fat,...

The Human Upgrade: Biohacking for Longevity &... ·

2025/02/20

Welcome to the metabolism masterclass!Dr. Ben Bikman (Ph.D Professor BYU), a powerhouse in metabolism science, joins Dave to expose the truth aboutinsulin resistance—the silent epidemic fueling obesity, chronic disease, and low energy. Forget the outdated calorie-counting nonsense (it doesn’t work)—Dr. Bikman revealshow your hormones, not just your diet, control your metabolismand what you can do to reset it fast.Fromdebunking diet mythsto uncovering why some people can eat 400 grams of

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00:54:51

Rick Rubin: How to Hack Your Mind for Creative...

The Human Upgrade: Biohacking for Longevity &... ·

2025/02/18

Most people wait for inspiration. But what if you could train your brain to create on demand?Rick Rubin has spent decades shaping the sound of legendary artists—Jay-Z, Johnny Cash, Metallica, and countless others—by tapping into the unseen forces of creativity. But what’s the secret behind his genius?In this must-listen episode, Rick sits down with Dave to explore thescience and soul of creativity, revealing how meditation, mindfulness, biohacking, and unconventional thinking fuel artistic

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00:56:49

Tony Robbins on the Ultimate Secrets to Wealth,...

The Human Upgrade: Biohacking for Longevity &... ·

2025/02/13

What’s keeping you stuck in a scarcity mindset instead of stepping into abundance? What truly sets successful people apart from those who struggle?Tony Robbins has spent decades answering these questions—coaching billionaires, world leaders, elite athletes, and everyday people to master their money, mindset, and mission. In this all-time classic podcast, he shares the hard-hitting truths about financial freedom, why fear is your biggest enemy, and how to break free from the psychological

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00:40:01

Timbaland's Blueprint: How to Lose 130 Pounds, Beat...

The Human Upgrade: Biohacking for Longevity &... ·

2025/02/11

From chart-topping hits to life-threatening lows—how did Timbaland go from producing for Jay-Z, Beyoncé, and Justin Timberlake to battling addiction and obesity? And more importantly, how did he take his life back?In this raw and revealing conversation, music icon Timbaland shares the blueprint behind his incredible transformation—how he broke free from opioid addiction, lost 130 pounds, and rewired his mindset for long-term success. He and Dave dive into the power of discipline, the

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01:02:00

Gary Brecka: The SECRET Blood Marker That Could Save...

The Human Upgrade: Biohacking for Longevity &... ·

2025/02/06

Could the right form of a single vitamin be the difference between thriving and barely surviving?In this Part 2 conversation, human biologist and longevity expertGary Breckareveals the#1 overlooked factorthat’s wrecking your health:methylation—your body’s ability to convert nutrients into fuel. If this process fails, your hormones, energy, and even mental health take a nosedive.Gary andDave dive deep intothe real cause of anxiety, ADHD, and mood disorders, the hiddengenetic reason why diets

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00:37:24

Gary Brecka: The World Is KILLING You—Use AI To...

The Human Upgrade: Biohacking for Longevity &... ·

2025/02/05

Why were our grandparents stronger, healthier, and living longer—without the “advancements” of modern medicine?Gary Brecka, one of the world’s leading experts in human longevity and performance, exposes thehidden crisisthat’s wrecking your hormones, slashing your energy, and cutting your lifespan short. In this no-holds-barred conversation with Dave Asprey, they break down thecorporate greed, medical corruption, and environmental toxinsdesigned to keep you sick, weak, and dependent.What’s

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