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PODCAST

The Human Upgrade: Biohacking for Longevity & Performance

For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance

health & fitness self-improvement

All Episodes

00:47:43

Modafinil Masterclass: Clarity, Drive, and Longevity...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/30

Most people chase fat loss, focus, and energy with caffeine or stimulants, but the real key to brain optimization and human performance is a pharmaceutical nootropic that activates your wakefulness circuits without jitters or a crash. In this episode, you’ll learn how Modafinil upgrades mitochondria, sharpens neuroplasticity, improves metabolism, and extends longevity with evidence-based tools used by elite thinkers, fighter pilots, and world leaders. This is not a sales pitch. It is an

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00:10:37

This Detox Organ Is Blocking Every Diet You Try...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/28

This episode reveals how your liver is the hidden key to fat loss, energy, and hormone balance, and shows you how fixing bile flow and mineral deficiencies can reboot your metabolism at the root cause.

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00:08:02

10-Minute Weekly Update : 1335

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/26

This episode delivers a rapid-fire, source-driven roundup of the top stories in biohacking, longevity science, cutting-edge health tech, and medical freedom—all distilled into actionable insights for your week.

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01:01:47

Should You STILL Be Eating Algae in 2025? (Longevity...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/25

Your mitochondria are the power plants of your cells, and when they break down, you lose energy, brain sharpness, and resilience against aging. In this episode, you’ll learn how to hack your mitochondria to supercharge human performance, prevent decline, and extend longevity with tools that are natural, effective, and backed by decades of research.Watch the condensed video highlight version of this episode (and much more!) on YouTube:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey

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01:03:43

Steven Pinker: Outsmarting an Irrational World : 1333

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/23

Your brain isn’t as rational as you think, and that blind spot can wreck your decision-making, relationships, and even your health. In this episode, you’ll learn how to spot the hidden cognitive traps that even the smartest people fall for, and how to upgrade your thinking so you can perform better, live longer, and make choices that actually serve you.Watch the condensed video highlight version of this episode (and much more!) on YouTube:https://www.youtube.com/@DaveAspreyBPRHost Dave

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00:10:21

How To Clear Brain Fog (Simple Methods) : 1332

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/21

Host Dave Asprey shares the science-backed biohacks he used to clear 15 years of brain fog—restoring mitochondrial energy, optimizing sleep, and upgrading nutrition to regain focus, memory, and mental clarity.

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01:09:25

Lisa Bilyeu: How to hack confidence : 1331

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/19

Lisa Bilyeu joins Host Dave Asprey to reveal how “radical confidence” turns fear, self-doubt, and the inner critic into fuel for growth, entrepreneurship, and lasting impact.

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01:10:28

Biohacking Your Voice? Here's How to Do It : 1330

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/18

If you’ve ever cringed at the sound of your own voice or struggled to hold attention in a room, this episode will change the way you speak and how others respond to you. You’ll discover how vocal tone, breath, and emotion act as biological levers you can train to improve your health, extend your longevity, and build magnetic charisma.Watch the condensed video highlight version of this episode (and much more!) on YouTube:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down

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00:57:29

Tom Cruise’s Secret FEAR Hack (+ Stress Biohacks for...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/16

Host Dave Asprey and Olympic coach Jim Murphy reveal how the Inner Excellence method transforms fear, shame, and stress into resilience, courage, and lasting joy.

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00:16:11

BONUS: How To Reverse Testosterone Decline After 40...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/14

Most men think declining testosterone is just “part of aging,” but in this video I reveal how I naturally raised mine in my 50s—without injections, drugs, or TRT—using biohacks around diet, sleep, and even light to restore energy, drive, and strength.

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00:30:52

Eat THESE Anti-Aging Mushrooms to Live Longer (Paul...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/12

This episode explores how medicinal mushrooms unlock powerful biohacks for anti-aging, longevity, brain performance, and even saving the bees.

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01:03:58

MIT Neuroscientist: The Ultimate Nootropic For Memory...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/11

Want to improve memory, unlock neuroplasticity, and achieve sharper brain optimization? This episode reveals how Transcendental Meditation (TM) functions as one of the most powerful nootropics for human performance, longevity, and resilience.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with neuroscientist and physician Dr. Tony Nader, the global leader of the Transcendental Meditation movement. With an MD and

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00:56:47

How To Deal With The Fear Of Death (Ethics Of...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/09

Suzanne O’Brien is a veteran hospice and oncology nurse, educator, and healthcare innovator.

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01:00:01

The Hidden Traps of “Healthy” Eating (Biohacking...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/05

Dave Asprey and Max Lugavere explore sugar’s controversial role as both a performance enhancer and a metabolic disruptor, while unpacking how cooking methods, food quality, and kitchen literacy shape resilience, health, and longevity.

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01:02:41

Sulforaphane, Curcumin, and NEW GLP-1 Drugs...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/04

Most people think broccoli is a superfood, but the reality is more nuanced. In this episode of The Human Upgrade, Host Dave Asprey explores the good and bad of broccoli—why adult broccoli can block thyroid function and cause gut issues, while broccoli seeds deliver sulforaphane, the powerful compound that activates all three of your body’s detox pathways. You’ll learn how sulforaphane protects against glyphosate, repairs leaky gut, and upgrades mitochondria, metabolism, and longevity.Watch

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01:29:29

Mast Cells Explained: Biohacking Inflammation,...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/02

Millions of people are living with unexplained symptoms like allergies, brain fog, anxiety, and chronic fatigue without realizing the hidden cause: mast cells gone rogue. In this episode of The Human Upgrade, Host Dave Asprey sits down with leading functional medicine physician Dr. Tania Dempsey to uncover how Mast Cell Activation Syndrome (MCAS) drives inflammation, disrupts mitochondria, and sabotages metabolism—and what you can do to switch it off.Watch this episode on YouTube for the

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01:09:44

What Is Uric Acid and How Does It Predict Your...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/29

Dr. David Perlmutter joins Host Dave Asprey to uncover how uric acid acts as a hidden metabolic switch—driving fat storage, disease risk, and longevity—and how simple biohacks like diet shifts, hydration, and targeted tracking can optimize your healthspan.

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01:15:10

Hacking Dopamine Naturally: Pain, Focus, and...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/28

Your dopamine system is being hijacked every day, and the way to reclaim it might surprise you. This episode reveals how pain, pleasure, and addiction are wired in your brain, and how to use that knowledge for real brain optimization, resilience, and longevity. You’ll discover why your dopamine levels control motivation, focus, mood, and even cravings—and the science-backed strategies that reset your neuroplasticity, metabolism, and reward system.Watch this episode on YouTube for the full

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01:46:41

You Have A 25% Chance to Lose All Your Memory...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/26

Alzheimer’s is not inevitable—and it may even be optional. In this groundbreaking episode, you’ll learn how to prevent, slow, and in some cases reverse cognitive decline using strategies that also enhance brain optimization, metabolism, and longevity.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey is joined by Dr. Dale Bredesen, a world-renowned neurologist and leading Alzheimer’s researcher who has published over 240

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00:53:48

The Hormone War Dividing Female and Male Longevity :...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/22

This episode explores how hormonal imbalance between men and women impacts longevity, perception, trust, and performance—through the lenses of biohacking, trauma, and spiritual neurobiology.

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203 results

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