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PODCAST

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade,Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee -has redefined what’s possible for the human mind and body. After more than a thousand episodes ofBulletproof Radio, he’s taking it to the next level withThe Human Upgrade™- a masterclass inbiohacking, longevity, and performance optimization.Each episode explorescutting-edge science, advanced technology, and proven biohacksto help youupgrade your energy, focus, metabolism, and resilience.You’ll

health & fitness self-improvement

All Episodes

01:18:33

Your Genes AREN’T Your Fate—The NEW Science of DNA...

The Human Upgrade: Biohacking for Longevity &... ·

2025/03/06

For decades, we’ve been told that our DNA is a fixed blueprint—an unchangeable code that dictates our health and lifespan. But what if that’s only half the story?Sharon Hausman-Cohen, a physician, researcher, and genomics expert at IntellxxDNA, joins Dave to reveal the cutting-edge science ofgenetic optimization—how understanding your DNA can unlocklonger life, better brain function, and even protection from chronic disease.Forget the old-school genetic reports that left you with useless

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00:27:39

How to Build New Habits and KEEP Them! BJ Fogg &...

The Human Upgrade: Biohacking for Longevity &... ·

2025/03/05

In this all-time classic episode, Dave brings together two of the world’s top habit experts—BJ Fogg, PhD, and James Clear—to break down the real science of behavior change.

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00:55:28

Hacking Oxytocin, How to Use Rapamycin, Level Up Your...

The Human Upgrade: Biohacking for Longevity &... ·

2025/02/27

In this first-ever AMA episode, Davetackles your biggest biohacking questions—straight fromThe Upgrade Collective! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you’d like to have your questions answered on the next AMA, click the link below for details on The Upgrade Collective membership, and get all sorts of extra biohacking add-ons for your life!In today’s episode: What if you could

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01:06:55

The New Fasting Protocol to Increase Lifespan by 96%...

The Human Upgrade: Biohacking for Longevity &... ·

2025/02/25

Can You Mimic Fasting—Without Actually Fasting?Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveala groundbreaking fasting mimeticthat could revolutionize how we approach aging, metabolism, and health.Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sacrifices? Scientists have identified key compounds that mimic fasting at the cellular level—offering a way to extend

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01:24:01

The Secret Molecule for Endless Energy | Dr. Andrew...

The Human Upgrade: Biohacking for Longevity &... ·

2025/02/21

Could a single molecule be the difference between vibrant longevity and early decline?Dr. Andrew Salzman—Harvard-trained physician, scientist, and creator of the first PARP1 inhibitor, Chief Medical Officer of Wonderfeel—joins Dave to reveal therealkey to living longer, fighting disease, and maximizing your energy:NAD.This master molecule fuels yourmitochondria, DNA repair, and cellular resilience, but here’s the catch—it plummets as you age.That means more fatigue, brain fog, inflammation,

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01:20:08

Fix Your Blood Sugar: The FASTEST Way to Burn Fat,...

The Human Upgrade: Biohacking for Longevity &... ·

2025/02/20

Welcome to the metabolism masterclass!Dr. Ben Bikman (Ph.D Professor BYU), a powerhouse in metabolism science, joins Dave to expose the truth aboutinsulin resistance—the silent epidemic fueling obesity, chronic disease, and low energy. Forget the outdated calorie-counting nonsense (it doesn’t work)—Dr. Bikman revealshow your hormones, not just your diet, control your metabolismand what you can do to reset it fast.Fromdebunking diet mythsto uncovering why some people can eat 400 grams of

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00:54:51

Rick Rubin: How to Hack Your Mind for Creative...

The Human Upgrade: Biohacking for Longevity &... ·

2025/02/18

Most people wait for inspiration. But what if you could train your brain to create on demand?Rick Rubin has spent decades shaping the sound of legendary artists—Jay-Z, Johnny Cash, Metallica, and countless others—by tapping into the unseen forces of creativity. But what’s the secret behind his genius?In this must-listen episode, Rick sits down with Dave to explore thescience and soul of creativity, revealing how meditation, mindfulness, biohacking, and unconventional thinking fuel artistic

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00:56:49

Tony Robbins on the Ultimate Secrets to Wealth,...

The Human Upgrade: Biohacking for Longevity &... ·

2025/02/13

What’s keeping you stuck in a scarcity mindset instead of stepping into abundance? What truly sets successful people apart from those who struggle?Tony Robbins has spent decades answering these questions—coaching billionaires, world leaders, elite athletes, and everyday people to master their money, mindset, and mission. In this all-time classic podcast, he shares the hard-hitting truths about financial freedom, why fear is your biggest enemy, and how to break free from the psychological

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00:40:01

Timbaland's Blueprint: How to Lose 130 Pounds, Beat...

The Human Upgrade: Biohacking for Longevity &... ·

2025/02/11

From chart-topping hits to life-threatening lows—how did Timbaland go from producing for Jay-Z, Beyoncé, and Justin Timberlake to battling addiction and obesity? And more importantly, how did he take his life back?In this raw and revealing conversation, music icon Timbaland shares the blueprint behind his incredible transformation—how he broke free from opioid addiction, lost 130 pounds, and rewired his mindset for long-term success. He and Dave dive into the power of discipline, the

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01:02:00

Gary Brecka: The SECRET Blood Marker That Could Save...

The Human Upgrade: Biohacking for Longevity &... ·

2025/02/06

Could the right form of a single vitamin be the difference between thriving and barely surviving?In this Part 2 conversation, human biologist and longevity expertGary Breckareveals the#1 overlooked factorthat’s wrecking your health:methylation—your body’s ability to convert nutrients into fuel. If this process fails, your hormones, energy, and even mental health take a nosedive.Gary andDave dive deep intothe real cause of anxiety, ADHD, and mood disorders, the hiddengenetic reason why diets

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00:37:24

Gary Brecka: The World Is KILLING You—Use AI To...

The Human Upgrade: Biohacking for Longevity &... ·

2025/02/05

Why were our grandparents stronger, healthier, and living longer—without the “advancements” of modern medicine?Gary Brecka, one of the world’s leading experts in human longevity and performance, exposes thehidden crisisthat’s wrecking your hormones, slashing your energy, and cutting your lifespan short. In this no-holds-barred conversation with Dave Asprey, they break down thecorporate greed, medical corruption, and environmental toxinsdesigned to keep you sick, weak, and dependent.What’s

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01:40:25

Ancient Secrets THEY Hid from You (That Still Work...

The Human Upgrade: Biohacking for Longevity &... ·

2025/01/30

Billy Carson, a Harvard-certified expert in ancient civilizations and an MIT-trained scholar in neuroscience, has spent decades decoding the mysteries of lost technology, quantum reality, and human optimization. Alongside Elisabeth Carson, a biohacker and neuroscience researcher, they bridge the gap between ancient wisdom and modern science—revealing secrets that could transform your mind, body, and reality. What if the Great Pyramid wasn’t just a monument but apowerful energy

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01:27:57

Stop Counting Calories! Diet Myths Exposed (And What...

The Human Upgrade: Biohacking for Longevity &... ·

2025/01/28

Everything you’ve been told about weight loss is a lie!In this episode, Dr. Nick Norwitz, a metabolic health expert with accolades from Oxford and Harvard, joins Dave to expose the biggest myth in dieting:Calorie Counting.Together, they dismantle outdated weight-loss advice and reveal the truth about metabolism that could revolutionize your health.Dr. Norwitz shares cutting-edge science and personal stories that challenge the “eat less, move more” narrative, uncovering why traditional

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01:34:40

How to Hack Your Stress and Engineer Your Tears to...

The Human Upgrade: Biohacking for Longevity &... ·

2025/01/23

What if the key to living longer isn’t avoiding stress—but mastering itJeff Krasno, founder of Commune and renowned stress expert, joins Dave to reveal why most of us have stress all wrong. In this fascinating conversation, Jeff redefines how we think about stress—showing how it can be your greatest ally instead of your worst enemy. From his groundbreaking new book Good Stress to the ancient practices that have stood the test of time, Jeff shares how to unlock the hidden potential of stress

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01:29:21

2025 Biohacking State of the Union: Master...

The Human Upgrade: Biohacking for Longevity &... ·

2025/01/21

What if you could cheat aging, indulge in life’s guilty pleasures, and still thrive?Dr. Sandra Kaufmann, a pioneering longevity expert and fearless explorer of the biochemical frontier, joins Dave to reveal how you canbend the rules of biologyto live longer, smarter, and stronger. Forget perfection—Dr. Kaufmann’s radically practical approach embraces the human side of longevity, showing you how to optimize your body while enjoying the ride.From downing Diet Cokes to defying traditional

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01:07:15

How to Be a Real-Life DR. STRANGE with These 8...

The Human Upgrade: Biohacking for Longevity &... ·

2025/01/16

Is there actual “magic” on this planet, or is it just in the movies?Dr. Barry Morguelan, a top surgeon and one of only nine living grandmasters of an ancient Lao Tzu lineage, joins Dave to share secrets that have been hidden for 5,000 years. Together, they explore how the principles behind quantum physics, energy mastery, and timeless healing techniques can revolutionize your health, mindset, and life.From breaking rocks with energy to healing broken bones with focused intent, Dr. Barry

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01:19:47

Add Decades to Your Life with THESE AI Tools and...

The Human Upgrade: Biohacking for Longevity &... ·

2025/01/14

What happens when nearly 60 years of combined biohacking expertise collide in one podcast?Peter Diamandis is a world-renowned futurist, space entrepreneur, and innovator behind groundbreaking ventures like the XPRIZE and Abundance 360. Dave sits down with Peter to combine their nearly 60 years of biohacking expertise, delivering the ultimate playbook for living longer and healthier.They dive into revolutionary AI-driven health solutions, mindset shifts that fuel vitality, and practical

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00:57:36

Improve your Vision Forever with These Three FREE...

The Human Upgrade: Biohacking for Longevity &... ·

2025/01/09

What if you could ditch your glasses forever by simply doing a 10-minute exercise each day?In this episode, Dave sits down with Dr. Bryce Appelbaum, a visionary in vision biohacking, to uncover how simple techniques can transform your eyesight. From near-far focusing to eye stretches, these exercises don’t just improve your vision—they enhance your brain’s performance, energy, and overall health.Dr. Bryce shares his own journey of overcoming severe vision challenges, the science behind

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00:55:44

Try These Age-Reversing Plants to Turn Back Time! How...

The Human Upgrade: Biohacking for Longevity &... ·

2025/01/07

What if the secret to living to 250 was simply sitting in the garden?In this episode, Dave sits down with Christian Drapeau, a leading expert in stem cell science, to explore the plants and natural practices that could unlock extreme longevity. From goji berries to reishi mushrooms, these age-old remedies do more than nourish—they activate your body’s innate repair system, boosting stem cells and accelerating healing.Christian dives into the fascinating stories behind these plants, their

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01:26:10

The TRUTH About Vaccines for Kids (A Pediatrician...

The Human Upgrade: Biohacking for Longevity &... ·

2025/01/02

Are we protecting our kids—or unknowingly putting their health at risk?Dr. Joel “Gator” Warsh isn’t just another pediatrician; he’s a bold voice speaking out on the vaccine debate that’s dividing parents, doctors, and society. In this episode, we pull back the curtain on one of the most censored and controversial topics of our time.With his integrative and functional approach, Dr. Warsh unpacks the startling rise in chronic illnesses among children and questions if we’re truly asking the

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