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PODCAST

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade,Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee -has redefined what’s possible for the human mind and body. After more than a thousand episodes ofBulletproof Radio, he’s taking it to the next level withThe Human Upgrade™- a masterclass inbiohacking, longevity, and performance optimization.Each episode explorescutting-edge science, advanced technology, and proven biohacksto help youupgrade your energy, focus, metabolism, and resilience.You’ll

health & fitness self-improvement

All Episodes

01:10:18

Master Stress in 10 Seconds with THIS Heartbeat...

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/30

Heart rate variability isn’t just a fitness metric, it’s the master signal of human performance, emotional regulation, and longevity. This episode reveals how you can use HRV to hack your nervous system, regulate stress in real time, and build true resilience from the inside out.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Rollin McCraty, Ph.D., Director of Research at the HeartMath Institute and a leading

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00:43:13

Biohacking Cannabis: The DNA Science of Plant...

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/28

Discover how decoding your DNA can unlock the full potential of plant medicine. This episode deliversa cannabis masterclass for biohackers, revealing how personalized genetics are transforming human performance, brain optimization, and longevity. You’ll learn how to identify your ideal cannabis and supplement protocols, balance your endocannabinoid system, and turn precision data into powerful healing.Watch this episode on YouTube for the full video

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00:18:27

This Legal Focus Powder Beats Any Dopamine Detox : 1352

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/26

Dopamine isn’t your real problem — low brain energy is. In this solo episode, Dave Asprey reveals how fatigue in your mitochondria, not dopamine addiction, is what’s draining your focus and motivation — and explains how creatine, the overlooked brain energy molecule, can rapidly recharge your ATP, sharpen cognition, and restore your mental performance in just minutes a day.

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00:05:57

Biohacking News Weekly Update : 1351

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/24

Dave Asprey breaks down five breakthrough stories in biohacking and health-tech — from vitamin D’s anti-aging power to gene-based rejuvenation, gut-driven autophagy, supplement reform, and the rise of AI-powered medical avatars reshaping the future of personalized health.

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00:34:28

How Biohackers Use Nicotine WITHOUT Getting Addicted ...

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/23

This is Part 2 of the Nicotine Masterclass. If you haven’t heard Part 1, start there for a full breakdown of nicotine’s mechanisms, myths, and the science behind its misunderstood role in longevity, nootropics, and human performance.Nicotine is one of the most misunderstood nootropics in the world—and one of the most powerful tools for brain optimization and longevity when used correctly. In this episode, Host Dave Asprey breaks down how to harness nicotine for cognitive enhancement,

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00:57:16

Why Women’s Joints Are Failing 10x Faster : 1349

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/21

Kiran Krishnan reveals how joint degeneration is driven by inflammatory cytokines and poor circulation—and shares breakthrough strategies using nutrition, mitochondrial support, and clinical research to reverse arthritis, rebuild cartilage, and slow biological aging.

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00:12:36

Why You Still Feel Tired And Foggy On A Perfect Diet...

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/19

This episode reveals the hidden biological disruptors—like EMFs, mold, and toxins—that sabotage your energy, focus, and longevity, even when your diet is perfect, and shows you how to eliminate them for truly lasting upgrades.

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00:06:01

10 Minute Weekly Biohacking Update : 1347

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/17

This episode delivers five cutting-edge biohacking breakthroughs—from AI heart scans to brain training and digital twins—plus a five-day protocol to upgrade your biology with real science, not guesswork.

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00:56:52

These Plants Turn On 1,100 Healing Genes In 24 Hours...

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/16

Most people try to “heal” their brain with supplements, mindset, or meditation—but this episode reveals the deeper protocol to actually grow a new brain, reverse stress damage, activate 1,100 healing genes, and unlock higher human performance at any age. You’ll learn how neuroplasticity, mitochondria repair, plant-based NRF2 activators, and energetic practices work together to rebuild the brain and extend longevity.Watch this episode on YouTube for the full video

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00:27:02

Solo Episode - Nicotine Masterclass (pt. 1) : 1345

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/14

Nicotine isn’t just addictive—it might be one of the most misunderstood nootropics in modern medicine. In this masterclass, you’ll learn how controlled, low-dose nicotine may enhance brain performance, boost neuroplasticity, improve mitochondrial function, and potentially extend lifespan. Host Dave Asprey breaks down the surprising science behind this controversial compound, separating fact from fear—and exposing the real risks that nobody talks about.Watch this episode on YouTube for the

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00:15:45

7 Toxic Foods POISONING Your Family's Health (Avoid...

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/13

These "toxic foods" are one of the biggest hidden threats to your health and most people are eating them every single day without realizing it. These cheap industrial foods are marketed as “healthy,” but the truth is they damage your cells, drive inflammation, and speed up aging. In this video, I’m exposing the dark history behind how they ended up in our food system, why regulators don’t protect you, and the toxic process used to make them.I’ll also show you what to cook with instead so you

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00:59:53

The WATER Hack That Boosts Mitochondria by 11%! : 1343

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/10

What if you could improve your mitochondria, oxygen efficiency, and recovery in just 20 minutes a day—by breathing energized water?This episode explores one of the most surprising breakthroughs in biohacking and how it can help you live longer, think clearer, and perform better.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHostDave Aspreytalks withRowena Gates, co-founder ofNanoVi, a therapeutic device backed by biophysics research that

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00:50:25

Digital Twins: The End of Human Drug Testing for...

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/09

AI is transforming medicine at a speed never seen before. In this episode, you’ll discover how digital twins and artificial intelligence will revolutionize drug discovery, eliminate human trials, and personalize your biology for longevity and high performance. Host Dave Asprey breaks down how AI can now simulate virtual cells and tissues, running clinical experiments in minutes instead of years to create truly individualized medicine.Watch this episode on YouTube for the full video

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01:02:39

The Hidden Key to Pain-Free Joints (Longevity Tips) ...

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/07

Most people think about heart disease and metabolism when they talk about longevity, but too few talk about joint health. In this episode, you’ll discover how to biohack your joints to prevent pain, reverse damage, and move like you’re decades younger. Host Dave Asprey reveals how functional movement, core stability, and recovery can transform joint health, helping you maintain pain-free performance for life.Watch this episode on YouTube for the full video

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00:14:05

Remote Work Is Making You FATTER (Do THIS to Stop It)...

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/05

Discover how remote work is quietly wrecking your hormones—and learn simple biohacks to fix posture, light, movement, and meal timing so you can boost energy, burn fat, and restore focus without quitting your job.

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00:10:17

10-Minute Weekly Update : 1339

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/03

This episode delivers five fast biohacking breakthroughs, from debunking apple cider vinegar for fat loss to smarter NMN use, sleep strategies that protect your brain, psilocybin’s lasting reset potential, and an AI tool catching cancer risk earlier.

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01:00:24

How Gravity Shapes Your Body, Brain, and Health : 1338

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/02

Gravity may be the most ignored signal in human biology, and it could be the missing key to unlocking fat loss, brain optimization, and true longevity. In this episode, you’ll learn how Earth’s pull shapes your metabolism, mood, and resilience, and discover practical hacks to fight “gravity intolerance” so you can perform better, live longer, and upgrade every system in your body.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave

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00:47:43

Modafinil Masterclass: Clarity, Drive, and Longevity...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/30

Most people chase fat loss, focus, and energy with caffeine or stimulants, but the real key to brain optimization and human performance is a pharmaceutical nootropic that activates your wakefulness circuits without jitters or a crash. In this episode, you’ll learn how Modafinil upgrades mitochondria, sharpens neuroplasticity, improves metabolism, and extends longevity with evidence-based tools used by elite thinkers, fighter pilots, and world leaders. This is not a sales pitch. It is an

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00:10:37

This Detox Organ Is Blocking Every Diet You Try...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/28

This episode reveals how your liver is the hidden key to fat loss, energy, and hormone balance, and shows you how fixing bile flow and mineral deficiencies can reboot your metabolism at the root cause.

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00:08:02

10-Minute Weekly Update : 1335

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/26

This episode delivers a rapid-fire, source-driven roundup of the top stories in biohacking, longevity science, cutting-edge health tech, and medical freedom—all distilled into actionable insights for your week.

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220 results

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