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PODCAST

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade,Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee -has redefined what’s possible for the human mind and body. After more than a thousand episodes ofBulletproof Radio, he’s taking it to the next level withThe Human Upgrade™- a masterclass inbiohacking, longevity, and performance optimization.Each episode explorescutting-edge science, advanced technology, and proven biohacksto help youupgrade your energy, focus, metabolism, and resilience.You’ll

health & fitness self-improvement

All Episodes

00:08:19

Aging Starts In Your Legs (Here’s The Fix) : 1408

The Human Upgrade: Biohacking for Longevity &... ·

2026/02/01

In this video, you’ll learn why your leg muscles age faster than the rest of your body, how damaged mitochondria silently drain your strength, and why traditional solutions like exercise and protein stop working after 40.

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01:04:27

The Nobel Prize Molecule That Nearly Doubles Lifespan...

The Human Upgrade: Biohacking for Longevity &... ·

2026/01/30

This episode breaks down how a Nobel Prize–winning carbon molecule called C60 may upgrade mitochondria, improve sleep and energy, and support extreme longevity by selectively buffering oxidative stress at the cellular level.

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01:07:11

Meet the Governor Who Wants Humans to Become Cyborgs ...

The Human Upgrade: Biohacking for Longevity &... ·

2026/01/29

This episode explores how transhumanism, AI, and longevity science are reshaping human performance, biological freedom, and the future of aging, as Host Dave Asprey challenges Zoltan Istvan on whether humans should upgrade biology, embrace technology, or redefine what it means to be human.

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01:02:20

Your Butt is a Longevity Organ (Here’s how to train...

The Human Upgrade: Biohacking for Longevity &... ·

2026/01/27

This episode reveals why muscle, especially your glutes, is a critical longevity organ that drives metabolism, brain health, resilience, and aging, and shows how strength training and protein can protect your body and mind for life.

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00:22:26

The Natural Ozempic In Your Gut (Eat THIS To Switch...

The Human Upgrade: Biohacking for Longevity &... ·

2026/01/25

Dave explains that GLP 1 is your gut’s built-in appetite off switch, why calorie cutting and even Ozempic can fail to fix the underlying gut brain signaling, and how to restore natural satiety by rebuilding the microbiome with resistant starch to boost butyrate, plus smart meal timing, sleep, and stress control.

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00:09:23

Biohacking News Weekly Update : 1403

The Human Upgrade: Biohacking for Longevity &... ·

2026/01/23

This week’s biohacking update breaks down new dietary guidelines, a longevity research breakthrough, ChatGPT’s move into health, the return of whole milk in schools, early data on GLP-1 drugs and aging, and a practical weekly upgrade you can actually use right now.

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01:13:21

This Brain Trick Feels Like Cheating (Do THIS) : 1402

The Human Upgrade: Biohacking for Longevity &... ·

2026/01/22

Most brain decline, mood instability, and impulsive behavior start with a breakdown in how the brain’s immune cells produce and use energy. This episode shows how mitochondrial health inside microglia influences cognition, emotion, and long-term brain resilience, and how everyday inputs quietly push those systems toward damage or repair.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey is joined by Dr. David Perlmutter, a

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00:42:30

Inside the Mind of the Mad Scientist Rewriting Aging ...

The Human Upgrade: Biohacking for Longevity &... ·

2026/01/20

Your body does notfailall at once. Aging starts when cells quietly shift into survival mode and never come back out. In this episode, you go inside the thinking of a true medical outlier to understand how stress, travel, toxins, and metabolic overload reprogram cells, shut down energy, and accelerate aging, and how restoring mitochondrial function can reverse that trajectory from the inside out.Watch this episode on YouTube for the full video

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00:22:45

I Lost 100 Pounds Of Fat By Drinking Fat (Just Do...

The Human Upgrade: Biohacking for Longevity &... ·

2026/01/18

This episode explains how drinking Danger Coffee with MCT oil and butter can suppress hunger, stabilize energy, increase fat burning, and support sustainable weight loss by shifting metabolism into a more efficient fat fueled state.

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00:46:24

The Superbrain Drug Politicians Use To Outsmart...

The Human Upgrade: Biohacking for Longevity &... ·

2026/01/16

This drug has been misunderstood for decades, and that confusion is costingpeoplefocus, learning speed, and cognitive performance. In this episode,you’lllearn why nicotine itself is not the problem, why delivery method and dose change EVERYTHING, and how oral nicotine can be used strategically for biohacking brain optimization, neuroplasticity, and human performance in a healthy and safe way.Watch this episode on YouTube for the full video

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01:16:24

Why 65% of People SUCK at Modern Relationships : 1398

The Human Upgrade: Biohacking for Longevity &... ·

2026/01/15

Most people are struggling in modern relationships, and it is not because they are broken. It is because the systems around them are. In this episode,you’lllearn why roughly 65 percent of peopleoperatefrom insecure attachment, why that quietly destroys energy, trust, and intimacy, and how secure attachment becomes a critical biohacking upgrade for human performance, longevity, and emotional resilience.Watch this episode on YouTube for the full video

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01:16:16

The 12 Greatest Mood Boosters on Earth : 1397

The Human Upgrade: Biohacking for Longevity &... ·

2026/01/13

Mood, motivation, and emotional resilience are not personality traits. They are biological systems. In this episode,you’llget the 12 greatest mood boosters on Earth, not as a clickbait supplement list, but as thereal biologicallevers that control dopamine sensitivity, hormones, neuroplasticity, and energy production.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down in Dubai with friend of the show, Lucas Aoun,

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00:12:21

I Cracked The Code To Staying Lean In My 50s (Here's...

The Human Upgrade: Biohacking for Longevity &... ·

2026/01/11

Dave Asprey explains why short fasts barely scratch the surface and how a properly executed 72-hour fast can activate deep cellular repair, mitochondrial renewal, and anti-aging pathways most people never reach.

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01:10:48

Reversing The American Food Pyramid | Calley Means :...

The Human Upgrade: Biohacking for Longevity &... ·

2026/01/09

In this rerun, Dave Asprey sits down with Calley Means to expose how broken incentives in food, healthcare, and public policy drive chronic disease, and why restoring metabolic health is the fastest path to reclaiming personal autonomy and human resilience.

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01:20:53

The Willpower Drug: How to Supplement Discipline : 1394

The Human Upgrade: Biohacking for Longevity &... ·

2026/01/08

Creatine is a foundational energy molecule that boosts brain and muscle ATP, supports cognition, sleep resilience, metabolism, and longevity, and explains why performance, cravings, and willpower all depend on mitochondrial energy rather than discipline alone.

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00:54:24

How Long Can Humans Really Live… (with Dan Buettner) ...

The Human Upgrade: Biohacking for Longevity &... ·

2026/01/06

You’reabout to hear one of the most honest longevity conversations ever recorded. Thisco hostedepisode brings together two longevity leaders with opposing views on how long humans can live, yet enormous respect for each other andthe science. Recorded live at Eudemonia, this discussion gives you clear frameworks for longevity, biohacking, human performance, andanti agingwithout all the tribal thinking that can plague modern health conversations!Watch this episode on YouTube for the full

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00:19:06

This Legal Boner Pill Is Hiding A Future Heart Attack...

The Human Upgrade: Biohacking for Longevity &... ·

2026/01/04

This episode explains why erectile dysfunction is not a bedroom problem but an early warning sign of cardiovascular and mitochondrial decline, often showing up years before heart attacks, and walks through how to reverse it by fixing circulation, inflammation, and vascular health rather than relying on pills.

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00:07:54

Biohacking News Weekly Update : 1391

The Human Upgrade: Biohacking for Longevity &... ·

2026/01/02

This week’s Human Upgrade breaks down five new studies shaping longevity and metabolic health, from early-life gut damage and immune aging to nutrient bottlenecks and eating windows, and shows how removing hidden biological stressors can quietly compound long-term resilience.

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00:52:45

The Secret Federal Plan to Feed Us Legal Poison : 1390

The Human Upgrade: Biohacking for Longevity &... ·

2026/01/01

You’reabout to learn how government approved food policies, regulatory loopholes, and corporate lobbying have quietly reshapedwhat’sallowed in the food supply and why these decisions are driving chronic inflammation, immune dysfunction, and neurological breakdown at scale. This episode exposes how biotoxins, ultra processed ingredients, and systemic regulatory failures contribute to long COVID, POTS, mold illness, chronic fatigue, anddysautonomiaand why so many people feel sick despite

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00:32:51

These 7 Superfoods Are Secretly Wrecking Your Body :...

The Human Upgrade: Biohacking for Longevity &... ·

2025/12/30

This solo masterclass on oxalates explains why many people who eat clean still struggle with joint pain, kidney stones, fatigue, brain fog, and chronic inflammation.You’lllearn how oxalates behave very differently from other plant compounds like lectins, phytates, and salicylates. Unlike those compounds, oxalates physically bind minerals and form microscopic crystals that can lodge in tissues, damage mitochondria, and accumulate over time. This episode will change how you think about

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