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PODCAST

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade,Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee -has redefined what’s possible for the human mind and body. After more than a thousand episodes ofBulletproof Radio, he’s taking it to the next level withThe Human Upgrade™- a masterclass inbiohacking, longevity, and performance optimization.Each episode explorescutting-edge science, advanced technology, and proven biohacksto help youupgrade your energy, focus, metabolism, and resilience.You’ll

health & fitness self-improvement

All Episodes

00:30:40

What Doctor's DON'T Tell You About Megadosing...

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/12

1:25 PMCreatine is not just a bodybuilding supplement anymore, and Host Dave Asprey breaks down the full science of why this cheap, safe, and massively underrated compound may be the single most versatile biohack available for boosting brain power, protecting mitochondria, building muscle, and extending longevity in both men and women.

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00:09:47

Superhuman Contact Lenses, Motivation Supplement...

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/10

A stealth bacterial infection hiding in cat scratches, a common amino acid quietly cutting men's lifespans, contact lenses that upgrade your vision beyond normal, a supplement stack that actually moves motivation, and a 30-second nervous system reset you can do for free — Dave breaks down five under-the-radar findings that are changing how serious biohackers think about daily health.

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01:12:26

Why Doctors Can't Fix Women in 2026 : 1446

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/09

Most women are suffering for years from anxiety, gut problems, low libido, and brain fog because no one is treating the real cause: their hormones. This episode is a masterclass in women's hormone optimization, covering everything from vaginal delivery of bioidentical hormones to why low estrogen destroys your gut, your sex drive, your mitochondria, and your marriage.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down

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00:54:21

The Underground World of Frog Venom Ceremonies : 1445

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/07

Frog venom burns your skin, makes you purge, and might be the most powerful healing tool you havenevertried. In this episode, Host Dave Asprey sits down with Kambo researcher and practitioner Caitlin Thompson to break down how intentional suffering through this ancient Amazonian medicine is producing dramatic results for people with autoimmune conditions, chronic illness, Lyme disease, addiction, and metabolic dysfunction. From thepeptidescience behind the purge to the biohacking case for

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00:18:10

Fix Mitochondria With NASA’s Secret Anti-Aging...

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/05

Dave Asprey breaks down why aging is driven by oxidative stress at the cellular level, and reveals how NASA-researched algae, specifically spirulina and chlorella, can activate your body's built-in antioxidant defenses to slow the process from the inside out.

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00:54:21

Your AC Is Making You Dumber : 1444

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/03

Toxic mold is silently destroying your health, relationships, and home — and Dave Asprey and Superstratum founder Seth Jones break down exactly what it costs you and how to finally fix it for good.

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00:55:15

Your Doctor Is Wrong About Autism (Here's How To...

The Human Upgrade: Biohacking for Longevity &... ·

2026/04/02

Autism is reversible, and the science to prove it already exists. This episode delivers a master class on the biological roots of autism, whatactually triggersit, and the protocols that have helped real families recover their children, including one mom who sold everything she owned to make it happen.Host Dave Asprey sits down with TracySlepcevic, bestselling author of Warrior Mom: A Mother's Journey in Healing Her Son with Autism, certified integrative health practitioner, Air Force

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01:02:24

Your Organic Protein Powder Is Slowly Killing You :...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/31

Most people buying "clean" supplements are unknowingly loading their bodies with heavy metals, rancid fish oil, and glyphosate, even inside products labeled organic and healthy. This episode breaks down exactly what the supplement industry refuses to tellyou andgives you the tools to stop poisoning yourself every morning.-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPR-Grab a discount onPuoriProducts by

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00:15:26

This Legal Sleep Powder Beats Melatonin Every Time :...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/29

A step-by-step breakdown of the exact brain states, amino acids, and light environment changes that separate people who fall asleep easily from people who lie awake staring at the ceiling.

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00:31:10

I Injected Stem Cells Into My Penis (Here's What...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/27

The most advanced stem cell clinic on the planet just figured out how to upgrade your brain like hardware, and Dave went to Costa Rica to be one of the first to try it.

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00:57:31

Arthur Brooks | Why Your Life Has No Meaning : 1438

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/26

The neuroscience of why optimizing your body means nothing if you're starving the half of your brain responsible for meaning, consciousness, and everything that makes life worth living.

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00:55:36

This Popular Fat Loss Shortcut Destroys Your Youth :...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/24

Your gut microbiome controls your brain chemistry, your stress response, your sleep, your metabolism, and your ability to lose weight, and most people have no idea how broken theirs actuallyis.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRGet 20% off your next purchase ofOMNi-BiOTiCwith code ‘Dave20’ at:https://omnibioticlife.com/In this episode, Host Dave Asprey and microbiome expert Hannah Kleinfeld break down the hidden gut science

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00:21:08

Give Me 21 Minutes And I'll Give You Perfect Vision...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/22

Your eyes have a built-in nightly repair cycle that most people unknowingly disrupt, and by adopting seven simple daily habits — including red light therapy, blueberries, cold exposure, grounding, distance viewing, deliberate blinking, and aligning with natural light cycles — you can reactivate that self-healing switch and restore or preserve your vision naturally.

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00:12:36

SNL Roasts MAHA, Pistachios Slap, ChatGPT Doctor...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/20

SNL, pistachios, AI doctors, your microbiome's architecture, colon cancer under 50, and a measles comeback — this week's news is a masterclass in why the assumptions you haven't questioned yet are the most dangerous ones.

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01:01:20

Here's Why You Still Feel Like Sh*t After Doing...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/19

Your thyroid controls your energy, your metabolism, your testosterone, your mood, and your ability to think clearly. Most doctors are testing it wrong and treating it wrong, and this episode tells you exactly what to do instead.-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with McCall McPherson, a physician associate, TEDx speaker, and founder of Modern Thyroid Clinic, Modern Weight Loss, and the advocacy

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00:58:56

Hair Regrowth, Pain Relief, and Altered States — The...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/17

What if a glowing pyramid sitting in your living room could restructure your biology, compress decades of meditation into minutes, and shift your brain into an altered state without drugs, breathwork, or effort? This episode reveals the science and experience behind one of the most unusual biohacking technologies Host Dave Asprey has everencountered.-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPR-Get $250 off from The Light System by using

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00:16:47

This Nobel Prize Discovery Reverses Aging In 72 Hours...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/15

A Nobel Prize-winning discovery reveals that triggering autophagy — your body's built-in cellular repair switch — through strategic 72-hour fasting can reverse biological aging, sharpen the brain, and regenerate tissues from the inside out.

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00:12:34

Your Telomeres Are a Lie, Bats Beat Aging, Sleep Meds...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/13

Your sleep tracker might be lying to you, bats are breaking the telomere model, a cheap kitchen seed is flattening glucose spikes, the first real longevity supplement trial just dropped hard data, carbon monoxide is quietly spiking in homes across the country, and fat plus carbs around your workout might actually be the move.

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01:03:19

Your Penis Is a Longevity Organ (Here's How to Hack...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/12

Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it.-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Dr. Justin Houman, a nationally recognizedurologistand Assistant Professor of Urology at Cedars-Sinai Medical Center. Fellowship-trained and specializing in men's health, male fertility, and sexual medicine, Dr. Houman

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00:57:57

AI Expert Says: Humans Are Just Mystical Meat Robots...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/10

What if understanding how AI thinks could reveal uncomfortable truths about how your own brain works, and give you powerful tools to make smarter decisions, resist manipulation, and upgrade your cognition at the root level?-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Tom Griffiths, the Henry R. Luce Professor of Information Technology, Consciousness, and Culture in the Departments of Psychology and

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314 results

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