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PODCAST

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade,Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee -has redefined what’s possible for the human mind and body. After more than a thousand episodes ofBulletproof Radio, he’s taking it to the next level withThe Human Upgrade™- a masterclass inbiohacking, longevity, and performance optimization.Each episode explorescutting-edge science, advanced technology, and proven biohacksto help youupgrade your energy, focus, metabolism, and resilience.You’ll

health & fitness self-improvement

All Episodes

00:51:49

How to Live Healthier Without Obsessing Over Health ...

The Human Upgrade: Biohacking for Longevity &... ·

2026/10/06

Miranda Kerr joins Dave Asprey to explore how simplifying health around clean living, sleep, stress management, meditation, family, and intentional skincare can create a more sustainable approach to wellness.

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00:19:07

It's Boring, But It Slashed ALL My Visceral Fat In My...

The Human Upgrade: Biohacking for Longevity &... ·

2026/10/04

Dave Asprey shares the five hacks that helped him lose over 100 pounds and feel decades younger, from inventing butter coffee in Tibet to eating more saturated fat, cutting anti-nutrients, intermittent fasting, and prioritizing nutrition over endless gym sessions.

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00:10:37

Vagus Nerve Memory, Cat Cancer Genes, Inherited...

The Human Upgrade: Biohacking for Longevity &... ·

2026/10/02

Dave Asprey breaks down new research on vagus nerve stimulation and memory, feline cancer genetics, inherited cognitive ability, mulberries and the microbiome, and how magnesium changes vitamin D metabolism.

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00:47:03

Dave’s Anti-Aging Skincare Routine: Exosomes,...

The Human Upgrade: Biohacking for Longevity &... ·

2026/10/01

Visithttps://www.younggoose.com/and use codeASPREY10to save on the skin longevity products discussed in this episode.Skin Longevity, Cellular Repair, Red Light Therapy & the Biology of Younger Skin with Young GooseHost Dave Asprey sits down withAmitay EshelandAnastasia Khodzhaeva, co-founders ofYoung Goose, to explore the emerging science of skin longevity, cellular aging, mitochondrial function, exosomes, NAD+, red light therapy, and what it may take to keep skin functioning younger

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00:56:58

The Silent Fatty Liver Epidemic: Why Thin, Sober...

The Human Upgrade: Biohacking for Longevity &... ·

2026/09/29

VisitLoveYourLiver.comand use codeDAVE7to access the special offer from de-liver-ance mentioned in this episode.Fatty Liver, GLP-1s, Alcohol, Hormones, Brain Fog, Weight Gain & LongevityHost Dave Asprey sits down withSiggi Clavien, Founder and CEO ofThe Liver Clinicandde-liver-ance, to explore why the liver may be one of the most overlooked organs in metabolism, hormone health, detoxification, brain function, weight management, and longevity.Siggi explains why fatty liver can develop

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00:14:24

Every Way to Melt Visceral Fat FAST In 14 Minutes : 1545

The Human Upgrade: Biohacking for Longevity &... ·

2026/09/27

Dave Asprey outlines six science-backed methods to melt visceral fat—ranging from high-protein eating and HIIT to cold exposure, weightlifting, quality sleep, and stress reduction—arguing that chronic stress is the root cause that must be addressed for lasting fat loss.

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00:14:40

Ozempic Hair, GLP-1 Kids, Gut-Brain Anxiety, Food...

The Human Upgrade: Biohacking for Longevity &... ·

2026/09/25

A roundup of five health stories — Novo Nordisk's interest in hair loss, nutritional deficiencies in kids on GLP-1s, stomach-brain synchronization and mental health, food preservatives linked to heart disease, and taurine's stress-protective effects in rats — closing with a reminder to audit the hidden downsides of any health intervention you're already doing.

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01:13:45

The Best Singular Hack To Change EVERYTHING About...

The Human Upgrade: Biohacking for Longevity &... ·

2026/09/24

Dr. Robert Waldinger shares findings from the 85-year Harvard Study of Adult Development revealing that the quality of our relationships—not wealth, fame, or power—is the single greatest predictor of health, happiness, and longevity, and offers practical strategies for building "social fitness" at any life stage.

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00:58:42

15g Every Morning for Anti-Aging Mitochondria : 1541

The Human Upgrade: Biohacking for Longevity &... ·

2026/09/22

Catharine Arnston on Spirulina, Chlorella, Mitochondria, Detox, Brain Energy, and LongevityVisithttps://energybits.com/and use codeHUMANUPGRADEfor20% off.Could one of the oldest foods on Earth also be one of the most overlooked tools for mitochondrial health, brain function, detoxification, and longevity?Host Dave Asprey sits down with Catharine Arnston, founder of ENERGYbits and author ofLove Your Health to Bits with Algae, to explore the biology of spirulina and chlorella and why these

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00:20:31

I Wasted 10 Years Stuck With Brain Fog Until I...

The Human Upgrade: Biohacking for Longevity &... ·

2026/09/20

A mold illness survivor explains how toxic mold in your home and body causes chronic brain fog, fatigue, and inflammation — and lays out a step-by-step plan to identify the source, remediate your environment, and detox what your body has already absorbed.

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01:02:36

Teal Swan - Beyond the Veil of Ego, AI & Wisdom : 1539

The Human Upgrade: Biohacking for Longevity &... ·

2026/09/18

Dave Asprey sits down with spiritual teacher Teal Swan to explore narcissism, betrayal, extrasensory perception, the nature of ego, divine masculine and feminine energy, and whether humanity can heal its deepest wounds.

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00:54:16

How to Hack Your Smell for Memory and Longevity WHILE...

The Human Upgrade: Biohacking for Longevity &... ·

2026/09/17

Dr. Michael Leon on Smell Training, Memory, Sleep, Alzheimer’s Risk, and Brain LongevityYour sense of smell may reveal more about your brain health than you realize, and stimulating it while you sleep may improve memory, sleep quality, and cognitive function.**Visithttps://memoryair.com/and use codeDAVE15for15% off.**Host Dave Asprey sits down with Dr. Michael Leon, Professor Emeritus of Neurobiology and Behavior at UC Irvine and one of the world’s most cited scientists, to explore why

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00:55:33

Josh Duhamel on Nootropics, Peptides, and...

The Human Upgrade: Biohacking for Longevity &... ·

2026/09/16

**Visit https://www.gatlan.com/ and use cod ‘DAVE’ to unlock a free consultation!**At 53, Josh Duhamel says he feels better than he did in his 30s.Host Dave Asprey sits down with actor and Gatlan Health founder Josh Duhamel to talk testosterone, peptides, nootropics, brain health, fatherhood, and what it takes to stay strong as you age.Josh shares why he started TRT in his early 40s, what changed once he began tracking his hormones, and why he decided to build a health company around

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00:55:39

The Peptide Secrets to a Youthful Face : 1536

The Human Upgrade: Biohacking for Longevity &... ·

2026/09/15

Carolina Reis de Oliveira on Reversing Skin Age, Menopause, GLP-1 Skin, and the Science of Senescent CellsYour skin is likely biologically older than you are, but new research suggests some of that aging may be reversible.**For Dave’s listeners only, visitoneskin.co/Dave for exclusive early access to the OS-01 Face Rich Cream!**Host Dave Asprey sits down with Carolina Reis de Oliveira, PhD, CEO and co-founder of OneSkin. Carolina holds a PhD in stem cell biology and tissue engineering, is a

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00:12:05

What 36 Hours Without Sugar Does to Your Body : 1535

The Human Upgrade: Biohacking for Longevity &... ·

2026/09/13

This episode walks through an hour-by-hour timeline of what happens in your body during 36 hours without sugar — from falling insulin and dwindling glycogen to fat burning, ketone production, autophagy, and hormonal reset — explaining how cutting sugar reverses insulin resistance and drives visible physical improvements.

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00:09:48

New Seafood Superfood, Apple Watch Health Age,...

The Human Upgrade: Biohacking for Longevity &... ·

2026/09/11

This week's biohacking roundup covers anti-aging plasmalogens from sea squirts, major new Apple Watch health-monitoring features (including passive hypertension detection), an FDA push to modernize botanical drug regulation, a study linking adolescent-onset cannabis dependence to cognitive decline, and a blueberry compound that may help muscle cells burn fat.

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01:09:00

Everything You Need To Know About Your Poop | Gut...

The Human Upgrade: Biohacking for Longevity &... ·

2026/09/08

Dr. Karan Rajan on Fiber Fermentation, Sodium Myths, and What Your Poop Reveals About Disease RiskYour poop is more predictive than almost any other health signal, and you are flushing that data away every single day without a second look.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Dr. Karan Rajan, a practicing NHS gastrointestinal surgeon, best-selling author, and Chief Science Officer at Throne, who has

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00:10:03

If I Had To Lose 50 Pounds FAST, I’d Do THIS : 1532

The Human Upgrade: Biohacking for Longevity &... ·

2026/09/06

Dave Asprey breaks down three science-backed rules — cutting ultra-processed food, adopting adequate fasting windows, and redesigning your environment — to lower insulin resistance and break the metabolic block that's stalling your fat loss.

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00:07:48

Raw Garlic, Egg Yolks, Heat Strokes, and Melatonin :...

The Human Upgrade: Biohacking for Longevity &... ·

2026/09/04

This episode debunks some viral raw garlic claims and reviews new research on HEPA filtration, egg yolk peptides, heatstroke's long-term health risks, and melatonin's link to heart failure — closing with a reminder to control how much stress you put your body through.

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01:58:16

Jenny McCarthy | The 3 Questions You’re NEVER...

The Human Upgrade: Biohacking for Longevity &... ·

2026/09/03

Jenny McCarthy on Reversing Autism, Healing Mold Toxicity, and the Biohacking Protocol Big Pharma Doesn't Want You to KnowBack with another long one! Autism, mold poisoning, and cognitive decline share more root causes than most doctors admit, and this episode hands you the biohacking playbook to reverse all three.Want to try Jenny's makeup and skincare line? Visithttps://bit.ly/Formless-Beautyand use code DAVE to unlock a discount.Host Dave Asprey sits down with Jenny McCarthy Wahlberg, a

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