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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

05:07

Cannabis: Promise, Peril, and Practice 🌿⚖️🧭

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/27

🌿 What does the evidence really say about medical cannabis? A new JAMA review highlights a clear message: cannabis helps few conditions—and harms may outweigh benefits for many. 📉 Small benefit for nausea ⚡ Moderate benefit for select pediatric seizures 💊 Limited evidence for pain, insomnia, or psychiatric use ❤️ Risks rise with high-potency products, especially for heart and mental health. 🧭 Clinicians: guide with evidence, screen carefully, use lowest-risk options.

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03:56

Dengue Blocked, Viral Load Dropped, Hope...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/27

Thrilled to see a major step forward in dengue prevention! 🦟💊 A new NEJM study reports that daily mosnodenvir, a first-in-class antiviral targeting the NS3–NS4B interaction, significantly reduced DENV-3 viral load and prevented infection in a controlled human challenge model. 📉🧬 It's early, but the results offer real hope for a long-awaited oral dengue prophylaxis—with encouraging safety, strong PK, and dose-dependent efficacy. 🚀🌍 Exciting moment for global infectious-disease innovation and

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04:46

Storms, Syncope, Survival 🌩️😵‍💫❤️ — Long QT Syndrome...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/26

Delighted to share a concise update on the latest NEJM review of Long QT Syndrome 🫀📘 — a masterful synthesis by Schwartz & Crotti that reframes how we recognize risk, personalize therapy, and prevent sudden death in this genetically mediated disorder. The piece highlights ion-channel biology, gene-specific triggers, the impact of modifier genes, and the effectiveness of a tiered therapeutic approach including beta-blockers, mexiletine, and left cardiac sympathetic denervation ⚡️🧬🛡️. For

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03:15

Dr RR Baliga's Philosophical Discourses: Gottfried...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/25

🧠✨ Leibniz: Harmony, Logic, and the Birth of the Digital Mind Celebrating Gottfried Wilhelm Leibniz — the mathematician-philosopher who co-created calculus, invented binary arithmetic, and envisioned a world stitched together by pre-established harmony. His Monadology reads like proto-systems theory, and his binary system is the quiet ancestor of every computer we use today. For clinicians and scientists, his legacy whispers: 🔹 Seek the sufficient reason behind every pattern 🔹 Value multiple

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05:15

Genes, Environment, Development 🧬🌿🧠— A 2025...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/24

🧬 New insights into autism: A 2025 JCI Viewpoint highlights how hundreds of genes, polygenic risk, and specific environmental factors converge during fetal brain development to shape autism likelihood. 🧠 Early biomarkers—from infant MRI and ERPs to machine-learning models using EHR data—are accelerating earlier, more tailored interventions. 🌱 Advances in gene therapy, IGF-1 pathways, and proteomics offer emerging therapeutic possibilities. 🤝 Centering autistic voices remains essential as

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04:58

Numbness • Nerves • Nuance 🦶⚡🧠 — Decoding Peripheral...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/23

🔍 Peripheral Neuropathy: What Clinicians Should Know 🧠⚡ Peripheral neuropathy affects ~1% of adults worldwide, with diabetes accounting for more than half of all cases. The JAMA review highlights why length-dependent patterns dominate, how metabolic stress injures long axons first, and why sensory symptoms outpace motor loss. Evidence-based evaluation still begins with glucose testing, vitamin B12 with methylmalonic acid, and serum protein electrophoresis. First-line therapies for neuropathic

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05:12

Stroke Risk, Stent Benefit, Surgical Uncertainty 🧠✨🔧

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/22

New NEJM insights on asymptomatic carotid stenosis 🧠🔍 The CREST-2 trials offer a landmark update: intensive medical therapy remains the cornerstone, while carotid stenting shows selective benefit when performed by expert operators. Endarterectomy, however, provides no significant advantage over modern medical management. With stricter blood-pressure and LDL targets, plus expanding use of PCSK9 inhibitors, the future of stroke prevention is increasingly precision-driven, medically optimized,

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06:26

UPFs, Diets, Disease: The Global Drift 🍔➡️🌍➡️⚠️

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/21

The new Lancet Series on ultra-processed foods offers a striking insight: as UPFs rise globally, traditional whole-food diets decline—bringing nutrient imbalance, overeating, toxic exposures, and hyper-palatable formulations that quietly reshape health trajectories. 🍔➡️⚠️ Across more than 100 prospective studies and multiple trials, higher UPF intake consistently links to obesity, type 2 diabetes, cardiovascular disease, kidney disease, depression, and higher all-cause mortality. 📉🩺 The

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04:50

Groceries, Guidance, Gains 🛒📞📉 — How DASH Delivery...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/20

Home-delivered DASH-patterned groceries paired with dietitian counseling meaningfully lowered blood pressure and LDL cholesterol among Black adults living in food deserts 🥗📉—as demonstrated in the GoFresh randomized trial (JAMA). An accompanying editorial highlights why future "food-as-medicine" programs must prioritize underconsumed, health-promoting foods and align with modern evidence favoring higher-fat DASH/Mediterranean patterns 🌱🫒. A powerful reminder: the right groceries can be

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04:57

Hemodialysis, Cardiovascular Burden, Therapeutic Hope...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/19

🩺 New insights in hemodialysis care. A major New England Journal of Medicine study reports that daily supplementation with long-chain omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid) led to a 43% reduction in serious cardiovascular events among adults receiving maintenance hemodialysis. 🐟💙 In a population where traditional cardioprotective therapies often fall short, these findings open a fresh path for investigation — and perhaps, future practice. 📉🔬 A confirmatory trial

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07:03

💊 Oral, Potent, Proven — Enlicitide Redefines LDL...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/18

🚀 A milestone moment in lipid therapeutics! The new JAMA trial on the oral PCSK9 inhibitor Enlicitide reports a ~60% reduction in LDL-C, with parallel decreases in ApoB and Lp(a)—all on top of maximally tolerated statin therapy. For individuals with heterozygous familial hypercholesterolemia (HeFH)—where reaching LDL targets remains a persistent challenge—this represents a major advance. An oral agent matching the potency of injectable PCSK9 inhibitors could reshape adherence, access, and

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03:07

One Cup of Coffee. Less Atrial Fib/Flutter. More Life...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/17

☕ DECAF Trial insight! A new JAMA study shows that daily caffeinated coffee may lower recurrence of atrial fibrillation compared with abstinence. Patients drinking ~1 cup/day had 47% recurrence vs 64% with abstinence (HR 0.61, p=0.01) 📉💓 No major safety concerns—challenging long-held beliefs that coffee is proarrhythmic. 💡Takeaway: For many patients with AF, enjoying their morning brew may be both safe and possibly beneficial. #AtrialFibrillation #Cardiology #JAMA #ClinicalTrials #HeartHealth

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04:42

Beyond the Culprit: Complete Revascularisation •...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/16

🚨 New insights from The Lancet 🚨 A major individual-patient-data meta-analysis (6 RCTs, 8,836 patients) shows that complete revascularisation in acute myocardial infarction significantly reduces cardiovascular death, all-cause mortality, and recurrent MI. 💓📉 Benefits were consistent across age, sex, STEMI/NSTEMI, and lesion characteristics — strengthening the case for a more comprehensive approach beyond the culprit lesion alone. 🔬🩺 A powerful reminder: treating the whole heart saves

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02:31

Olezarsen Cuts Triglycerides. Calms Pancreas. Changes...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/15

🧬 New NEJM data on Olezarsen! In patients with severe hypertriglyceridemia, monthly RNA-targeted therapy delivered major triglyceride reductions (−62% to −72%) and a significant drop in acute pancreatitis risk (rate ratio 0.15). ✨ Improvements extended to ApoC-III, remnant cholesterol, and non-HDL cholesterol, with consistent benefits across both CORE-TIMI trials. 💡 A promising step forward in precision lipid therapy and pancreatitis prevention.

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03:16

MI Aftercare: The Beat Goes On—With or Without...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/14

📘 New Evidence from NEJM In a large meta-analysis of 17,801 patients with preserved LVEF after MI, beta-blockers did not reduce death, recurrent MI, or heart failure. Event rates were low, and outcomes were similar with or without therapy. 🫀📊 This clarifies practice for a growing post-MI population with LVEF ≥50%—precision matters more than tradition. 🎯 Full study: New England Journal of Medicine (2025). #Cardiology 💙 #ClinicalEvidence #MI #HeartHealth

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03:02

NOAC Monotherapy Wins in Afib with Drug Eluting...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/13

📢 ADAPT AF-DES Trial — A Safer Path Forward! In patients with atrial fibrillation beyond 1 year after drug-eluting stent implantation, NOAC monotherapy delivered striking benefits over combination therapy. ✅ Lower net adverse clinical events ✅ Marked reduction in major/CRNM bleeding ✅ Similar ischemic protection A beautifully simple strategy with meaningful impact. Published in NEJM (2025). 💊🛡️📉💓

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03:53

OCEAN Trial: Ablate Afib. Assess. Anticoagulate? 🌊

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/12

🌊 OCEAN Trial offers fresh insight into antithrombotic therapy after successful AF ablation. In 1284 patients followed for 3 years, event rates were remarkably low 🌟. Rivaroxaban did not show superiority over aspirin for preventing stroke, systemic embolism, or covert embolic events, while bleeding risk was higher with anticoagulation. 🧠 96% had no new infarcts on MRI at follow-up. Published in NEJM (2025) — a valuable contribution to nuanced AF post-ablation care.

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05:27

Dr RR Baliga's Philosophical Discourses: John Locke...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/11

🧠 John Locke: Experience • Liberty • Toleration Born a physician-philosopher, Locke championed empiricism — the idea that knowledge begins with experience, not dogma. His tabula rasa shaped modern psychology, while his Two Treatises of Government defined rights, consent, and freedom that echo through modern democracies. For clinicians, his legacy reminds us to: 🔹 Trust observation and evidence over authority 🔹 Respect patient autonomy and informed consent 🔹 Foster pluralism and toleration in

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04:52

Evolocumab in Primary Prevention." 🧬🛡️🎯 LDL: Down...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/10

🚀 VESALIUS-CV delivers powerful evidence: in high-risk patients without prior MI or stroke, evolocumab significantly reduced 3-point MACE by 25% and 4-point MACE by 19%, with LDL-C lowered to a median of 45 mg/dL. 💡 These results expand the horizon of prevention, showing that deep LDL reduction is both safe and effective in averting first cardiovascular events. 🫀 Strong science. Clear signal. A new chapter in preventive cardiology. #Cardiology #LDL #Prevention #VESALIUSCV

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04:48

Capillary Clues, Clinical Wins: Targeting Capillary...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/09

🫀 Septic Shock, Refined at the Fingertips ⏱️ A powerful new JAMA (2025) trial brings us one step closer to truly personalized resuscitation. The ANDROMEDA-SHOCK-2 study shows that targeting capillary refill time (CRT) — a simple bedside sign — can shorten time on organ support vs usual care, without increasing mortality. Key insight: Sometimes the most elegant solutions are low-tech, high-touch, and right at the bedside. 🧠 Precision 🤚 Physiology 💡 Pragmatism #Sepsis #CriticalCare

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