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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

05:25

⏳➡️⏰ Can Science Make Old Immune Cells Young Again?

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/20

🧬✨ Can we make the ageing immune system young again? A fascinating Nature study shows that a three-part mRNA cocktail (DFI) can temporarily rejuvenate T cells in aged mice, improving responses to vaccines and cancer immunotherapy—without breaking immune tolerance. By turning the liver into a short-term factory for key immune signals (DLL1, FLT3L, IL-7), the authors demonstrate that immune ageing is modifiable, not fixed. This elegant work—covered by Heidi Ledford in Nature—opens provocative

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05:10

Protein Moderation: Age Slower, Live Better 🧬⏳❤️

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/19

🧬 Protein Restriction, Aging, and Longevity ⏳ A remarkable new study in Cell shows that moderate protein restriction—especially when started in midlife—can reprogram aging biology across 41 organs, improving metabolic and cardiovascular health. 🫀⚙️ Using deep multi-organ proteomics in mice and human plasma validation, the authors demonstrate benefits mediated through ↓ IGF-1, ↓ mTOR, ↑ AMPK, and activation of brown adipose tissue. Importantly, the data also caution that extreme protein

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03:59

Waves, Not Lone Rangers 🌊⚔️🧬: How Neutrophils Work...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/18

🧬 Rethinking Neutrophils: From Lone Cells to Living Systems 🧠⚔️ For over a century, neutrophils were seen as short-lived foot soldiers of immunity. This new Cell review reframes them as something far more interesting: a coordinated, adaptive collective. ✨ Key ideas: • Short-lived cells, long-term memory • Two compartments: granulopoietic + mature • Plastic, circadian, tissue-adaptive behavior • Major implications for inflammation, cancer, and immunotherapy A powerful example of how systems

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04:36

🌙 Timing Is Tissue: Circadian Control of Neutrophils...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/17

⏰🫀 Does the heart care about the time of day? Yes—profoundly. A new study in the Journal of Experimental Medicine reveals a circadian checkpoint in neutrophils that determines how much damage occurs after myocardial infarction. Morning ischemia triggers more injury, while nighttime CXCL12–CXCR4 signaling reprograms neutrophils, relocating them into the infarct core and sparing healthy myocardium—without impairing antimicrobial defense. 🌙🧬 This work reframes infarct biology from how much

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05:24

Dr RR Baliga's Philosophical Discourses: Georg...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/16

Exploring Hegel's Vision of Progress and Freedom 🌍🔄✨ Reflecting on Georg Wilhelm Friedrich Hegel's remarkable insight that history is a dynamic journey toward greater human freedom. His dialectical lens — the idea that contradictions are not dead ends but engines of development — offers a powerful way to think about institutions, leadership, and change. 🔍💡 From Phenomenology of Spirit to Philosophy of Right, Hegel challenges us to see ourselves as part of a larger unfolding story where reason,

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05:40

Curing Cancer, Guarding the Heart 🛡️ |...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/15

🫀🧬 Cardio-Oncology: where modern cancer cures meet the heart As cancer survival improves, cardiovascular toxicity has emerged as a defining challenge of our time. From BTK inhibitor–associated atrial fibrillation ⚡, to immune checkpoint inhibitor myocarditis 🔥, to VEGF-driven hypertension 🩸, the heart increasingly pays the price of precision oncology. This FAQ-driven, clinician-ready Cardio-Oncology resource, grounded in the 2025 ACC Concise Clinical Guidance published in the Journal of the

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04:35

🧬 Prediabetes: Normalize Glucose, Save Hearts, Gain...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/14

🧬 Prediabetes remission is not just metabolic—it's cardiovascular medicine. ❤️ A new analysis in The Lancet Diabetes & Endocrinology shows that achieving remission to normoglycaemia—not merely delaying diabetes—was associated with a ~50% reduction in cardiovascular death or heart failure hospitalisation, with benefits persisting for 20–30 years across U.S. and Chinese cohorts ⏳📉. 🔍 The message is profound and practical: normalize glucose early, protect the heart long-term. Remission may

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04:54

Fat, Fire, and Fibrosis 🔥🧬🛑 Unmasking the Metabolic...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/13

🔬 New Insights on MASLD from JAMA 🍃 I recently reviewed an excellent JAMA article on Metabolic Dysfunction–Associated Steatotic Liver Disease (MASLD)—now recognized as the most common chronic liver disease worldwide. The review highlights how metabolic dysfunction, inflammation, and fibrosis converge to drive long-term risks, including cardiovascular disease, hepatocellular carcinoma, and extrahepatic cancers. Key advances include better noninvasive fibrosis assessment (FIB-4, elastography),

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10:07

The Brain's Hidden Rivers, Healing Flows, Hope Ahead

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/12

In this week's exploration, I dive into the brain's hidden "plumbing"—the glymphatic and meningeal lymphatic systems—drawing from a remarkable report in Science magazine (Dec 2025). The piece outlines emerging Alzheimer's strategies ranging from VEGF-C and Aquaporin-4 gene therapy to vasomotion drugs, CO₂ breathing, massage-based lymphatic stimulation, and even experimental lymphovenous surgery. A quiet revolution is underway—hope flowing through the brain's deepest channels. 💧🌊 #Neuroscience

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05:51

Obesity, Innovation, Action: The WHO Roadmap for...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/11

🌍 New WHO Guidance on GLP-1 Therapies: A Turning Point in Obesity Care 💉📘 The latest JAMA report highlights a pivotal moment in global health: the WHO's evidence-informed guideline on GLP-1 therapies for adults living with obesity. With over 1 billion people affected worldwide, this chronic, relapsing disease demands integrated, equitable, lifelong care. The guidance underscores two essentials: 💊 Long-term GLP-1 therapy for those living with obesity 🤝 Intensive behavioral support to amplify

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06:04

🔥 Activated Immunity, Aggravated Coronary Plaques,...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/10

Delving into the latest JAHA review on immune checkpoint inhibitors and the heart has been illuminating 🔍❤️. As immunotherapy transforms cancer care, we're learning that unleashed T-cells can also stir the silent storms within vulnerable plaques ⚡🩺. This piece beautifully unpacks how ICIs may accelerate atherosclerosis, heighten ACS risk, and challenge our diagnostic instincts—especially when myocarditis and ischemia mimic one another 🎯🧬. As we push the frontier of cancer survival,

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07:19

Dr RR Baliga's Philosophical Discourses: Immanuel...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/09

Immanuel Kant: The Architect of Modern Reason 🧠✨ Fascinating to revisit Kant's legacy — the thinker who reshaped how we understand knowledge, morality, and human freedom. His ideas on autonomy, duty, and the categorical imperative continue to guide ethical reasoning in science, leadership, and society. From Critique of Pure Reason to Perpetual Peace, Kant invites us to think boldly: What can I know? What should I do? What may I hope? 🌍📚 His work still challenges us to act with integrity,

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05:29

📊 Detect, Diagnose, Defend: Protecting the Heart...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/08

🚀 Immune checkpoint inhibitors have transformed cancer care—but they come with a cardiovascular shadow. A new International Cardio-Oncology Society (IC-OS) position statement offers the clearest guidance yet on myocarditis, pericarditis, arrhythmias, ACS, and noninflammatory HF linked to ICI therapy. 🫀💡 Key insights include: • Early recognition with troponin, ECG, and CMR 🧪📊 • Smoldering vs. nonsevere vs. fulminant myocarditis distinctions 🔍 • Steroid-first management and the evolving role

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06:03

From GFR to Global Health: CKD's Rising Tide 🌊📉🌐

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/07

Chronic kidney disease now affects nearly 850 million people worldwide, yet early detection and simple, evidence-based interventions can dramatically change the trajectory of both kidney and cardiovascular health. 🌍🩺 The latest Lancet Seminar highlights powerful tools—eGFR + albuminuria staging, SGLT2 inhibitors, RAS blockade, statins, and GLP-1 therapies—that allow every clinician to make a measurable impact. 💊📉 A reminder that timely action is kidney protection. 💧✨

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03:37

📅🔍🧠: A Natural Experiment Reveals Dementia-Slowing...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/06

🚀 New insights from Cell shine a light on an unexpected ally in the fight against cognitive decline. A natural experiment from Wales shows that the shingles (herpes zoster) vaccine doesn't just prevent viral reactivation—it may also reduce new mild cognitive impairment and lower dementia-related mortality over long-term follow-up. 🔍 Using a strict birthday-based eligibility cutoff, the study provides causal evidence—rare in population dementia research—that vaccination may slow disease across its

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04:56

Covid, RSV, Influenza: The 2025–26 NEJM Update 🧬🔥📊

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/05

📘 New NEJM Evidence for the 2025–26 Vaccine Season is out—and it delivers clarity at a time we need it most. The systematic review of 511 studies shows strong, consistent protection against hospitalization from Covid-19, RSV, and Influenza, with reassuring safety profiles across age groups. 💉🛡️ Key insights: improved VE for updated Covid-19 strains, high efficacy of maternal RSV vaccination and nirsevimab for infants, and solid influenza performance. 📊👶 A valuable guide for clinicians,

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05:46

Winning Against HFrEF 🥇💓🛠 Diagnose Early. Treat with...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/04

New Lancet Seminar on heart failure with reduced ejection fraction. 💓📘, this videocast walks listeners through the essentials of diagnosis, natriuretic peptides, imaging pathways, and the four foundational therapies shaping modern heart failure care. It's a clear, evidence-driven journey—designed to inform, clarify, and elevate bedside practice. Tune in to explore the science, the strategy, and the future of treating HFrEF. 🫀🔬✨ 🫀🔬✨

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06:20

Seeing CAD Clearly 🔍❤️: Plaque, Perfusion, Prognosis 📸💓📈

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/03

🔍💓 Chronic Coronary Artery Disease: Seeing What Matters Before It Hurts Just finished reviewing the 2025 Lancet paper on contemporary non-invasive imaging for chronic CAD, and the message is striking: how we see the heart shapes how well we save it. From CT angiography that unmasks non-obstructive plaque 🖥️➡️🫀 to stress PET/CMR that maps true ischemia under load 💨📊, multimodality imaging is redefining diagnosis, risk, and long-term outcomes. The evidence is clear: better imaging leads to

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03:25

Dr RR Baliga's Philosophical Discourses: David Hume...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/02

Exploring David Hume 🧠✨ Just revisited David Hume's extraordinary contributions to modern thought — a reminder of how deeply empiricism, skepticism, and the science of human nature shape our intellectual world. His insights on causation, the limits of reason, and the power of moral sentiment continue to resonate across philosophy, psychology, economics, and evidence-based decision-making. 🌍📚 Hume challenges us to look closely, question boldly, and reason with humility — a timeless guide for

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04:42

Heart Failure Rising 📈 | Risks Rewired 🔄 | America's...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/01

The U.S. heart failure landscape is transforming—and fast. 🫀📊 A new JACC analysis reveals a 35-year shift from ischemic to metabolic drivers of heart failure, with obesity, dysglycemia, and chronic kidney disease rising sharply, even as blood pressure, cholesterol, smoking, and myocardial infarction decline. 📉⚖️ These trends demand a new generation of HF trials—more inclusive, prevention-focused, metabolism-centered, and designed to capture outcomes beyond cardiovascular death. 🚀🧬 A

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815 results

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