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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

16:55

Residual Risk in CAD: What Remains, Why It Matters,...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/04

🫀 Residual Risk in Coronary Artery Disease Even after "optimal" therapy, many patients remain at risk. Why? Because atherosclerosis is more than LDL—it's thrombosis 🩸, inflammation 🔥, and metabolism ⚖️ working in concert. This FAQ-based slide deck distills contemporary insights on residual thrombotic, lipid, metabolic, and inflammatory risk, and highlights emerging therapies—from dual-pathway inhibition 💊 to GLP-1 receptor agonists 🧬 and colchicine—that help close the gap between treatment

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06:17

Dr RR Baliga's Philosophical Discourses: Swami...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/03

Swami Vivekananda reminded the world that spiritual strength and social service are inseparable 🕉️🔥 From Chicago in 1893 to India's national awakening, his message was simple yet radical: each soul is potentially divine—and serving humanity is serving the Divine 🌍🤝 More than a monk or philosopher, Vivekananda remains a timeless call to courage, compassion, and inner awakening ✨📚

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03:17

🫀 Sense. 🧠 Signal. 🛡️ Scar. A Heart–Brain–Immune Loop...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/02

🫀🧠🛡️ Sense. Signal. Scar. A striking Cell study reframes myocardial infarction as a systems disease, not a heart-only event. Using single-cell and spatial transcriptomics in murine MI, the authors identify a triple-node heart–brain–immune loop: TRPV1-positive vagal sensory neurons (injury sensing) → hypothalamic paraventricular nucleus AT1aR neurons (central integration) → superior cervical ganglion IL-1β signaling (sympathetic–immune effector arm). Intervening at any node improved ejection

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06:49

👉 Urge. Move. Repeat: The Modern Story of Restless...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/01

🦵🌙 Restless Legs Syndrome: more than a sleep complaint RLS affects ~3% of adults and is frequently missed or misdiagnosed as insomnia or anxiety. The latest evidence underscores three practical shifts: think iron (even when "normal"), choose gabapentinoids first, and beware dopaminergic augmentation. For internists and frontline clinicians, recognizing RLS early can meaningfully improve sleep, mood, and quality of life—and may even reduce downstream cardiovascular risk. 🧠🩺💤

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05:58

⚙️ The Operating System of Cancer: Hallmarks,...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/01/31

🧠🩺 Why cancers behave the way they do—and why treatments fail For internists, cancer is not just an oncologic diagnosis but a systems disease: driven by dysregulated growth, immune evasion, metabolic reprogramming, inflammation, and adaptive resistance. The Hallmarks of Cancer framework offers a unifying clinical lens—explaining recurrence, cachexia, immunotherapy variability, and late relapse—without drowning us in molecular minutiae. Understanding how tumors survive stress, therapy, and time

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08:09

🕔🏃‍♂️ Five Minutes More, Fewer Funerals

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/01/30

📟🪑🏃‍♂️ A striking accelerometer-based analysis in The Lancet suggests that small, realistic behavior shifts could translate into meaningful mortality gains at the population level. For the least active adults, +5 minutes/day of moderate-to-vigorous physical activity (MVPA) was associated with preventing ~6% of deaths; applying a similar increase broadly (excluding the most active) could prevent ~10%. Reducing sedentary time by 30 minutes/day was associated with preventing ~3% (high-risk) to ~7%

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06:26

A Disease of Legs, A Warning for Life 🦵⚠️❤️

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/01/29

🦵❤️ Peripheral Artery Disease is not just a leg problem—it's a life-threatening cardiovascular signal. Up to 60% of patients are asymptomatic, yet PAD doubles to triples the risk of myocardial infarction, stroke, and death. Evidence is clear: exercise therapy, statins, antiplatelet or rivaroxaban-based strategies, blood-pressure control, and GLP-1/SGLT2 therapies save limbs and lives. 🚶‍♂️💊🫀 When walking hurts—or quietly fades—cardiovascular risk rises. PAD deserves the same urgency as

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37:03

Numbers That Matter 🔢🫀🌍: The AHA 2026 Cardiovascular...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/01/28

🫀 What do the 2026 AHA Statistics really tell us? The latest AHA update makes one message unmistakably clear: prevention works—but only when systems work. From Life's Essential 8 🧭 to the rise of cardiovascular–kidney–metabolic (CKM) health 🩺🧪, the data show that blood pressure control, sleep 😴, physical activity 🚶‍♂️, nutrition 🥗, and nicotine cessation 🚭 shape not only heart outcomes, but brain health 🧠, equity ⚖️, and healthcare costs 💰. The challenge ahead isn't discovering new

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03:34

Dr RR Baliga's Philosophical Discourses: Sri...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/01/27

Sri Ramakrishna Paramahamsa showed that spiritual truth is lived, not debated 🌼🙏 Through devotion, deep experience, and simple parables, he taught that all religions are different paths to the same Reality 🛤️✨ His enduring message—serve humanity as the Divine—continues to inspire seekers, caregivers, and leaders alike ❤️🌍

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06:05

Cardiac Pace with a Purpose: Protect EF 🛡️🔌📉

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/01/26

CRT—now framed as cardiac physiologic pacing—remains a cornerstone for HFrEF patients with LVEF ≤50% and either high ventricular pacing burden or a wide QRS, with the biggest gains in LBBB and QRS ≥150 ms. ⚡🫀📈 Traditional biventricular pacing has randomized-trial evidence (>10,000 patients) showing better symptoms, quality of life, remodeling, fewer HF hospitalizations, and survival benefit in selected groups; meanwhile His bundle and left bundle branch pacing are rapidly expanding options, with

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05:29

🌍🏠❤️ From Clinic to Community: Closing the BP Control...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/01/25

🩺 Hypertension control in the U.S. has stalled—despite better meds, better evidence, and better tools. 📉 The "paradox" isn't a mystery so much as a systems problem: therapeutic inertia, fragmented care, cost barriers, and inconsistent use of validated home BP monitoring. 🧩 What works is boring (and therefore powerful): standardized treatment protocols, team-based care, rapid follow-up, combination therapy when appropriate, and performance feedback loops. 🧰📊 If we treat BP control like a

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08:38

🧬🛡️🕰️ Why Cancer Usually Waits for Old Age

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/01/24

🧬 Why does cancer mostly strike later in life? This review frames an elegant answer: evolution built layered anti-cancer "barriers" optimized to protect us through reproductive years—not indefinitely. 🛡️ With aging, those safeguards fray: tissues remodel, epigenetic "noise" rises, inflammation smolders, and immune surveillance softens—so clones that were once contained can progress. 🕰️🔥 A favorite reminder is 🐘 Peto's paradox: bigger, longer-lived species aren't overwhelmed by cancer,

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07:39

Diverse Exercise, Lower Death Risk 🎯🏃‍♂️⬇️⚰️

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/01/23

🏃‍♀️🏋️‍♂️ Does variety in physical activity matter for longevity? A large prospective analysis suggests it does: people who engaged in a wider mix of activity types tended to have lower all-cause mortality, even after accounting for total activity and key covariates. 🌈📉 Key practical takeaway: don't just "do more"—do different (walk + cycle + swim + strength, etc.). ✅🫀 As always, this is observational data (residual confounding + self-report remain). Still, it's a compelling nudge toward

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04:10

🧠➡️❤️ Rewiring the Heart: When the Vagus Nerve Saves...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/01/22

🧠❤️ Rewiring the Heart—Literally A striking Science Translational Medicine study shows that early reconnection of the right vagus nerve to the heart preserves ventricular mechanics, synchrony, and myocardial health—even when only ~20% of vagal fibers regenerate. 🧵🫀 Using a clinically relevant minipig model, the authors demonstrate that loss of parasympathetic input drives oxidative stress, inflammation, and premature cardiac aging—while targeted nerve repair reverses these pathways,

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03:07

Dr RR Baliga's Philosophical Discourses: Friedrich...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/01/20

Friedrich Nietzsche challenged the modern mind to think bravely, live honestly, and create meaning rather than inherit it 🧠⚡ From "God is dead" to self-overcoming, his ideas push us to confront nihilism and affirm life with courage and creativity 🔥🎭 More than a philosopher, Nietzsche remains a provocation—asking each of us: what values will you create? 🚀📚

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06:37

From Beige Fat to BP: What Every Cardiologist Should...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/01/19

Did you know the fat around our arteries is more than just padding? 🧬🩺 Recent findings show that deleting PRDM16 in perivascular adipose tissue transforms protective beige fat into fibrotic tissue, upregulating QSOX1 and driving hypertension 🩸📈. Activating brown fat or targeting QSOX1 could offer novel therapies. As internists, staying curious about adipose–vascular cross-talk might reshape how we tackle hypertension. 💡🔥 #Cardiology #InternalMedicine #Hypertension"

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03:59

🧬🧠❤️ The Immune System Is Not Just Defense — It Is...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/01/16

🧬🧠❤️ The Immune System Is Not Just Defense — It Is Physiology A superb Science Review (Nahrendorf, Ginhoux, Swirski, 2025) reframes immunity as a systems integrator, shaping brain function, heart rhythm, metabolism, pregnancy, and tissue repair—quietly maintaining homeostasis across the lifespan. Immune cells are not visitors; they are residents, communicators, and regulators in every organ system. 🧩 Defense meets regulation. 🧩 Immunology meets physiology. 📖 Science, August 2025 — a

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05:22

🫀🧬 Chemo's Quiet Aftermath: A New Macrophage Map of...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/01/15

🧬💥 New cardio-oncology insight: DNA-damaging chemotherapy (highlighting carboplatin) can reprogram the heart's immune "resident staff"—specifically CCR2− cardiac-resident macrophages—followed by monocyte-driven repopulation that looks "resident-like." 🫀🛡️ In a mouse model, this post-chemo macrophage landscape was linked to less adverse remodeling after hypertensive stress (AngII/PE), with reduced fibrosis and cardiomyocyte hypertrophy and lower remodeling gene signals. 📉🔬 Take-home: beyond

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04:19

🧠🌊 Clearing the Brain: CSF Flow, Sleep, and...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/28

🧠💧 How does the brain clean itself—and defend itself? A landmark Neuron review unifies two once-separate stories: brain waste clearance and immune surveillance. The glymphatic system, powered by CSF flow, sleep, and vascular pulsatility, works hand-in-glove with meningeal lymphatics to clear toxins (β-amyloid, tau) and present brain antigens to the immune system. 💤 Sleep is not rest—it's maintenance. 🛡️ Clearance is not plumbing—it's immunity in motion. 🧠 When this system falters,

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05:38

🌱 Slow Starts, Strong Finishes: How Legends Are...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/27

🏆 How do world-class performers really develop? A fascinating Science review (Güllich et al., 2025) overturns a deeply held belief: early stars are rarely future legends. Across sports, science, music, and chess, peak performers often showed slower early progress, less early specialization, and more multidisciplinary practice. The lesson is lyrical in its simplicity: breadth before depth, patience before acceleration. For educators, mentors, and institutions, this challenges how we identify

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