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PODCAST

Mendelspod Podcast

Offering a front row seat to the Century of Biology, veteran podcast host Theral Timpson interviews the who"s who in genomics and genomic medicine. www.mendelspod.com

science & medicine natural sciences

All Episodes

7:30

Diagnostic Trends in 2024 with Mara Aspinall,...

Mendelspod Podcast ·

2024/06/27

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comOne might think the pandemic would have been good for diagnostic companies. So why the financial hangover?Mara Aspinall has 30 years of leadership in genomics and the diagnostics industry. This has led her to her current role as a new partner at Illumina Ventures, a venture fund independent from Illumina that is focused on funding diagnostics and tools companies.Mara publishes the fantastic newsletter Sensitive and

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26:38

The Actionable Epigenome with Bret Barnes, Illumina

Mendelspod Podcast ·

2024/06/18

The genome has been the core focus of biomedical research for twenty years. Although the genome is prewritten and predetermined, much biology happens after it appears. One area is epigenomics, which is the modification of genomic outcomes.Bret Barnes has spent his career at Illumina developing the DNA methylation Infinium arrays that have become the workhorse of epigenomic studies around the world. Barnes says he was torn as a young person between biochemistry and computer science. He fortuitously

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6:04

Not All Prenatal Screens Are the Same: Jennifer...

Mendelspod Podcast ·

2024/06/13

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comNot content to offer “me too” products, a new company in the prenatal arena, Billion to One (BTO), is reimagining prenatal testing. Last year, their new Unity Fetal Risk Screen was featured in the American Journal of Human Genomics as a top advancement in applying genomics to clinical care. Joining us today is Jennifer Hoskovec, Senior Director of Medical Affairs at BTO. She says the new Unity Screen offers two steps in

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30:20

Harvard's Marc Lipsitch on the New White House Policy...

Mendelspod Podcast ·

2024/06/04

This week, we saw Dr. Anthony Fauci being grilled by an angry congress over, among other things, the origin of COVID-19, which is estimated killed at least 25 million people. He was asked about how the National Institute of Allergy and Infectious Diseases, which he directed until 2022, funded risky virus research at the Wuhan lab in China.Ever since the pandemic broke out, scientists, as well as policymakers, have been debating new restrictions on pathogen research, and last month, the White House

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24:12

Liquid Biopsy Goes Beyond Cancer: Diana Abdueva and...

Mendelspod Podcast ·

2024/05/23

A new precision medicine startup has launched that uses transcriptomic and epigenetic information to help with therapy for a wide range of chronic disorders. Hayward, California-based Aqtual emerged from stealth at the end of last year with data on its first assay, a blood-based test for rheumatoid arthritis.Today, we’re joined by Diana Abdueva, Aqtual’s Founder and CEO, and Maggie Louie, VP of Translational Research and Strategic Partnerships."We are complex organisms that work beautifully for many

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6:17

Cell Therapy Will Transform Medicine as We Know It,...

Mendelspod Podcast ·

2024/05/16

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comToday, we pursue an exciting area of medicine for the first time: cell therapy for solid tumors.Most, if not all, of our audience will be familiar with the success of CAR-T therapies for blood cancers. But only 10% of cancer is in the blood. The other 90% develop solid tumors. Jason Bock is the CEO and founder of CTMC, a new company aiming to speed the advancement of the entire field of cell therapies. First, we cover

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32:38

Two Industry Leaders on Dealing with the Growing...

Mendelspod Podcast ·

2024/05/14

The Clinical Knowledge Base (CKB) powered by The Jackson Laboratory (JAX) is a dynamic digital resource for interpreting complex cancer genomic profiles in the context of gene variant knowledge and protein impact, therapies, and clinical trials. Illumina has teamed up with JAX in the newly released Connected Insights software, which integrates CKB as a knowledge source.We’re joined by Cara Statz from JAX and Erica Schnettler from Illumina to discuss how their combined technologies are helping

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19:25

Single Cell Spatial Proteomics with Filip Karlsson,...

Mendelspod Podcast ·

2024/05/09

A paper out this week in Nature Methods demonstrates a new technology which shows novel patterns of protein spatial polarization and co-localization in immune cells. The technology launched by Swedish startup Pixelgen has been dubbed “molecular pixelation” because it uses DNA pixels to tag and reveal relative locations. Unlike most other spatial technologies, molecular pixelation does not involve microscopy.Lead author of the paper, Filip Karlsson, joins us today to explain the technology and how it

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33:59

The Precision Medicine Optimist: Damon Hostin, Illumina

Mendelspod Podcast ·

2024/05/07

Damon Hostin has had an active and exciting journey in genomic medicine. He’s now at Illumina, where his title is illuminative: Lead, Health System Market Access.A regular on the precision medicine stage, Damon has some insights into what he calls the “blindingly fast progression” of genomic medicine that should convince the most jaded of its critics. Compared to other areas of medicine, we are witnessing a rapid uptake of new science. Damon’s biography includes work at Celera in the age of the

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5:24

An Ethics First Approach to Genetic Research and Drug...

Mendelspod Podcast ·

2024/05/02

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comSarah LeBaron von Baeyer studied anthropology at Yale. Today she serves as the Director of Ethics Engagement at the new drug development company, Variant Bio, not a job she ever imagined at university.

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28:46

How Do You Train Genomics AI? On Natural Selection...

Mendelspod Podcast ·

2024/04/30

In today’s show, we talk with Kyle Fahr, the VP and Distinguished Scientist leading Illumina’s Artificial Intelligence Lab."We lack a way of training genomics AI as readily as you would for natural language processing, says Fahr. "There are vast amounts of data, but there are no labels, no supervision. One of the most powerful tools that we’ve found is using clues from natural selection.Fahr says the company began the AI lab seven years ago when deep learning took off. Two of the team’s AI

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5:41

The Pre-Symptomatic Space with Patrick Short, Sano...

Mendelspod Podcast ·

2024/04/25

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comToday, we continue our look into the gap in the adoption of precision medicine. Why are those who need it not getting genetic testing? Patrick Short is the Host of The Genetics Podcast and CEO and Co-founder of Sano Genetics.

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8:02

Systemwide Implementation of Precision Medicine at...

Mendelspod Podcast ·

2024/04/18

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comThrough its Center for Personalized Medicine, the University of Colorado Health offers its 2.2 million patients some of the country's most advanced precision medicine initiatives.

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5:03

Is this New Tech a Game Changer for Spatial Biology?

Mendelspod Podcast ·

2024/04/11

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comA new spatial biology company is promising to shake up the field. Last month, Curio Bioscience launched a new technology to early access customers that provides transcriptomic spatial data without the need to b…

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25:15

Synthetic Biology in 2024 with John Cumbers

Mendelspod Podcast ·

2024/03/26

John Cumbers is back on the show to preview the annual SynBioBeta, the leading global conference for the synthetic biology crowd. This year’s show includes 18 tracks on AI, space, longevity, and DNA synthesis. Speakers will include Stephen Wolfram and Stephen Quake, who will discuss large language models and biology.While 2024 saw a total investment of over $6 billion (not as high as the pandemic year of 2021), John says the new technologies and startups keep coming."We’re seeing just a ton of new

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30:51

Illumina Scales Variant Calling and Genome...

Mendelspod Podcast ·

2024/03/21

Most of the news coming from Illumina has had to do with their leadership in the sequencing instrument space. What is lesser known is that they offer an end-to-end solution for the clinical lab, including variant calling and genome interpretation.In this podcast, we’re joined by Sam Strom, Principal Scientist at Illumina and a certified Clinical Lab Director. Sam comes to Illumina from the clinical testing side; for example, he’s co-chair for the expert curation panel for Parkinson’s Disease and

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5:09

The Renaissance in DNA Synthesis Continues: Cosimo...

Mendelspod Podcast ·

2024/03/19

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comToday, we feature a new DNA synthesis company out of Sweden that is making a name with long, single-stranded DNA at scale. How long? Over 10,000 bases. Why single-stranded vs. genes? And what is meant by scale?According to Cosimo Ducani, CEO and co-founder of Moligo Technologies, the business of making DNA is just getting started. So much for thinking it was a mature business in the early 2000s when Integrated DNA

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22:24

Jennifer Wipf of Ginkgo Bioworks on RNA Therapeutics...

Mendelspod Podcast ·

2024/03/12

The rise of RNA therapeutics and cell therapies promises to take us where we’ve never been in medicine. The growing understanding of RNA, mRNA, and circular RNA and their crucial roles in disease has led to their application in targeting previously “undruggable” targets. Meanwhile, new cell therapies are promising cures to diseases that have plagued us without mercy. Scientists now ask what can’t we do. Still, biology remains dauntingly complex.At the base of these fields is a revolution in

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5:38

Precision Medicine for Dogs: Christina Lopes, OneHealth

Mendelspod Podcast ·

2024/02/22

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 Number one unmet medical need for dogs6:25 Using “extra label” for cross species12:57 Ideal for understanding human cancers21:25 Playing catch-up with human medicine28:04 1,000 pet clinic customersPrecision medicine for dogs?— as in tumor profiling for the right therapies to treat man’s best friends at the right time? Yes, that’s right. …

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40:29

Taking Gene Therapy to the Next Level: Rahul Kakkar...

Mendelspod Podcast ·

2024/02/15

There’s a new genome editing company that everyone is talking about this year. Tome Biosciences came out of stealth in December, claiming the ability to insert DNA sequences of any size at any location across in vivo and ex vivo modalities. Their website says they’re “taking us into the final chapter of medicine.”Tome’s CEO, Rahul Kakkar, joins us today on the program. He’s a physician-scientist (cardiology) who has previously led a couple of biotech companies, Pandion Therapeutics and Corvidia

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