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PODCAST

Mendelspod Podcast

Offering a front row seat to the Century of Biology, veteran podcast host Theral Timpson interviews the who"s who in genomics and genomic medicine. www.mendelspod.com

science & medicine natural sciences

All Episodes

47:28

All of Us Comes of Age. And So Does Its Funding: Josh...

Mendelspod Podcast ·

2026/08/18

Welcome to the second episode of Mendelspod’s 16th season. We’re grateful to everyone who has followed the show over the years, and we have a terrific lineup ahead as we continue asking some bigger questions about where biology and medicine are going.Few projects embody those ambitions quite like the NIH All of Us Research Program. The latest release includes data from more than 747,000 participants, 535,000 whole genomes, 480,000 electronic health records, and—for the first time—long-read

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41:01

Season Opener: Is Biology Having Its Newtonian...

Mendelspod Podcast ·

2026/08/13

Welcome to Mendelspod’s 16th season!It’s hard to believe we’ve been doing this for just over 15 years, following first and foremost the people reshaping biology and medicine. But also the technologies and ideas. Our original vision was to feature the “people behind the headlines” and you’ll see that what we continue to do in this first show of the new season. A sincere thank you to everyone who has listened, watched, subscribed, sponsored, recommended guests, shared a show, told your friends,

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32:55

From the Archives: Erdinc Sezgin and the Physics of...

Mendelspod Podcast ·

2026/08/06

On Mendelspod, we’re always searching for scientists who are looking at biology in new ways. Sometimes that means a new technology. Sometimes it means asking entirely different questions. Erdinc Sezgin is bringing the tools of physics to biology.Sezgin is a group leader at the Max Planck Institute of Molecular Cell Biology and Genetics, where he heads the Membrane Biophysics Group. His research focuses on one of the most familiar yet least understood structures in biology: the cell membrane.In this

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23:57

From the Archives: How Cellanome Is Changing the Way...

Mendelspod Podcast ·

2026/07/30

One of the biggest technology shifts we saw in biology over the past year came from the young company, Cellanome. Instead of relying only on static single-cell snapshots, the Cellanome platform enables longitudinal observation of live cells.In this conversation, Pier Federico Gherardini, VP of Computational Biology at Cellanome, joins Matthew Spitzer of UCSF, whose lab is putting the Cellanome platform to work in cancer immunology.The new CellCage technology allows researchers to follow individual

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29:01

Agilent and Oxford Nanopore Discuss Bringing Long...

Mendelspod Podcast ·

2026/07/09

Acute leukemia patients often wait days or even weeks for the full battery of molecular tests needed to guide treatment decisions. Dr. Parth Shah from Dartmouth believes long read sequencing can dramatically shorten that timeline. In this episode, Shah joins Agilent's Rita Shaknovich and Oxford Nanopore's Claire Attwooll to discuss some details of how long reads are beginning to move from research applications into routine clinical testing.Along the way, we explore the role of targeted enrichment,

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4:00

Liquid Biopsy for the Tumor Microenvironment: with...

Mendelspod Podcast ·

2026/06/30

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comWe’ve become remarkably good at reading cancer cells. Spatial biology enabled us to read them in context. Today we discuss a new Nature study suggesting that the tumor microenvironment—the immune cells, stromal cells, and surrounding biology that often determines whether a therapy succeeds or fails—can be measured from a simple blood draw, or liquid biopsy. To do that we’re joined by Dr. Vincent Miller, an oncologist

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4:59

Can Liquid Biopsy Transform Chronic Disease? Hamed...

Mendelspod Podcast ·

2026/06/25

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comFor the past decade, liquid biopsy has largely been defined by oncology. Tumors shed DNA carrying mutations and epigenetic changes which allows researchers to detect cancer and monitor response. With this physicians are increasingly able to guide treatment. But chronic diseases are different. There is no tumor. Biological signals are subtle and quite d…

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46:26

The UAE’s Big Bet on Genomic Medicine with Mohamed...

Mendelspod Podcast ·

2026/06/23

The future of genomics has arrived in Abu Dhabi.On today’s show, Dr. Mohamed Alameri of the UAE Department of Health and Albarah El-Khani of M42 describe one of the most ambitious precision medicine efforts underway anywhere in the world: the Emirati Genome Program, which has already sequenced more than 900,000 genomes and is rapidly integrating that data into everyday healthcare.The UAE program is not only a large sequencing effort and database—soon to be made available for research anywhere—but a

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41:11

Ryan Flynn of Harvard on Non-Coding RNA

Mendelspod Podcast ·

2026/06/18

On today’s show, Dr. Ryan Flynn of Harvard Medical School and Boston Children’s Hospital takes us into a newly emerging layer of biology: the architecture of the cell surface itself. Flynn first gained attention for the discovery of glycoRNA — RNA molecules displayed on the outside of cells — a finding that challenged the traditional picture of the cell surface as a world composed primarily of proteins and glycans. RNA has long been understood mainly as a carrier of genetic information (messenger

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32:54

Gary Schroth on Connecting Cellular Behavior to the...

Mendelspod Podcast ·

2026/06/11

For decades, biology has been driven by the powerful notion that if we could sequence enough genomes, transcriptomes, epigenomes, then we could finally explain the cell. On today’s show, Gary Schroth, the Chief Scientific Officer at Cellanome, argues that something essential was still missing.Schroth spent nearly two decades at Illumina helping build the sequencing revolution. He has now joined Cellanome to pursue an expanded vision of biology that connects transcriptomics with live-cell imaging.

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27:06

Two-Thirds of High-Risk Breast Cancer Patients May...

Mendelspod Podcast ·

2026/06/09

Today on the show, we’re discussing a new study just presented at ASCO 2026 that could change how chemotherapy decisions are made for a large group of breast cancer patients.During ASCO we spoke with Phil Febbo, Chief Scientific and Medical Officer at Veracyte, and John Leite, the company’s Chief Commercial Officer, looking at the results from the OPTIMA study, a large prospective trial involving roughly 4,500 patients with clinically high-risk ER-positive, HER2-negative breast cancer. The study

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31:31

Building the Diagnostic Layer of Modern Cancer Care...

Mendelspod Podcast ·

2026/05/29

For years, precision oncology has largely been discussed through the lens of breakthrough drugs. But there’s another story running underneath modern cancer care: the quiet rise of companion diagnostics. These tests are increasingly deciding who receives those therapies in the first place. In many cases, the real bottleneck is no longer discovering a drug target. It’s building a reliable system for identifying the right patient at the right moment in the disease. That challenge sits at the center of

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44:22

Mapping the Multi-Omic Era with Eric Green of Illumina

Mendelspod Podcast ·

2026/05/28

Dr. Eric Green returns to Mendelspod in a new role: Chief Medical Officer of Illumina. After more than three decades at the National Human Genome Research Institute, where he helped guide genomics from research initiatives to clinical reality, he now joins one of the industry’s most influential companies at a moment when the field is expanding beyond DNA alone.Green takes us on a tour around the world of multi-omics, which he says is not a branding exercise but a practical response to the limits of

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4:34

Inside Proteomics at Thermo Fisher with Yan Zhang

Mendelspod Podcast ·

2026/05/21

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comFor years, proteomics was described as the missing layer of biology. Why missing? Because measuring proteins at scale turned out to be vastly harder than sequencing DNA.That may finally be changing.In today’s episode Theral speaks with Dr. Yan Zhang, President of Proteomic Sciences at Thermo Fisher Scientific, about the rapid evolution of large-scale p…

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23:19

Separating Epigenetic Signals Improves Early Cancer...

Mendelspod Podcast ·

2026/05/19

We’ve gotten very good at reading DNA. We’re just beginning to understand how to read its state.On today’s show, Rob Osborne, Senior Vice President of R&D at Biomodal, discusses new evidence that separating two epigenetic marks—5-methylcytosine and 5-hydroxymethylcytosine—can improve early cancer detection from liquid biopsy. In a recent Nature Communications Medicine study, his team showed that analyzing these signals independently in circulating DNA significantly enhanced detection of Stage I

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4:23

Digital Controls for Cancer Drug Trials? Irina...

Mendelspod Podcast ·

2026/05/15

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comOn today’s show, a fascinating discussion about digital twins for medical research— leading to the 64 million dollar question of how much of the current AI wave in healthcare may eventually prove real.Drawing on her background in cancer research and now as CEO of Concr, Dr. Irina Babina joins us to argue that the future of oncology may depend less on g…

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37:59

Solexa Co-Inventor Shankar Balasubramanian on...

Mendelspod Podcast ·

2026/05/07

An inventor of Solexa sequencing by synthesis has a new idea.On today’s show, Sir Shankar Balasubramanian revisits the accidental origins of Solexa sequencing, born not from a sequencing project at all, but from curiosity-driven experiments watching DNA polymerase at work. What followed helped transform DNA sequencing from a specialized pursuit into a routine engine of modern biology. But as Shankar makes clear, the biggest surprise may not have been genomics itself—it was how next-generation

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35:29

The Case for a 6-Base Genome with Peter Fromen, CEO...

Mendelspod Podcast ·

2026/04/28

You’ve heard of 5-base genomics. How about 6-base? It turns out that separating 5-methylcytosine (mC) and 5-hydroxymethylcytosine (hmC) is pretty important.Peter Fromen has had a front-row seat to the evolution of sequencing, from the rise of high-throughput genomics at Illumina to long-read technologies at PacBio. Now, as CEO of Biomodal, he’s focused on integrating genetics and epigenetics into a single workflow—and showing that the regulatory layer of the genome may be where the next

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32:55

The Next Frontier in Biology: Physics? Erdinc Sezgin...

Mendelspod Podcast ·

2026/04/24

There’s a famous line attributed to Ernest Rutherford, the father of nuclear physics: “All science is either physics or stamp collecting.” It’s still provocative. But it’s unfair to biology. Long before today’s omics era, biologists were uncovering causality everywhere from evolution and natural selection to Mendelian inheritance. They have never merely catalogued life. They have explained it. But modern biology has also generated extraordinary inventories of genes, proteins, and pathways, and

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39:36

The Eligible But Under-Tested: Genomic Medicine in...

Mendelspod Podcast ·

2026/04/14

What is the value of someone’s genome over their life? Is a genome today what it was 10 years ago? How does the adoption of genomic testing compare to other areas in medicine, such as imaging or electronic health records?Today we take a pretty comprehensive look at genomic testing in practice with Damon Hostin, Head of Market Access, Clinical Solutions at Illumina. Damon brings a rare perspective to this conversation. He’s been in the field since the Celera era, when sequencing was helping define

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