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PODCAST

Mendelspod Podcast

Offering a front row seat to the Century of Biology, veteran podcast host Theral Timpson interviews the who"s who in genomics and genomic medicine. www.mendelspod.com

science & medicine natural sciences

All Episodes

5:41

Christian Henry of PacBio on Long Reads at Scale,...

Mendelspod Podcast ·

2024/02/13

This is a free preview of a paid episode. To hear more, visit www.mendelspod.com0:00 Long reads at scale has made what difference?6:15 The long or short of it: How does one decide?12:31 Long reads in the clinic20:37 Apton tech to compete with Illumina’s NovaSeq X26:30 Plans for next instruments35:00 Surveying the competitionIn our first post-AGBT show of the year, we’re talking with the CEO of Pacific Biosciences, Ch…

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40:23

Robert Michel, Editor at The Dark Report, on Gap in...

Mendelspod Podcast ·

2024/02/06

Why aren’t more folks receiving genetic testing?In a study published in JAMA last year, Stanford cancer researcher Alison Kurian found a surprising gap between those who need genetic testing and those who receive it. Among more than a million patients with cancer, only 6.8% underwent germline testing.Today, we begin a new series exploring this gap in testing with Robert Michel. He's the Editor-in-Chief at The Dark Report, reporting on the laboratory industry since 1996. Robert says the problem

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37:31

Turning to Next Gen Proteomics for Novel Biomarkers:...

Mendelspod Podcast ·

2024/01/30

Batten disease is a group of neurodegenerative lysosomal storage disorders that result from pathogenic variants in one of 13 CLN genes. Collectively, Batten disease affects approximately 1 in 100,000 individuals worldwide, making it the most common pediatric neurodegenerative disorder. The most common form of Batten Disease, CLN3 disease, is a rare and fatal autosomal recessive disorder caused by mutations in CLN3. Individuals with CLN3 disease typically experience vision loss in early childhood,

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36:24

What Have We Learned from the Brain Map Project So...

Mendelspod Podcast ·

2024/01/23

After ten years, the human brain mapping project has achieved some major milestones, says Tom Nowakowski, a researcher at UCSF, on today’s program. He says that mapping the brain is a “moon shot” easily on par with the Human Genome Project.So much of biology is basic quantification. Brain scientists are beginning to quantify how many kinds of brain cells there are. They are learning more about the function of various cells such as glial cells.. And they are developing a common language with each

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23:49

Quality Healthcare Should Not Depend on Which Book...

Mendelspod Podcast ·

2024/01/16

Karen Tumulty, a political writer for the Washington Post, was diagnosed with multiple myeloma. She was told she had five years to live. Then she went to book club with friends. On the way home she came out about her diagnosis—and that changed her life. Someone in the car happened to be the President of the Personalized Medicine Coalition, Ed Abrahams. He made a referral and that led to better treatment and better survival. Karen’s story, along with that of her brother, is a must-listen for

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4:54

Real Probiotics: Colleen Cutcliffe, CEO, Pendulum...

Mendelspod Podcast ·

2024/01/09

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comFun fact: we are composed of 90% bacterial cells and 10% human cells. Surely, the company that begins to turn that knowledge into health products will be the next billion-dollar startup. Pendulum Therapeutics is doing just that. Started in 2012, the company now boasts a full product line of probiotics that are not your typical probiotics. In 2020, the company released a scientific study showing that their glucose

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3:41

Todd Druley of Mission Bio on Single Cell Multi-Omics

Mendelspod Podcast ·

2024/01/04

This is a free preview of a paid episode. To hear more, visit www.mendelspod.com"We can now begin to look at disease before it happens,” says today’s guest, Todd Druley. He’s the Chief Medical Officer at Mission Bio who has been offering the world’s first single cell and multi-omics instrument.

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47:45

Kevin Davies on Gene Therapy in 2023

Mendelspod Podcast ·

2023/12/26

This month, the FDA approved the first CRISPR-based gene therapy called Casgevy (pronounced with a soft g). It’s a one-and-done treatment for sickle cell disease and is being hailed as major step forward in medicine. Joining us to discuss this breakthrough is our return champion, Kevin Davies, author of Editing Humanity: The CRISPR Revolution and the New Era of Genome Editing and Executive Editor of the CRISPR Journal and GEN Biotechnology.Kevin takes us into the science of the new gene therapy and

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5:56

History and State of Proteomics 2023 with John Yates

Mendelspod Podcast ·

2023/12/19

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comMany of our shows this year have explored a new wave of proteomics tools and research. So today, we wanted to get a snapshot of the field of proteomics, and to do that, we turned to John Yates III, Ernest W. Hahn Professor at The Scripps Research Institute. John was on the proteomics side of the famous Lee Hood lab in the 1980s. The most exciting work to come out of Hood’s lab was the first automated DNA sequencer

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4:47

New Philosophy of Biology Series on PBS: A Preview...

Mendelspod Podcast ·

2023/12/12

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comThis month, a new philosophy of biology series premiers on PBS hosted by Robert Lawrence Kuhn. The series will go for thirteen episodes and includes over 250 interview clips with some of the world’s leading biologists and philosophers, including Richard Dawkins, Terrence Deacon, Peter Godfrey Smith, and Samir Okasha. Show titles include: Why Philosophy of Biology?, Philosophy of Units/Levels of Natural Selection, and

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6:23

Mapping the Meta Proteome: John Shon, CTO, Serimmune

Mendelspod Podcast ·

2023/12/05

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comJohn Shon is the Chief Technology Officer at Serimmune, a company specializing in precision immunology. Serimmune maintains a library of over 10 million random peptides that can mimic almost any disease. With this library, they are able to comprehensively map the relationship between antibodies and antigens.What does this mean? Take COVID, for instance; rather than just offering a diagnostic, Serimmune can show

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26:22

Supercharged Killer Cells Effective Against...

Mendelspod Podcast ·

2023/11/28

Our guest today introduced us to a new kind of immunotherapy called Super-NK. Imagine CAR-T, but in this case, the immune cells from the patient are not engineered, but rather “supercharged.” What’s remarkable is that the company is having success with the therapy against neurological conditions such as Alzheimer’s and Parkinson's.Paul Song is the CEO of NKGen Biotech. The company just presented results from a Phase I trial at the 16th Annual Clinical Trials on Alzheimer’s Disease Conference

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6:07

Chris Hall and Rich Chen of Personalis on Next Gen...

Mendelspod Podcast ·

2023/11/21

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comPersonalis, a company launched during the early days of whole genome testing and analysis, is claiming to have the most sensitive MRD testing available to date. They are demonstrating this with the results of their recently released TRACERx study of patients with non-small cell lung cancer. CEO Chris Hall and CMO Rich Chen both join us to profile these exciting results and debut the entrance of Personalis into MRD

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9:27

State of Sequencing 2023: Shawn Baker and Keith Robison

Mendelspod Podcast ·

2023/11/14

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 Delivering on last year’s announcements8:50 Illumina14:25 Long reads25:50 PacBio vs Oxford Nanopore31:36 Element38:27 MGI45:47 The rise of proteomics51:20 What next?The end of the year approaches, and we look back today on the state of DNA sequencing with two of our return champions, Shawn Baker, genomics consultant, and…

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43:11

Newborn Sequencing 2023 Part II: What Evidence Is...

Mendelspod Podcast ·

2023/11/07

Chapters:0:00 State of the field: reviewing ICoNS conference22:20 What evidence is enough?Today, we’re joined by a panel of four guests who have all attended the recent International Conference on Newborn Sequencing held at the Royal Institution in London. This discussion serves as the second part in a series we are co-producing with GenomeWeb that began with last month’s panel. At the conference, researchers representing 12 newborn sequencing research programs in the US, the UK, Europe,

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6:36

Lincoln Nadauld on the State of Precision Medicine in...

Mendelspod Podcast ·

2023/10/17

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 Precision oncology is standard of care13:50 Culmination Bio23:25 Hopeful about early cancer screening25:45 Biggest challenge for the field?When Lincoln Nadauld began Precision Genomics at Utah-based Intermountain Healthcare, he told the administrators that precision oncology is coming and will be standard of care. He urged them to d…

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6:16

Nothing Is "Undruggable:" Alex Federation, CEO, Talus...

Mendelspod Podcast ·

2023/10/12

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 What are transcription factors?7:00 The MARMOT platform11:22 In the ’90s, people thought kinases were undruggable19:00 Where’s the company at today?We begin today’s show with definitions. What are transcription factors? What is functional proteomics? And what is meant by “undruggable?"According to a study in Nature from las…

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6:29

Mass Spec Advances in a New Age of Proteomics: Rosy...

Mendelspod Podcast ·

2023/10/10

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 Attending this year’s Human Proteome Organization (HUPO) conference4:40 Mass spec vs. sequencing8:12 How does the Orbitrap Astral fit into the market?12:55 Customer applicationsThermo Fisher Scientific is a name synonymous with life science tools. They have been at the vanguard of every important trend in our field for decades.…

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6:14

This Is Very Cool: Treating Cancer with Sound

Mendelspod Podcast ·

2023/10/03

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 What does treatment look like?7:25 Light treatment has been approved for years20:10 Could this be a primary therapy for all cancers?25:05 Challenges?We often cover new therapies for cancer. They are usually derived from “chemistry." But what about using “physics” in a non-invasive way for treatment? A new company named SonA…

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34:50

The Future of Clinical Proteomics with Jenny Van Eyk...

Mendelspod Podcast ·

2023/09/27

Chapters:0:00 “It’s a magical time.”9:55 Tracking low-concentration proteins in real-time19:20 What next?24:40 Proteins act in community29:30 Challenges ahead?Many new drugs and clinical diagnostics are being derived from proteins. Today we take our proteomics series into the clinic with Jenny Van Eyk from Cedars Sinai Hospital in Los Angeles and Daniel Hornburg of the proteomics company, Seer. Jenny works at that sweet spot with one foot in the clinic and the other in research,

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562 results

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