Mendelspod Podcast

3:41

Todd Druley of Mission Bio on Single Cell Multi-Omics

Mendelspod Podcast ·

2024/01/04

This is a free preview of a paid episode. To hear more, visit www.mendelspod.com"We can now begin to look at disease before it happens,” says today’s guest, Todd Druley. He’s the Chief Medical Officer at Mission Bio who has been offering the world’s first single cell and multi-omics instrument.

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47:45

Kevin Davies on Gene Therapy in 2023

Mendelspod Podcast ·

2023/12/26

This month, the FDA approved the first CRISPR-based gene therapy called Casgevy (pronounced with a soft g). It’s a one-and-done treatment for sickle cell disease and is being hailed as major step forward in medicine. Joining us to discuss this breakthrough is our return champion, Kevin Davies, author of Editing Humanity: The CRISPR Revolution and the New Era of Genome Editing and Executive Editor of the CRISPR Journal and GEN Biotechnology.Kevin takes us into the science of the new gene therapy and

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5:56

History and State of Proteomics 2023 with John Yates

Mendelspod Podcast ·

2023/12/19

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comMany of our shows this year have explored a new wave of proteomics tools and research. So today, we wanted to get a snapshot of the field of proteomics, and to do that, we turned to John Yates III, Ernest W. Hahn Professor at The Scripps Research Institute. John was on the proteomics side of the famous Lee Hood lab in the 1980s. The most exciting work to come out of Hood’s lab was the first automated DNA sequencer

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4:47

New Philosophy of Biology Series on PBS: A Preview...

Mendelspod Podcast ·

2023/12/12

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comThis month, a new philosophy of biology series premiers on PBS hosted by Robert Lawrence Kuhn. The series will go for thirteen episodes and includes over 250 interview clips with some of the world’s leading biologists and philosophers, including Richard Dawkins, Terrence Deacon, Peter Godfrey Smith, and Samir Okasha. Show titles include: Why Philosophy of Biology?, Philosophy of Units/Levels of Natural Selection, and

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6:23

Mapping the Meta Proteome: John Shon, CTO, Serimmune

Mendelspod Podcast ·

2023/12/05

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comJohn Shon is the Chief Technology Officer at Serimmune, a company specializing in precision immunology. Serimmune maintains a library of over 10 million random peptides that can mimic almost any disease. With this library, they are able to comprehensively map the relationship between antibodies and antigens.What does this mean? Take COVID, for instance; rather than just offering a diagnostic, Serimmune can show

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26:22

Supercharged Killer Cells Effective Against...

Mendelspod Podcast ·

2023/11/28

Our guest today introduced us to a new kind of immunotherapy called Super-NK. Imagine CAR-T, but in this case, the immune cells from the patient are not engineered, but rather “supercharged.” What’s remarkable is that the company is having success with the therapy against neurological conditions such as Alzheimer’s and Parkinson's.Paul Song is the CEO of NKGen Biotech. The company just presented results from a Phase I trial at the 16th Annual Clinical Trials on Alzheimer’s Disease Conference

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6:07

Chris Hall and Rich Chen of Personalis on Next Gen...

Mendelspod Podcast ·

2023/11/21

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comPersonalis, a company launched during the early days of whole genome testing and analysis, is claiming to have the most sensitive MRD testing available to date. They are demonstrating this with the results of their recently released TRACERx study of patients with non-small cell lung cancer. CEO Chris Hall and CMO Rich Chen both join us to profile these exciting results and debut the entrance of Personalis into MRD

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9:27

State of Sequencing 2023: Shawn Baker and Keith Robison

Mendelspod Podcast ·

2023/11/14

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 Delivering on last year’s announcements8:50 Illumina14:25 Long reads25:50 PacBio vs Oxford Nanopore31:36 Element38:27 MGI45:47 The rise of proteomics51:20 What next?The end of the year approaches, and we look back today on the state of DNA sequencing with two of our return champions, Shawn Baker, genomics consultant, and…

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43:11

Newborn Sequencing 2023 Part II: What Evidence Is...

Mendelspod Podcast ·

2023/11/07

Chapters:0:00 State of the field: reviewing ICoNS conference22:20 What evidence is enough?Today, we’re joined by a panel of four guests who have all attended the recent International Conference on Newborn Sequencing held at the Royal Institution in London. This discussion serves as the second part in a series we are co-producing with GenomeWeb that began with last month’s panel. At the conference, researchers representing 12 newborn sequencing research programs in the US, the UK, Europe,

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6:36

Lincoln Nadauld on the State of Precision Medicine in...

Mendelspod Podcast ·

2023/10/17

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 Precision oncology is standard of care13:50 Culmination Bio23:25 Hopeful about early cancer screening25:45 Biggest challenge for the field?When Lincoln Nadauld began Precision Genomics at Utah-based Intermountain Healthcare, he told the administrators that precision oncology is coming and will be standard of care. He urged them to d…

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6:16

Nothing Is "Undruggable:" Alex Federation, CEO, Talus...

Mendelspod Podcast ·

2023/10/12

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 What are transcription factors?7:00 The MARMOT platform11:22 In the ’90s, people thought kinases were undruggable19:00 Where’s the company at today?We begin today’s show with definitions. What are transcription factors? What is functional proteomics? And what is meant by “undruggable?"According to a study in Nature from las…

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6:29

Mass Spec Advances in a New Age of Proteomics: Rosy...

Mendelspod Podcast ·

2023/10/10

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 Attending this year’s Human Proteome Organization (HUPO) conference4:40 Mass spec vs. sequencing8:12 How does the Orbitrap Astral fit into the market?12:55 Customer applicationsThermo Fisher Scientific is a name synonymous with life science tools. They have been at the vanguard of every important trend in our field for decades.…

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6:14

This Is Very Cool: Treating Cancer with Sound

Mendelspod Podcast ·

2023/10/03

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 What does treatment look like?7:25 Light treatment has been approved for years20:10 Could this be a primary therapy for all cancers?25:05 Challenges?We often cover new therapies for cancer. They are usually derived from “chemistry." But what about using “physics” in a non-invasive way for treatment? A new company named SonA…

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34:50

The Future of Clinical Proteomics with Jenny Van Eyk...

Mendelspod Podcast ·

2023/09/27

Chapters:0:00 “It’s a magical time.”9:55 Tracking low-concentration proteins in real-time19:20 What next?24:40 Proteins act in community29:30 Challenges ahead?Many new drugs and clinical diagnostics are being derived from proteins. Today we take our proteomics series into the clinic with Jenny Van Eyk from Cedars Sinai Hospital in Los Angeles and Daniel Hornburg of the proteomics company, Seer. Jenny works at that sweet spot with one foot in the clinic and the other in research,

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41:27

Elinor Karlsson on Darwin’s Ark

Mendelspod Podcast ·

2023/09/18

Today’s show is made free by the generous support of Twist Bioscience. Twist works in service of people changing the world for the better in fields such as medicine, agriculture, industrial chemicals, and data storage. Their unique silicon-based DNA synthesis platform provides precision that is otherwise unavailable. Check out their products at www.twistbioscience.com. And join them as they write the future of science.Chapters:0:00 Pet dogs have complex genetics and phenotypic data8:00

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8:12

Long DNA for Difficult Applications: Dan Lin-Arlow,...

Mendelspod Podcast ·

2023/09/13

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 World’s longest oligo8:45 Why is it difficult to synthesize long DNA?12:00 Proprietary TdT conjugate16:00 A billion-dollar market24:20 The computation model and its challenges28:35 More customers using generative AIMendelspod is now reader supported. Please consider upgrading to a paid subscription for the price of a couple cof…

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6:07

Next Gen CRISPR Therapies with Trevor Martin, CEO of...

Mendelspod Podcast ·

2023/09/05

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comChapters:0:00 Novel Cas enzymes help overcome CRISPR challenges11:37 New pipeline of therapies will go after novel targets14:52 How does the new platform open up possibilities for new diagnostics?21:05 What risks do you think about?26:47 What are the company’s two-year goals?31:07 On the possibilitiesCRISPR technology is enabling a new generation …

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8:25

13th Season Opener: Mike Snyder on Microsampling and...

Mendelspod Podcast ·

2023/08/24

This is a free preview of a paid episode. To hear more, visit www.mendelspod.com0:00 Latest paper on multi-omics microsampling6:30 Is it useful? Two scenarios13:00 How might entrepreneurs bring this to healthcare?18:15 How do you convince physicians?25:48 Are you a reductionist?31:00 Impact of generative AI38:15 Thoughts on the renaissance in proteomicsWe open our 13th season here at Mendelspod with guest, Mike Snyder, S…

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45:24

Gene Patent Decision at 10 Years, State of Genetic...

Mendelspod Podcast ·

2023/06/15

Ten years ago this week, the Supreme Court unanimously ruled that genes could not be patented. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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33:57

Proteomics Bigger than Genomics, It’s Just Taking...

Mendelspod Podcast ·

2023/06/01

Today we feature Quantum-SI, one of the new wave of proteomics tools companies. The company was founded by serial life science entrepreneur, Jonathan Rothberg, originally as a long read sequencing company. Though the company pivoted to proteomics, they kept the sequencing part. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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