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PODCAST

Mendelspod Podcast

Offering a front row seat to the Century of Biology, veteran podcast host Theral Timpson interviews the who"s who in genomics and genomic medicine. www.mendelspod.com

science & medicine natural sciences

All Episodes

39:22

Lance Baldo of Freenome on their Approach to Early...

Mendelspod Podcast ·

2022/12/08

When excitement around early cancer detection first surfaced, we heard about the “pan-cancer” test that would look for any and all cancers, and early. Now that we’re some years into it, the approach is turning out to be more of a narrow one. Which cancer will we likely see targeted first with an FDA cleared test? Colorectal, according to today’s guest. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit

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34:30

Mara Aspinall on COVID

Mendelspod Podcast ·

2022/11/29

Winter is here. In America, we're just back from the Thanksgiving holiday when many of us travel and get together. And so far there is no great COVID surge this year. Or is there?Today's guest says there likely is, and we don't know it because of the most significant shift in our pandemic response: at-home testing. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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44:25

Terry Lo of Vizgen on Spatial Genomics

Mendelspod Podcast ·

2022/11/27

Today spatial biology company, Vizgen, makes their debut on on the program.When Vizgen CEO Terry Lo was first involved in developing what we now call spatial biology at Perkin Elmer, he admits that he never thought it would have a genomics side to it. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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52:31

Proteomics at Scale Empowers Genomics in New Ways:...

Mendelspod Podcast ·

2022/11/22

It’s the age of multi omics. Or multi comics, if you don't catch spell check. A few weeks ago at the annual meeting of the American Society for Human Genetics, we were pleased to find not only genomics companies but some proteomics outfits finding a home. As we chatted with one of these, Olink Proteomics, we were blown away to hear that they were announcing the publication of 1,000 scientific papers. It wasn’t so long ago that genomics companies were boasting this kind of milestone. Has

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35:46

A New Tool in the Genomics Kit with Ivan Liachko of...

Mendelspod Podcast ·

2022/11/14

Have you ever heard of proximity ligation? We knew of it in research form back in the day, but not that it had been commercialized until this summer. It’s not every day we come across a powerful new genomics tool on this program. Which begs the question, where have Ivan Liachko and his company, Phase Genomics, been hiding?The company received a grant this summer from the Bill Gates Foundation as well as the NIH to pursue phage therapeutics. That’s using viruses to go after bacterial

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34:42

Paul Kruszka of GeneDx/Sema4 on Groundbreaking...

Mendelspod Podcast ·

2022/11/13

Last week, during the first International Conference on Newborn Sequencing, a landmark study to sequence the genomes of 100,000 newborns was announced. Called the GUARDIAN study, the project is the brainchild of Wendy Chung, Professor of Pediatrics at Columbia University. The study will take place in New York State and is somewhat similar to an ongoing project in the U.K. being done by Genomics England. This is a public episode. If you'd like to discuss this with other subscribers or get access to

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33:43

Is PGx Having a Moment? Kristine Ashcraft, Invitae

Mendelspod Podcast ·

2022/11/10

Pharmacogenomic testing, or PGx, is considered low-hanging fruit, a no-brainer for the application of genetic testing in the clinic. And some may think it is small fruit. Not so, says today’s guest, Kristine Ashcraft."Currently we lose a life every two minutes in the United States to non-optimized medications,” says Kristine in today’s show. She has spent over twenty years working to see pharmacogenomic testing adopted into standard-of-care medicine. Kristine serves today as the Medical Affairs

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36:41

Christian Henry on Revio, Onso and the New Vision at...

Mendelspod Podcast ·

2022/11/03

Last week with a crowd of 1,200 customers in a Los Angeles nightclub, sequencing company Pacific Bioscience launched two new sequencers, both long and short read, Revio and Onso. It was a night of great technology, music, and anticipation. Their customers have waited a long time for this moment. Revio offers long read whole genomes at scale for under $1,000. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit

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41:46

The Revolution in Single Molecule Sequencing...

Mendelspod Podcast ·

2022/10/18

A new generation of biologists is pushing the limits of third-generation sequencing, furthering the technology's development and defining new applications to answer biology’s most pressing questions.This is the express goal for the lab of Vijay Ramani, assistant professor at UCSF in the department of Biophysics and Biochemistry. Vijay also has an appointment in the Institute of Data Science and Biotechnology at the Gladstone Institute, and in 2019 he was named to the Forbes 30 under 30 rising stars

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47:28

Will Hwang of Mass General on Discovery of Novel...

Mendelspod Podcast ·

2022/10/11

In our age of specialization, today’s guest, Dr. Will Hwang of Massachusetts General, went against the trend and received three bachelor degrees in different fields.Or is this the new trend?Will says that despite the diversity of pursuits, there was a thread that ran throughout his life as a student. He always liked to look at things at the fundamental unit. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit

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31:41

Going Beyond Time Barriers: Arutha Kulasinghe on the...

Mendelspod Podcast ·

2022/10/07

Arutha Kulasinghe was pumped for the AGBT (Advances in Genome Biology and Technology) Conference this year. He is the Principal Investigator for the Clinical-oMx Lab at the University of Queensland. Dr. Kulasinghe has pioneered spatial transcriptomics using digital spatial profiling approaches in the Asia-Pacific region, contributing to world-first studies for lung, head, and neck cancer and COVID-19. Not gathering last year due to the pandemic, the AGBT conference has became a kind of revival

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44:03

Invitae’s Data Manager, Farid Vij, on New Genome...

Mendelspod Podcast ·

2022/09/22

One thinks of Invitae as a leading genetic testing company that has worked to improve clinical quality while bringing prices down. And they are, and they have. But after listening to today's show, you will see that their vision is bigger than that.Farid Vij is the President and General Manager of Data at Invitae. A year ago Invitae bought a company he co-founded called Ciitizen which was focused on providing patients with access to their complete medical records. This is a public episode. If

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24:20

Satellite Bio out with a New Tissue Based Approach to...

Mendelspod Podcast ·

2022/08/25

Satellite Bio is named descriptively for the way its platform works. Out of stealth in the past few months with what you might call a middle ground approach to generative medicine between stem cell therapy and organ transplant, the company takes its name from the tissue therapy constructs they surgically implant in patients. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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41:32

We Have to Get Sequencing Back to Moore’s Law: Gilad...

Mendelspod Podcast ·

2022/06/23

There was a tweet thread at the end of the recent Advances in Genome Biology and Technology (AGBT) conference where researchers took a moment of silence for all the sequencing companies that have announced big plans at the conference and then died. It was clearly aimed at this year’s sequencing tools entrant and buzz-generating Ultima Genomics. The company emerged from stealth the week before AGBT announcing the $100 genome with a purse of $600 million backed by funders including Khosla Ventures,

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35:33

RNA Therapeutics: A New Paradigm for Drug...

Mendelspod Podcast ·

2022/06/16

Has the pandemic unleashed the molecule of RNA to be the new future of drug development?Tim Mercer is the Director of the BASE Lab at the University of Queensland which has recently become one of Australia’s leading national facilities for the manufacture and research of RNA technologies. Tim is the next guest in our series on enzymatic DNA synthesis which he says is "a quantum shift” in our ability to synthesize DNA.Tim then goes on to explore the future of mRNA vaccines and other RNA

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54:08

The System is Working. We Need More Engagement, Says...

Mendelspod Podcast ·

2022/06/09

Heidi Rehm’s talents for genomics are legendary. Our field has devoured them like a hungry beast.Discovering an appreciation for the natural logic of genetics in her early school years, Heidi would later learn she was good at the standardization of genomic databases for clinical use. This would make her a pioneering superstar of genomic medicine. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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41:42

The Promise of Exosomes Now Realized, Says Paul...

Mendelspod Podcast ·

2022/06/02

The area of early cancer detection continues to become ever more exciting these days. Each month more companies add liquid biopsies to their product offering as new technologies advance and are able to recognize cancer with increased sensitivity and specificity, particularly from cell-free DNA in the blood. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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58:41

Lee Cronin on Origin of Life, Genomics, Aliens and More

Mendelspod Podcast ·

2022/06/01

While we’re able to sit outside on a warm summer’s night under the ocean of stars, let us contemplate some of the bigger questions. We’re very excited to start out our twelfth season of the podcast with the chemist, Lee Cronin, from the University of Glasgow. Lee published an original and fundamental theory about the universe in the weeks after we taped which has profound implications for the question about the origin of life and could have some interesting applications in genomics. This is a public

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50:19

Eric Green on the Future of the NHGRI

Mendelspod Podcast ·

2022/05/28

Dr. Eric Green has been the Director of the National Human Genome Research Institute (NHGRI) at the National Institutes of Health (NIH) since 2009. Two years ago, he and his colleagues at the Institute came up with a strategic plan for the next ten years. Today we discuss the plan with the director and get his outlook on the future of human genomics.Dr. Green says human genomics can be roughly divided into four chapters. This is a public episode. If you'd like to discuss this with other

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30:03

5-Base Sequencing: Jonas Korlach and Tomi Pastinen

Mendelspod Podcast ·

2022/05/25

Pacific Biosciences has introduced a new method for detecting DNA methylation simultaneously with DNA sequencing. They are calling it 5-base sequencing.Today on the program, Jonas Korlach, PacBio’s Chief Scientific Officer, and Tomi Pastinen, the Director of the Genomic Medicine Center at Children’s Mercy Research Institute in Kansas City join us to describe the new breakthrough and connect it to clinical possibilities. This is a public episode. If you'd like to discuss this with other subscribers

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