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PODCAST

Pharm to Table

LC Campeau, Dani Schultz

A podcast hosted by L.-C. Campeau and Dani Schultz that dives into the stories about the people behind the chemistry and science that happens at #MerckChemistry. Follow us on X (formerly Twitter) at @PharmToTablePod, @DrLCSquare, @danithechemist Email us comments and suggestions at pharmtotablepod@gmail.com

science chemistry

All Episodes

00:36:44

S2:E5 - The Catalysis Laboratory at Merck: 20 Years...

Pharm to Table ·

2023/04/10

In this month's episode, and our 1st of 3 parts dedicated the 20th anniversary of Merck's Catalysis Laboratory, Dani and L.-C. sit down and chat with Shane Krska (@swkrska) who was one of the founding members of the Catalysis Laboratory. Shane walks us through the genesis of the group, its early impact on our projects and people. In this first 10 years of the laboratory, there was a heavy focus on asymmetric hydrogenation and cross-coupling, as well as developing all the tools necessary to

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00:34:49

S2.E4: The Total Synthesis of Darobactin A (or is it...

Pharm to Table ·

2023/02/28

For this month's episode, Dani and LC dive into the challenges of strained cyclic peptide synthesis with Niki Patel and Dave Petrone who recently completed the total synthesis of Darobactin A in collaboration with Professor Sarlah's group at UIUC. Now this wasn't Merck's first foray into natural product total synthesis, in fact Darobactin A is part of a rich legacy of total syntheses at Merck that spans 80 years! Niki and Dave share how the internal Merck team first envisioned putting this molecule

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00:25:25

S2.E3: All I Want for Christmas Is Candy, Chainsaws,...

Pharm to Table ·

2022/12/22

For our special Holiday extravaganza, Dani and LC reminisce about the holidays while in grad school (think candy throw downs and chainsaws) before diving into the cookie jar of questions from some of our favorite listeners! What is a good way to figure out if you'd be a better fit for a medicinal chemistry or process chemistry role? (@billthechemist) What do you know now that you wished you knew during your undergraduate or early graduate school? (@MichaelAxiotes) How is pregnancy and

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00:36:21

S2.E2: Enabling medicinal chemistry knowledge...

Pharm to Table ·

2022/12/07

For S2E2, we’re joined by drug hunting legends Doug Beshore and Izzat Raheem who recently co-authored a recent (and popular) paper in J. Med. Chem. on building a culture of knowledge exchange. Ironically, it’s easier to learn through the literature than from your organization, colleagues or group members - especially if colleagues have taken on different roles. As a result, building and maintaining a culture where prior knowledge is easily accessible and updatable is paramount to a healthy learning

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00:32:30

S2.E1: No Bald Eagles We're Harmed in the Recording...

Pharm to Table ·

2022/11/01

We kick off season 2 with a bang, talking about complex molecule synthesis with John McIntosh and Nastaran Salehi. Cyclic dinucleotides (CDNs) are a total synthesis fan's dream with 10 stereocenters (including 2 at phosphorus) arranged around a 13 membered macrocycle formed by 2 non-canonical nucleosides. These endogenous secondary messenger molecules have attracted attention because of their activation of the immune system via the STING pathway. We go into all aspects of the innovative biocatalytic

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00:10:16

S2 Kickoff: Answering Your Questions & S2 Sneak Peak

Pharm to Table ·

2022/10/24

For our kickoff of Season 2, LC and Dani get together (in person!) to reflect on what’s changed since the Pharm to Table pod started in late 2020, answer a listener question (only 9 months late!) on whether a postdoc is needed for an industrial job, and give a sneak peak on what’s to come for Season 2. Whether you listen in the car or in the lab - buckle up and don that PPE - as Season 2 is destined to be full of energy, laughs and awesome #MerckChemistry. Follow the Pharm to Table podcast on

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00:09:23

Snack: What it's Like to Immigrate to the US for Work

Pharm to Table ·

2022/07/18

Cecilia Bottecchia is originally from Italy and Francois Levesque is native of Canada. Both have had very international pathways during their studies which have ultimately brought them to #MerckChemistry in the US. We asked them to tell us a little bit about this transition and have a little fun with a Canadian vs Italian food quiz!

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00:31:36

S1.E10: Hot Tub Flow Time Machine

Pharm to Table ·

2022/07/01

For the 10th, and final course of season 1, Dani and LC jump in the hot tub flow time machine with Cecilia Bottecchia and Francois Levesque, co-recipient of the Peter Dunn Green Chemistry Award, and learn how to discover, develop and scale-up a photobromination in flow! But don't let this deceptively simple bromination fool you - this reaction turned out to be a full course meal of challenges! We go into all aspects of the reaction, including: 1) Why they decided to use light vs AIBN to facilitate

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00:41:20

S1.E9: ChemSpeed, Daft Punk and Twinkly Lights

Pharm to Table ·

2022/05/09

For the 9th course, Dani and LC do the robot dance with Melodie Christensen (@chemchristensen on Twitter) #MerckChemistry Enabling Technologies group. Melodie shares her unique career path with us, including her current PhD with @procastiprof - more >10 years after starting her career in pharma. Resident expert in reaction automation, robotics and self-optimizing reactions, Melodie shares her journey in high-throughput and data-rich experimentation. We discuss her award winning paper in JOC and

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00:08:11

Snack: Spring ACS Symposia Organizer Sneak Peak -...

Pharm to Table ·

2022/03/21

ChemTwitter told us it takes 3 minutes to run a TLC plate, so today we‘re bringing you 3 good minutes with Sue Zultanski (Associate Principal Scientist, Discovery Process Chemistry). Sue first joined our #MerckChemistry Discovery group in 2006 before obtaining her PhD and then starting in Merck Process in 2016. Since joining, Sue has sought solutions across boundaries, weaving deep mechanistic understanding into developing robust manufacturing routes (OPRD) and also through an academic-industrial

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00:05:49

Snack: Spring ACS Symposia Organizer Sneak Peak -...

Pharm to Table ·

2022/03/14

ChemTwitter told us it takes 3 minutes to run a TLC plate, so today we‘re bringing you 3 good minutes with David Thaisrivongs (Director) and Jenny Obligacion (Associate Principal Scientist) from our Rahway, NJ Process Chemistry group. David and Jenny tell us about a symposia featuring Outstanding Chemists of Color, their motivation for creating this event and the broader implications highlighting Chemists of Color can have on the equity, diversity and inclusion in our field. Complete speaker lineup

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00:08:55

Snack: Spring ACS Symposia Organizer Sneak Peak -...

Pharm to Table ·

2022/03/07

ChemTwitter told us it takes 3 minutes to run a TLC plate, so today we‘re bringing you 3 good minutes with Marion Emmert (Principal Scientist, Catalysis and Enabling Technologies) and Colin Lam (Associate Principal Scientist, Computational and Structural Chemistry). Marion joined #MerckChemistry in 2018 (after a successful career in academia) and has brought her love for catalysis into drug discovery (Google Scholar). Colin joined #MerckChemistry in 2016 and has flexed his computational might on a

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00:06:38

Snack: Spring ACS Symposia Organizer Sneak Peak -...

Pharm to Table ·

2022/02/28

ChemTwitter told us it takes 3 minutes to run a TLC plate, so today we‘re bringing you 3 good minutes with Xiaoshen Ma, Associate Principal Scientist in our Boston Discovery Chemistry group. Xiaoshen joined #MerckChemistry in 2018 and has been influential in advancing drug discovery through the exploration of bicyclo[1.1.1]pentanes (aka BCP's) as bioisosteres for arenes - the work of which is already making an impact(Google Scholar). Today, Xiaoshen stopped by to give a sneak peak on Synthetic

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00:34:57

S1.E8: Biocatalytic Cascades, the Rube Goldberg of...

Pharm to Table ·

2022/02/14

For the 8th course, Dani and LC ride the biocatalytic cascade with Ania Fryszkowska (@fryania on Twitter) and Greg Hughes (@greg_hughes on Twitter) from the #MerckChemistry Process Chemistry group. Greg, a process chemistry pro, kicks off this episode by giving a high-level overview of the drug development process and the differences in designing clinical supply route vs. a final commercial route. Ania, a biocatalysis superstar, then takes us on a retrosynthetic journey that ultimately led to a

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00:35:19

S1.E7: Surfin' the ProTides - Fun With Nucleosides :...

Pharm to Table ·

2022/01/31

For the 7th course, Dani and LC serve up ahearty helping of nucleoside chemistry with Artis Klapars and Dan DiRocco from the #MerckChemistry Rahway NJ Process Chemistry group. We tee off this episode by diving into the ProTide pool to find out what exactly ProTides are why they are so important for the development of common antiviral and anticancer drugs. Then, Artis and Dan tell us about their efforts to develop a green solution to the ProTide synthesis problem by designing a multifunctional

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00:35:27

S1.E6: Nuc, Nuc, Nuc'ing on Heaven's Door - Fun With...

Pharm to Table ·

2022/01/10

For the 6th course, Dani and LC serve up adelicious discussion with Steve Silverman (@asymtmm on Twitter) from the #MerckChemistry Kenilworth NJ Discovery Process Chemistry group. Steve tells us about an industrial-academic collaboration he's leading with Professor Rob Britton's laboratory at Simon Fraser University (@BrittonLab on Twitter) where they discovered a short de novo route to nucleoside analogs. We discuss why nucleoside analogues are so important to pharmaceutical development and why,

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00:25:36

Holiday Snack: All I Want for Christmas Is ... ANSWERS!

Pharm to Table ·

2021/12/20

For our special Holiday Snack episode we invite Eric Ashley (Director of Discovery Process Chemistry, @DrERAChem), Yeon-Hee Lim (Director of Discovery Chemistry, @alchemistyhl) and James Roane (Senior Scientist, Discovery Chemistry) from our South San Francisco research laboratories to join us and answer YOUR questions! What topics or case studies to help students understand drug discovery better? What was the most surprising thing about starting your career and navigating the transition from grad

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00:07:04

Snack: #TLCchat with Cecilia Bottecchia, photoflow...

Pharm to Table ·

2021/11/15

ChemTwitter told us it takes 3 minutes to run a TLC plate, so today we‘re brining you 3 good minutes with Cecilia Bottecchia, Senior Scientist in Flow Chemistry group. Cecilia joined #MerckChemistry a little >2 years ago bringing her flow experience to Merck and immediately having an impact (Google Scholar). She was recently the co-recipient of the Peter Dunn Green Chemistry Award for the development of a greener manufacturing process featuring a photo-flow bromination. We discuss her experience

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00:35:57

S1.E5: Paint the Town ERED!

Pharm to Table ·

2021/11/01

For the 5th course, join Dani and LC as they sit down with #MerckChemistry's Meg Shaw and Chihui An to discuss their biocatalytic approach in transforming readily available acrylic acids to chiral α-substituted carboxylic acids - a reoccurring motif in drug development. As this story evolved (no pun intended), we’ll hear how Meg (Process Chemistry) and Chihui (Biocatalysis) joined forces to develop an ene-reductase (ERED) to effect the asymmetric reduction of acrylic acids and ultimately why

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00:06:36

Snack: #TLCchat with Becky Ruck, new topic editor at...

Pharm to Table ·

2021/10/18

ChemTwitter told us it takes 3 minutes to run a TLC plate, so today we‘re brining you 3 good minutes with Becky Ruck, Executive Director and Head of Enabling Technologies in Small Molecule Process R&D. Becky has amassed an amazing portfolio of amazing science (Google Scholar) in a variety of roles at #MerckChemistry. She recently took on a role as a Topic Editor for ACS Catalysis to help bring more industrial science to the journal. Having led recruiting for many years, Becky gives prospective

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50 results

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