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PODCAST

Pharm to Table

LC Campeau, Dani Schultz

A podcast hosted by L.-C. Campeau and Dani Schultz that dives into the stories about the people behind the chemistry and science that happens at #MerckChemistry. Follow us on X (formerly Twitter) at @PharmToTablePod, @DrLCSquare, @danithechemist Email us comments and suggestions at pharmtotablepod@gmail.com

science chemistry

All Episodes

00:37:22

SE4:E5 - Evolution of a Green Chemistry Trailblazer

Pharm to Table ·

2025/10/13

In this episode, Dani and LC welcome Jeff Moore, recipient of the 2025 ACS Affordable Green Chemistry Award, to discuss his pioneering work in biocatalysis at Merck. The conversation explores the evolution (pun intended) of biocatalytic processes in pharmaceutical manufacturing, highlighting key milestones such as the adoption of transaminases and imine reductases, and their impact on drug synthesis and sustainability. Jeff shares stories from his career, including how being 'lazy' when

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00:35:53

SE4:E4 - MedChem Masters: Molecules, Mentors and...

Pharm to Table ·

2025/08/19

In this episode, Dani and LC interview Dr. Shane Krska, recipient of the ACS Arthur C. Cope Award, and Dr. Petr Vachal, recipient of the ACS Earle B. Barnes Award for Leadership in Chemical Research Management. Shane shares his pioneering work in catalytic methods and high-throughput experimentation (HTE) for drug discovery, while Petr discusses his leadership role driving innovation at Merck. They reflect on their career journeys from graduate school to industry, emphasizing personal growth and the

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00:33:48

S4:E4 - London Calling ... Spirocycles

Pharm to Table ·

2025/05/19

This month we sit down with Damien Valette, Olivia Boyd and David Petrone to chat about their latest paper in Organic Letters on the desymmetrization of prochiral dienones to control all-carbon quaternary centers. This reaction leverages biocatalysis, specifically an ene-reductase [ERED] enzymes (which are making their second appearance on the pod - see S1:E5).David, Damien and Olivia walk us through the discovery of the reaction and why it's uniquely suited to set these challenging

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00:26:40

S4:E2 - Making Sulfur Smell like Success!

Pharm to Table ·

2025/04/21

Join us on the Pharm to Table podcast for a delightful chat with Ethan Wappes from our South San Francisco site, as we dive into the exciting world of thiophene synthesis! Ethan is a member of our Discovery Process Chemistry group and worked alongside medicinal chemists to devise a better synthetic route towards substituted thiophenes. Ethan shares insights from his recent Org. Lett. on a novel Rh-catalyzed [3+2] method that opens the door to highly substituted dihydrothiophenes, enhancing our

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00:28:57

S4:E1 Chemistry Unplugged: Listener Q&A and Future...

Pharm to Table ·

2025/01/27

We're kicking off Season 4 (holy cow!) by having a lively discussion answering listener questions on everything from our favorite Boc deprotection methods to the role of AI in the world of chemistry. We also share how flow chemistry is being used in discovery and process chemistry and conclude with what we feel would be disruptive chemistry innovations that could shape 2025. Plus, find out how you can influence the conversation by sharing what you want to hear more of in 2025!

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00:36:09

S3:E10 - Look what ADCs made us do

Pharm to Table ·

2024/11/18

Antibody drug conjugates, or ADCs, are all the rage in the industry right now and chemists play an important role in their development. This month we sat down with Serge Ruccolo and Marion Emmert to talk about their papers in this area. Their work addresses two main challenges of ADC development: 1) potent handling of cytotoxic payloads and 2) selective unmasking of cysteine residues to enable conjugation to the antibody.Tune in to hear how one develops these chemistries; How electrochemistry and

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00:32:50

S3:E9 - Surfing peptide production by going with the...

Pharm to Table ·

2024/10/17

Ready to go with the flow? Then this episode is for you! In this episode, we dive into the exciting world of Continuous-Flow Solid-Phase Peptide Synthesis (CF-SPPS) with special guests Kyle Ruhl and Mike DiMaso. We kick off the episode with a brief overview on various techniques used to synthesize peptides and how each method fits within the drug discovery/development timeline. From there, we serve up their recent paper on leveraging flow to synthesize peptides - exploring the challenges they faced,

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00:26:13

S3:E8 - So you think you want to start a chemistry...

Pharm to Table ·

2024/09/16

Join Dani and LC as they peel back the layers on podcasting in chemistry. This insightful episode dives into their recently published Organic Letters editorial "Should You Start a Chemistry Podcast?" with special contributor and corresponding author Matt Horwitz from Synthesis Workshop sharing his unique perspective.But that's not all - get ready for an artistic twist as Brendan Burkett from Chemscrapes reveals how he transforms chemistry concepts into visually striking designs for

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00:24:58

S3:E7 - Your Rx for a Pharma Job: Insider Secrets...

Pharm to Table ·

2024/08/05

Time for the main course! Our #MerckChemistry hiring experts are dishing out more savory tips to help you get hired in pharma.In this second part, they'll guide you through mastering the job talk, nailing those crucial on-site interviews, and evaluating offers strategically. Learn how to deliver an engaging presentation, handle tough questions, and leave a lasting impression. Get advice on navigating those 1:1 interviews with poise. Once you've aced the interviews, find out how to weigh

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00:26:46

S3:E6 - Your Rx for a Pharma Job: Insider Secrets...

Pharm to Table ·

2024/07/10

Looking to kickstart your career in the pharmaceutical industry? This episode is a must-listen! We have special guests Jamie McCabe Dunn, Val Shurtleff and our very own Dani Schultz - hiring managers in Discovery and Process Chemistry - to share insider tips. In part 1 we talk about building a rock-solid network, crafting a standout CV that gets noticed, and acing those crucial first interviews. We also answer listener questions submitted on LinkedIn. Whether you're a fresh grad or an

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00:34:49

S3:E5 - When Robots Work-It-Up!

Pharm to Table ·

2024/06/05

Alexandra Sun and Harrison Rose join the pod to share their work on a vision-guided automated liquid-liquid extraction (LLE) platform. That's right, before our robot overlords overtake us, they are going to help chemists and engineers with work-ups first! Even though it's often taken for granted, liquid-liquid extractions are part of virtually every chemical reaction for product isolation. Developing these unit operations is critical to chemists and engineers who design processes and

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00:21:27

S3:E4 - "Asta La Vista, Baby" - The Aminator

Pharm to Table ·

2024/04/22

Patrick Fier and Suhon Kim join the pod to share their lates collaboration on a new C-N cross-coupling protocol which leverages a novel multifunctional template reagent. The work emerged from a side-project that started many years ago on the creation of the "Aminator" reagent which inspired the latest reaction. The couplings have very broad scope and Suhong and Patrick explain their motivation for pursuing the work and insights about the reaction enabled by this reagent. We learned a lot on this

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00:34:48

S3:E3 - A chemist, a physicist and an enzyme walk...

Pharm to Table ·

2024/02/20

Nadine Kuhl (process chemist) and Jacob Forstater (engineer and physicist) join the pod to share a pretty neat story that had its origins from a chemical catalog brochure advertising a new and green solvent called Cyrene. From that brochure blossomed a really amazing biocatalytic transamination to make a key chiral amine building block. In order to make this process more robust and tolerant of organic solvents, the team immobilized the transaminase enzyme and leveraged a Spinchem rotating bed

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00:34:48

S3:E2 - Barton-McCombie Beware!

Pharm to Table ·

2024/01/15

Charles Yeung (@Charles_chem) joins the pod to share some of the latest results from a collaboration with Prof. Wickens' lab (@WickensGroup) at the University of Wisconsin Madison. In their latest paper published in Angewandte Chemie, they disclose a practical and general protocol for alcohol dehydrogenation - putting the Barton-McCombie on notice! The work was supported by a Merck post-doctoral fellow, Myriam Mikhael (@MyriaMikhael), who shares her experience as an industrial PDF.Read the

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00:19:50

S3.E1: All I Want for the holidays are...

Pharm to Table ·

2023/12/11

For our special Holiday extravaganza, Dani and LC share their holiday plans before diving into the cookie jar of questions from some of our favorite listeners! How is R&D in industry similar to and different from how research is done in academia? (@DrSauce96) What is the most annoying academic misconception about work in the pharmaceutical industry? (@Teachforaliving) What things do you wish you knew before starting in industry? (@lifeof_dan) What is your favorite coupling reaction to

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00:35:12

S2.E8: Peptides, Cross-Electrophile Coupling and...

Pharm to Table ·

2023/07/17

For this month's episode, Dani and LC serve up a recently published JACS article on Ni-catalyzed pyridinium cross-electrophile coupling for non-canonical amino acid synthesis and peptide late-stage functionalization which was done in collaboration with Professor Mary Watson’s group. In this episode, Dani and LC share the importance of investing in non-canonical amino acid chemistry with #MerckChemistry scientists Amélie Dion and Dipa Kalyani. We discuss what drew them to pyridinium

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00:30:26

S2.E7: So Far, So Cyanide: Green, air-tolerant and...

Pharm to Table ·

2023/06/15

For this month's episode, Dani and LC go all in on Ni-catalyzed cyanations with Caleb Hethcox who recently published 2 papers on the topic - one with a phenomenal intern, Geraldo Duran-Camacho. Caleb shares how the internal team first identified this challenge and the solutions they explored to replace precious metal catalysts for cyanation reactions! Ultimately, the team identified a Ni-catalyzed system (go base metals!) and depending on the application, different reduction conditions which

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00:31:20

S2:E6 - The Catalysis Laboratory at Merck: 20 Years...

Pharm to Table ·

2023/05/22

Dr. Becky Ruck joins Dani and LC for the grand finale of our journey reviewing the history of the Merck Catalysis Laboratory. She highlights how her background in physical organic chemistry led to deeper role of understanding mechanism and kinetics in development of reactions - a strength of Becky's which ultimately influenced the direction of the Catalysis group. Becky also gives a forward looking perspective as leader of the Process Research & Development Enabling Technologies organization

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00:10:09

Snack: The Catalysis Laboratory at Merck - 20 Years...

Pharm to Table ·

2023/04/24

L.-C. and Dani talk about the next era in the Catalysis Lab's evolution, highlighting the democratization of high-throughput experimentation tools for end-users and the development of nanomole-scale HTE. It was also in this period that the Catalysis Laboratory's expanded its capabilities in photochemistry developing screening tools to invent and scale-up novel photochemical synthetic methods, including decatungstate mediate reactions and photoredox catalysis. Read the paper we discussed

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00:36:44

S2:E5 - The Catalysis Laboratory at Merck: 20 Years...

Pharm to Table ·

2023/04/10

In this month's episode, and our 1st of 3 parts dedicated the 20th anniversary of Merck's Catalysis Laboratory, Dani and L.-C. sit down and chat with Shane Krska (@swkrska) who was one of the founding members of the Catalysis Laboratory. Shane walks us through the genesis of the group, its early impact on our projects and people. In this first 10 years of the laboratory, there was a heavy focus on asymmetric hydrogenation and cross-coupling, as well as developing all the tools necessary to

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