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PODCAST

Concentrating on Chromatography

Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether

science chemistry

All Episodes

00:16:48

Episode 60: Why Capillary LC Is the Future of LC-MS...

Concentrating on Chromatography ·

2026/05/11

What makes capillary LC so powerful—and why are more scientists paying attention to it?In this episode of @ChromatographyTalk , David sits down with Samuel Foster of Axcend to discuss how capillary liquid chromatography is changing the conversation around LC-MS sensitivity, solvent consumption, instrument footprint, and chromatographic efficiency.Sam explains how lower flow rates can dramatically improve electrospray ionization performance, why capillary LC can reduce solvent usage by orders of

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00:30:15

Episode 59: The Future of Ion Chromatography | PFAS...

Concentrating on Chromatography ·

2026/05/04

How are PFAS regulations changing, and what role will ion chromatography play in the future of environmental testing?In this episode of @ChromatographyTalk , David interviews Jay Gandhi, PhD, Vertical Markets Manager at Metrohm USA, for an in-depth discussion on PFAS analysis, the rise of AOF (Adsorbable Organic Fluorine) testing, and the development of EPA 1621 and ISO 18127 standards.With more than 30 years of experience in ion chromatography, Jay shares valuable perspective on how the field has

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00:23:45

Episode 58: How Separation Science Is Taught vs. How...

Concentrating on Chromatography ·

2026/04/27

What do students really learn before they ever touch an analytical instrument? And is chemistry education keeping up with the pace of modern chromatography, mass spectrometry, and sample preparation?In this episode of Concentrating on Chromatography, David speaks with instructor Natasha Le about the realities of teaching chemistry and separation science to today’s students—many of whom are pursuing careers in medicine, pharmacy, dentistry, and healthcare rather than research.Natasha shares what

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00:46:02

Episode 57: Frugal Science Meets Sample Prep: A...

Concentrating on Chromatography ·

2026/04/20

What if you could dry biofluid samples in the field—without a vacuum system, freeze dryer, or full lab setup?In this episode of Concentrating on Chromatography, I sit down with Rajas Poorna and Charles Anderson to explore their work on a frugal, field-deployable alternative to traditional lyophilization through the Evapinator project.Originally inspired by the principles of frugal science, their approach rethinks how we stabilize and prepare biofluid samples like blood and plasma—especially in

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00:21:45

Episode 56: Fighting Antibiotic Resistance with...

Concentrating on Chromatography ·

2026/04/13

In this episode of Concentrating on Chromatography, host Dave Oliva sits down with Chris Reid to explore how chemical biology and LC-MS are being used to tackle one of the most urgent global challenges: antimicrobial resistance.As antibiotic resistance continues to rise—and new drug development struggles to keep pace—researchers are looking beyond traditional approaches. Instead of targeting how bacteria build their cell walls, Chris’s work focuses on how they break them down, opening the door to

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00:30:53

Episode 55: PFAS in Water: Why We’re Missing 96% of...

Concentrating on Chromatography ·

2026/04/06

What if most PFAS contamination isn’t even being measured?In this episode of Concentrating on Chromatography, we sit down with Dr. Leigh Terry from the University of Alabama to explore one of the biggest challenges in environmental analysis today: understanding—and accurately measuring—PFAS in water systems.While most regulatory methods focus on a small number of compounds like PFOA and PFOS, there may be thousands of PFAS compounds in the environment—and much of that burden goes undetected.--- 🔬

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00:34:19

Episode 54: AQbD Explained: How Design of Experiments...

Concentrating on Chromatography ·

2026/03/31

In this episode of Concentrating on Chromatography, David Oliva sits down with Amanda Guiraldelli Mahr to break down one of the most important (and often misunderstood) concepts in analytical chemistry: Analytical Quality by Design (AQbD).If you’ve ever relied on trial-and-error for method development—or wondered how top labs are using Design of Experiments (DOE), modeling, and AI to work smarter—this episode is for you.Amanda shares insights from her work across small molecules, peptides, proteins,

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00:20:30

Episode 53: How GLP-1 Drugs Are Analyzed:...

Concentrating on Chromatography ·

2026/03/23

In this episode of Concentrating on Chromatography, we sit down with Kelly Broster McMahon to explore the analytical science behind one of the most important pharmaceutical trends today: GLP-1 therapeutics.Drugs like Semaglutide have transformed the treatment of diabetes and obesity—but ensuring their safety, efficacy, and quality requires cutting-edge analytical workflows.In this conversation, we break down how chromatography and high-resolution mass spectrometry (LC-MS) work together to

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00:52:53

Episode 52: Mass Spec Without Chromatography? How...

Concentrating on Chromatography ·

2026/03/16

Can mass spectrometry work without chromatography?In this episode of Concentrating on Chromatography, host David Oliva speaks with Jeff Zonderman of Bruker about how Direct Analysis in Real Time (DART) mass spectrometry is enabling rapid sample analysis with little or no chromatography.Traditional LC-MS workflows rely on chromatography, solvent-intensive sample preparation, and complex instrumentation. DART offers a different approach—allowing laboratories to analyze samples directly, reducing

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00:28:23

Episode 51: Did Mars Destroy Its Own Biosignatures? |...

Concentrating on Chromatography ·

2026/03/09

What if Mars already had biosignatures… and destroyed them?In this episode of Concentrating on Chromatography, host David Oliva sits down with Megan Farrah from Tufts University to explore how GC-MS is being used to reconstruct potential biosignatures under simulated Martian conditions.Inside a Mars Simulation Chamber, Megan irradiates sterols and hopanes — two of NASA’s priority targets for life detection — in soil matrices containing oxychlorine salts similar to those detected by Mars missions.Her

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00:46:25

Episode 50: LC-MS Is Throwing Away 99% of Your Signal...

Concentrating on Chromatography ·

2026/02/24

Liquid chromatography–mass spectrometry (LC-MS) has been the backbone of modern analytical workflows for decades — but what if one of its most trusted components is also its biggest bottleneck?In Episode 50 of Concentrating on Chromatography, host Dave Oliva sits down with Daniel DeBord, Chief Technology Officer at MOBILion Systems, to explore how high-resolution ion mobility may be changing the way scientists think about precursor isolation in tandem MS.Traditional MS/MS workflows rely on

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00:13:17

Episode 49: UV–Vis vs LC–MS: Studying Light-Induced...

Concentrating on Chromatography ·

2026/02/19

Light can heal. Light can power devices. But light can also destroy molecules.In this episode of Concentrating on Chromatography, we sit down with Kshmeya Chopra to explore how phthalocyanines — highly conjugated macrocycles used in photodynamic therapy, sensing, and organic electronics — respond to prolonged light exposure.Using UV–Vis spectroscopy, Kshmeya and her research team systematically investigated how:• The central metal (Zn²⁺ vs In³⁺)• Degree of fluorination• Axial ligands• Solvent

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00:35:03

Episode 48: Using LC-MS & GC-MS to Decode Photoredox...

Concentrating on Chromatography ·

2026/02/17

In this episode of Concentrating on Chromatography, we sit down with Lindsay Repka to discuss how LC-MS and GC-MS transformed her lab’s approach to photoredox chemistry.What began as a project to develop a visible-light photocrosslinking handle unexpectedly led to a major discovery: the solvent (DMF) was reacting with the photocatalyst itself. Using high-resolution LC-MS, Lindsay’s team observed multiple solvent adducts forming — sometimes with complete catalyst consumption. That discovery reshaped

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00:18:29

Episode 47: Tracking Toxic PCBs in River Water using...

Concentrating on Chromatography ·

2026/02/12

In this episode of Concentrating on Chromatography, David speaks with Francis Femi Oloy about using chromatography to uncover hidden pollutants in real-world water systems.Femi’s team analyzed polychlorinated biphenyls (PCBs) in six major rivers in southwestern Nigeria — compounds that were banned decades ago but still persist in the environment. Using a workflow that many analytical labs will recognize — liquid–liquid extraction, cleanup, rotary evaporation, nitrogen blowdown, and GC-ECD detection

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00:35:35

Episode 46: How LA-ICP-MS Imaging Reveals Disease in...

Concentrating on Chromatography ·

2026/02/09

How do you see proteins, metals, and disease processes inside real tissue — and still trust the numbers?In this episode of Concentrating on Chromatography, David sits down with Monique Mello, analytical chemist, educator, and LA-ICP-MS imaging specialist, to explore how laser ablation ICP-MS (LA-ICP-MS) and immuno-mass spectrometry imaging (iMSI) are transforming pathology, environmental science, and translational research.Monique shares her journey from public-health and pathology labs in Brazil to

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00:25:26

Episode 45: How Chemists Design Cancer-Targeting...

Concentrating on Chromatography ·

2026/02/05

How do chemists design molecules that safely carry radioactive metals through the body to target cancer cells?In this episode of Concentrating on Chromatography, David sits down with Simona Mastroianni and Marianna Tosato to explore the chemistry behind radiopharmaceuticals — drugs that combine radioactive isotopes with specially designed chelators to diagnose and treat cancer.Their latest research focuses on the theranostic pair lead-203 and lead-212, a powerful combination that enables both

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00:19:17

Episode 44: Drug Discovery Where the Market Doesn’t...

Concentrating on Chromatography ·

2026/02/02

Neglected and opportunistic infectious diseases affect some of the world’s most vulnerable populations—but often receive the least attention from traditional drug discovery pipelines.In this episode of Concentrating on Chromatography, host David Oliva sits down with Brad Haubrich to explore how early-stage drug discovery is being applied to fungal and parasitic pathogens, including those responsible for neglected tropical diseases and infections that disproportionately affect immunocompromised

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00:17:26

Episode 43: Detecting Haloacetic Acids in Water with...

Concentrating on Chromatography ·

2026/01/29

Haloacetic acids (HAAs) are disinfection byproducts formed when chlorine or bromine reacts with organic matter in water—and some are linked to serious health concerns. In this episode of Concentrating on Chromatography, we sit down with Jessica Whitehouse, MSc student at the University of Calgary, to discuss how she developed a GC-MS method to detect and quantify HAAs in real-world water samples.During her undergraduate research at Thompson Rivers University, Jessica tackled a major challenge faced

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00:35:05

Episode 42: Selective Separations: What Membrane...

Concentrating on Chromatography ·

2026/01/26

In this episode of Concentrating on Chromatography, host David Oliva sits down with Dr. Steven Weinman, Associate Professor of Chemical and Biological Engineering at the University of Alabama, to explore how membrane science and chromatography intersect in modern separation challenges.Steven shares his journey from chemical engineering student to membrane researcher, and explains how membranes are used not only for water purification, but also for sample preparation, pre-treatment, and concentration

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00:20:08

Episode 41: N‑Glycans, Whey Protein, and the Gut...

Concentrating on Chromatography ·

2026/01/07

How do the hidden carbohydrate structures on your favorite protein powders shape the gut microbiome? In this episode of Concentrating on Chromatography, Matthew Bolino, M.S., from the University of Nevada, Reno, breaks down his latest research on N‑glycans from common dietary proteins (whey, egg white, soy, and pea) and how their structural diversity influences microbial fermentation and short‑chain fatty acid production.Bolino explains what N‑glycans are, why they behave like fiber in the gut, and

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