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PODCAST

Concentrating on Chromatography

Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether

science chemistry

All Episodes

00:30:53

Episode 55: PFAS in Water: Why We’re Missing 96% of...

Concentrating on Chromatography ·

2026/04/06

What if most PFAS contamination isn’t even being measured?In this episode of Concentrating on Chromatography, we sit down with Dr. Leigh Terry from the University of Alabama to explore one of the biggest challenges in environmental analysis today: understanding—and accurately measuring—PFAS in water systems.While most regulatory methods focus on a small number of compounds like PFOA and PFOS, there may be thousands of PFAS compounds in the environment—and much of that burden goes undetected.--- 🔬

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00:34:19

Episode 54: AQbD Explained: How Design of Experiments...

Concentrating on Chromatography ·

2026/03/31

In this episode of Concentrating on Chromatography, David Oliva sits down with Amanda Guiraldelli Mahr to break down one of the most important (and often misunderstood) concepts in analytical chemistry: Analytical Quality by Design (AQbD).If you’ve ever relied on trial-and-error for method development—or wondered how top labs are using Design of Experiments (DOE), modeling, and AI to work smarter—this episode is for you.Amanda shares insights from her work across small molecules, peptides, proteins,

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00:20:30

Episode 53: How GLP-1 Drugs Are Analyzed:...

Concentrating on Chromatography ·

2026/03/23

In this episode of Concentrating on Chromatography, we sit down with Kelly Broster McMahon to explore the analytical science behind one of the most important pharmaceutical trends today: GLP-1 therapeutics.Drugs like Semaglutide have transformed the treatment of diabetes and obesity—but ensuring their safety, efficacy, and quality requires cutting-edge analytical workflows.In this conversation, we break down how chromatography and high-resolution mass spectrometry (LC-MS) work together to

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00:52:53

Episode 52: Mass Spec Without Chromatography? How...

Concentrating on Chromatography ·

2026/03/16

Can mass spectrometry work without chromatography?In this episode of Concentrating on Chromatography, host David Oliva speaks with Jeff Zonderman of Bruker about how Direct Analysis in Real Time (DART) mass spectrometry is enabling rapid sample analysis with little or no chromatography.Traditional LC-MS workflows rely on chromatography, solvent-intensive sample preparation, and complex instrumentation. DART offers a different approach—allowing laboratories to analyze samples directly, reducing

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00:28:23

Episode 51: Did Mars Destroy Its Own Biosignatures? |...

Concentrating on Chromatography ·

2026/03/09

What if Mars already had biosignatures… and destroyed them?In this episode of Concentrating on Chromatography, host David Oliva sits down with Megan Farrah from Tufts University to explore how GC-MS is being used to reconstruct potential biosignatures under simulated Martian conditions.Inside a Mars Simulation Chamber, Megan irradiates sterols and hopanes — two of NASA’s priority targets for life detection — in soil matrices containing oxychlorine salts similar to those detected by Mars missions.Her

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00:46:25

Episode 50: LC-MS Is Throwing Away 99% of Your Signal...

Concentrating on Chromatography ·

2026/02/24

Liquid chromatography–mass spectrometry (LC-MS) has been the backbone of modern analytical workflows for decades — but what if one of its most trusted components is also its biggest bottleneck?In Episode 50 of Concentrating on Chromatography, host Dave Oliva sits down with Daniel DeBord, Chief Technology Officer at MOBILion Systems, to explore how high-resolution ion mobility may be changing the way scientists think about precursor isolation in tandem MS.Traditional MS/MS workflows rely on

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00:13:17

Episode 49: UV–Vis vs LC–MS: Studying Light-Induced...

Concentrating on Chromatography ·

2026/02/19

Light can heal. Light can power devices. But light can also destroy molecules.In this episode of Concentrating on Chromatography, we sit down with Kshmeya Chopra to explore how phthalocyanines — highly conjugated macrocycles used in photodynamic therapy, sensing, and organic electronics — respond to prolonged light exposure.Using UV–Vis spectroscopy, Kshmeya and her research team systematically investigated how:• The central metal (Zn²⁺ vs In³⁺)• Degree of fluorination• Axial ligands• Solvent

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00:35:03

Episode 48: Using LC-MS & GC-MS to Decode Photoredox...

Concentrating on Chromatography ·

2026/02/17

In this episode of Concentrating on Chromatography, we sit down with Lindsay Repka to discuss how LC-MS and GC-MS transformed her lab’s approach to photoredox chemistry.What began as a project to develop a visible-light photocrosslinking handle unexpectedly led to a major discovery: the solvent (DMF) was reacting with the photocatalyst itself. Using high-resolution LC-MS, Lindsay’s team observed multiple solvent adducts forming — sometimes with complete catalyst consumption. That discovery reshaped

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00:18:29

Episode 47: Tracking Toxic PCBs in River Water using...

Concentrating on Chromatography ·

2026/02/12

In this episode of Concentrating on Chromatography, David speaks with Francis Femi Oloy about using chromatography to uncover hidden pollutants in real-world water systems.Femi’s team analyzed polychlorinated biphenyls (PCBs) in six major rivers in southwestern Nigeria — compounds that were banned decades ago but still persist in the environment. Using a workflow that many analytical labs will recognize — liquid–liquid extraction, cleanup, rotary evaporation, nitrogen blowdown, and GC-ECD detection

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00:35:35

Episode 46: How LA-ICP-MS Imaging Reveals Disease in...

Concentrating on Chromatography ·

2026/02/09

How do you see proteins, metals, and disease processes inside real tissue — and still trust the numbers?In this episode of Concentrating on Chromatography, David sits down with Monique Mello, analytical chemist, educator, and LA-ICP-MS imaging specialist, to explore how laser ablation ICP-MS (LA-ICP-MS) and immuno-mass spectrometry imaging (iMSI) are transforming pathology, environmental science, and translational research.Monique shares her journey from public-health and pathology labs in Brazil to

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00:25:26

Episode 45: How Chemists Design Cancer-Targeting...

Concentrating on Chromatography ·

2026/02/05

How do chemists design molecules that safely carry radioactive metals through the body to target cancer cells?In this episode of Concentrating on Chromatography, David sits down with Simona Mastroianni and Marianna Tosato to explore the chemistry behind radiopharmaceuticals — drugs that combine radioactive isotopes with specially designed chelators to diagnose and treat cancer.Their latest research focuses on the theranostic pair lead-203 and lead-212, a powerful combination that enables both

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00:19:17

Episode 44: Drug Discovery Where the Market Doesn’t...

Concentrating on Chromatography ·

2026/02/02

Neglected and opportunistic infectious diseases affect some of the world’s most vulnerable populations—but often receive the least attention from traditional drug discovery pipelines.In this episode of Concentrating on Chromatography, host David Oliva sits down with Brad Haubrich to explore how early-stage drug discovery is being applied to fungal and parasitic pathogens, including those responsible for neglected tropical diseases and infections that disproportionately affect immunocompromised

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00:17:26

Episode 43: Detecting Haloacetic Acids in Water with...

Concentrating on Chromatography ·

2026/01/29

Haloacetic acids (HAAs) are disinfection byproducts formed when chlorine or bromine reacts with organic matter in water—and some are linked to serious health concerns. In this episode of Concentrating on Chromatography, we sit down with Jessica Whitehouse, MSc student at the University of Calgary, to discuss how she developed a GC-MS method to detect and quantify HAAs in real-world water samples.During her undergraduate research at Thompson Rivers University, Jessica tackled a major challenge faced

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00:35:05

Episode 42: Selective Separations: What Membrane...

Concentrating on Chromatography ·

2026/01/26

In this episode of Concentrating on Chromatography, host David Oliva sits down with Dr. Steven Weinman, Associate Professor of Chemical and Biological Engineering at the University of Alabama, to explore how membrane science and chromatography intersect in modern separation challenges.Steven shares his journey from chemical engineering student to membrane researcher, and explains how membranes are used not only for water purification, but also for sample preparation, pre-treatment, and concentration

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00:20:08

Episode 41: N‑Glycans, Whey Protein, and the Gut...

Concentrating on Chromatography ·

2026/01/07

How do the hidden carbohydrate structures on your favorite protein powders shape the gut microbiome? In this episode of Concentrating on Chromatography, Matthew Bolino, M.S., from the University of Nevada, Reno, breaks down his latest research on N‑glycans from common dietary proteins (whey, egg white, soy, and pea) and how their structural diversity influences microbial fermentation and short‑chain fatty acid production.Bolino explains what N‑glycans are, why they behave like fiber in the gut, and

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00:32:50

Episode 40: Mass Spectrometry, Surface Sampling and...

Concentrating on Chromatography ·

2025/12/31

In this episode, we interview Daniel Reddy, 2025 CAS Future Leader and PhD candidate at Queen's University, about his groundbreaking research on automated mass spectrometry and dried matrix spots (DMS).Dan's work combines computer vision, 3D printer automation, and laser micromachining to revolutionize sample preparation—reducing CO₂ emissions by 28-fold and organic solvent use by 21-fold compared to traditional methods.What You'll Learn:How to give a mass spectrometer "sight"

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00:46:42

Episode 39: The Evolving Chromatographer: How Agilent...

Concentrating on Chromatography ·

2025/12/23

Join us as we sit down with Jim Gearing, Associate Vice President of Marketing for Agilent's Gas Phase Division, to explore how the world of chromatography is changing and how intelligent instrument design is meeting users where they are.This interview was conducted in collaboration with Separation Science, the premier online learning platform for analytical scientists, providing expert content on chromatography, mass spectrometry, sample preparation, and related laboratory techniques.In this

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00:58:46

Episode 38: How Mass Spectrometry Actually Works: The...

Concentrating on Chromatography ·

2025/12/17

In this episode of Concentrating on Chromatography, we sit down with Dr. Lee Polite from Axion Training Institute to break down one of analytical chemistry's most powerful yet misunderstood techniques: gas chromatography-mass spectrometry (GC/MS).What You'll Learn:- Why GC and MS are the "perfect pair" – and what happens when you try to use MS alone- The electron gun: how molecules get ionized and why they become positively charged (not negatively!)- The magnetic sector vs

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00:27:15

Episode 37: Why Fake Banana Flavor Doesn't Taste Like...

Concentrating on Chromatography ·

2025/12/10

Connor Johnson, a researcher from the University of Alberta, discusses his award-winning honours project analyzing the volatile organic compounds (VOCs) in two banana species using headspace gas chromatography-mass spectrometry (HS-GC-MS). He completed this specific project as an undergraduate at Thompson Rivers University (TRU).For over 60 years, commercial banana flavoring has remained unchanged—even though the fruit it's supposed to mimic changed in the 1950s. Connor's research reveals

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00:33:54

Episode 36: PFAS, Mycotoxins & Food Safety Testing...

Concentrating on Chromatography ·

2025/12/02

Join us for an in-depth conversation with Holly Lee, Global Technical Marketing Specialist at SCIEX, as we explore the cutting edge of food and environmental safety testing. Holly shares her expertise on analyzing ultra-short chain PFAS like TFA, masked mycotoxins, pesticide residues, and the latest LC-MS/MS workflows transforming laboratory efficiency.In this episode of Concentrating on Chromatography, we discuss:PFAS Analysis & Challenges- Why ultra-short chain PFAS compounds like

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55 results

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