Loading...

PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

02:00

🫀 The Infarct Ends. The Risk Doesn't.

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/11

🫀 The infarct ends. The risk doesn't. After myocardial infarction, atherosclerosis, thrombosis, inflammation, depression, deconditioning—and declining adherence—can sustain risk for decades. Our editorial proposes Persistent Prevention: 🔄 reassess evolving risk, 🎯 treat residual risk, 💊 sustain therapy when indicated, 🏃 prioritize cardiac rehabilitation, and 🧠 address psychosocial health. The goal: move from a static discharge bundle to a dynamic, lifelong prevention plan. ❤️ #Cardiology

en

02:18

🫀 The Spleen–Heart Axis: Could the spleen hold a...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/10

🫀 Could the spleen hold a missing clue to coronary artery disease? Kamineni et al. used deep learning to extract 107 splenic MRI features in >42,000 UK Biobank participants. 🔬 Ten were associated with CAD, while genomics identified 219 loci—including the enigmatic 9p21 CAD locus. 🧬 The intriguing message: splenic texture—not simply size—may reflect a hematopoietic–inflammatory–genetic axis underlying CAD. ⚠️ External clinical replication was limited, so this is mechanistic discovery, not yet a

en

01:33

🚨❤️ Pregnancy as a Cardiovascular Stress Test: A...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/09

🤰❤️ Pregnancy may be one of our earliest cardiovascular stress tests. A Lancet editorial reminds us that cardiovascular disease complicates up to 15% of pregnancies and accounts for up to one-third of maternal deaths. Gestational hypertension predicts a 6× higher risk of later chronic hypertension, while pre-eclampsia is associated with up to a 3.5× higher risk of heart failure. 💡 The message for physicians: adverse pregnancy outcomes are cardiovascular warning signals—not endpoints. Think

en

01:26

Great Doctors Series: Pietro d'Abano⚕️ The Great...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/08

🔥 Medicine, Heresy & the Stars: Pietro d'Abano Meet Pietro d'Abano (c.1257–1315/16)—physician, philosopher, astrologer, and one of medieval medicine's great intellectual boundary-crossers. 🩺📚 Drawing on Aristotle, Avicenna and Averroes, his Conciliator tried to reconcile medicine with natural philosophy. His willingness to question accepted explanations eventually collided with the Inquisition. ⚖️🔥 A fascinating reminder that medical progress has always depended on curiosity—and sometimes

en

02:02

🔥 Drop Aspirin? Not So Fast in High-Ischemic-Risk...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/07

🩸 Drop aspirin after 12 months? A-CLOSE says: not so fast. In 3,203 high-ischemic-risk patients after drug-eluting stenting, clopidogrel alone was noninferior to extended DAPT for net clinical events (5.0% vs 5.1%). But beneath that reassuring composite was a striking trade-off: ischemic events were higher with clopidogrel alone (3.7% vs 1.6%; HR 2.33), while bleeding was lower (1.8% vs 4.1%; HR 0.43). ⚖️ The lesson: "noninferior" does not mean clinically interchangeable. Individualize ischemic

en

02:28

💉 Lysis Before Collapse: PRAGUE-26 Changes the PE...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/06

🫁 Stable—but not safe. Should we intervene before patients crash? PRAGUE-26 randomized 558 patients with intermediate-high–risk acute pulmonary embolism to catheter-directed low-dose alteplase + anticoagulation or anticoagulation alone. The 7-day composite of death, recurrent PE, or cardiorespiratory decompensation/collapse fell from 6.8% to 0.7% (RR 0.10; P<0.001)—mainly through fewer episodes of decompensation. 🎯 Major bleeding was not increased, although 2 intracranial hemorrhages occurred with

en

02:12

💊 Food as Medicine—from Beneath the Waves

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/05

🦪 Small Creatures, Mighty Nutrition, Global Impact Could aquatic invertebrates help close the global micronutrient gap? 🌊 A fascinating Nature study finds that current production supplies the equivalent annual requirements of vitamin B12 and selenium for >5 billion people—and copper, omega-3 fatty acids, iodine and zinc for >1 billion. 🦐 💡 Bivalves are particularly rich in iron, iodine, zinc and B12. But nutrition on paper is not nutrition on the plate: sustainability, safety, access,

en

02:08

🔌 Unplugging Pulmonary Hypertension: Can Denervation...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/04

🫀 Cut the Signal, Cut the Risk? Could pulmonary-artery denervation change the trajectory of heart failure–related pulmonary hypertension? In PADN-HF-PH, 264 symptomatic patients were randomized to denervation + guideline-directed medical therapy or medical therapy alone. Clinical worsening at 2 years: 25.7% vs 51.5% (HR 0.49; P=0.006). ⚡ A provocative concept: pulmonary sympathetic overactivity may be a modifiable therapeutic target. 🎯 But no sham control, China-only enrollment, and mortality

en

02:08

🧬 Semaglutide, Senescence & Survival: Can GLP-1 Slow...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/03

🧬 Could semaglutide do more than treat obesity and diabetes? A fascinating study in aged female mice suggests that late-life semaglutide may act partly as a calorie-restriction mimetic—improving cognition, physical function and glucose control while attenuating multiple hallmarks of ageing. 🐭⏳ Most strikingly, median lifespan increased from 742 to 834 days. The biology implicates nutrient sensing, NAD⁺–sirtuin and insulin–IGF1 pathways.

en

01:58

30% Fewer Cardiovascular Events: Statins Still Matter...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/02

🫀 Should we start a statin after age 70? STAREE delivers an important answer. In 9,971 adults ≥70 without cardiovascular disease, diabetes, or dementia, atorvastatin 40 mg reduced major cardiovascular events by 30% over 5.9 years (HR 0.70; NNT 37). 💊 Yet it did not prolong disability-free survival (HR 0.94). The benefit was driven largely by fewer myocardial infarctions and coronary revascularizations. 🎯 Take-home: age alone should not close the door on cardiovascular prevention—but preventing

en

02:24

✍️ The Great Translator: How Constantine of Africa...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/01

🌍 The Monk, the Manuscripts, the Medical Bridge How did Arabic medical knowledge reach medieval Europe? 📚🩺 Meet Constantine the African (c. 1010–1087)—North African physician, multilingual translator, and Benedictine monk at Monte Cassino. His Latin translations of major Arabic medical works helped transmit centuries of scholarship to Salerno and beyond. 🌉 His enduring lesson: medicine advances when knowledge crosses borders. 🎙️ Great Doctors Series — Dr RR Baliga's Podkast for the Kurious Doc

en

02:23

🫀 Plaque in Your 20s? The REACT Wake-Up Call

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/31

🫀 Atherosclerosis doesn't wait for middle age. In the REACT study of 16,808 adults without known ASCVD, silent plaque was found in 57.1% overall—and even in 8.7% of men and 6.7% of women aged 18–29. Plaque burden rose dramatically with age and increasingly involved multiple arterial territories. 🚨 Even more provocative: conventional 10-year risk classification identified only a minority with existing silent disease. Low predicted risk does not necessarily mean plaque-free arteries. 🔍 Prevention

en

02:06

🛡️ One Risk Factor in Atrial Fibrillation: Is It Time...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/30

🫀 AF + just one stroke-risk factor: anticoagulate or not? The SINGLE-AF randomized trial tackled this common clinical gray zone. At 24 months, the composite of stroke, systemic embolism, major bleeding, or cardiovascular death occurred in 0.5% with a DOAC vs 1.5% without anticoagulation (HR 0.31; P=0.03). 🎯 ⚠️ Only 17 primary events occurred, so the effect estimate remains imprecise. Anticoagulation for Atrial Fibrillation with Intermediate Stroke Risk.pdf 💡 Takeaway: SINGLE-AF strengthens the

en

02:27

🫀 Primary, Secondary, Procedural: Myocardial...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/29

🫀 MI has been redefined—and the numbers are gone. The Fifth Universal Definition of Myocardial Infarction (2026) replaces the familiar numerical MI types with a clinically intuitive trio: 🔴 Primary MI — acute coronary pathology 🟢 Secondary MI — supply–demand imbalance from another acute illness 🔵 Procedure-related MI — complication of a cardiac procedure The crucial message? 🩸 Troponin elevation is myocardial injury—not automatically MI. Context, ischemia, ECG and imaging matter. 🎙️ Dr RR

en

02:02

Dapagliflozin Before the Cardiac Surgery: Kidney...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/28

🫀💊 Can 4 doses help protect the kidney after cardiac surgery? MERCURI-2 randomized 784 patients to perioperative dapagliflozin or placebo. AKI within 7 days fell from 52% to 28%—RR 0.54, an absolute reduction of ~24% and NNT ≈4. 📉 Intriguingly, the signal was driven largely by urine-output–defined AKI; creatinine-only AKI was unchanged. Hard 30-day outcomes were also unchanged. 🎙️ A provocative new chapter in perioperative cardiorenal protection. 🛡️

en

02:10

Shingles Shot, Heart Shield? 🛡️❤️

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/27

💉 Shingles Shot, Heart Shield? 🛡️❤️ Could recombinant shingles vaccination protect more than the skin? In a natural experiment involving >72,000 matched adults ≥60 years, the recombinant vaccine was associated with 9% lower cardiovascular disease burden over 7 years, including lower burdens of ischemic heart disease and heart failure. 📉🫀 💡 Intriguingly, AS01-induced immune reprogramming and reduced IL-6 responses offer a potential mechanistic clue. ⚠️ Association ≠ causation—but this signal

en

02:18

⚖️ Pooling Without Fooling: When Meta-Analysis...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/26

🔎 Can you believe that meta-analysis? Meta-analyses sit near the summit of evidence-based medicine—but pooling more studies does not automatically produce more truth. 📊 Lee and colleagues offer a powerful clinical lesson: credibility requires alignment of evidence, methods, and inference. Ask first: Should these studies have been pooled at all? 🧠 Look for prospective planning, robust source data, adequate events, explainable heterogeneity, transparency, and honest uncertainty. 🎯 The goal? Fewer,

en

02:15

🧠 Physician, Philosopher, Polymath: The Genius of...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/25

🩺 Avicenna: Medicine, Mind & a Millennium of Influence Nearly 1,000 years ago, Ibn Sina—Avicenna—was already asking questions that still animate medicine: How should we observe disease? How do reason and experience guide diagnosis? How are mind and body connected? 🧠 His monumental Canon of Medicine traveled from the Islamic world into European universities and influenced generations of physicians. 📖🌍 Meet the physician, philosopher & polymath whose curiosity refused to stay in one discipline

en

02:18

🫀 Smart Drugs, Vulnerable Hearts: Antibody Drug...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/24

🎯 Target the Tumor, Guard the Heart! ❤️ Antibody-drug conjugates are transforming breast cancer therapy—but precision oncology does not eliminate cardiovascular risk. 🧬🫀 This excellent JACC: CardioOncology Primer explores how the antibody, linker & payload may contribute to cardiotoxicity. HER2-directed ADCs carry the clearest cardiac signal, with T-DXd showing higher and more variable LVEF decline than T-DM1, while TROP-2–directed ADCs currently show limited cardiac signals. 🔑 The future:

en

02:17

Cardiovascular-Kidney-Metabolic syndrome Starts...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/23

🫀 Can vascular injury begin in your early 20s? Apparently, yes. In 1,283 young adults (mean age 22.9 years), ~79% had Stage 1–3 Cardiovascular-Kidney-Metabolic (CKM) syndrome. Higher CKM stage tracked with poorer Life's Essential 8 scores and greater carotid arterial injury. 🚨 Strikingly, even Stage 1—excess adiposity—was associated with thicker carotid intima-media. 🎯 The message for clinicians: young adulthood is not a vascular grace period. Primordial prevention must start early.

en

1,081 results

Similar Podcasts

NÖÖRDS - Der Podcast

NÖÖRDS

Science News Daily

brief.news

Astronomy Cast

Fraser Cain and Dr. Pamela Gay

The SCP Experience

Dr. NoSleep Studios

Strange Bites

Lance Martin