Loading...

PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

02:16

🧠 Menopause, Molecules & Memory: Is the Brain Sending...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/10/12

🧠 Menopause, Molecules & Memory Could menopause be a "stress test" for the brain? 🔬 Researchers identified 16 brain-related blood proteins elevated after menopause. The signature tracked with higher FSH and lower estradiol, while inflammatory cytokines were especially elevated in women reporting night sweats. 🩸 Intriguingly, several of the same proteins were elevated in older women with cognitive decline or dementia. 💡 Menopause may offer a critical midlife window to identify brain

en

02:20

🐾 Why Big Dogs Age Faster: An Epigenetic Answer

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/10/11

🐕 Bigger Dogs, Faster Clocks, Shorter Lives? A fascinating Science study analyzed 1,640 DNA methylomes from 894 dogs. 🧬 Epigenetic age predicted mortality, with each additional year of residual biological age associated with a 15% higher mortality hazard. Most strikingly, larger dogs showed 31% stronger age-related transposable-element demethylation, especially involving evolutionarily young LINE1 elements. 💡 Large dogs may not simply die earlier—their molecular aging appears compressed and

en

02:20

2026 Nobel Chemistry Prize: ⚗️ Tiny Tilt, Giant...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/10/10

🏆🧬 Tiny Tilt, Giant Shift: How Chemistry Chooses a Side Why does life favor one molecular "hand"? The 2026 Chemistry Nobel honors Henri Kagan and Kenso Soai for showing how tiny chiral imbalances can become dramatically amplified. ⚗️ In Soai's landmark experiment, just 2% enantiomeric excess became 87%—and later autocatalytic reactions reached 99.99%. 💊 Why physicians should care: stereochemistry can determine whether a drug works at all—think L-DOPA. A tiny molecular bias can become biological

en

02:30

🛡️ Beyond Cholesterol: GIMAP6, Vascular Defense &...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/10/09

🧬 Can atherosclerosis become lethal even without high cholesterol? A fascinating Cell study identifies GIMAP6 as an immune–vascular safeguard. Loss of GIMAP6 disrupts endothelial integrity and activates a mitoROS → PPARγ → CD36 pathway, driving macrophage lipid uptake, foam cells, inflammation, atherosclerosis, MI and heart failure—even without hyperlipidemia. ❤️ Human hypomorphic GIMAP6 variants also tracked with premature cardiovascular disease. 💡 Take-home: LDL matters enormously—but

en

02:19

Beyond Breast Cancer 🩻❤️: When a Mammogram Warns the...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/10/08

🩻 Could a mammogram also offer a window into cardiovascular risk? ❤️ Breast arterial calcification (BAC), once largely dismissed as incidental, is increasingly recognized as a cardiovascular risk signal. Greater BAC burden has been associated with adverse outcomes, including stroke and heart failure. Maryland now requires BAC notification on routine mammograms. 💡 The practical message: see BAC → think cardiovascular risk assessment. ⚠️ But BAC ≠ coronary artery calcium, and we still lack

en

01:42

🌿➡️🧠 From Algae to the Brain: Optogenetics Wins the...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/10/07

🏆💡 From algae to the brain—a Nobel journey! The 2026 Nobel Prize in Physiology or Medicine honors Karl Deisseroth, Peter Hegemann & Georg Nagel for discoveries involving light-gated ion channels and optogenetics. 🌿 Channelrhodopsin in algae ➡️ 💡 Blue light opens the channel ➡️ ⚡ Ions flow ➡️ 🧠 Neurons can be precisely controlled Optogenetics gave neuroscience something extraordinary: the ability to manipulate defined neural circuits with remarkable temporal precision. Algae → Light → Ions →

en

02:36

💊 Great Doctors Series: Paracelsus—When Poison...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/10/06

☠️ Only the dose makes the poison. Meet Paracelsus (1493–1541)—physician, alchemist, provocateur, and a father of toxicology. ⚗️ He challenged Galen and Avicenna, championed observation over unquestioned authority, brought chemistry and minerals into therapeutics, studied miners' diseases, and emphasized cleaner wound care. 🩺 His most enduring insight was beautifully simple: toxicity depends on dose. 💊 🎙️ Great Doctors Series: Paracelsus—The Dose, the Poison & the Revolution Where Curiosity Meets

en

01:45

Missed by Stockholm, Remembered by Science magazine

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/10/05

🏅 Six breakthroughs. Zero Nobels. Medicine transformed. Why do some discoveries that fundamentally reshape biology never receive science's most famous prize? 🧬🧠 From Avery showing that DNA carries hereditary information, to Milner redefining memory, Till & McCulloch establishing stem cells, Pawson decoding cell signaling, Barres revealing the active biology of glia, and the Human Genome Project—these are discoveries whose influence far exceeds any medal. 🔬 💡 Great science doesn't need

en

02:42

Survodutide Strikes Twice: Weight Down, Glycemia Down 📉

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/10/04

en

02:00

🔥 The 25% Effect: Retatrutide Redefines Weight Loss

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/10/03

In TRIUMPH-1, once-weekly retatrutide produced mean weight loss of up to 25% at 80 weeks—but the story extends beyond the scale. ⚖️ 🦵 Less knee osteoarthritis pain 😴 Fewer obstructive sleep apnea events ❤️ Improved cardiometabolic measures 🩸 89–93% with prediabetes reverted to normoglycemia A triple GIP/GLP-1/glucagon receptor agonist may reshape how we think about obesity: not simply kilograms lost, but disease burden reduced. 💡 ⚠️ Gastrointestinal adverse effects remain important.

en

02:12

Eat More, Eat Less, Live Better 🍎❤️: The 2026 ACC...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/10/02

🥗 Can we eat our way to a healthier heart? ❤️ The 2026 ACC Scientific Statement shifts the conversation from isolated nutrients to foods, dietary patterns, and degree of processing. 🌱 The message is remarkably practical: eat more vegetables, fruits, legumes, whole grains, nuts, seeds and healthy unsaturated fats; eat less ultra-processed food, refined grains, sugary drinks, processed meats and excess sodium. 🫒 Mediterranean and DASH patterns remain center stage. 🎙️ Dr RR Baliga's Podkast for the

en

01:46

🧬 One Mutation, Massive Risk: EGFR T790M and...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/20

🧬 Rare Variant, Real Risk: EGFR T790M and Lung Cancer Can lung cancer risk be inherited—even in never-smokers? 🫁🚭 In >3.3 million individuals, germline EGFR T790M was rare (~1 in 15,850) but strongly associated with lung cancer (OR 25.18). The association was particularly striking among never-smokers, and the variant showed remarkable lung-cancer specificity. A Southern Appalachian founder effect also revealed how genes, geography & history can converge on modern disease risk. 🗺️🧬 💡 A

en

02:30

🌱 A Probiotic for Longevity? Microbes, Metabolites &...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/19

🦠 Could a gut microbe help counter inflammaging? A fascinating Nature Aging study identifies Bifidobacterium pseudocatenulatum as a candidate geroprotective species that declines with age. Its metabolite 5-AVAB also falls with aging. In naturally aged mice, probiotic treatment improved intestinal homeostasis, reduced multiorgan inflammaging, enhanced cognitive–motor performance, and extended healthspan; 5-AVAB reproduced several benefits. 🧠💪 🎯 Microbiome → metabolite → inflammaging → healthspan

en

02:58

🌾 60–100 Grams a Day: The Whole-Grain Cardiometabolic...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/18

🌾 Whole Grains, Real Gains! 🫀 How much whole grain does it take to move cardiometabolic risk factors? A meta-analysis of 87 randomized trials suggests a sweet spot around 60–100 g/day dry weight. Benefits were most clinically relevant for lipids and systolic blood pressure, while effects on several other risk factors were modest. 📉 💡 The lesson: cardiovascular prevention may come not from one dramatic dietary effect, but from multiple small gains working together. 🎙️ Dr RR Baliga's Podkast for

en

02:05

🫀 The Heart's Forgotten Drain: Aging, Lymphatics &...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/17

🫀 Could the aging heart have a drainage problem? A fascinating study in Nature Cardiovascular Research shows that aging reduces cardiac lymphatic vessels, with tighter junctions, impaired clearance, inflammation, edema, fibrinogen and amyloid accumulation. 🔥 🧬 Mechanistically: aging → ↓VEGFC → ↑nuclear IL-33 → lymphatic endothelial cell loss/remodeling. 🎯 IL-33 silencing or VEGFC restoration rescued lymphatic density and reduced inflammation—but VEGFC did not reverse established diastolic

en

02:07

🩸 Reengineering Coagulation: Bridging Factors,...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/16

🩸 Can you replace factor VIII without actually replacing factor VIII? Emicizumab does something more ingenious: this bispecific antibody bridges factor IXa and factor X, functionally recreating a critical role of factor VIIIa. 🔬 After screening ~40,000 candidates, researchers engineered a therapy that enables convenient subcutaneous prophylaxis and works with or without factor VIII inhibitors. 💉 🏆 Recognized with the 2026 Lasker–DeBakey Clinical Medical Research Award, it offers a powerful

en

02:20

Great Doctors Series: 🦠 Fracastoro, Fomites & the...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/15

🦠 Before Germ Theory: Fracastoro, Fomites & the Seeds of Contagion In 1546—centuries before microbes could be seen—Girolamo Fracastoro proposed that epidemic diseases spread through transferable "seeds" or "spores": by direct contact, contaminated objects, or even at a distance. 🔬 He introduced fomes, the root of our modern term fomite, and his poem Syphilis gave the disease its enduring name. 📜 A physician, poet & Renaissance polymath whose great insight was simple: contagion follows physical

en

01:59

🧠 Orexin Awakens: Sleep, Science & Serendipity

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/14

🧠 From Discovery to Lasker to Drug Therapy! In 1998, Emmanuel Mignot and Masashi Yanagisawa helped launch discoveries that transformed our understanding of orexin and narcolepsy—work now recognized with the 2026 Albert Lasker Award for Basic Medical Research. 🏆 The translational arc is remarkable: 🔬 orexin deficiency → narcolepsy type 1 → diagnostic biomarker → mechanism-based therapy. Today, we can 🌙 block orexin signaling for insomnia or ☀️ activate OX2R to restore wakefulness in narcolepsy. A

en

01:53

🎭 Afib Ablation vs Sham: When Rhythm and Relief Part...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/13

🫀 Less AF—but not more relief? PVI-SHAM-AF delivers a provocative lesson. In symptomatic atrial fibrillation, catheter ablation substantially reduced AF detected on Holter, yet did not demonstrate superiority over sham for AF-related quality of life at 6 months. 🎭 💡 The clinical pearl: rhythm control and patient-perceived benefit are not interchangeable outcomes. A fascinating reminder that in procedural medicine, what the monitor records and what the patient feels may tell different stories

en

01:56

🍞 Starch, Signals & Systemic Immunity: Not All Carbs...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/12

🍞 Same calories—but very different immune signals. A randomized controlled feeding trial examined 44 adults after ~15% weight loss on a very-low-carbohydrate diet. Reintroducing refined starch activated immune and metabolic pathways, increased adipsin/complement signaling, and produced activation signatures across NK cells, monocytes, T cells, dendritic cells & neutrophils. 🧬🔥 💡 Take-home: Carbohydrate quality may matter as much as quantity when considering immunometabolic effects. ⚠️ Small,

en

1,081 results

Similar Podcasts

NÖÖRDS - Der Podcast

NÖÖRDS

Science News Daily

brief.news

Astronomy Cast

Fraser Cain and Dr. Pamela Gay

The SCP Experience

Dr. NoSleep Studios

Strange Bites

Lance Martin