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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

02:08

🔌 Unplugging Pulmonary Hypertension: Can Denervation...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/04

🫀 Cut the Signal, Cut the Risk? Could pulmonary-artery denervation change the trajectory of heart failure–related pulmonary hypertension? In PADN-HF-PH, 264 symptomatic patients were randomized to denervation + guideline-directed medical therapy or medical therapy alone. Clinical worsening at 2 years: 25.7% vs 51.5% (HR 0.49; P=0.006). ⚡ A provocative concept: pulmonary sympathetic overactivity may be a modifiable therapeutic target. 🎯 But no sham control, China-only enrollment, and mortality

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02:08

🧬 Semaglutide, Senescence & Survival: Can GLP-1 Slow...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/03

🧬 Could semaglutide do more than treat obesity and diabetes? A fascinating study in aged female mice suggests that late-life semaglutide may act partly as a calorie-restriction mimetic—improving cognition, physical function and glucose control while attenuating multiple hallmarks of ageing. 🐭⏳ Most strikingly, median lifespan increased from 742 to 834 days. The biology implicates nutrient sensing, NAD⁺–sirtuin and insulin–IGF1 pathways.

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01:58

30% Fewer Cardiovascular Events: Statins Still Matter...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/02

🫀 Should we start a statin after age 70? STAREE delivers an important answer. In 9,971 adults ≥70 without cardiovascular disease, diabetes, or dementia, atorvastatin 40 mg reduced major cardiovascular events by 30% over 5.9 years (HR 0.70; NNT 37). 💊 Yet it did not prolong disability-free survival (HR 0.94). The benefit was driven largely by fewer myocardial infarctions and coronary revascularizations. 🎯 Take-home: age alone should not close the door on cardiovascular prevention—but preventing

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02:24

✍️ The Great Translator: How Constantine of Africa...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/01

🌍 The Monk, the Manuscripts, the Medical Bridge How did Arabic medical knowledge reach medieval Europe? 📚🩺 Meet Constantine the African (c. 1010–1087)—North African physician, multilingual translator, and Benedictine monk at Monte Cassino. His Latin translations of major Arabic medical works helped transmit centuries of scholarship to Salerno and beyond. 🌉 His enduring lesson: medicine advances when knowledge crosses borders. 🎙️ Great Doctors Series — Dr RR Baliga's Podkast for the Kurious Doc

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02:23

🫀 Plaque in Your 20s? The REACT Wake-Up Call

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/31

🫀 Atherosclerosis doesn't wait for middle age. In the REACT study of 16,808 adults without known ASCVD, silent plaque was found in 57.1% overall—and even in 8.7% of men and 6.7% of women aged 18–29. Plaque burden rose dramatically with age and increasingly involved multiple arterial territories. 🚨 Even more provocative: conventional 10-year risk classification identified only a minority with existing silent disease. Low predicted risk does not necessarily mean plaque-free arteries. 🔍 Prevention

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02:06

🛡️ One Risk Factor in Atrial Fibrillation: Is It Time...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/30

🫀 AF + just one stroke-risk factor: anticoagulate or not? The SINGLE-AF randomized trial tackled this common clinical gray zone. At 24 months, the composite of stroke, systemic embolism, major bleeding, or cardiovascular death occurred in 0.5% with a DOAC vs 1.5% without anticoagulation (HR 0.31; P=0.03). 🎯 ⚠️ Only 17 primary events occurred, so the effect estimate remains imprecise. Anticoagulation for Atrial Fibrillation with Intermediate Stroke Risk.pdf 💡 Takeaway: SINGLE-AF strengthens the

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02:27

🫀 Primary, Secondary, Procedural: Myocardial...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/29

🫀 MI has been redefined—and the numbers are gone. The Fifth Universal Definition of Myocardial Infarction (2026) replaces the familiar numerical MI types with a clinically intuitive trio: 🔴 Primary MI — acute coronary pathology 🟢 Secondary MI — supply–demand imbalance from another acute illness 🔵 Procedure-related MI — complication of a cardiac procedure The crucial message? 🩸 Troponin elevation is myocardial injury—not automatically MI. Context, ischemia, ECG and imaging matter. 🎙️ Dr RR

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02:02

Dapagliflozin Before the Cardiac Surgery: Kidney...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/28

🫀💊 Can 4 doses help protect the kidney after cardiac surgery? MERCURI-2 randomized 784 patients to perioperative dapagliflozin or placebo. AKI within 7 days fell from 52% to 28%—RR 0.54, an absolute reduction of ~24% and NNT ≈4. 📉 Intriguingly, the signal was driven largely by urine-output–defined AKI; creatinine-only AKI was unchanged. Hard 30-day outcomes were also unchanged. 🎙️ A provocative new chapter in perioperative cardiorenal protection. 🛡️

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02:10

Shingles Shot, Heart Shield? 🛡️❤️

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/27

💉 Shingles Shot, Heart Shield? 🛡️❤️ Could recombinant shingles vaccination protect more than the skin? In a natural experiment involving >72,000 matched adults ≥60 years, the recombinant vaccine was associated with 9% lower cardiovascular disease burden over 7 years, including lower burdens of ischemic heart disease and heart failure. 📉🫀 💡 Intriguingly, AS01-induced immune reprogramming and reduced IL-6 responses offer a potential mechanistic clue. ⚠️ Association ≠ causation—but this signal

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02:18

⚖️ Pooling Without Fooling: When Meta-Analysis...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/26

🔎 Can you believe that meta-analysis? Meta-analyses sit near the summit of evidence-based medicine—but pooling more studies does not automatically produce more truth. 📊 Lee and colleagues offer a powerful clinical lesson: credibility requires alignment of evidence, methods, and inference. Ask first: Should these studies have been pooled at all? 🧠 Look for prospective planning, robust source data, adequate events, explainable heterogeneity, transparency, and honest uncertainty. 🎯 The goal? Fewer,

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02:15

🧠 Physician, Philosopher, Polymath: The Genius of...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/25

🩺 Avicenna: Medicine, Mind & a Millennium of Influence Nearly 1,000 years ago, Ibn Sina—Avicenna—was already asking questions that still animate medicine: How should we observe disease? How do reason and experience guide diagnosis? How are mind and body connected? 🧠 His monumental Canon of Medicine traveled from the Islamic world into European universities and influenced generations of physicians. 📖🌍 Meet the physician, philosopher & polymath whose curiosity refused to stay in one discipline

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02:18

🫀 Smart Drugs, Vulnerable Hearts: Antibody Drug...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/24

🎯 Target the Tumor, Guard the Heart! ❤️ Antibody-drug conjugates are transforming breast cancer therapy—but precision oncology does not eliminate cardiovascular risk. 🧬🫀 This excellent JACC: CardioOncology Primer explores how the antibody, linker & payload may contribute to cardiotoxicity. HER2-directed ADCs carry the clearest cardiac signal, with T-DXd showing higher and more variable LVEF decline than T-DM1, while TROP-2–directed ADCs currently show limited cardiac signals. 🔑 The future:

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02:17

Cardiovascular-Kidney-Metabolic syndrome Starts...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/23

🫀 Can vascular injury begin in your early 20s? Apparently, yes. In 1,283 young adults (mean age 22.9 years), ~79% had Stage 1–3 Cardiovascular-Kidney-Metabolic (CKM) syndrome. Higher CKM stage tracked with poorer Life's Essential 8 scores and greater carotid arterial injury. 🚨 Strikingly, even Stage 1—excess adiposity—was associated with thicker carotid intima-media. 🎯 The message for clinicians: young adulthood is not a vascular grace period. Primordial prevention must start early.

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02:14

The Trial of Epigenetic Aging Clocks ⏰: ⏳ Promise,...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/22

⏳ Can we measure aging before disease arrives? A fascinating Nature Medicine analysis puts epigenetic aging clocks to the test. Across 51 intervention studies and 3,128 blood samples, reliable next-generation clocks—particularly DunedinPACE and PCGrimAge—were the most responsive. 🧬 Pharmacologic interventions generated especially strong signals. Responsiveness of epigenetic aging biomarkers to longevity interventions in humans.pdf But here is the clinical pearl: a clock moving backward does not yet

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02:13

🧬 Live Long, Age Smart, Stay Immune: The Centenarian...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/21

🧬 Why do some people reach 100+ with remarkable resilience? Centenarians don't simply escape immune aging—they appear to adapt to it. Preserved NK-cell function, altered T-cell populations, delayed autophagy decline, modulation of inflammageing, and distinctive transcriptomic, epigenetic and gut-microbial signatures may help maintain immune homeostasis. 💯🛡️ Fascinating lessons from nature's longest-lived humans—and perhaps clues for extending healthspan, not merely lifespan. 🔬♻️

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02:54

Repigment, Reframe, Restore: JAK Inhibition A New Era...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/20

🎨 Repigment, Reframe, Restore: A New Era for Vitiligo Vitiligo is far more than a cosmetic condition. In two phase 3 Viti-Up trials, oral upadacitinib 15 mg significantly improved facial and total-body repigmentation at 48 weeks. 💊 But here is the deeper lesson: better pigmentation ≠ complete patient benefit. Only 13–15% reported their vitiligo as "a lot less" or "no longer" noticeable. 👁️ The future of vitiligo care must measure not only pigment, but also dignity, mental health, long-term safety

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02:25

🧬 Detect, Decode, Decide: The Promise of Liquid Biopsy

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/19

🧬 Detect, Decode, Decide: The Promise of Liquid Biopsy Can a blood test tell us what cancer is doing before imaging can? 🩸 Circulating tumor DNA (ctDNA) can identify actionable variants, track treatment response, detect resistance, and reveal molecular residual disease. In colorectal cancer, molecular relapse was detected ~8.7 months earlier than with imaging surveillance. 🔬 But important questions remain: when should we test, how often, and should ctDNA positivity alone trigger treatment?

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03:56

Great Doctors Series: 🩺 Rhazes--Observe, Question, Heal

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/18

🩺 Great Doctors Series: Rhazes (c. 865–925 CE) More than 1,000 years ago, Persian physician Rhazes (Al-Razi) practiced a remarkably modern kind of medicine: observe the patient, question authority, compare outcomes, and care for everyone—rich or poor. 🔬 He distinguished smallpox from measles, pioneered writing on childhood disease, challenged Galen when observations disagreed, and profoundly influenced medical education in Europe. 📚🌍 His timeless prescription? Observe carefully. Question

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02:05

Short Sprints, Big Signals ⚡ — Rewiring Interorgan...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/17

⚡ Short Sprints, Big Signals: How Exercise Intensity Changes the Message Exercise may be more than movement—it may be an interorgan conversation. 🧬🫀 A fascinating human multi-omics study shows that sprint-interval exercise produces broader and faster changes in circulating proteins and metabolites than moderate-intensity exercise. Muscle and adipose tissue appear central to this molecular dialogue, while many sprint-responsive proteins are associated with favorable cardiometabolic outcomes. 💡

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02:14

🧠❤️ Heart, Brain, Body: The ACC's New Playbook for...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/08/16

🧠❤️ The aging heart does not age alone. The 2026 ACC Scientific Statement reminds us that cardiovascular disease, cognitive impairment, and frailty are intertwined manifestations of biological aging. Cognitive Impairment and Frailty in Older Adults With Cardio vascular Disease- 2026 ACC Scientific Statement.pdf For clinicians, the message is practical: 🔍 screen cognition and frailty, 🚶 assess gait and strength, 🏋️ build resilience through multidomain exercise, 🥗 optimize nutrition, and 💊

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