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PODCAST

The Orange Pill Podcast

The Orange Pill Podcast 🎙️ Your go-to source for the latest in the dietary supplement and natural health product industry! Brought to you by KGK Science, a global leader in clinical research and regulatory consulting, this podcast delivers: ✔️ Breaking industry news and trends ✔️ Educational insights and practical takeaways ✔️ Discussions on cutting-edge research ✔️ Landmark cases and notable events shaping the field Join us as we bridge the gap between science, regulation, and everyday impact.

health & fitness nutrition

All Episodes

44:29

Episode 52: The Pink Tax on Pills: Decoding the $91B...

The Orange Pill Podcast ·

2025/08/28

The women’s health supplement market is booming, projected to hit nearly $91 billion by 2033. But is this growth empowering women, or exploiting them? In this episode, we unpack the drivers behind the surge, from the self-care movement and influencer marketing to life-stage–specific formulas targeting PMS, fertility, and menopause.We also dive into the risks of a largely unregulated market, the red flags consumers should watch for, and the critical role of third-party testing and professional

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36:53

Episode 51: The Protein Bar Arms Race and the Rise of...

The Orange Pill Podcast ·

2025/08/26

The protein wars are heating up, and one bar is leading the charge. In this episode, we unpack the “protein bar arms race” and the meteoric rise of the David Bar—a hyper-optimized, influencer-backed product redefining the category. From its extreme protein-to-calorie ratio and luxury branding to its aggressive supply chain play with Epogee, David is more than just a snack; it’s a symbol of the cultural obsession with protein and optimization.We explore: Why protein is now the undisputed king

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54:13

Episode 50: The End of Secret Ingredients: GRAS...

The Orange Pill Podcast ·

2025/08/21

The FDA’s “Generally Recognized as Safe” (GRAS) rule was meant to keep food safe. But for decades, the self-GRAS loophole has allowed companies to introduce new additives without FDA review or public disclosure.In this episode of the Orange Pill Podcast, we break down the unprecedented wave of reform efforts in 2025: Executive action from HHS Secretary RFK Jr. and FDA Commissioner Marty Makary. Congressional bills aiming to permanently close the loophole. State-level legislation in New

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41:33

Episode 49: Leaked Report: Can MAHA Really Make...

The Orange Pill Podcast ·

2025/08/19

In this episode, we dive deep into the Make America Healthy Again (MAHA) Commission’s leaked strategy report, submitted to President Trump earlier this month and quietly leaked before its official release. The “Make Our Children Healthy Again Strategy” lays out sweeping changes to how the federal government addresses childhood chronic disease, from overhauling nutrition guidelines and banning food dyes, to tackling overmedicalization and rethinking the role of ultra-processed foods.But the report

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25:43

Episode 48:Tariffs, Trade & Turbulence: How the EU-US...

The Orange Pill Podcast ·

2025/08/14

The new EU-US trade deal is here, and it’s sending shockwaves through the dietary supplement industry. While it avoids the 30% tariff originally proposed, the agreement imposes a steep 15% tariff on about 70% of EU exports to the US, up from the previous 1.2%.In this episode, we break down: Who’s Hit Hardest: Why finished dietary supplements aren’t exempt, and what that means for European brands. The Ingredient Exception: Which vitamins, minerals, amino acids, and other key nutrients escape the

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40:47

Episode 47: Federal Action on Ultra-Processed Foods

The Orange Pill Podcast ·

2025/08/12

In this episode, we unpack a major federal push to tackle the diet-related chronic disease crisis in America, with ultra-processed foods (UPFs) in the crosshairs. The U.S. Departments of Health and Human Services and Agriculture, working alongside the FDA and NIH, are launching coordinated initiatives to:Define “ultra-processed foods” with a uniform federal standard. Fund groundbreaking nutrition research through the new Nutrition Regulatory Science Program (NRSP). Increase transparency in

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23:35

Episode 46: The GRAS "Loophole" and Robert F. Kennedy...

The Orange Pill Podcast ·

2025/08/07

In this episode of the Orange Pill Podcast, we dive into Health Secretary Robert F. Kennedy Jr.’s aggressive push to dismantle the GRAS (“Generally Recognized as Safe”) pathway — a move that’s shaking up both Big Food and the supplement industry. We explore: The origins and exploitation of the GRAS "loophole" Why ultraprocessed foods are in the crosshairs What this crackdown means for dietary supplements Former FDA Commissioner David Kessler’s bold citizen petition Whether this is a turning point

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31:50

Episode 45: FDA Actions on Kratom and...

The Orange Pill Podcast ·

2025/08/05

The FDA is sounding the alarm. In a major regulatory move, the agency is recommending that 7-hydroxymitragynine (7-OH)—a potent synthetic derivative of kratom—be scheduled under the Controlled Substances Act. Why? Because this lab-created version of kratom’s active compound is up to 500% more potent than its natural form and is increasingly tied to severe health risks, including liver toxicity, seizures, substance use disorder, and even death. In this episode, we break down: The FDA and DEA's

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28:29

Episode 44: Canada's Evolving CBD Regulations and...

The Orange Pill Podcast ·

2025/07/31

This episode explores Canada’s evolving approach to CBD regulation, focusing on proposed changes that would allow low-dose cannabidiol products to be sold as Natural Health Products without a prescription. It covers the gaps in the current framework under the Cannabis Act, the results of public consultations, and Health Canada’s ongoing efforts to balance safety, access, and industry growth. The discussion also touches on implications for pharmacies, veterinary products, product labeling, and the

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18:05

Episode 43: Cost Recovery Chaos – What’s Really...

The Orange Pill Podcast ·

2025/07/29

Part One of Our Deep Dive into NHP Regulation ReformCanada’s Natural Health Product (NHP) industry is facing its biggest regulatory shake-up in decades — and we’re here to break it all down. In this must-listen episode, we unpack the newly revised Product Licence Application (PLA) Class system and the controversial cost recovery program introduced by Health Canada. From how Class I, II, and III applications work, to the major fee hikes and implementation timelines, we explore how these changes will

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35:30

Episode 42: Beta-Alanine’s Emerging Role in Cognitive...

The Orange Pill Podcast ·

2025/07/24

This episode explores the surprising benefits of CarnoSyn® beta-alanine beyond sports. A new study reveals that a low, sustained-release dose improved cognitive function and reduced depression scores in older adults with below-average baseline scores—without side effects.We break down the science behind brain carnosine, its link to BDNF and mood, and what this means for the healthy aging supplement market. Plus, a look at the regulatory pathway led by KGK Science and what’s next for SR

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22:02

Episode 41: The "Ensuring Safe and Toxic-Free Foods...

The Orange Pill Podcast ·

2025/07/22

In this episode, we unpack the newly introduced Ensuring Safe and Toxic-Free Foods Act of 2025, spearheaded by Senators Markey and Booker. This legislation aims to reform the FDA’s GRAS (Generally Recognized as Safe) system, which has long allowed food companies to self-approve potentially harmful additives without FDA oversight. We explore how this act seeks to phase out self-GRAS determinations, prohibit toxic substances, and demand full transparency in food safety evaluations. Tune in for a deep

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15:57

Episode 40: The Impact of Magnesium on Brain Health...

The Orange Pill Podcast ·

2025/07/17

Can magnesium slow brain aging?New research says yes. This episode breaks down emerging evidence on magnesium’s role in preserving brain volume, protecting against white matter lesions, and lowering dementia risk. We explore why post-menopausal women see the strongest benefits, how magnesium regulates neuroinflammation, and what you can do to increase intake through food and supplements. Find out why magnesium is becoming a key focus in brain health, cognitive longevity, and healthy aging.

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28:23

Episode 39: Tariff policies are reshaping the dietary...

The Orange Pill Podcast ·

2025/07/15

How do tariffs shape your supplements? In this episode, we break down the economic and regulatory impact of the 2025 Reciprocal Tariff System and Executive Order 14257 on the dietary supplement industry. Learn how key ingredients like CoQ10 and Vitamin B Complex secured tariff exemptions—saving the industry over $200 million in just over two months—and why supplement leaders are pushing back against pharmaceutical-level scrutiny. We also unpack the latest US-China trade truce and what it means for

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29:32

Episode 38: Crossing Barriers: The Omega-3...

The Orange Pill Podcast ·

2025/07/10

In this episode of the orange pill podcast, we spotlight a groundbreaking clinical trial that could redefine how omega-3s are delivered to the brain and eyes. Aker BioMarine has partnered with KGK Science to launch the first-ever human clinical trial on Lysoveta, a next-gen omega-3 ingredient that uses lyso-phosphatidylcholine (LPC) to deliver EPA and DHA across the blood-brain and blood-retina barriers. Why does that matter? Because targeted delivery to the brain and eyes has long been the holy

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35:59

FDA's Human Foods Program and New Dietary Ingredient...

The Orange Pill Podcast ·

2025/07/08

In this episode of the Orange Pill Podcast, we unpack the FDA’s newly released 2025 Human Foods Programme guidance agenda and the persistent challenges stalling finalization of the long-awaited New Dietary Ingredient (NDI) guidance. From the implications of regulatory orders that demand a "10-for-1" rule, to open questions around bioidentical molecules and the fate of the self-affirmed GRAS pathway, we explore what’s at stake for dietary supplement stakeholders.We also dive into how industry can

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20:00

Episode 36: Class Action Lawsuit Against Amazon...

The Orange Pill Podcast ·

2025/07/01

In this episode of the Orange Pill Podcast, we unpack the federal class action lawsuit alleging deceptive labeling practices on dietary supplements sold through one of the world’s largest online retailers. Plaintiffs claim the company systematically omits mandatory disclaimers and promotes unapproved health claims—leaving consumers under the false impression that the products are FDA-approved.With the court denying a motion to dismiss, discovery will now proceed into not only the purchased

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33:57

Episode 35: Unreliable Melatonin Supplement Doses and...

The Orange Pill Podcast ·

2025/06/26

A new FDA study reveals that many melatonin supplements—especially those marketed for children—contain wildly inaccurate doses, ranging from 0% to over 600% of what is listed on the label. In this episode, we unpack the science and regulatory implications of this inconsistency. Why is a powerful hormone treated like a harmless vitamin? What does this mean for consumer safety, especially among children? We explore the risks, expert recommendations, and what regulators and manufacturers need to do

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21:56

OPP EP 34: Paraxanthine as a Caffeine Alternative

The Orange Pill Podcast ·

2025/06/24

Episode 34 takes a closer look at paraxanthine (Px) — the main metabolite of caffeine — and why it might be the next big thing in clean, functional energy. With claims of fewer jitters, smoother focus, and a safer toxicity profile, Px is drawing attention from both scientists and the beverage industry.This episode explores: How paraxanthine compares to caffeine in terms of safety and effectiveness Its nootropic and physical performance benefits Why new coffee products are being formulated

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33:55

Episode 33: Psyllium Husk – "Nature’s Ozempic" and...

The Orange Pill Podcast ·

2025/06/19

Psyllium husk is taking the wellness world by storm, but is it just hype, or a true hero in your supplement stack?In this episode, we break down what makes psyllium more than just a fiber. From its rising nickname “Nature’s Ozempic” to its documented benefits in digestion, heart health, and even colorectal cancer prevention, we look at where the science stands today. We also touch on dosage safety, clinical findings, and what formulators and regulators need to keep in mind as psyllium’s popularity

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