PODCAST

One in Six Billion

Andrew Hattersley and Maggie Shepherd

A podcast about diabetes and genes hosted by Andrew Hattersley and Maggie Shepherd.

health & fitness medicine

All Episodes

37:44

Series 3 Episode 9. Ru Kovvuri and Rhian Clissold ...

One in Six Billion ·

2025/01/21

Send us a textRu Kovvuri explains about her battle to get a diagnosis and support for her daughter who had multiple medical problems and learning difficulties as a result of a deletion of the HNF1B gene. Rhian Clissold discusses her research to improve the diagnosis of the HNF1B syndrome and recognise the associated learning difficulties seen with loss (deletion) but not the spelling mistakes (mutations) in the HNF1B gene.

en-gb

48:13

Series 3 episode 8. HNF1Beta syndrome: kidney...

One in Six Billion ·

2025/01/07

Send us a textGrant King talks about his diagnostic journey where his low birth weight, childhood kidney disease, diabetes, liver dysfunction and infertility were at 32 years finally recognised as all being due to a change in the HNF1Beta gene. Dr Coralie Bingham explains how her research during her PhD in Exeter led to HNF1Beta being established as the commonest cause of inherited kidney disease and all the key parts of the HNF1Beta syndrome being recognised.

en-gb

37:05

Series 3 episode 7. Natalie Raphael and Alice Hughes...

One in Six Billion ·

2024/12/24

Send us a textNatalie Raphael was diagnosed as having glucokinase MODY at the end of her first pregnancy. In her second pregnancy she had a recently introduced blood test that showed her fetus had not inherited her change in the glucokinase gene so was at risk of growing large. As a result of this she was given long-acting insulin to lower her glucose. Alice Hughes is the researcher who did the key study that proved the new blood test was both practical and accurate in glucokinase pregn...

en-gb

37:38

Series 3 episode 6. Gill Preston, Gill Spyer, and Ali...

One in Six Billion ·

2024/12/10

Send us a textIt was a great surprise for Gill Preston, who was active and slim, when she was diagnosed with gestational diabetes in her first pregnancy. Her raised fasting glucose did not come down with tablets or insulin. Luckily she met Andrew Hattersley in the diabetes pregnancy clinic, who recognised she had glucokinase MODY. Gill Spyer, working for her PhD as a research doctor showed that in glucokinase pregnancy the size of the baby depended on whether they inherited the genetic change...

en-gb

32:38

Series 3 episode 5. Andrew Lotery and Amanda Stride:...

One in Six Billion ·

2024/11/26

Send us a textIn this episode we talk to Andrew Lotery about how he was found to have a raised fasting glucose on an insurance medical. He was treated as Type 2 diabetes but he questioned this as he was young. slim and physically fit. A chance reading of a research funder’s newsletter led him to the Exeter team and a diagnosis of glucokinase MODY. Amanda Stride worked as a research registrar in Exeter. She showed that in glucokinase MODY the fasting glucose was raised from birth a...

en-gb

33:54

Series 3 episode 4. Janette and Alice: Big babies...

One in Six Billion ·

2024/11/12

Send us a textIn this episode we talk to Janette and her daughter Alice who were both correctly diagnosed with HNF4A MODY having been initially told they had Type 1 diabetes. The diagnosis not only allowed them to stop insulin but also explained the mystery of two of Jeanette’s children that were born as large babies and collapsed soon after birth with low blood sugar. Andrew explains how it was discovered that babies that inherited the HNF4A genetic change were on average over 800g heavier a...

en-gb

27:48

Series 3 episode 3. Mary Lee and Ewan Pearson:...

One in Six Billion ·

2024/10/29

Send us a textMary Lee was thought to have Type 1 diabetes for over 3 decades; she was finally diagnosed with HNF1A MODY and was able to stop her insulin injections and get excellent blood sugar control with a sulphonylurea tablet. We hear from Ewan Pearson how sulphonylurea tablets were found to be excellent glucose lowering treatment when Andrew’s clinical observations of his HNF1A MODY patients were followed up by Ewan with a clinical trial.

en-gb

26:25

Series 3 episode 2. Kevin Colclough and Bev Shields...

One in Six Billion ·

2024/10/15

Send us a textKevin Colclough describes how the genetic testing in diabetes has improved over the 2 decades he has worked in the Exeter NHS diagnostic lab. His work means now over 60 types of single gene diabetes are looked for in one sequencing test. Bev Shields talks about how she developed the amazing MODY calculator that uses common clinical characteristics to work out how likely a person with diabetes is to have maturity onset diabetes of the young (MODY).

en-gb

29:01

Series 3 episode 1. Mary Humphries: The doctor...

One in Six Billion ·

2024/10/01

Send us a textMary Humphries tells how her son Dan was diagnosed with diabetes aged 16 and it was assumed he had type 1 diabetes and treated with insulin. On insulin he had terrible problems with low blood sugars frequently losing consciousness and not managing to concentrate at school or at home. Mary was very worried that he was getting worse on the insulin and asked about genetic tests because she had recently been diagnosed with Type 2 diabetes and there was diabetes in all ge...

en-gb

24:04

Series 2 episode 9. Nick Thomas. Type 1 diabetes in...

One in Six Billion ·

2024/09/17

Send us a textDr Nick Thomas talks about Type 1 diabetes in the older adult. In an iconoclastic study he showed most cases of Type 1 diabetes occur in adults rather than children. In older adults it is very hard to recognise as 98-99% of people with diabetes have Type 2 diabetes. Older adults with Type 1 diabetes have just as rapid a decline in their own insulin and need all the expert care offered to children.

en-gb

38:57

Series 2 episode 8. Simon Goode and Angus Jones....

One in Six Billion ·

2024/09/03

Send us a textSimon Goode was diagnosed with Type 2 diabetes aged 28. He explains how it took 6 months of feeling unwell before it was realised he had Type 1 diabetes instead. Exeter Professor, Angus Jones, has done research showing that mistakes in the diagnosis Type of 1 diabetes are common in the older adult and offers solutions to help doctors get the diagnosis right.

en-gb

35:45

Series 2 Episode 7. Jean Claude Katte. Type 1...

One in Six Billion ·

2024/08/20

Send us a Text Message.Dr Jean Claude Katte explains how in Sub Saharan Africa diagnosis, treatment and monitoring of Type 1 diabetes in children and young adults is so much harder than in Europe. He discusses with Maggie and Andrew his own exciting research that has shown that around 60% of African children with diabetes do not have the typical autoimmune Type 1 diabetes seen in over 90% of children with diabetes in Europe. Jean Claude aims to do more research to discover what causes t...

en-gb

47:35

Series 2 episode 6. Mendy Korer and Matt Johnson. ...

One in Six Billion ·

2024/08/06

We hear from Mendy Korer about the enormous challenges of living with a child who was diagnosed with Type 1 diabetes aged 11 months. Matt Johnson, a research fellow in Exeter talks about his exciting work understanding what makes the immune system destroy the insulin making beta-cells in very young children.

en-gb

29:58

Series 2 Episode 5 Richard Oram – genius genetics...

One in Six Billion ·

2024/07/23

Professor Richard Oram had the innovative idea of turning complex analysis of the genetic changes into a single number that estimate the likelihood of developing Type 1 diabetes. He explains to Andrew and Maggie how this has helped diagnosis of Type 1 diabetes and is being used around the world in studies aiming to prevent or delay diabetes in children.

en-gb

40:51

Series 2 Episode 4. Partha Kar – the super hero who...

One in Six Billion ·

2024/07/09

Contact the showProfessor Partha Kar has made sure the technical advances in measuring blood sugar are available to everyone living with Type 1 diabetes in the UK. Partha had to overcame massive hurdles to make sure the technology was not just available to a privileged few. He discusses with Maggie and Andrew his inspirational leadership style and philosophy that have helped him to move mountains in the NHS.Vote for One in Six Billion in the British Podcast Awards: https://www.britishpo...

en-gb

33:06

Series 2 Episode 3. Jean Dudderidge and Jill Epton....

One in Six Billion ·

2024/06/25

Contact the showJean Dudderidge and Jill Epton talk about what it has been like to live with Type 1 diabetes for over 50 years. They discuss the massive advances in the measurement of blood sugar over the decades and how they now benefit greatly from continuous glucose monitoring.

en-gb

45:01

Series 2 Episode 2. Moira Murphy and Mark McCarthy....

One in Six Billion ·

2024/06/11

Contact the showMoira Murphy and Mark McCarthy talk about how a unified UK team of scientists came to be world leaders in decoding the genetic susceptibility to Type 2 diabetes.

en-gb

24:52

Series 2 Episode 1. Tim Frayling and Rachel Freathy....

One in Six Billion ·

2024/05/28

Contact the showWe talk to Tim Frayling and Rachel Freathy about how they discovered the “Fat gene”. Working with Oxford, the Exeter team showed a genetic change near FTO predisposed to obesity. This was the first and largest common genetic change altering weight.

en-gb

31:45

Special episode 4. Tim Frayling – From PhD student to...

One in Six Billion ·

2024/05/14

Contact the showIn this special episode, we hear from Professor Tim Frayling who was Andrew and Sian’s first PhD student in 1995. He rapidly became the head of the analysis for the genetic susceptibility for Type 2 diabetes. His leadership has made Exeter an international leader in polygenic trait genetics.

en-gb

42:30

Special episode 3. Sian Ellard – establishing a world...

One in Six Billion ·

2024/04/30

Contact the showIn this special episode, we hear from Professor Sian Ellard who, like Andrew and Maggie, started in Exeter in 1995. Sian set up the Exeter molecular genetics laboratory from scratch. Through Sian’s leadership, this laboratory became world leading for both research and NHS diagnostic testing.

en-gb

52 results

One in Six Billion

All Episodes

Similar Podcasts

Доктор Тройняшкин

Доктор Тройняшкин

The Dry Eye Treatment PODCAST

Dry Eye Treatment

Différent et alors ?

PATRICK SULAY

Kyle Kingsbury Podcast

Kyle Kingsbury

The Real Weight Loss Coach

Matty Lansdown