PODCAST

One in Six Billion

Andrew Hattersley and Maggie Shepherd

A podcast about diabetes and genes hosted by Andrew Hattersley and Maggie Shepherd.

health & fitness medicine

All Episodes

25:29

Special Episode 8: Steve Chapman, Andrew Hattersley...

One in Six Billion ·

2025/10/28

In the final episode of the One in Six Billion podcast Andrew and Maggie reflect with producer Steve Chapman on the fun they have had making 51 podcasts with 70 guests in the past 2 years. Send us a text

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35:47

Series 4 Episode 8. Rohini Bajekal and Shivani Misra....

One in Six Billion ·

2025/10/14

Rohini Bajekal describes how she had years of receiving inappropriate lifestyle advice before Glucokinase MODY was diagnosed. Dr Shivani Misra’s research has shown that failure to diagnose monogenic diabetes is even common in South Asians than in the white European population. Send us a text

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21:27

Series 4 episode 7. Sarah Richardson. Small...

One in Six Billion ·

2025/09/30

Sarah Richardson talks about her new exciting research on insulin producing beta-cells that are single cells or small clusters rather than in islets. These extra-islet beta-cells make up most of the insulin producing capacity of the pancreas in young children and are particularly susceptible to immune attack in Type 1 diabetes. This important research explains why the loss of insulin producing cells in Type 1 diabetes is more severe in young children and informs future work on tre...

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18:55

Series 4 episode 6: Hannah Robinson and Nick Thomas....

One in Six Billion ·

2025/09/16

Hannah Robinson was the first adult in the UK to be given the new immunotherapy drug Teplizumab, which aims to slow down the development of type 1 diabetes. Hannah had multiple pancreatic autoantibodies and hence is on the path to developing Type 1 diabetes (Series 4 Episode 3). Her consultant, Nick Thomas, arranged 14 consecutive daily hospital visits for her to receive the drug through a drip. Send us a text

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34:42

Series 4 episode 5. Jerry Gore and Rob Andrews. ...

One in Six Billion ·

2025/09/02

Jerry Gore has always lived life on the edge; he had tackled some of the highest, and most inhospitable mountain climbs in the world before he was diagnosed with Type 1 diabetes aged 40. His Type 1 diabetes has not held him back and he has learnt how to live well with his Type 1 diabetes when climbing at extreme altitude and bitter cold. He helps people living with Type 1 diabetes throughout the world, especially in S E Asia as co-founder of Action4Diabetes (A4D). Rob Andrews is a...

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36:46

Series 4 episode 4. Chris Bright and Rob Andrews....

One in Six Billion ·

2025/08/19

Chris Bright was diagnosed with Type 1 diabetes aged 8 but this did not stop him having a very successful football career including playing international futsal for Wales. He describes the challenges he faced and how he over came them. He has established The Diabetes Football Community that supports football for everyone living with Type 1 diabetes. Dr Rob Andrews helps people with Type 1 diabetes compete in all sports at the highest level. He has set up the Exercise for Type 1 Di...

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25:48

Series 4 episode 3: Hannah Robinson and Nick Thomas

One in Six Billion ·

2025/08/05

First steps in delaying adult-onset Type 1 diabetes When Hannah Robinson was diagnosed with gestational diabetes and found to have islet auto-antibodies she was recognised as being on the path to future Type 1 diabetes. With help from her diabetes consultant, Dr Nick Thomas, she became the first adult in the UK to be given Teplizumab, a new treatment that delays the onset of Type 1 diabetes. Send us a text

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24:24

Series 4 Episode 2. Rachel Besser. Identifying...

One in Six Billion ·

2025/07/22

Dr Rachel Besser explains how new treatment options means it is now important to identify children before they get symptomatic Type 1 diabetes. Rachel is working to make sure testing for risk of Type 1 diabetes is done in the best way for children and their families. Send us a text

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24:28

Series 4 Episode 1: Richard Oram. First steps towards...

One in Six Billion ·

2025/07/08

Richard Oram explains how recent advances have meant we can now delay type 1 diabetes with immunotherapy. To do this we need to be able to identify people at very high risk of developing Type 1 diabetes. Richard thinks genetic analysis could play a part in this identification. Send us a text

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33:22

Series 3 Episode 17. Jennifer and Helen. Prader Willi...

One in Six Billion ·

2025/06/24

Jennifer and her mother Helen explain how being born Prader Willi syndrome has had a lifelong impact. One challenge is that Jennifer is continually hungry, and so limiting access to food is needed at all times. Send us a text

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28:59

Special episode 7. Maggie Shepherd (part 2)....

One in Six Billion ·

2025/06/10

Professor Maggie Shepherd reflects back on her career and how she made the massive steps from being a clinical nurse to becoming a nationally leading researcher and educator. Send us a text

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29:54

Special episode 6. Andrew Hattersley (part 2)....

One in Six Billion ·

2025/05/27

Andrew Hattersley describes how teamwork and mutual support has helped the Exeter diabetes research team expand and flourish over the past 30 years Send us a text

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32:24

Series 3 Episode 16. Grace Bervoets and Amanda...

One in Six Billion ·

2025/05/13

Grace Bervoets talks about living with cystic fibrosis and cystic fibrosis related-diabetes. Amanada Stride, who works as a diabetes consultant helping people with cystic fibrosis related-diabetes, explains the many challenges of this unusual type of diabetes. Send us a text

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42:58

Series 3 Episode 15. Tom Staniford. MDP syndrome

One in Six Billion ·

2025/04/29

Tom Staniford talks about living with the MDP syndrome, an extremely rare genetic condition. MDP syndrome includes Mandibula hypoplasia, Deafness, and Progeroid features amongst its widespread features. Tom developed Type 2 diabetes as a teenager because of a loss of fat under the skin (lipodystrophy) despite being very thin and active. Tom has used his communication and media skills to help other people with MDP syndrome get diagnosed and receive the right care. Send us a text

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33:26

Series 3 Episode 14: Farah O'Regan and Matt Johnson....

One in Six Billion ·

2025/04/15

Farah O'Regan talks about how her son who had Down syndrome and a severe congenital heart condition needing surgery diagnosed in pregnancy and then developed Type 1 diabetes on day 2 of life. In early childhood he was diagnosed with 2 more autoimmune conditions, coeliac disease and hypothyroidism. Researcher Matt Johnson explains his research which has established that Down syndrome directly results in very early-onset autoimmune diabetes. Send us a text

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34:53

Series 3 Episode 13. Abby Gardener and Tim Barrett....

One in Six Billion ·

2025/04/01

Send us a text Abby Gardener describes how she was diagnosed with Wolfram syndrome after developing both insulin-treated diabetes and diabetes insipidus (when the urine cannot concentrate) and how this has impacted her life. Professor Tim Barrett talks about how, throughout his career, he has been researching and providing care for patients with Wolfram syndrome. He explains that it is now recognised that there are a range of features that can result from the genetic change (WFS1...

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36:01

Series 3 Episode 12. Cassi Connelly. Familial Partial...

One in Six Billion ·

2025/03/18

Send us a text Cassi Connelly talks about her experience of having familial partial lipodystrophy characterised by a loss of fat and muscular appearance of her arms and legs. She had multiple medical problems including diabetes for decades before the diagnosis of familial partial lipodystrophy was finally confirmed by a genetic test. Her treatment is now better tailored to her needs.

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29:14

Series 3 Episode 11. Rebecca Goodman. Living well...

One in Six Billion ·

2025/03/04

Send us a text Rebecca Goodman talks to Andrew and Maggie about what it is like to grow up with Bardet-Biedl syndrome. Features of Bardet-Biedl syndrome include extra fingers and toes, progressive blindness, kidney problems, obesity due to an uncontrolled appetite, insulin resistance and diabetes. Despite this long list of medical issues Rebecca lives independently and enjoys a full and fun life.

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24:01

Special episode 5. John Dennis. Research...

One in Six Billion ·

2025/02/18

Send us a text We talk to John Dennis, a data science researcher working in the University of Exeter. He used data from 1 million people with Type 2 diabetes to discover how the clinical characteristics of a patient alter the glucose lowering with different treatments. John’s 5 drug model, published in the Lancet in late February 2025, uses simple clinical information to identify, for the first time, the best glucose lowering treatment for a patient. The model selected best treatment lo...

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33:05

Series 3 Episode 10. Julie Reynolds and Kash Patel....

One in Six Billion ·

2025/02/04

Send us a text Julie Reynolds describes how she gradually lost her hearing in her 30’s and developed diabetes in her 40’s these 2 conditions also developed in in her mother, her children and other maternal relative. This led to a diagnosis of maternally inherited diabetes and deafness that results from a change in the mitochondrial DNA. Kash Patel explains the science between diabetes, deafness and a maternal inheritance and why there is a lot of variation in the presence and severity o...

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One in Six Billion

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