x

75% of people globally want unbiased news (Pew Research) but are concerned they're not getting that.

Get balanced coverage with Symby. See how stories are covered across diverse outlets and spot when one side covers a story the other skips.

PODCAST

The Synthesis of Wellness®

Chloe Porter is dedicated to health research and optimization. She is the host of The Synthesis of Wellness ® Podcast; an engineer; and an acclaimed health science speaker, expert, and best-selling author known for her deep dives into gastrointestinal function, functional health, and health optimization.

health & fitness alternative health

All Episodes

00:14:47

181. The Oral-Gut Axis | Oral Biofilm Formation, Oral...

The Synthesis of Wellness® ·

2025/05/30

In this episode, we detail the oral microbiome and its relationship with the intestinal microbiome, detailing the oral-gut microbiota axis. We discuss the stepwise development of oral biofilm, the transition from plaque to dental calculus, and potential systemic impacts of oral dysbiosis, while highlighting intestinal health and focusing on Fusobacterium nucleatum. We then detail possible symptoms of oral dysbiosis as well as testing modalities. Topics:1. Overview of the Oral Microbiome and the

en

00:13:59

180. Intestinal Mycobiome | The Role That Beneficial...

The Synthesis of Wellness® ·

2025/05/23

In this encore episode, we detail the intestinal mycobiome and the mechanisms by which beneficial microbes aid in regulating opportunistic fungal species: Candida albicans. We discuss Candida overgrowth virulence and how disruptions in microbial balance, immune function, and epithelial integrity impact Candida's pathogenicity. Additionally, we discuss the role of mast cells in the lamina propria, their involvement in mucosal immunity, and how Mast Cell Activation Syndrome (MCAS) can be exacerbated

en

00:15:00

179. Intestinal Motility & SIBO | Interactions Among...

The Synthesis of Wellness® ·

2025/05/16

In this encore episode, we detail the pathophysiology of intestinal methanogen overgrowth (IMO), hydrogen-dominant small intestinal bacterial overgrowth (H₂-SIBO), and hydrogen sulfide-dominant SIBO (H₂S-SIBO), discussing their mechanistic interactions and overlap. We discuss methanogenic archaea, as well hydrogen sulfide- and hydrogen-producing microbes and their contributions to altered gastrointestinal motility, epithelial barrier function, and neuromuscular signaling. We detail host endogenous

en

00:13:15

178. The Stomach & Gastric Acid | Vitamin B12...

The Synthesis of Wellness® ·

2025/05/09

In this episode, we highlight the stomach's role in vitamin B12 absorption and bioavailability, detailing the cellular composition of the gastric mucosa and further highlighting mucous cells, parietal cells, and chief cells. We also briefly discuss Helicobacter pylori and common symptoms, while detailing H. pylori's survival mechanisms in the acidic gastric environment as well as potential impacts on the gastric mucosal barrier. Topics:1. Introduction- Overview of the stomach's role in B12

en

00:14:28

177. The Gut-Immune Axis, Intestinal Barrier...

The Synthesis of Wellness® ·

2025/05/02

In this episode, we highlight vitamin D₃ in gastrointestinal health, with a focus on intestinal barrier function and the gut-immune axis. We discuss how vitamin D is metabolized into its active form, 1,25-dihydroxyvitamin D, and how 1,25-dihydroxyvitamin D can support the intestinal mucosa, while highlighting the intestinal epithelium and immune cells in the lamina propria. Through this, we further detail the role of regulatory T cells in supporting immune balance and modulating immune

en

00:13:51

176. The Gut-Immune Axis and Small Intestinal Fungal...

The Synthesis of Wellness® ·

2025/04/25

In this episode, we discuss the gut-immune axis and Small Intestinal Fungal Overgrowth (SIFO), with a mechanistic focus on immune activation and epithelial barrier disruption. We detail contributing factors to and symptoms of SIFO. We further discuss the anatomical positioning and immunological functions of mast cells within the lamina propria, highlighting mast cell activation syndrome, while detailing how SIFO and SIBO can serve as upstream triggers for mast cell activation.Topics:1. The

en

00:15:51

175. Thiamine, Vitamin B1 | Thiamine,...

The Synthesis of Wellness® ·

2025/04/18

In this episode, we detail the role of vitamin B1 (thiamine) in supporting gastrointestinal function, highlighting intestinal motility through vitamin B1's involvement in acetyl-CoA and acetylcholine synthesis. We discuss thiamine insufficiency as well as how small intestinal bacterial overgrowth (SIBO) can further affect thiamine availability. We further detail host defense mechanisms—including gastric acid, pancreatic enzymes, and gastrointestinal motility—that work in concert to regulate

en

00:16:23

174. Connections Between Histamine Intolerance,...

The Synthesis of Wellness® ·

2025/04/11

In this encore episode, we discuss the role of histamine within the gastrointestinal tract, detailing its regulation of gastric acid secretion and impact on intestinal motility. We examine how histamine-producing enterochromaffin-like (ECL) cells, mast cells, and gut microbiota contribute to histaminergic signaling, and how enzymatic degradation via diamine oxidase (DAO) maintains homeostasis. Additionally, we discuss histamine intolerance, highlighting the impacts of dysbiosis (as well as SIBO or

en

00:15:19

173. Gastrointestinal Dysmotility | The Effects of...

The Synthesis of Wellness® ·

2025/04/04

In today's episode, we detail the enteric nervous system and regulation of gastrointestinal motility. We discuss factors including dysautonomia, stress, microbial overgrowth, and more, with regards to potential effects upon gastrointestinal motility. We further detail symptoms of altered GI motility. Topics:1. Introduction to Gastrointestinal Motility- Orchestrated contraction of smooth muscles that propel contents along the digestive tract. - Roles in mixing, absorption, and preventing

en

00:14:37

172. Hypochlorhydria & Small Intestinal Bacterial...

The Synthesis of Wellness® ·

2025/03/28

In this episode, we detail the cellular make-up of the gastric lining, highlighting hydrochloric acid (HCl) secretion and its role in digestion, micronutrient absorption, and microbial defense. We discuss potential pathophysiological consequences of hypochlorhydria, including impaired digestive signaling, bacterial overgrowth in the small intestine (SIBO), and more. Lastly, we detail upstream microbial control, focusing on the influence of the oral microbiome and oral dysbiosis.Topics: 1

en

00:54:43

171. Combating Inflammation and Pain, Supporting...

The Synthesis of Wellness® ·

2025/03/26

We are honored to be joined by Forrest Smith, the CEO and Founder of Kineon. Forrest has a 20-year history of building successful startups in tech hardware. He is passionate about health, wellness, and advancing technology to help others, and he has spent his adult life building remarkable products around innovative supply chain. Aside from his founder position in multiple companies, Forrest has held several positions, from Director of Asian Operations for a Fortune 500 company to Director of

en

00:15:42

170. Intestinal Mycobiome | The Role of Beneficial...

The Synthesis of Wellness® ·

2025/03/21

In this episode, we detail the intestinal mycobiome and the mechanisms by which beneficial microbes aid in regulating opportunistic fungal species: Candida albicans. We discuss Candida overgrowth virulence and how disruptions in microbial balance, immune function, and epithelial integrity impact Candida's pathogenicity. Additionally, we discuss the role of mast cells in the lamina propria, their involvement in mucosal immunity, and how Mast Cell Activation Syndrome (MCAS) can be exacerbated by

en

00:15:01

169. Immunoglobulins in Intestinal Health and Immune...

The Synthesis of Wellness® ·

2025/03/14

In this episode, we detail the role of immunoglobulins in gut-immune function, examining their involvement in mucosal defense, microbial regulation, and immune homeostasis within the intestines. We discuss the mechanisms of antibody production, highlighting how secretory IgA (sIgA) contributes to intestinal barrier integrity and pathogen neutralization. We also detail low secretory immunoglobulin A levels and Candida overgrowth. Lastly, we go through tools to support the gut-immune axis including

en

00:18:37

168. Intestinal Motility and Overlap Among Intestinal...

The Synthesis of Wellness® ·

2025/03/07

In this episode, we detail the pathophysiology of intestinal methanogen overgrowth (IMO), hydrogen-dominant small intestinal bacterial overgrowth (H₂-SIBO), and hydrogen sulfide-dominant SIBO (H₂S-SIBO), discussing their mechanistic interactions and overlap. We discuss methanogenic archaea, as well hydrogen sulfide- and hydrogen-producing microbes and their contributions to altered gastrointestinal motility, epithelial barrier function, and neuromuscular signaling. We detail host endogenous defense

en

00:16:09

167. The Gut-Immune Axis | Gastrointestinal Mucus &...

The Synthesis of Wellness® ·

2025/02/28

In this episode, we detail the gut-immune axis, focusing on the protective mucus layer, antimicrobial peptides, and the role of lactoferrin in intestinal health. We discuss endogenous secretions and how lactoferrin functions as an antimicrobial, immunomodulatory, and iron-regulating glycoprotein, influencing microbial balance and intestinal barrier integrity. Additionally, we highlight lactoferrin testing and levels. We finish by going through supplementation as a phenomenal tool.Topics: 1. The

en

00:19:16

166. Increased Intestinal Permeability &...

The Synthesis of Wellness® ·

2025/02/21

In this episode, we detail the bidirectional relationship between the HPA axis and the intestinal barrier, illustrating how HPA axis dysfunction and cortisol dysregulation can impact intestinal permeability. We further discuss how intestinal dysbiosis can contribute to HPA axis overstimulation. Lastly, we detail some of the roles of short-chain fatty acids (SCFAs) and secretory IgA (sIgA) in this bidirectional relationship.Topics: 1. Overview of the HPA Axis and Gut Bidirectional Relationship-

en

00:17:46

165. Hydrogen Sulfide Dominant Small Intestinal...

The Synthesis of Wellness® ·

2025/02/14

In this episode, we go through the pathophysiology of hydrogen sulfide (H₂S)-dominant small intestinal bacterial overgrowth (SIBO), focusing on its role in intestinal motility disruption, microbial dysbiosis, and epithelial barrier dysfunction. We detail the interplay between the enteric nervous system (ENS), interstitial cells of Cajal (ICCs), and migrating motor complex (MMC) in regulating small intestinal transit and how excess H₂S modulates smooth muscle activity, inflammatory signaling, and

en

00:17:03

164. Intestinal Dysbiosis and The Roles of...

The Synthesis of Wellness® ·

2025/02/07

In this episode, we discuss the relationship between the intestinal mucus layer and secretory immunoglobulin A (sIgA), highlighting both as key components of the gut's first line of defense against pathogens, toxins, and environmental stressors. We detail how dysbiosis and microbial overgrowths can impact sIgA levels and can disrupt mucus integrity and function, contributing to increased intestinal permeability and inflammation. We then examine several additional factors influencing sIgA

en

00:19:00

163. The Gut-Immune Axis & Mycobiome | Intestinal...

The Synthesis of Wellness® ·

2025/01/31

In this episode, we go through the gut-immune axis and mycobiome, focusing on the mechanisms underlying intestinal fungal overgrowth. We highlight the roles of the intestinal mucus layer, intestinal epithelial cells, lamina propria, and secretory immunoglobulin A (sIgA) in maintaining homeostasis and defending against fungal overgrowth. We also detail the pathogenic transition of Candida from its commensal yeast form to an invasive hyphal state, as well as the resulting disruptions to immune

en

00:56:22

162. Supporting Methylation and Optimizing Vitamin...

The Synthesis of Wellness® ·

2025/01/29

We are honored to be joined today by Chris Soppet. Chris is the founder of Spectrum Sciences, a health and wellness brand with the vision of bringing the healing power of vitamin B12 to the greatest number of folks out there. He received his inspiration from his son, who recovered from autism in large part due to the remarkable power of vitamin B12. Chris shares this hope through a very tangible means – The Vitamin B12 Protocol. After using various other B12 products on the market, he was

en

201 results

Similar Podcasts

Доктор Тройняшкин

Доктор Тройняшкин

The Dry Eye Treatment PODCAST

Dry Eye Treatment

Différent et alors ?

PATRICK SULAY

Kyle Kingsbury Podcast

Kyle Kingsbury

The Real Weight Loss Coach

Matty Lansdown