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PODCAST

The Synthesis of Wellness®

Chloe Porter is dedicated to health research and optimization. She is the host of The Synthesis of Wellness ® Podcast; an engineer; and an acclaimed health science speaker, expert, and best-selling author known for her deep dives into gastrointestinal function, functional health, and health optimization.

health & fitness alternative health

All Episodes

00:40:00

201. Supporting Antioxidant Defenses | Phenolic...

The Synthesis of Wellness® ·

2025/11/26

In this episode, we are joined by Dr. Peter Matos who is trained in occupational and preventative medicine and the CEO of O-Liv.Topics: 1. Overview of Phenolic Compounds2. Polyphenols as Antioxidants- Free radicals.- Endogenous vs exogenous antioxidants.3. Olive Phenolic Compounds - Key EVOO phenolics: oleocanthal, hydroxytyrosol, oleuropein.- How phenolic levels differ in the olive fruit, leaf, and oil.- Impact of cultivation, storage, and harvest timing on phenolic levels.- Bioavailability

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00:14:10

200. Intestinal Mycobiome | Small Intestinal Fungal...

The Synthesis of Wellness® ·

2025/11/21

In this encore episode, we detail Small Intestinal Fungal Overgrowth (SIFO), with a focus on fungal biofilm formation and its role in promoting microbial persistence and evasion of host immune responses. We discuss the phenotypic plasticity of Candida species, as well as biofilm matrices adherent to the intestinal mucosa. We further highlight common symptoms of SIFO as well as the effects of hypochlorhydria, impaired motility, diminished commensal bacterial populations, and weakened mucosal

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00:51:49

199. The Skin Barrier, Skin Health, and Skin...

The Synthesis of Wellness® ·

2025/10/29

In this episode, we are joined by Olga Goldberger, founder of IOKA Skin + Science. Olga holds a Master’s degree in Molecular Biology, and she strived to create a skincare system that applied science to active botanical ingredients that would penetrate the skin and support skin health on the cellular level.Topics: 1. Anatomy and Function of the Skin Barrier- Structure of the epidermis, highlighting the Stratum Corneum.- Role of corneocytes and intercellular lipids in barrier integrity. 2. Emulsifiers

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00:14:59

198. Small Intestinal Bacterial Overgrowth &...

The Synthesis of Wellness® ·

2025/09/19

In this encore episode, we detail hypochlorhydria while reviewing gastric lining anatomy, highlighting hydrochloric acid (HCl) secretion and its role in digestion, micronutrient absorption, and microbial defense. We discuss potential downstream effects of hypochlorhydria, including impaired digestive signaling, bacterial overgrowth in the small intestine (SIBO), and more. Lastly, we detail upstream microbial control, focusing on possible influences of the oral microbiome and oral dysbiosis.Topics:

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00:15:48

197. Hydrogen Sulfide-Dominant SIBO |...

The Synthesis of Wellness® ·

2025/09/12

In this encore episode, we detail hydrogen sulfide (H₂S)-dominant small intestinal bacterial overgrowth (SIBO), focusing on intestinal motility. We briefly review anatomy, focusing on and detailing the interplay between structures supporting motility. Lastly, we detail possible symptoms of hydrogen sulfide-dominant SIBO as well as possible overlap between or among subtypes.Topics:1. Introduction to Hydrogen Sulfide-Dominant SIBO - Overview of hydrogen sulfide (H₂S) SIBO - H₂S production -

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00:15:22

196. The Stomach, Gastric Acid, & Vitamin B12 | With...

The Synthesis of Wellness® ·

2025/09/05

In this encore episode, we highlight the stomach's role in vitamin B12 absorption and bioavailability, detailing the cellular composition of the gastric mucosa and further highlighting mucous cells, parietal cells, and chief cells. We also briefly discuss Helicobacter pylori and common symptoms, while detailing H. pylori's potential impacts on the gastric mucosal barrier. Topics:1. Introduction- Overview of the stomach's role in B12 absorption- Helicobacter pylori 2. H. pylori Overview-

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00:44:54

195. Histamine Intolerance and Diamine Oxidase...

The Synthesis of Wellness® ·

2025/09/03

In this episode, we are joined by Helmut Schmutz. Helmut developed the original, patented diamine oxidase formulation, and his work serves as a driving force in the innovation at OmneDiem. Topics: 1. Histamine- Exogenous versus endogenous histamine.- Mast cells as a source of endogenous histamine.- Endogenous histamine signaling needed for diverse physiological functions.- Intestinal microbes as a source of histamine production.- Food as a source of histamine.2. Dietary Histamine- Foods higher in

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00:18:29

194. The Oral-Gut Axis | The Oral Microbiome and The...

The Synthesis of Wellness® ·

2025/08/22

In this encore episode, we detail the oral-gut microbiota axis, detailing the oral microbiome and its relationship with the intestinal microbiome. We discuss the development of oral biofilm, the transition from plaque to dental calculus, and potential impacts of oral dysbiosis, while highlighting intestinal health and focusing on Fusobacterium nucleatum. Topics:1. Overview of the Oral Microbiome and the Oral-Gut Axis - The oral cavity and the gut: microbially dense sites. - Anatomically distinct but

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00:15:06

193. The Intestinal Mucosal Barrier &...

The Synthesis of Wellness® ·

2025/08/15

In this episode, we detail the structure and function of the intestinal mucosal barrier, highlighting key roles that zinc plays in supporting various aspects of mucosal barrier integrity. We detail key anatomical features, including the mucus layer, epithelial cells, and tight junctions, before discussing zinc’s physiological roles, its relationship with copper, and factors that can affect zinc levels. The discussion further details mechanistic features of zinc absorption as well as specialized

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00:51:59

192. Integrative Dermatology, Eczema, Acne, & The...

The Synthesis of Wellness® ·

2025/08/13

We are honored to be joined today by Dr. Barbara Paldus. Dr. Barbara Paldus is a scientist, serial entrepreneur, and the founder of Codex labs. She holds over 50 US patents and has started multiple companies in various industries, including climate monitoring and biotechnology. She hasdeveloped Codex Labs in order to deliver affordable, clinically proven skin-gut-brain solutions that support the gut microbiome and healthy skin, without sacrificing sustainability. Topics: 1. Eczema- Characteristic

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00:14:24

191. The Gut-Immune Axis | Intestinal Secretory IgA,...

The Synthesis of Wellness® ·

2025/08/08

In this encore episode, we detail the gut-immune axis, focusing on the protective mucus layer and the roles of secretory immunoglobulin A and lactoferrin in intestinal health. We discuss endogenous secretions as well as highlight lactoferrin testing and levels. Topics: 1. The Intestinal Barrier & Mucus Layer- The intestinal lumen, microbiome, mucus layer, epithelial cells, and lamina propria.- The mucus layer: antimicrobial peptides (AMPs) and secretory IgA (sIgA).- Intestinal epithelial cells

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00:15:00

190. IMO, SIBO Subtypes | Interactions Among...

The Synthesis of Wellness® ·

2025/08/01

In this encore episode, we detail overlap among intestinal methanogen overgrowth (IMO), hydrogen-dominant small intestinal bacterial overgrowth (H₂-SIBO), and hydrogen sulfide-dominant SIBO (H₂S-SIBO), discussing their mechanistic interactions. We discuss methanogenic archaea, as well hydrogen sulfide- and hydrogen-producing microbes and their contributions to altered gastrointestinal motility, epithelial barrier function, and neuromuscular signaling. We detail host endogenous defense mechanisms,

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00:17:57

189. Gastrointestinal Motility | The Role of Vitamin...

The Synthesis of Wellness® ·

2025/07/25

In this encore episode, we highlight the role of vitamin B1 (thiamine) in supporting gastrointestinal function, focusing on intestinal motility while detailing vitamin B1's involvement in acetyl-CoA and acetylcholine synthesis. We discuss thiamine insufficiency as well as how small intestinal bacterial overgrowth (SIBO) may further affect thiamine availability. We further detail host defense mechanisms—including gastric acid, pancreatic enzymes, and gastrointestinal motility—that work in concert

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00:14:47

188. The Stomach | Symptoms of H. pylori &...

The Synthesis of Wellness® ·

2025/07/18

In this episode, we detail connections between H. pylori and hypochlorhydria, while highlighting possible downstream effects on nutrient absorption. We examine how reduced gastric acidity can impair the liberation and assimilation of certain micronutrients, including iron, calcium, vitamin B12, and more; and we further discuss the impact of low stomach acid upon downstream digestive enzyme activation and gut microbial balance. The discussion also highlights the role of compromised gastric acidity in

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00:14:52

187. Intestinal Mycobiome | Small Intestinal Fungal...

The Synthesis of Wellness® ·

2025/07/11

In this episode, we detail Small Intestinal Fungal Overgrowth (SIFO), with a focus on fungal biofilm formation and its role in promoting microbial persistence and evasion of host immune responses. We discuss the phenotypic plasticity of Candida species, as well as biofilm matrices adherent to the intestinal mucosa. We further highlight common symptoms of SIFO as well as the effects of hypochlorhydria, reduced pancreatic enzyme and bile output, impaired motility, diminished commensal bacterial

en

00:14:28

186. The Gut-Immune Axis, Intestinal Barrier...

The Synthesis of Wellness® ·

2025/07/04

In this encore episode, we highlight vitamin D₃ in gastrointestinal health, with a focus on intestinal barrier function and the gut-immune axis. We discuss how vitamin D is metabolized into its active form, 1,25-dihydroxyvitamin D, and how 1,25-dihydroxyvitamin D can support the intestinal mucosa, while highlighting the intestinal epithelium and immune cells in the lamina propria. Through this, we further detail the role of regulatory T cells in supporting immune balance and modulating immune

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00:15:19

185. Gastrointestinal Dysmotility | The Effects of...

The Synthesis of Wellness® ·

2025/06/27

In this encore episode, we detail the enteric nervous system and regulation of gastrointestinal motility. We discuss factors including dysautonomia, stress, microbial overgrowth, and more, with regards to potential effects upon gastrointestinal motility. We further detail symptoms of altered GI motility. Topics:1. Introduction to Gastrointestinal Motility- Orchestrated contraction of smooth muscles that propel contents along the digestive tract. - Roles in mixing, absorption, and preventing

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00:12:54

184. Hypochlorhydria & Small Intestinal Bacterial...

The Synthesis of Wellness® ·

2025/06/20

In this encore episode, we detail the cellular make-up of the gastric lining, highlighting hydrochloric acid (HCl) secretion and its role in digestion, micronutrient absorption, and microbial defense. We discuss potential pathophysiological consequences of hypochlorhydria, including impaired digestive signaling, bacterial overgrowth in the small intestine (SIBO), and more. Lastly, we detail upstream microbial control, focusing on the influence of the oral microbiome and oral dysbiosis.Topics: 1

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00:12:31

183. The Gut-Immune Axis | Gastrointestinal Mucus &...

The Synthesis of Wellness® ·

2025/06/13

In this encore episode, we detail the gut-immune axis, focusing on the protective mucus layer and the role of lactoferrin in intestinal health. We discuss endogenous secretions and how lactoferrin functions as an antimicrobial, immunomodulatory, and iron-regulating glycoprotein, influencing microbial balance and intestinal barrier integrity. Additionally, we highlight lactoferrin testing and levels. We finish by going through supplementation as a phenomenal tool.Topics: 1. The Intestinal Barrier

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00:13:49

182. Hydrogen Sulfide Dominant Small Intestinal...

The Synthesis of Wellness® ·

2025/06/06

In this encore episode, we go through the pathophysiology of hydrogen sulfide (H₂S)-dominant small intestinal bacterial overgrowth (SIBO), focusing on its role in intestinal motility disruption, microbial dysbiosis, and epithelial barrier dysfunction. We detail the interplay between the enteric nervous system (ENS), interstitial cells of Cajal (ICCs), and migrating motor complex (MMC) in regulating small intestinal transit and how excess H₂S modulates smooth muscle activity, inflammatory signaling,

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201 results

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