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PODCAST

The ReProgram

Dr. George Murphy

The ReProgram is dedicated to exploring how we can extend the healthy human lifespan through science and self-understanding. Hosted by Dr. George Murphy, each episode dives into the rapidly evolving fields of aging biology, longevity, regenerative medicine, and geroscience. From cellular rejuvenation and advanced therapeutics to lifestyle strategies that build resilience against disease, we examine what the science actually shows—and what it doesn’t. No hype. No myths. Just rigorous, evidence-based

science life sciences

All Episodes

00:27:30

Peptides for Longevity: What No One Tells You About...

The ReProgram ·

2026/03/23

In this episode—Part 3 of the Peptides 101 series—we move beyond healing and performance to examine one of the most compelling and misunderstood frontiers in modern medicine: longevity and anti-aging peptides.But this is where the conversation changes.Because using peptides to recover from injury is fundamentally different from using them to modify the trajectory of aging itself.In this episode, we break down the biology behind commonly discussed longevity peptides—including Epitalon, MOTS-c, and

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00:25:09

The Secret Lives of Super Agers: What 100-Year-Olds...

The ReProgram ·

2026/03/09

ReProgram Episode 10In this insightful interview, Dr. Stacy Andersen, a behavioral neuroscientist and expert in aging research, shares her journey into the study of exceptional longevity, the characteristics of centenarians, and the biological and lifestyle factors that contribute to healthy aging. Discover how resilience to disease, genetic protective factors, and lifestyle choices intertwine to shape the future of longevity.Keywordslongevity, centenarians, healthy aging, resilience, genetics,

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00:28:05

Can We Measure Aging? The Truth About Biological...

The ReProgram ·

2026/02/23

ReProgram Episode 9In this episode of the Reprogram podcast, Dr. George Murphy interviews Dr. Nicholas Skivir, an expert in biological aging clocks. They discuss the differences between biological and chronological age, the complexities of measuring aging, and the construction and application of biological aging clocks. The conversation delves into factors influencing biological age, the role of disease in aging, and the potential future applications of biological aging clocks in clinical practice

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00:28:13

Peptides for Healing & Performance: BPC-157, TB-500 &...

The ReProgram ·

2026/02/09

In this episode of Peptides 101, Dr. George Murphy delves into the application of peptide science in real-world scenarios, focusing on the distinction between peptides as signals versus supplements. He discusses the compelling nature of healing peptides, particularly BPC 157 and TB 500, and the importance of understanding the scientific evidence behind their use. The conversation emphasizes the gap between anecdotal claims and clinical data, urging listeners to approach peptide use with caution and

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00:18:29

Peptides 101: The Biology Behind the Hype

The ReProgram ·

2026/01/26

The ReProgram Episode 8A: The first in a 3 part series In this episode, Dr. George Murphy delves into the world of peptides, exploring their scientific basis, the misconceptions surrounding them, and the importance of understanding their structure and function. He discusses the differences between natural and synthetic peptides, the manufacturing process, and the potential risks associated with peptide use. The conversation aims to provide clarity in a landscape filled with hype and misinformation,

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00:16:26

Ozempic Isn’t a Weight-Loss Drug | The Real Science...

The ReProgram ·

2026/01/12

The ReProgram Episode 7In this episode of the Reprogram Podcast, Dr. George Murphy explores the rise of GLP-1 drugs like Ozempic, Wegovy, and Mounjaro, discussing their mechanisms, effects on metabolism, and implications for aging and healthspan. He emphasizes that these drugs are not merely weight loss solutions but agents that act on multiple organs to reprogram how the body regulates energy and hunger. The conversation also addresses the potential benefits and drawbacks of these drugs, including

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00:37:12

Episode 6 - Inside the Aging Brain: Dementia,...

The ReProgram ·

2025/12/29

This episode of the ReProgram podcast, featuring Dr. Benjamin Wolozin, delves into the complexities of neurodegenerative diseases and brain aging, with a focus on Alzheimer's. The discussion covers the diversity of these diseases, diagnostic challenges, and the future of research. The conversation is enriched with personal stories and expert insights, providing a comprehensive understanding of the topic.Keywordsmemory, aging, dementia, Alzheimer’s, cognitive health, sleep, phospho-tau, biomarkers,

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00:29:32

Episode 5 - The Rise of Longevity Clinics

The ReProgram ·

2025/12/16

In this episode of the Reprogram podcast, Dr. George Murphy explores the burgeoning world of longevity clinics, particularly in Thailand, where anti-aging treatments have become mainstream. He delves into the science behind stem cell therapies, the rise of IV drip bars, and the booming aesthetic dermatology industry. The conversation highlights the accessibility and affordability of these treatments in Thailand, while also addressing the potential pitfalls and the importance of navigating this

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00:30:52

Episode 4 - Caloric Restriction, Metabolism, and...

The ReProgram ·

2025/12/01

In this episode of the Reprogram Podcast, Dr. George Murphy hosts Dr. Rozalyn Anderson, a leading expert in caloric restriction and metabolism and how they impact healthful aging. They delve into the science of aging, focusing on caloric restriction and its impact on longevity. Dr. Anderson shares her journey from yeast genetics to studying aging in animal models, and finally, to applying what was learned to humans, highlighting the metabolic processes that contribute to aging and how caloric

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00:47:36

Episode 1 - Stem cells and Regenerative Medicine

The ReProgram ·

2025/11/17

In this episode of the Reprogram podcast, Dr. George Murphy and Dr. Gustavo Mostoslavsky delve into the world of stem cells and regenerative medicine. They discuss the fundamental properties of stem cells, their classifications, and the controversies surrounding their use in treatments. The conversation highlights the groundbreaking discovery of induced pluripotent stem cells (iPSCs) and their potential therapeutic applications, as well as the emerging field of organoids. The episode emphasizes the

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00:55:59

Episode 3 - Centenarians and Exceptional Longevity

The ReProgram ·

2025/11/17

In this episode of the Reprogram podcast, Dr. George Murphy hosts Dr. Tom Perls, a leading expert in human exceptional longevity. They discuss Dr. Perls' journey into gerontology, the New England Centenarian Study, and the factors contributing to exceptional longevity. The conversation covers the genetic and environmental influences on aging, the role of centenarians in understanding longevity, and practical advice for living a centenarian-like life.Keywordslongevity, centenarians, aging,

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00:13:51

Episode 2 - The Mystery of Aging

The ReProgram ·

2025/11/17

In this episode of the Reprogram podcast, Dr. George Murphy explores the enigmatic topic of aging, discussing its definitions, cultural significance, and the latest scientific advancements aimed at understanding and potentially reversing the aging process. The conversation delves into the historical obsession with aging, the current state of research, and the implications of emerging therapies.Keywordsaging, science, medicine, longevity, epigenetics, biological clocks, senescence, gene therapy,

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00:06:10

Episode 0 - Introducing The ReProgram Podcast

The ReProgram ·

2025/11/10

In the premier episode of The ReProgram podcast, Dr. George Murphy introduces the concept of reprogramming oneself for resilience against disease and disability. He shares his existential crisis about focusing on disease treatment rather than prevention, leading to a new approach centered on studing dynamic resilience, or our ability to robustly respond to insult and injury. The episode also outlines topics for future discussions, including the history and use of stem cells in regenerative medicine,

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33 results

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