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PODCAST

The ReProgram

Dr. George Murphy

The ReProgram is dedicated to exploring how we can extend the healthy human lifespan through science and self-understanding. Hosted by Dr. George Murphy, each episode dives into the rapidly evolving fields of aging biology, longevity, regenerative medicine, and geroscience. From cellular rejuvenation and advanced therapeutics to lifestyle strategies that build resilience against disease, we examine what the science actually shows—and what it doesn’t. No hype. No myths. Just rigorous, evidence-based

science life sciences

All Episodes

00:43:51

Can We Slow Human Aging? What Would Count as Proof? |...

The ReProgram ·

2026/09/28

🎬 EPISODE OVERVIEWThe Longevity Consortium is mapping the biology of aging. We review the NIH-funded research aiming to delay chronic disease.The NIH-supported Longevity Consortium is a massive effort to understand the biology of aging to reduce risks of cancer, dementia, and frailty. We examine their five core focus areas, ranging from exceptional longevity cohorts to candidate drug screening. Dr. Nik Schork and Dr. George Murphy break down the current strategy for targeting age-related

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00:15:28

Can Magic Mushrooms Change How We Age? The Psilocybin...

The ReProgram ·

2026/09/21

🎬 EPISODE OVERVIEWCould the compound in magic mushrooms influence how we age? Psilocybin research is producing intriguing findings, but changing brain activity, treating depression and extending human life are very different claims.In Episode 27, Dr. George Murphy puts psilocybin through The ReProgram Scorecard. He examines experiments in human cells and aged mice, brain imaging and plasticity studies, inflammatory markers, and clinical research on depression.The episode also explores preliminary

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00:12:27

Ozempic Extended Mouse Lifespan. Does That Change the...

The ReProgram ·

2026/09/14

ReProgram Episode 26: GLP-1 Drugs for Longevity🎬 EPISODE OVERVIEWA drug millions of people already take extended median lifespan by approximately 12% in older female mice. Does that change the case for GLP-1 drugs as longevity therapies?In this update, Dr. George Murphy reopens The ReProgram Scorecard to examine a new Nature study of late-life semaglutide treatment. He explores the survival findings, improvements in physical and cognitive performance, and the questions that determine how broadly we

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00:28:51

The Hidden Dangers of Aging Blood: What You Need to Know

The ReProgram ·

2026/09/07

ReProgram Episode 25: 🩸 YOUR BLOOD MAY BE AGING BEFORE YOU ARE🧠 Episode OverviewBlood aging is often overlooked, but the hematopoietic stem cells inside your bone marrow carry a decades-long history.Your blood is not just a fluid; it is a continuously renewing organ system. As the stem cells that manufacture your blood cells age, they can shift immune composition and increase susceptibility to inflammation. This process is central to understanding how systemic aging actually unfolds, moving beyond

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00:02:21

Start Here: The ReProgram | Longevity Science Without...

The ReProgram ·

2026/08/31

Welcome to The ReProgram.Longevity science moves a lot slower than longevity marketing.The ReProgram explores the biology of aging, longevity drugs, regenerative medicine, nutrition, exercise, biotechnology, and the emerging science that may help us live longer, healthier lives.Mechanism over marketing. Evidence over anecdotes. Trade-offs over hype.Understand Aging. Build Resilience. Extend Healthspan.

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00:29:09

Can We Reprogram Aging? Epigenetics, Cell Identity &...

The ReProgram ·

2026/08/24

🎬 EPISODE OVERVIEWEvery cell in your body contains essentially the same DNA, yet a neuron behaves nothing like a skin cell. So what actually gives a cell its identity — and how permanent is that identity?In this episode, Dr. George Murphy sits down with epigenetics and cellular reprogramming expert Dr. Jose Polo to explore how cells establish identity, how that identity can be rewritten, and what reprogramming really means for aging and rejuvenation.They discuss why cellular reprogramming is not

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00:20:29

Creatine for Longevity? What the Science Actually Shows

The ReProgram ·

2026/08/17

🧠 EPISODE OVERVIEWCreatine is cheap, widely available, and backed by an unusually large body of human research. But its biology extends well beyond the gym.The creatine–phosphocreatine system helps cells rapidly regenerate ATP when energy demand rises—in both muscle and brain.In this episode, we examine the evidence for creatine and muscle preservation, cognition and brain resilience, kidney safety, dosing, and emerging high-dose brain protocols.And most importantly: does any of this make creatine

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00:37:02

Can We Make Our Pets Live Longer? The Science of Pet...

The ReProgram ·

2026/08/10

🐾 EPISODE OVERVIEWThis episode asks a deceptively simple question: Can we actually help our dogs and cats live longer, healthier lives?We explore why companion animals are unusually powerful models of aging, why “one dog year equals seven human years” is biologically wrong, what the Dog Aging Project is revealing, what pet owners can reasonably do today, and where emerging interventions like rapamycin, canine longevity drugs, AIM therapy, and gene therapy fit into the evidence.🔑 KEYWORDSPet

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00:33:59

Can We Reprogram Aging Through Mitochondria? | Dr....

The ReProgram ·

2026/08/03

🧠 Episode OverviewMitochondria are known as the powerhouses of the cell—but energy production is only part of their story.In this episode of The ReProgram, Dr. George Murphy speaks with mitochondrial biologist Dr. Stefan Isaac about mitochondrial DNA, heteroplasmy, stress signaling, mitophagy, genome editing, and the possibility of transferring healthy mitochondria into damaged or aging cells.They also explore a central longevity paradox: more mitochondrial activity may not always be better

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00:15:46

The ReProgram Scorecard: Metformin and Longevity

The ReProgram ·

2026/07/20

🧠 Episode OverviewMetformin is inexpensive, widely prescribed, and supported by decades of clinical experience. It is also one of the most frequently discussed drugs in longevity medicine.But does metformin actually slow human aging?In this episode, Dr. George Murphy puts metformin through The ReProgram Scorecard, examining its biological mechanisms, human evidence, safety, accessibility, and likely value for people with—and without—metabolic disease.The central distinction is context. Metformin

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00:27:11

Dr. Raghav Sehgal: Can We Measure How Fast You Are...

The ReProgram ·

2026/07/13

🧠 Episode OverviewWhat if your age on paper is not the number that matters most?In this episode of The ReProgram, Dr. George Murphy sits down with Dr. Raghav Sehgal at the Gordon Research Conference Systems Aging Meeting in Maine.Dr. Sehgal discusses his work analyzing dozens of putative longevity interventions across epigenetic clocks, why DNA methylation data are uniquely useful for cross-study harmonization, and why some interventions may move aging biomarkers only in specific biological

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00:13:22

Dr. Mimi Shirasu-Hiza: Can Meal Timing Slow Aging?

The ReProgram ·

2026/07/06

🧠 Episode OverviewWhat if aging is shaped not only by what you eat, how much you exercise, or which genes you inherit — but also by when your body does things each day?In this episode of The ReProgram, Dr. George Murphy sits down with Dr. Mimi Shirasu-Hiza at the Gordon Research Conference Systems Aging Meeting in Maine.Dr. Shirasu-Hiza is a Professor of Genetics and Development at Columbia University and an international expert in circadian gene regulation, aging, and health.This conversation

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00:31:16

Dr. Rich Miller: “There Are No Biomarkers of Aging”

The ReProgram ·

2026/06/29

🧠 Episode OverviewWhat if “biological age” as a single number is the wrong way to think about aging?In this episode of The ReProgram, Dr. George Murphy sits down with Dr. Rich Miller at the Gordon Research Conference Systems Aging Meeting in Maine.Dr. Miller is a Professor of Pathology at the University of Michigan and one of the leaders of the Interventions Testing Program, the gold standard for testing longevity interventions in genetically diverse mice.This conversation challenges some of the

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00:25:48

GLP-1 Agonists and Longevity: The First ReProgram...

The ReProgram ·

2026/06/15

🧠 Episode OverviewAre GLP-1 agonists longevity drugs?Not weight loss drugs.Not cosmetic drugs.Not simply appetite drugs.In this episode of The ReProgram, Dr. George Murphy launches a new recurring format: The ReProgram Scorecard — a science-first framework for grading popular longevity interventions through the same lens every time:Mechanistic plausibility.Human evidence.Magnitude of likely benefit.Safety and downside risk.Who may benefit most.Who should be cautious.Cost and accessibility.Longevity

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00:21:43

Can AI Decode Human Aging?

The ReProgram ·

2026/06/01

ReProgram Episode 14AI and Longevity: Hype, Hope, and the Biology of Aging🧠 Episode OverviewWhat if your doctor could look at your bloodwork, medical history, genome, proteins, metabolites, microbiome, and health trajectory - and tell you more than whether you are sick today?Can artificial intelligence decode human aging?AI will not magically cure aging. It will not replace biology. And it will not tell us exactly how to live forever.But it may help us do something incredibly important:See patterns

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00:22:12

NAD and Aging: Did We Get the Story Wrong

The ReProgram ·

2026/05/18

ReProgram Episode 14The NAD Myth? What the New Human Data Really Say🧠 Episode OverviewIn this episode of The ReProgram, Dr. George Murphy takes a critical but balanced look at one of the most popular ideas in the longevity space:That NAD levels decline with age — and that boosting NAD may help slow aging.But new human data challenge one of the most common assumptions behind the NAD story:Whole-blood NAD levels may not decline with age.This episode explores what that finding means — and what it does

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00:44:18

Measuring and Modifying Biological Age: What the...

The ReProgram ·

2026/05/04

ReProgram Episode 13🧠 Episode OverviewWhat does it actually mean to measure your biological age—and can it be changed? In this episode of The ReProgram, Dr. George Murphy sits down with Dr. Jesse Poganik, a leading scientist in the field of biological aging clocks and biomarkers of aging. Together, they unpack the science behind biological age—how it’s measured, what it reflects, and whether it represents a causal driver of aging or simply a readout of deeper biological processes. This conversation

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00:20:26

The Biology of Recovery: Why Adaptation Fails in...

The ReProgram ·

2026/04/20

ReProgram Episode 12Most people think they need to do more.Train harder. Push further. Add more stimulus.But what if the real problem isn’t effort…What if your body can no longer recover from what you’re already doing?In this episode of The ReProgram, Dr. George Murphy reframes aging, performance, and longevity through a different lens:Recovery capacity.Rather than viewing aging as simple decline, this episode explores a more fundamental idea:that aging is the progressive loss of dynamic

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00:24:35

Muscle, Strength and The Biology of Staying Capable

The ReProgram ·

2026/04/06

In this episode of The ReProgram, Dr. George Murphy reframes skeletal muscle as far more than tissue for movement or aesthetics.Muscle is one of the body’s most powerful regulators of metabolic stability, resilience, recovery, and long-term functional independence.This conversation explores why the loss of muscle with age is not simply about weakness—it is a systems-level shift that affects glucose regulation, balance, neuromuscular coordination, recovery from stress, and ultimately how aging is

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00:27:30

Peptides for Longevity: What No One Tells You About...

The ReProgram ·

2026/03/23

In this episode—Part 3 of the Peptides 101 series—we move beyond healing and performance to examine one of the most compelling and misunderstood frontiers in modern medicine: longevity and anti-aging peptides.But this is where the conversation changes.Because using peptides to recover from injury is fundamentally different from using them to modify the trajectory of aging itself.In this episode, we break down the biology behind commonly discussed longevity peptides—including Epitalon, MOTS-c, and

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32 results

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