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PODCAST

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade,Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee -has redefined what’s possible for the human mind and body. After more than a thousand episodes ofBulletproof Radio, he’s taking it to the next level withThe Human Upgrade™- a masterclass inbiohacking, longevity, and performance optimization.Each episode explorescutting-edge science, advanced technology, and proven biohacksto help youupgrade your energy, focus, metabolism, and resilience.You’ll

health & fitness self-improvement

All Episodes

00:15:45

7 Toxic Foods POISONING Your Family's Health (Avoid...

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/13

These "toxic foods" are one of the biggest hidden threats to your health and most people are eating them every single day without realizing it. These cheap industrial foods are marketed as “healthy,” but the truth is they damage your cells, drive inflammation, and speed up aging. In this video, I’m exposing the dark history behind how they ended up in our food system, why regulators don’t protect you, and the toxic process used to make them.I’ll also show you what to cook with instead so you

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00:59:53

The WATER Hack That Boosts Mitochondria by 11%! : 1343

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/10

What if you could improve your mitochondria, oxygen efficiency, and recovery in just 20 minutes a day—by breathing energized water?This episode explores one of the most surprising breakthroughs in biohacking and how it can help you live longer, think clearer, and perform better.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHostDave Aspreytalks withRowena Gates, co-founder ofNanoVi, a therapeutic device backed by biophysics research that

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00:50:25

Digital Twins: The End of Human Drug Testing for...

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/09

AI is transforming medicine at a speed never seen before. In this episode, you’ll discover how digital twins and artificial intelligence will revolutionize drug discovery, eliminate human trials, and personalize your biology for longevity and high performance. Host Dave Asprey breaks down how AI can now simulate virtual cells and tissues, running clinical experiments in minutes instead of years to create truly individualized medicine.Watch this episode on YouTube for the full video

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01:02:39

The Hidden Key to Pain-Free Joints (Longevity Tips) ...

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/07

Most people think about heart disease and metabolism when they talk about longevity, but too few talk about joint health. In this episode, you’ll discover how to biohack your joints to prevent pain, reverse damage, and move like you’re decades younger. Host Dave Asprey reveals how functional movement, core stability, and recovery can transform joint health, helping you maintain pain-free performance for life.Watch this episode on YouTube for the full video

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00:14:05

Remote Work Is Making You FATTER (Do THIS to Stop It)...

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/05

Discover how remote work is quietly wrecking your hormones—and learn simple biohacks to fix posture, light, movement, and meal timing so you can boost energy, burn fat, and restore focus without quitting your job.

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00:10:17

10-Minute Weekly Update : 1339

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/03

This episode delivers five fast biohacking breakthroughs, from debunking apple cider vinegar for fat loss to smarter NMN use, sleep strategies that protect your brain, psilocybin’s lasting reset potential, and an AI tool catching cancer risk earlier.

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01:00:24

How Gravity Shapes Your Body, Brain, and Health : 1338

The Human Upgrade: Biohacking for Longevity &... ·

2025/10/02

Gravity may be the most ignored signal in human biology, and it could be the missing key to unlocking fat loss, brain optimization, and true longevity. In this episode, you’ll learn how Earth’s pull shapes your metabolism, mood, and resilience, and discover practical hacks to fight “gravity intolerance” so you can perform better, live longer, and upgrade every system in your body.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave

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00:47:43

Modafinil Masterclass: Clarity, Drive, and Longevity...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/30

Most people chase fat loss, focus, and energy with caffeine or stimulants, but the real key to brain optimization and human performance is a pharmaceutical nootropic that activates your wakefulness circuits without jitters or a crash. In this episode, you’ll learn how Modafinil upgrades mitochondria, sharpens neuroplasticity, improves metabolism, and extends longevity with evidence-based tools used by elite thinkers, fighter pilots, and world leaders. This is not a sales pitch. It is an

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00:10:37

This Detox Organ Is Blocking Every Diet You Try...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/28

This episode reveals how your liver is the hidden key to fat loss, energy, and hormone balance, and shows you how fixing bile flow and mineral deficiencies can reboot your metabolism at the root cause.

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00:08:02

10-Minute Weekly Update : 1335

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/26

This episode delivers a rapid-fire, source-driven roundup of the top stories in biohacking, longevity science, cutting-edge health tech, and medical freedom—all distilled into actionable insights for your week.

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01:01:47

Should You STILL Be Eating Algae in 2025? (Longevity...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/25

Your mitochondria are the power plants of your cells, and when they break down, you lose energy, brain sharpness, and resilience against aging. In this episode, you’ll learn how to hack your mitochondria to supercharge human performance, prevent decline, and extend longevity with tools that are natural, effective, and backed by decades of research.Watch the condensed video highlight version of this episode (and much more!) on YouTube:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey

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01:03:43

Steven Pinker: Outsmarting an Irrational World : 1333

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/23

Your brain isn’t as rational as you think, and that blind spot can wreck your decision-making, relationships, and even your health. In this episode, you’ll learn how to spot the hidden cognitive traps that even the smartest people fall for, and how to upgrade your thinking so you can perform better, live longer, and make choices that actually serve you.Watch the condensed video highlight version of this episode (and much more!) on YouTube:https://www.youtube.com/@DaveAspreyBPRHost Dave

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00:10:21

How To Clear Brain Fog (Simple Methods) : 1332

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/21

Host Dave Asprey shares the science-backed biohacks he used to clear 15 years of brain fog—restoring mitochondrial energy, optimizing sleep, and upgrading nutrition to regain focus, memory, and mental clarity.

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01:09:25

Lisa Bilyeu: How to hack confidence : 1331

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/19

Lisa Bilyeu joins Host Dave Asprey to reveal how “radical confidence” turns fear, self-doubt, and the inner critic into fuel for growth, entrepreneurship, and lasting impact.

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01:10:28

Biohacking Your Voice? Here's How to Do It : 1330

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/18

If you’ve ever cringed at the sound of your own voice or struggled to hold attention in a room, this episode will change the way you speak and how others respond to you. You’ll discover how vocal tone, breath, and emotion act as biological levers you can train to improve your health, extend your longevity, and build magnetic charisma.Watch the condensed video highlight version of this episode (and much more!) on YouTube:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down

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00:57:29

Tom Cruise’s Secret FEAR Hack (+ Stress Biohacks for...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/16

Host Dave Asprey and Olympic coach Jim Murphy reveal how the Inner Excellence method transforms fear, shame, and stress into resilience, courage, and lasting joy.

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00:16:11

BONUS: How To Reverse Testosterone Decline After 40...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/14

Most men think declining testosterone is just “part of aging,” but in this video I reveal how I naturally raised mine in my 50s—without injections, drugs, or TRT—using biohacks around diet, sleep, and even light to restore energy, drive, and strength.

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00:30:52

Eat THESE Anti-Aging Mushrooms to Live Longer (Paul...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/12

This episode explores how medicinal mushrooms unlock powerful biohacks for anti-aging, longevity, brain performance, and even saving the bees.

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01:03:58

MIT Neuroscientist: The Ultimate Nootropic For Memory...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/11

Want to improve memory, unlock neuroplasticity, and achieve sharper brain optimization? This episode reveals how Transcendental Meditation (TM) functions as one of the most powerful nootropics for human performance, longevity, and resilience.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with neuroscientist and physician Dr. Tony Nader, the global leader of the Transcendental Meditation movement. With an MD and

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00:56:47

How To Deal With The Fear Of Death (Ethics Of...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/09

Suzanne O’Brien is a veteran hospice and oncology nurse, educator, and healthcare innovator.

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