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PODCAST

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade,Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee -has redefined what’s possible for the human mind and body. After more than a thousand episodes ofBulletproof Radio, he’s taking it to the next level withThe Human Upgrade™- a masterclass inbiohacking, longevity, and performance optimization.Each episode explorescutting-edge science, advanced technology, and proven biohacksto help youupgrade your energy, focus, metabolism, and resilience.You’ll

health & fitness self-improvement

All Episodes

00:35:54

3 Longevity Drugs I QUIT (And the 4 I Take Instead) ...

The Human Upgrade: Biohacking for Longevity &... ·

2026/09/01

The 3 "Longevity Drugs" That Fail the Data, and 4 Repurposed Ones Worth ConsideringBack with another solo episode, this one on Big Pharma! Metformin, rapamycin, and statins are three of the most trusted names in longevity, and none of them hold up the way you've been told. This episode breaks down the human data behind the drugs everyone assumes are safe, and reveals four lesser-known repurposed pharmaceuticals that might do more for your metabolism, mitochondria, and lifespan.Watch this

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00:09:43

7 Brain Compounds I Take For Superhuman Focus : 1528

The Human Upgrade: Biohacking for Longevity &... ·

2026/08/30

can you give me a you'll learn section for this episode, similar to this one: You'll also learn: Why your body actively destroys NAD+ faster as you age, and why that's the real driver of fatigue and brain fog How the gap between NAD+ production and destruction widens every year, quietly draining your cellular energy The early signs your NAD+ levels are already too low, from slow-healing skin to workouts that take days to recover from What actually flips your body's NAD+ production back on, and the

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01:13:33

Change Your Morning, Change Your Life! Hal Elrod : 1527

The Human Upgrade: Biohacking for Longevity &... ·

2026/08/28

Dave Asprey interviews Hal Elrod about his updated Miracle Morning book, weaving in candid tangents on diet, masculinity, cancer survival, and morning/evening routines for peak performance.

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01:01:46

Learn THIS And You’ll Become Impossible To Trigger :...

The Human Upgrade: Biohacking for Longevity &... ·

2026/08/27

Jonny Miller on Nervous System Mastery, Grief, and Why High Performers Can't Afford to Stay Stuck in Their HeadsYour nervous system is running every decision, relationship, and reaction in your life, and you won't notice how much it's costing you until something breaks. This episode gives you the exact framework for building real nervous system mastery instead of running on autopilot until it fails.Watch this episode on YouTube for the full video experience:

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01:01:59

Jim Kwik: If You're Using AI Like This, You're...

The Human Upgrade: Biohacking for Longevity &... ·

2026/08/25

Jim Kwik on Memory, AI, and Why Natural Intelligence Beats Artificial IntelligenceYour brain is quietly outsourcing itself to AI, and you won't notice until it's gone. This episode gives you the exact framework to use artificial intelligence as a tool for brain optimization instead of a crutch that erodes your memory, focus, and critical thinking.Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Jim Kwik, one

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00:14:42

The Most Important Longevity Molecule I've Ever Found...

The Human Upgrade: Biohacking for Longevity &... ·

2026/08/23

Dave Asprey explains why declining NAD+ drives aging, fatigue, and cognitive decline, and lays out a diet, fasting, exercise, and supplementation protocol to rebuild it.

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00:35:32

The Scientist Monk: Gurudev Sri Sri Ravi Shankar : 1523

The Human Upgrade: Biohacking for Longevity &... ·

2026/08/21

Dave Asprey sits down with Gurudev Sri Sri Ravi Shankar for a wide-ranging conversation on curiosity, non-dual consciousness, breathwork's power to calm the mind, and using ancient wisdom to address modern problems like violence, disconnection, and fear.

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01:03:07

The Wild New Theory of Cancer (It's GOOD For You?) :...

The Human Upgrade: Biohacking for Longevity &... ·

2026/08/20

Quantum Scientist Patrick Coles Reveals How Tumors Protect Your Mitochondria From Toxic OverloadCancer might not be the enemy your doctor says it is. What if tumors are actually your body's emergency detox system, built on purpose to protect you from something far more dangerous?Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Patrick Coles, Ph.D., Chief Scientist at Normal Computing, where he develops novel

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02:46:40

Scream Cream and Weekly Injections (Double Episode) |...

The Human Upgrade: Biohacking for Longevity &... ·

2026/08/18

Dave Asprey and Gabby Reece Talk Testosterone Therapy, Scream Cream, Autism as a Superpower, Cancer Protocols, and Surviving Fame in This Double Interview EpisodeMega-Episode time! Your hormones might be causingsymptoms you've been blaming on aging,stress, or your heart. This doubleinterview episode gives you a real lookat biohacking fromtwo different angles: cutting-edgelongevity science and the livedexperience of hormone optimizationafter 50.Watch this episode on YouTube for the full

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00:15:10

It's Weird, But It Turns On Your Anti-Aging Switch :...

The Human Upgrade: Biohacking for Longevity &... ·

2026/08/16

Save Up To $600: SUNLIGHTEN.COM/DAVETry TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Most people see chronic fatigue and brain fog as permanent conditions caused by getting older, but this video cuts through that misconception by explaining that these symptoms are actually the direct result of damaged mitochondria piling up inside your cells because a specific longevity switch called mitophagy has

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00:10:54

Depressing Fruit, Vitamin (C)ancer, Sheep Wool, Oral...

The Human Upgrade: Biohacking for Longevity &... ·

2026/08/14

Dave breaks down an FDA-cleared inhaled Alzheimer's trial, a breakthrough in adult brain self-repair, a wool-derived alternative to collagen for bone regeneration, promising oral GLP-1 weight loss data, why the standard exercise guidelines fall far short of real heart protection, and the newly clarified science behind IV vitamin C's anti-cancer effect, closing with what Linus Pauling's fifty-year vindication teaches about revisiting the ideas you gave up on too soon.

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00:41:29

Dave Solo Pod: The Original Smart Drug Masterclass :...

The Human Upgrade: Biohacking for Longevity &... ·

2026/08/13

Piracetam, Racetams & Nootropics: Dave Asprey on the Original Smart Drug, Brain Optimization and How to Biohack Memory, Focus and Cognitive DeclineWe're excited to bring you another Dave solo education masterclass, this one breaking down the molecule that started the entire nootropics industry: RacetamsWatch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey pulls back the curtain on piracetam and the racetam family, the original

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01:11:13

Steven Greer | UAP’s and Remote Viewing Techniques...

The Human Upgrade: Biohacking for Longevity &... ·

2026/08/11

UFOs, UAPs, Non-Human Contact & Zero-Point Energy: Dr. Steven Greer on Government Disclosure, Consciousness and the Truth About Extraterrestrial IntelligenceGetready tohave your entire understanding ofreality challenged. This episodereveals the science behind non-humanintelligence contact, thephysics of consciousness, and why thebiggest secret in human history couldrewrite everything you know aboutenergy, medicine, and human potential.Watch this episode on YouTube for the full video

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00:13:32

300mg Improves Appearance of Wrinkles In 7 Days...

The Human Upgrade: Biohacking for Longevity &... ·

2026/08/09

Skin ages faster when oxidative stress overwhelms your defenses, so this episode explains why glutathione — the body's master antioxidant — protects collagen better than collagen itself, and how a new delivery system (RO-GSH) finally makes topical glutathione work, visibly improving wrinkles and skin tone in just one week.

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00:10:33

Longevity Music, Anti-Aging Nasal Spray, How To Look...

The Human Upgrade: Biohacking for Longevity &... ·

2026/08/07

This week's biohacking roundup covers a drug-repurposing screen for longevity, protein restriction's anti-aging effects via FGF21, a new cadaver-derived skin injectable, arts engagement slowing biological aging, and a review of 41 studies testing biohacking interventions (including semaglutide) against epigenetic clocks.

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01:00:43

Here's How You Can Have a 3-hour Orgasm (real!) : 1514

The Human Upgrade: Biohacking for Longevity &... ·

2026/08/06

The Orgasm Code: How Pleasure Rewires Your Nervous System for Longevity & Healing | Regena Thomashauer (Mama Gena)Most people think pleasure is a distraction from performance. This episode proves the opposite: your orgasm is a biohacking tool wired directly into your nervous system, your hormones, and your longevity.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Regena Thomashauer, known worldwide as Mama

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01:12:44

I Take 150 Pills a Day (But This One Is My Workhorse)...

The Human Upgrade: Biohacking for Longevity &... ·

2026/08/04

The Gut-Lung Axis: The Missing Link in Chronic Inflammation & Aging | Dr. Vivek LalYour lungs have a microbiome, and almost no one is talking about it. This episode reveals the hidden pathway behind asthma, chronic inflammation, and slow aging, and gives you a science-backed way to biohack your breath from the inside out.Get A generous discount on Resbiotic by going to:https://resbiotic.com/and using code ‘DAVE20’Host Dave Asprey sits down with Dr. Vivek Lal, MD, FAAP, a double

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00:13:54

I Wish I Knew This Anti-Aging Hack Sooner : 1512

The Human Upgrade: Biohacking for Longevity &... ·

2026/08/02

This episode explains how aging is driven by declining antioxidant defenses and mitochondrial damage, and makes the case for glutathione—delivered topically via Glutaryl—as a practical way to support cellular repair.

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00:08:49

Chicken Diarrhea, TV Kills You Quicker, CO2 for...

The Human Upgrade: Biohacking for Longevity &... ·

2026/07/31

This episode covers five health research stories: sildenafil's anti-cancer potential, TV watching's effect on brain aging in men, ambient heat's impact on biological aging, superbug risks from industrial chicken farming, and a CO2-based technique to trigger the brain's glymphatic waste-clearance system.

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00:55:24

The $18 Million Pills Nobody Can Explain | Igniton :...

The Human Upgrade: Biohacking for Longevity &... ·

2026/07/30

Inside Igniton: The Quantum Supplement Science Boosting Memory, Sleep, and LongevityThere's a subatomic particle most scientists don't even know exists, and one entrepreneur just spent $18 million building a private lab to prove it can upgrade your longevity, focus, and sleep. This episode goes inside the lasers, vacuum chambers, and cold plasma behind the new science of quantum-charged supplements.Get 15% off your next purchase at: igniton.com/daveHost Dave Asprey sits down with Ashley

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