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PODCAST

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade,Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee -has redefined what’s possible for the human mind and body. After more than a thousand episodes ofBulletproof Radio, he’s taking it to the next level withThe Human Upgrade™- a masterclass inbiohacking, longevity, and performance optimization.Each episode explorescutting-edge science, advanced technology, and proven biohacksto help youupgrade your energy, focus, metabolism, and resilience.You’ll

health & fitness self-improvement

All Episodes

01:01:47

Should You STILL Be Eating Algae in 2025? (Longevity...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/25

Your mitochondria are the power plants of your cells, and when they break down, you lose energy, brain sharpness, and resilience against aging. In this episode, you’ll learn how to hack your mitochondria to supercharge human performance, prevent decline, and extend longevity with tools that are natural, effective, and backed by decades of research.Watch the condensed video highlight version of this episode (and much more!) on YouTube:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey

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01:03:43

Steven Pinker: Outsmarting an Irrational World : 1333

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/23

Your brain isn’t as rational as you think, and that blind spot can wreck your decision-making, relationships, and even your health. In this episode, you’ll learn how to spot the hidden cognitive traps that even the smartest people fall for, and how to upgrade your thinking so you can perform better, live longer, and make choices that actually serve you.Watch the condensed video highlight version of this episode (and much more!) on YouTube:https://www.youtube.com/@DaveAspreyBPRHost Dave

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00:10:21

How To Clear Brain Fog (Simple Methods) : 1332

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/21

Host Dave Asprey shares the science-backed biohacks he used to clear 15 years of brain fog—restoring mitochondrial energy, optimizing sleep, and upgrading nutrition to regain focus, memory, and mental clarity.

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01:09:25

Lisa Bilyeu: How to hack confidence : 1331

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/19

Lisa Bilyeu joins Host Dave Asprey to reveal how “radical confidence” turns fear, self-doubt, and the inner critic into fuel for growth, entrepreneurship, and lasting impact.

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01:10:28

Biohacking Your Voice? Here's How to Do It : 1330

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/18

If you’ve ever cringed at the sound of your own voice or struggled to hold attention in a room, this episode will change the way you speak and how others respond to you. You’ll discover how vocal tone, breath, and emotion act as biological levers you can train to improve your health, extend your longevity, and build magnetic charisma.Watch the condensed video highlight version of this episode (and much more!) on YouTube:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down

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00:57:29

Tom Cruise’s Secret FEAR Hack (+ Stress Biohacks for...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/16

Host Dave Asprey and Olympic coach Jim Murphy reveal how the Inner Excellence method transforms fear, shame, and stress into resilience, courage, and lasting joy.

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00:16:11

BONUS: How To Reverse Testosterone Decline After 40...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/14

Most men think declining testosterone is just “part of aging,” but in this video I reveal how I naturally raised mine in my 50s—without injections, drugs, or TRT—using biohacks around diet, sleep, and even light to restore energy, drive, and strength.

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00:30:52

Eat THESE Anti-Aging Mushrooms to Live Longer (Paul...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/12

This episode explores how medicinal mushrooms unlock powerful biohacks for anti-aging, longevity, brain performance, and even saving the bees.

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01:03:58

MIT Neuroscientist: The Ultimate Nootropic For Memory...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/11

Want to improve memory, unlock neuroplasticity, and achieve sharper brain optimization? This episode reveals how Transcendental Meditation (TM) functions as one of the most powerful nootropics for human performance, longevity, and resilience.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with neuroscientist and physician Dr. Tony Nader, the global leader of the Transcendental Meditation movement. With an MD and

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00:56:47

How To Deal With The Fear Of Death (Ethics Of...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/09

Suzanne O’Brien is a veteran hospice and oncology nurse, educator, and healthcare innovator.

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01:00:01

The Hidden Traps of “Healthy” Eating (Biohacking...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/05

Dave Asprey and Max Lugavere explore sugar’s controversial role as both a performance enhancer and a metabolic disruptor, while unpacking how cooking methods, food quality, and kitchen literacy shape resilience, health, and longevity.

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01:02:41

Sulforaphane, Curcumin, and NEW GLP-1 Drugs...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/04

Most people think broccoli is a superfood, but the reality is more nuanced. In this episode of The Human Upgrade, Host Dave Asprey explores the good and bad of broccoli—why adult broccoli can block thyroid function and cause gut issues, while broccoli seeds deliver sulforaphane, the powerful compound that activates all three of your body’s detox pathways. You’ll learn how sulforaphane protects against glyphosate, repairs leaky gut, and upgrades mitochondria, metabolism, and longevity.Watch

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01:29:29

Mast Cells Explained: Biohacking Inflammation,...

The Human Upgrade: Biohacking for Longevity &... ·

2025/09/02

Millions of people are living with unexplained symptoms like allergies, brain fog, anxiety, and chronic fatigue without realizing the hidden cause: mast cells gone rogue. In this episode of The Human Upgrade, Host Dave Asprey sits down with leading functional medicine physician Dr. Tania Dempsey to uncover how Mast Cell Activation Syndrome (MCAS) drives inflammation, disrupts mitochondria, and sabotages metabolism—and what you can do to switch it off.Watch this episode on YouTube for the

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01:09:44

What Is Uric Acid and How Does It Predict Your...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/29

Dr. David Perlmutter joins Host Dave Asprey to uncover how uric acid acts as a hidden metabolic switch—driving fat storage, disease risk, and longevity—and how simple biohacks like diet shifts, hydration, and targeted tracking can optimize your healthspan.

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01:15:10

Hacking Dopamine Naturally: Pain, Focus, and...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/28

Your dopamine system is being hijacked every day, and the way to reclaim it might surprise you. This episode reveals how pain, pleasure, and addiction are wired in your brain, and how to use that knowledge for real brain optimization, resilience, and longevity. You’ll discover why your dopamine levels control motivation, focus, mood, and even cravings—and the science-backed strategies that reset your neuroplasticity, metabolism, and reward system.Watch this episode on YouTube for the full

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01:46:41

You Have A 25% Chance to Lose All Your Memory...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/26

Alzheimer’s is not inevitable—and it may even be optional. In this groundbreaking episode, you’ll learn how to prevent, slow, and in some cases reverse cognitive decline using strategies that also enhance brain optimization, metabolism, and longevity.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey is joined by Dr. Dale Bredesen, a world-renowned neurologist and leading Alzheimer’s researcher who has published over 240

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00:53:48

The Hormone War Dividing Female and Male Longevity :...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/22

This episode explores how hormonal imbalance between men and women impacts longevity, perception, trust, and performance—through the lenses of biohacking, trauma, and spiritual neurobiology.

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01:07:06

The 10-Second At-Home Walk Test for Longevity (Easy...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/21

Walking speed predicts your risk of death better than cholesterol—and this episode reveals why. You’ll learn how to test your biological age at home in just 10 seconds, and how to use that information to upgrade your human performance, extend your longevity, and tailor your biohacking strategy for maximum results. Discover the overlooked role of pelvic floor strength, glute activation, and neuromuscular training in brain optimization, metabolism, and injury prevention.Watch this episode on

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01:08:04

PhD at MIT: The Longevity Molecule That Reverses...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/19

Learn how to slow, and even reverse, your biological age with cutting-edge science on the molecule that controls your longevity. Host Dave Asprey sits down with Dr. Leonard Guarente, an MIT PhD and one of the most respected longevity researchers in the world, to reveal how NAD+, sirtuins, and DNA methylation clocks can help you hack aging, upgrade your mitochondria, and extend your healthspan. This episode gives you the real science, proven by over 250 studies, behind supplements,

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00:59:50

Still Fasting in 2025? Here’s How to Make It Work...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/15

How do you activate your body’s natural repair system? How can you hack stem cells for faster recovery, brain optimization, and peak human performance? This episode reveals how to trigger stem cell release, direct them to the right tissues, and stack biohacking tools for maximum regeneration. You’ll learn science-backed strategies for boosting mitochondria, enhancing neuroplasticity, and extending longevity through targeted supplements, fasting, and functional medicine techniques.Watch this

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220 results

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