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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

08:00

🧬 Mito Moms. Safe Starts. Healthy Babies. The Promise...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/19

🚨 New Podcast Alert! 🎙️🧬 Curious about how modern medicine is tackling devastating mitochondrial DNA diseases like MELAS, LHON, and NARP? Our latest podcast dives into four landmark NEJM articles covering cutting-edge advances—from embryo screening (PGT) to groundbreaking mitochondrial replacement therapy (MRT). 🧪👶 Join us as we explore science, ethics, and hope at the frontier of germline medicine.⚖️💡 #MitochondrialMedicine #Genetics #PrecisionMedicine #ReproductiveHealth #NEJM #Podcast

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02:50

Flatlines to Frontlines ⚡️🫀🧬: ECG-AI Fusion Detect...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/18

🚨 AI meets ECG 🧠⚡ New insights show that a simple ECG — when powered by deep learning — can detect structural heart diseases like LV systolic dysfunction, HCM, and aortic stenosis with AUROCs >0.90! 🫀📈 📊 Sample size: 54,000+ | NPV >98% | p < 0.001 ✅ Low-cost, non-invasive, high-accuracy screening? Yes, please. 🧠 Time to rethink the ECG as a frontline diagnostic tool. #Cardiology #ArtificialIntelligence #ECG #StructuralHeartDisease #DigitalHealth #MedTech #MachineLearning #HCM #LVSD

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07:31

🤔Pee Points & Prostate Problems: What Docs Should Know

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/18

New Podcast Episode Alert! 🎙️ “💧Block, Burst, or Both?💥 Understanding Male LUTS” Up to 40% of men over 50 face lower urinary tract symptoms—from weak stream to nocturia. This week, we unpack the landmark JAMA 2025 review by Drs. Wei, Dauw, and Brodsky. 🧠💊 Tune in as we explore: 🔹 BPH vs Overactive Bladder 🔹 When to treat—and how 🔹 Meds, muscles, and minimally invasive magic 🔹 What every clinician should know before referring 🚑 🎧 Whether you’re a primary care doc, urologist, or just

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04:47

Wall Thick? Echo Quick! AI Picks! 🧱🔁🤖

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/17

🚀 Just out in European Heart Journal! A novel AI model detects cardiac amyloidosis 🫀 using only a single apical 4-chamber echo clip 🎥🤖 Trained on a multiethnic, multisite cohort 🌍, this deep learning tool achieved AUROC 0.93—outperforming traditional risk scores like TCAS and IWT 📈💥 💡 Smarter screening, faster referrals, fewer missed diagnoses. 🔗 Read more and explore how AI is reshaping heart failure diagnostics👇 #Cardiology #AIinMedicine #Echocardiography #HeartFailure

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03:05

🔥 Wakeful Sparks, 🧠 Tired Minds, 🧯 Sleep’s Mito Fix

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/17

🧠✨ New Insights into Why We Sleep! ✨🛏️ Just read a groundbreaking study in Nature showing that leaky mitochondria in sleep-inducing neurons (dFBNs) drive the pressure to sleep! 😴🧬 Turns out, electron overflow and oxidative stress during wakefulness aren’t just metabolic side effects—they’re biological signals telling the brain it’s time to rest. 🔋➡️💥➡️🛌 Mitochondrial fission decreases sleep, fusion promotes it, and sleep literally resets neuronal metabolism. A must-read for anyone

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04:20

📊 Polygenic Risk Scores, 💉 Biomarkers, ❤️ Prevention:...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/16

🚨 New Insights on Heart Attack Risk! 🧬❤️ A must-read from Circulation: Genomic and Precision Medicine—Bhattacharya et al. show that Polygenic Risk Score (PRS) rivals traditional giants like hypertension in predicting MI! 💥 📊 With an R² loss of 12.4% and PAR of 38.4%, PRS isn’t just academic—it’s actionable. Add in hsCRP and Lp(a), and we’re entering a new era of CAD risk stratification. 🔍 From base to full model: ➡️ R²: 0.021 → 0.053 ➡️ C-statistic: 0.65 → 0.73 ➡️ PAR: 84.3% Let’s

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04:09

💪🍊 “Flavonoid Fightback: Apigenin Saves Muscle, Not...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/16

🚨 New Research Alert! 💡 Just explored a fascinating preclinical study on apigenin 🧪—a flavonoid found in parsley & chamomile 🌿—that prevents muscle loss in aging, obese rats 🐀💪. 📉 While it didn’t stop weight gain or fat buildup, apigenin boosted muscle mass, reduced fibrosis 🦵, and activated anabolic signaling (p70S6K) 🔁. 💊 Could this be a future nutraceutical for sarcopenic obesity and healthy aging? More clinical research needed—but the signal is strong. 🚦 #Apigenin #Flavonoids

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04:29

“Shock, Sync, Save 🫀: 2025 AUC Updates Explained”

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/15

🚨 New in 2025! The ACC/AHA Appropriate Use Criteria for ICDs, CRT, and Pacing just got a major upgrade! 🫀📊 Covering 335 real-world scenarios, this document is your go-to guide for when (and when not) to implant. 💡 What’s 🔥 in the update? ⚡ Leadless & conduction system pacing 🔁 CRT refined for better outcomes 🧠 Smart use in LVADs, post-transplant, & more 👩‍⚕️ Clinicians: Make device decisions with clarity, confidence, and evidence. 📥 Download our podcast + slides to stay ahead.

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03:00

Dr. RR Baliga’s Philosophical Discourses: : Adi...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/15

🧘‍♂️📿 Discover the timeless wisdom of Adi Shankaracharya (788–820 CE) — the master of Advaita Vedanta who redefined spirituality with concepts like Atman, Brahman & Sanyasa. His teachings on non-duality still inspire seekers worldwide. 🌍📚 #Philosophy #Vedanta #Spirituality

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05:27

Coronary Plaque Rupture. Erosion. Revelation. 🔬🫀🧠

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/14

🫀 New insights from Covani et al. and Ben-Yehuda’s editorial reveal a striking paradox: more cardiovascular risk factors 🔥 = more plaque rupture, but less erosion! 🧊 Using OCT imaging, they show how traditional risks drive inflammatory, rupture-prone plaques, while erosion may follow a different path altogether—less lipid, less inflammation, more mystery. 🧬 🎯 Takeaway: Precision prevention must evolve. Not all plaques (or patients) follow the same script. 🔗 Dive into this convergence of

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02:49

🌫️ The Exposome Effect: What’s in Your Air, Food, and...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/14

🌍🔬 What’s shaping your health beyond your genes? Introducing our latest Got Knowledge Doc podcast episode: “Beyond Genes, Beneath the Skin 🧬🌫️” — a deep dive into the exposome, the totality of your environmental exposures from womb to tomb. From microplastics to sleep, PFAS to social stress, we’re mapping the missing link in precision medicine. 🎧 Tune in to explore why the future of health might depend less on your DNA and more on your data trail. 🧠 Prevention. 📊 Policy. 💊

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03:02

💓 TREGs, Fibrosis & Hope: Rewiring the HCM Heart

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/13

🚨 New Insights in Hypertrophic Cardiomyopathy (HCM)! 💓 Groundbreaking research shows that regulatory T cells (TREGs) can reduce fibrosis, suppress inflammation, and even improve heart function in HCM 🧬🛡️ From adoptive TREG transfer to IL-2 therapy, immunomodulation is emerging as a promising strategy alongside genetic and myosin-targeted treatments 💉📉 🧠 A must-read for cardiologists, immunologists & translational researchers! 📄 Wang et al., Sci. Transl. Med. 2025 🔗 #Cardiology #HCM

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02:29

💤🧠 Flush, Sleep, Forget: The Glymphatic Code in...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/13

🧠💤 Just dropped our latest Got Knowledge Doc podcast: “Flush, Sleep, Forget: The Glymphatic Code in Alzheimer’s Disease” 🧬🎧 We explore how the brain’s nighttime rinse cycle clears toxic proteins like amyloid β and tau—and what happens when that system breaks down. From rodent models to human MRI, it’s a story of sleep, science, and hope. 🌙🔬 Listen in to learn how advancing glymphatic research might open doors to early detection and prevention of Alzheimer’s. 🧪🧩 #AlzheimersDisease

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04:21

Gut Talks to the Heart 🥗💓🧠: The Incretin Connection

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/12

🚨 New Podcast Episode! 🎙️ “Gut Talks to the Heart 🥗💓🧠: The Incretin Connection” Did you know that GLP-1 and GIP do far more than control blood sugar? These humble gut hormones orchestrate perfusion, reduce inflammation, protect the brain, heart, kidneys—and may even slow cognitive decline. 💊 From diabetes care to cardio-renal-neuro protection, incretin-based therapies are rewriting the rules of metabolism. 🔗 Tune in to learn how your next meal could be triggering an endocrine symphony

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03:55

👄 Mouths Heal Better: What Your Skin Can Learn from...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/12

Exciting new insights from Science Translational Medicine (2025)! Researchers uncovered how the GAS6–AXL–FAK axis determines whether wounds heal with scars or regeneration. 🧬💉 💡 Activating AXL with GAS6 rewires fibrotic healing into scarless repair — especially in the oral mucosa. 💥 Blocking AXL flips the script, leading to fibrosis even in normally regenerative tissues. This could revolutionize how we approach scar prevention and tissue regeneration. 🩹✨ #RegenerativeMedicine

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04:53

☕ Evidence Per Cup: Coffee and Cardiovascular Outcomes

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/11

☕💓 Is your daily brew helping or harming your heart? New evidence from a comprehensive European Heart Journal review suggests that moderate coffee consumption (1–4 cups/day) is linked to reduced risks of hypertension, type 2 diabetes, coronary artery disease, heart failure, stroke, and even mortality. 🧬 Benefits often persist regardless of caffeine content, and filtered coffee appears safest for lipid profiles. ⚠️ But beware: excessive intake and unfiltered brews may raise LDL. 📊 Great read

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03:17

Longevity’s Guardians?: The Brain and Immune System Duo

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/11

🧠🧬 New research alert! Plasma proteomics from 44,000+ UK Biobank participants reveals that the brain and immune system are powerful predictors of longevity. A youthful brain and immune system cut mortality risk nearly in half—more so than any other organ. This could reshape how we think about aging, diagnostics, and preventive medicine. 📊 Machine learning + blood proteins = next-gen aging biomarkers. 🔗 Study link: https://doi.org/10.1038/s41591-025-03798-1 #Longevity #Proteomics

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04:42

Five to Thrive: Slash Your Cardiovascular Disease...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/10

📣 New insights from a global study on cardiovascular disease! 🌍❤️ Even without traditional risk factors, your lifetime risk of CVD isn’t zero — but midlife action can add a decade or more of healthy life. 🧠💡 Key takeaway: Knowing is not enough — we must apply. 🩺📊✅ #CardiovascularHealth #PreventionMatters #GlobalHealth #PrecisionMedicine #PublicHealth 💪🌎🧬

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02:46

Fat Depot Drama: From Swell to Well 🏕️📉😊

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/10

🔬 Just read a fascinating News & Views in Nature on how weight loss reshapes adipose tissue beyond just shedding fat! 🧬 Using single-nucleus RNA-seq and spatial profiling, researchers found that bariatric surgery reverses stress, inflammation, and senescence in fat depots—yet some immune memory lingers. 🧠🔥 A compelling case for adipose plasticity—and why cellular “memory” may be the key to sustained metabolic health. 💡💪 #ObesityResearch #AdiposeRemodeling #WeightLossScience #Senescence

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03:23

Sugar Switches: HFpEF’s Hidden Code 🧩🫀🧬

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/09

🧠💓 Just read a fascinating new study in Cell Metabolism (July 2025): dislocation of hexokinase 1 from mitochondria increases O-GlcNAcylation in endothelial cells — a hidden driver of HFpEF! Reversing this sugar-tagging with OGA overexpression or OGT inhibition restores heart function in mice. Precision metabolism meets cardiology. 🔬❤️‍🔥 #HFpEF #OGlcNAcylation #EndothelialDysfunction #CardioResearch #MetabolicTherapeutics #CellMetabolism

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