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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

06:44

Renal Nerves 🔥 Blood Pressure 💉 Device Therapy 🚀

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/20

💡 Renal Denervation: A New Era in Hypertension Care 🩺 Despite decades of effective medications, only ~25% of patients worldwide achieve blood pressure control. Non-adherence remains a huge barrier. 📉 This Nature Reviews Cardiology article (Fisher & Kirtane, Sept 2025) explores the journey of renal denervation (RDN) — from Smithwick’s sympathectomy in the 1950s to today’s FDA-approved radiofrequency 🔥 and ultrasound 🔊 catheter systems. ✅ Sham-controlled trials show RDN lowers BP by 5–10

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06:02

Diverticulitis 📊🔬💊: Patterns, Pitfalls, and Practice

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/20

📘 New Insights on Diverticulitis 📊🔬💊 Did you know that while 1–4% of people with diverticulosis develop diverticulitis, it still accounts for ~200,000 hospitalizations annually in the US and >$6.3B in healthcare costs? 🚑💰 ✅ CT scan remains the gold standard for diagnosis 🖼️ ✅ Observation & pain control are first-line for uncomplicated cases 💊 ✅ Antibiotics reserved for high-risk groups (elderly, immunocompromised, pregnant, systemic illness) ⚠️ ✅ Surgery indicated for recurrent or

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06:24

Hypertension: Old Foe 🥊, Novel Therapies 🛡️, Brighter...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/19

🚨 Hypertension remains the world’s #1 killer — yet fewer than 1 in 4 patients achieve control. 💊 Exciting innovations are reshaping the field: ✔️ Aprocitentan (endothelin receptor antagonist) – first new class in decades ✔️ siRNA (zilebesiran) – 6-monthly dosing, tackling adherence ✔️ Aldosterone synthase inhibitors – overcoming “aldosterone escape” ✔️ Non-steroidal MRAs & neprilysin inhibitors – precision targeting with broader benefits ✔️ Single-pill & quadpill combos – simplifying therapy,

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04:21

Dr RR Baliga's Philosophical Discourses: Ramanuja...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/19

🌟 Ramanuja (1017–1137 CE), one of India’s greatest theologians, shaped Vishishtadvaita Vedanta (Qualified Non-Dualism). His vision of Atman (self) and Brahman (supreme reality), united through bhakti (devotion), transformed Hindu theology and inspired generations. 🕉️📖 💡 His commentaries on the Upanishads, Bhagavad Gita, and Brahma Sutras laid the foundation of Sri Vaishnavism and emphasized a path of devotion, grace, and liberation (moksha). ✨ 🙏 A reminder for today’s healthcare providers

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03:43

👥 Risk, Representation, Reality: Rethinking CVD...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/18

🧬 South Asians make up 25% of the world—yet just 3% of major cardiovascular trials. A new systematic review (310 RCTs, 1M+ participants) reveals stark underrepresentation, especially outside India. No South Asians in trials for heart failure, cardiac arrest, or valvular disease. 📉 The data gap is real—and it’s limiting care. 🔍 We need global trial designs that are inclusive, disaggregated, and powered for equity. Let’s change the research playbook. 💡 #CardioTrials #SouthAsianHealth

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04:47

🏙️ Steps, Cities, Change: How Urban Design Boosts...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/18

🚶‍♀️📲 New research alert! A massive natural experiment tracking 7,447 relocations across 1,609 US cities reveals that urban walkability directly boosts physical activity 🏙️💪 📈 Moving to more walkable cities increased daily steps by ~1,100 and doubled compliance with MVPA guidelines! 🎯 A powerful case for urban design as preventive medicine. 🔗 A must-read for public health advocates, city planners, and digital health innovators! #Walkability #UrbanHealth #DigitalEpidemiology #MVPA

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08:45

ENaC ⚙️ RAAS ⚡ Immunity 🧬: The Gender Divide in...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/17

🧂 Salt sensitivity of blood pressure (SSBP) is an independent risk factor for CVD. 🚹🚺 Women are more salt-sensitive than men, especially after menopause. ⚙️ Key drivers: RAAS, ENaC, natriuresis, and immune pathways. 💉 Estrogen protects, testosterone raises pressure, menopause tips the balance. 🐀 From Dahl’s rats to Conn’s syndrome, SSBP research shows why sex-specific, personalized therapy is the future of hypertension care. 🔗 Nature Reviews Cardiology

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06:26

Fatty Liver, Failing Heart, Future Risks 🍔🫀⚠️

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/17

Liver, Lipids, and the Left Ventricle 🩸🫀🧬 The NEJM review reminds us that fatty liver isn’t just a liver problem. MASLD drives risk for heart disease, diabetes, kidney dysfunction, and even cancers. 🚨 Cardiovascular disease remains the leading cause of death in MASLD—outpacing cirrhosis and cancer. 🫀💔 With new tools like FIB-4, VCTE, ELF, and promising drugs such as resmetirom and GLP-1/GIP agonists, we’re entering an era where treating the liver can protect the heart. 💊🌱 #MASLD

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04:45

⚖️ Switch or Stay? DOACs vs Warfarin in Frail AF...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/16

🧓💊 The COMBINE-AF substudy offers important guidance for managing frail, elderly, VKA-experienced patients with atrial fibrillation. Switching to standard-dose DOACs reduced stroke/systemic embolism risk and cut intracranial & fatal bleeding 🧠🛡️, but raised gastrointestinal bleeding rates 🍽️🩸—especially with certain agents. Sensitivity analyses show apixaban & edoxaban may offer a safer bleeding profile. These findings highlight the need for shared decision-making ⚖️ and integrated ABC pathway

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03:53

SuperAgers 💪, Super Brains 🧠, Super Insights 🔍

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/16

🧠 Meet the Northwestern SuperAgers—individuals 80+ with memory scores rivaling those decades younger! 📚 They show thicker cortices, more von Economo neurons, fewer neurofibrillary tangles, and remarkable social engagement. 🏆 Their brains offer clues to resisting age-related decline—reshaping how we view aging potential. ✨ #SuperAgers #HealthyLongevity #BrainHealth

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13:16

High Blood Pressure 2025 ACC/AHA Guideline: Measure....

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/15

🚨 Hot off the press! The 2025 ACC/AHA High Blood Pressure Guidelines are here 🩺📊 — bringing sharper strategies to detect, treat & prevent hypertension. From HBPM 🏠 to PREVENT risk scoring 🎯 and protecting against end-organ damage 🫀🧠, these updates empower clinicians & patients alike. Measure it. Manage it. Maintain it. 💪🌟 #Hypertension #Cardiology #Guidelines

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04:27

Hosts, Microbes & Life – The Holobiont Revolution

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/15

🌳 Trees aren’t just trees – they’re bustling holobionts 🌱🧫! New Nature research reveals that living wood hosts vast, specialized microbiomes, with heartwood and sapwood fostering distinct microbial worlds. These microbes shape carbon & nitrogen cycling 🌍, influence tree health 🌳💪, and reflect deep host–microbe coevolution 🧬. Rethinking forests as holobionts could transform conservation, climate strategies, and sustainable forestry. #Nature #Microbiome #Holobiont #Forests

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06:23

💙 Prevent • Protect • Prolong – The Full Spectrum of...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/14

💙 Heart failure prevention is a lifelong journey – from identifying those at risk 🩺, to managing pre-HF 🚦, to optimizing care in advanced stages 🫀. This joint HFSA & ASPC statement bridges primary, secondary & tertiary prevention, targeting traditional risks (HTN, diabetes, obesity) ⚠️, non-traditional risks (genetics, SDOH) 🌍, and leveraging tools like biomarkers 🔬, cardiac rehab 🏃, and heart-healthy diets 🥗. Detect early. Act decisively. Prolong life. #HeartHealth #Prevention

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04:34

Gut Microbes, Diet, & Disease 🌿🥗🚫

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/14

🦠 Your gut is home to trillions of microbes shaping digestion, immunity, and even mood! 🌿 This new study of 150 adults over 12 weeks found 📈 higher alpha diversity (p=0.003) and clear shifts in microbiome composition, with Faecalibacterium ↑ and Bacteroides ↓. Such changes could boost metabolic and immune health—but more research is needed for long-term insights. 💡 Nurture your inner ecosystem with smart diet and lifestyle choices! 🥗⚖️ #GutHealth #Microbiome #PrecisionMedicine

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04:07

Shielding the Heart ❤️🛡️: ARNI’s Role in Cardiotoxic...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/13

🚀 Breaking News in Cardio-Oncology! 🫀🎗️ A new randomized trial in European Journal of Heart Failure shows that low-dose sacubitril/valsartan (an angiotensin receptor–neprilysin inhibitor) given before adjuvant therapy in early breast cancer patients completely prevented cancer therapy-related cardiac dysfunction (CTRCD) over 12 months — 0% vs 26.3% in standard care (p=0.006, NNT=3.8). 💡 Why it matters: CTRCD remains a major risk with anthracyclines and HER2-targeted therapy. Early ARNI

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06:03

“Age Less, Live More, Thrive Longer 🧬💪⏳

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/13

🧬 Geroscience is redefining how we think about aging — shifting focus from treating one disease at a time to targeting the biological processes that drive all age-related conditions. From 🍽️ caloric restriction and 💊 metformin, to 🛡️ rapalogs and 🔍 senolytics, the evidence is mounting: intervening in aging biology may improve healthspan, resilience, and quality of life. 📊 The latest JAMA review highlights promising strategies, gaps in clinical evidence, and the urgent need for long-term

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05:40

“Sulfur Signals 🔬 | HFpEF ❤️ | Synergy Unlocked 🔑”

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/12

🚨 New Insights in HFpEF Therapy! 🫀🔬 A groundbreaking JACC: Basic to Translational Science study shows that hydrogen sulfide (H₂S) deficiency is not just a byproduct—but a central driver of cardiometabolic heart failure with preserved ejection fraction (HFpEF). Using human plasma analysis + two robust preclinical models, researchers found: ⚠️ ~80–90% reduction in circulating H₂S 💔 Diastolic dysfunction, fibrosis, vascular impairment linked to low H₂S 💊 H₂S donors (JK-1, DATS) improved heart,

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03:57

Dr RR Baliga's Philosphical Discourses: Al-Ghazali...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/12

🌟 Al-Ghazali (1058–1111 CE) – The “Proof of Islam” 🌟 A Shafi’i jurist, Ash’arite theologian, Sufi mystic, and philosopher, Al-Ghazali transformed Islamic thought by uniting orthodox theology with spiritual depth. 📜✨ From his Tahafut al-Falasifa 🧠🔥 (Incoherence of the Philosophers) challenging Aristotelian science, to his Ihya Ulum al-Din 📖💫 reviving the heart of the Islamic faith, he inspired generations in the Islamic world and beyond—shaping Christian, Jewish, and modern philosophical

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08:12

Fabry Hearts 💖, Hidden Signals 🩺, Bold Solutions 🚀

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/11

💖 Fabry Disease & the Heart 🫀 A rare genetic condition with a big cardiac footprint—Fabry disease can cause left ventricular hypertrophy, arrhythmias, microvascular angina, and heart failure even when ejection fraction is preserved. 🔍 Early detection is key – Genetic testing, advanced imaging (CMR with T1 mapping, strain echocardiography), and awareness of “red flag” signs can change outcomes. 💊 Therapies are evolving – From enzyme replacement therapy to migalastat, and promising gene and

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05:17

Steps, Speed, Strength 💡🚶‍♀️💪 – Boosting Cadence to...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/08/11

🚶‍♀️💨 Small Steps, Big Gains for Frail Adults! 🏆📈 A new study in PLOS ONE shows that prefrail and frail older adults can safely increase walking cadence — and that even a modest boost of +14 steps/min can raise the odds of hitting a clinically meaningful improvement in the 6-Minute Walk Test by ~10%. 📊 High-intensity walking participants averaged 100 steps/min vs. 77 in casual walkers, with 65% achieving the Minimal Clinically Important Difference (MCID) in functional capacity. 💡

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