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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

01:45

Missed by Stockholm, Remembered by Science magazine

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/10/05

🏅 Six breakthroughs. Zero Nobels. Medicine transformed. Why do some discoveries that fundamentally reshape biology never receive science's most famous prize? 🧬🧠 From Avery showing that DNA carries hereditary information, to Milner redefining memory, Till & McCulloch establishing stem cells, Pawson decoding cell signaling, Barres revealing the active biology of glia, and the Human Genome Project—these are discoveries whose influence far exceeds any medal. 🔬 💡 Great science doesn't need

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02:42

Survodutide Strikes Twice: Weight Down, Glycemia Down 📉

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/10/04

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02:00

🔥 The 25% Effect: Retatrutide Redefines Weight Loss

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/10/03

In TRIUMPH-1, once-weekly retatrutide produced mean weight loss of up to 25% at 80 weeks—but the story extends beyond the scale. ⚖️ 🦵 Less knee osteoarthritis pain 😴 Fewer obstructive sleep apnea events ❤️ Improved cardiometabolic measures 🩸 89–93% with prediabetes reverted to normoglycemia A triple GIP/GLP-1/glucagon receptor agonist may reshape how we think about obesity: not simply kilograms lost, but disease burden reduced. 💡 ⚠️ Gastrointestinal adverse effects remain important.

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02:12

Eat More, Eat Less, Live Better 🍎❤️: The 2026 ACC...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/10/02

🥗 Can we eat our way to a healthier heart? ❤️ The 2026 ACC Scientific Statement shifts the conversation from isolated nutrients to foods, dietary patterns, and degree of processing. 🌱 The message is remarkably practical: eat more vegetables, fruits, legumes, whole grains, nuts, seeds and healthy unsaturated fats; eat less ultra-processed food, refined grains, sugary drinks, processed meats and excess sodium. 🫒 Mediterranean and DASH patterns remain center stage. 🎙️ Dr RR Baliga's Podkast for the

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01:46

🧬 One Mutation, Massive Risk: EGFR T790M and...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/20

🧬 Rare Variant, Real Risk: EGFR T790M and Lung Cancer Can lung cancer risk be inherited—even in never-smokers? 🫁🚭 In >3.3 million individuals, germline EGFR T790M was rare (~1 in 15,850) but strongly associated with lung cancer (OR 25.18). The association was particularly striking among never-smokers, and the variant showed remarkable lung-cancer specificity. A Southern Appalachian founder effect also revealed how genes, geography & history can converge on modern disease risk. 🗺️🧬 💡 A

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02:30

🌱 A Probiotic for Longevity? Microbes, Metabolites &...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/19

🦠 Could a gut microbe help counter inflammaging? A fascinating Nature Aging study identifies Bifidobacterium pseudocatenulatum as a candidate geroprotective species that declines with age. Its metabolite 5-AVAB also falls with aging. In naturally aged mice, probiotic treatment improved intestinal homeostasis, reduced multiorgan inflammaging, enhanced cognitive–motor performance, and extended healthspan; 5-AVAB reproduced several benefits. 🧠💪 🎯 Microbiome → metabolite → inflammaging → healthspan

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02:58

🌾 60–100 Grams a Day: The Whole-Grain Cardiometabolic...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/18

🌾 Whole Grains, Real Gains! 🫀 How much whole grain does it take to move cardiometabolic risk factors? A meta-analysis of 87 randomized trials suggests a sweet spot around 60–100 g/day dry weight. Benefits were most clinically relevant for lipids and systolic blood pressure, while effects on several other risk factors were modest. 📉 💡 The lesson: cardiovascular prevention may come not from one dramatic dietary effect, but from multiple small gains working together. 🎙️ Dr RR Baliga's Podkast for

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02:05

🫀 The Heart's Forgotten Drain: Aging, Lymphatics &...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/17

🫀 Could the aging heart have a drainage problem? A fascinating study in Nature Cardiovascular Research shows that aging reduces cardiac lymphatic vessels, with tighter junctions, impaired clearance, inflammation, edema, fibrinogen and amyloid accumulation. 🔥 🧬 Mechanistically: aging → ↓VEGFC → ↑nuclear IL-33 → lymphatic endothelial cell loss/remodeling. 🎯 IL-33 silencing or VEGFC restoration rescued lymphatic density and reduced inflammation—but VEGFC did not reverse established diastolic

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02:07

🩸 Reengineering Coagulation: Bridging Factors,...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/16

🩸 Can you replace factor VIII without actually replacing factor VIII? Emicizumab does something more ingenious: this bispecific antibody bridges factor IXa and factor X, functionally recreating a critical role of factor VIIIa. 🔬 After screening ~40,000 candidates, researchers engineered a therapy that enables convenient subcutaneous prophylaxis and works with or without factor VIII inhibitors. 💉 🏆 Recognized with the 2026 Lasker–DeBakey Clinical Medical Research Award, it offers a powerful

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02:20

Great Doctors Series: 🦠 Fracastoro, Fomites & the...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/15

🦠 Before Germ Theory: Fracastoro, Fomites & the Seeds of Contagion In 1546—centuries before microbes could be seen—Girolamo Fracastoro proposed that epidemic diseases spread through transferable "seeds" or "spores": by direct contact, contaminated objects, or even at a distance. 🔬 He introduced fomes, the root of our modern term fomite, and his poem Syphilis gave the disease its enduring name. 📜 A physician, poet & Renaissance polymath whose great insight was simple: contagion follows physical

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01:59

🧠 Orexin Awakens: Sleep, Science & Serendipity

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/14

🧠 From Discovery to Lasker to Drug Therapy! In 1998, Emmanuel Mignot and Masashi Yanagisawa helped launch discoveries that transformed our understanding of orexin and narcolepsy—work now recognized with the 2026 Albert Lasker Award for Basic Medical Research. 🏆 The translational arc is remarkable: 🔬 orexin deficiency → narcolepsy type 1 → diagnostic biomarker → mechanism-based therapy. Today, we can 🌙 block orexin signaling for insomnia or ☀️ activate OX2R to restore wakefulness in narcolepsy. A

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01:53

🎭 Afib Ablation vs Sham: When Rhythm and Relief Part...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/13

🫀 Less AF—but not more relief? PVI-SHAM-AF delivers a provocative lesson. In symptomatic atrial fibrillation, catheter ablation substantially reduced AF detected on Holter, yet did not demonstrate superiority over sham for AF-related quality of life at 6 months. 🎭 💡 The clinical pearl: rhythm control and patient-perceived benefit are not interchangeable outcomes. A fascinating reminder that in procedural medicine, what the monitor records and what the patient feels may tell different stories

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01:56

🍞 Starch, Signals & Systemic Immunity: Not All Carbs...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/12

🍞 Same calories—but very different immune signals. A randomized controlled feeding trial examined 44 adults after ~15% weight loss on a very-low-carbohydrate diet. Reintroducing refined starch activated immune and metabolic pathways, increased adipsin/complement signaling, and produced activation signatures across NK cells, monocytes, T cells, dendritic cells & neutrophils. 🧬🔥 💡 Take-home: Carbohydrate quality may matter as much as quantity when considering immunometabolic effects. ⚠️ Small,

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02:00

🫀 The Infarct Ends. The Risk Doesn't.

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/11

🫀 The infarct ends. The risk doesn't. After myocardial infarction, atherosclerosis, thrombosis, inflammation, depression, deconditioning—and declining adherence—can sustain risk for decades. Our editorial proposes Persistent Prevention: 🔄 reassess evolving risk, 🎯 treat residual risk, 💊 sustain therapy when indicated, 🏃 prioritize cardiac rehabilitation, and 🧠 address psychosocial health. The goal: move from a static discharge bundle to a dynamic, lifelong prevention plan. ❤️ #Cardiology

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02:18

🫀 The Spleen–Heart Axis: Could the spleen hold a...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/10

🫀 Could the spleen hold a missing clue to coronary artery disease? Kamineni et al. used deep learning to extract 107 splenic MRI features in >42,000 UK Biobank participants. 🔬 Ten were associated with CAD, while genomics identified 219 loci—including the enigmatic 9p21 CAD locus. 🧬 The intriguing message: splenic texture—not simply size—may reflect a hematopoietic–inflammatory–genetic axis underlying CAD. ⚠️ External clinical replication was limited, so this is mechanistic discovery, not yet a

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01:33

🚨❤️ Pregnancy as a Cardiovascular Stress Test: A...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/09

🤰❤️ Pregnancy may be one of our earliest cardiovascular stress tests. A Lancet editorial reminds us that cardiovascular disease complicates up to 15% of pregnancies and accounts for up to one-third of maternal deaths. Gestational hypertension predicts a 6× higher risk of later chronic hypertension, while pre-eclampsia is associated with up to a 3.5× higher risk of heart failure. 💡 The message for physicians: adverse pregnancy outcomes are cardiovascular warning signals—not endpoints. Think

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01:26

Great Doctors Series: Pietro d'Abano⚕️ The Great...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/08

🔥 Medicine, Heresy & the Stars: Pietro d'Abano Meet Pietro d'Abano (c.1257–1315/16)—physician, philosopher, astrologer, and one of medieval medicine's great intellectual boundary-crossers. 🩺📚 Drawing on Aristotle, Avicenna and Averroes, his Conciliator tried to reconcile medicine with natural philosophy. His willingness to question accepted explanations eventually collided with the Inquisition. ⚖️🔥 A fascinating reminder that medical progress has always depended on curiosity—and sometimes

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02:02

🔥 Drop Aspirin? Not So Fast in High-Ischemic-Risk...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/07

🩸 Drop aspirin after 12 months? A-CLOSE says: not so fast. In 3,203 high-ischemic-risk patients after drug-eluting stenting, clopidogrel alone was noninferior to extended DAPT for net clinical events (5.0% vs 5.1%). But beneath that reassuring composite was a striking trade-off: ischemic events were higher with clopidogrel alone (3.7% vs 1.6%; HR 2.33), while bleeding was lower (1.8% vs 4.1%; HR 0.43). ⚖️ The lesson: "noninferior" does not mean clinically interchangeable. Individualize ischemic

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02:28

💉 Lysis Before Collapse: PRAGUE-26 Changes the PE...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/06

🫁 Stable—but not safe. Should we intervene before patients crash? PRAGUE-26 randomized 558 patients with intermediate-high–risk acute pulmonary embolism to catheter-directed low-dose alteplase + anticoagulation or anticoagulation alone. The 7-day composite of death, recurrent PE, or cardiorespiratory decompensation/collapse fell from 6.8% to 0.7% (RR 0.10; P<0.001)—mainly through fewer episodes of decompensation. 🎯 Major bleeding was not increased, although 2 intracranial hemorrhages occurred with

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02:12

💊 Food as Medicine—from Beneath the Waves

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/09/05

🦪 Small Creatures, Mighty Nutrition, Global Impact Could aquatic invertebrates help close the global micronutrient gap? 🌊 A fascinating Nature study finds that current production supplies the equivalent annual requirements of vitamin B12 and selenium for >5 billion people—and copper, omega-3 fatty acids, iodine and zinc for >1 billion. 🦐 💡 Bivalves are particularly rich in iron, iodine, zinc and B12. But nutrition on paper is not nutrition on the plate: sustainability, safety, access,

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