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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

02:46

Fat Depot Drama: From Swell to Well 🏕️📉😊

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/10

🔬 Just read a fascinating News & Views in Nature on how weight loss reshapes adipose tissue beyond just shedding fat! 🧬 Using single-nucleus RNA-seq and spatial profiling, researchers found that bariatric surgery reverses stress, inflammation, and senescence in fat depots—yet some immune memory lingers. 🧠🔥 A compelling case for adipose plasticity—and why cellular “memory” may be the key to sustained metabolic health. 💡💪 #ObesityResearch #AdiposeRemodeling #WeightLossScience #Senescence

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03:23

Sugar Switches: HFpEF’s Hidden Code 🧩🫀🧬

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/09

🧠💓 Just read a fascinating new study in Cell Metabolism (July 2025): dislocation of hexokinase 1 from mitochondria increases O-GlcNAcylation in endothelial cells — a hidden driver of HFpEF! Reversing this sugar-tagging with OGA overexpression or OGT inhibition restores heart function in mice. Precision metabolism meets cardiology. 🔬❤️‍🔥 #HFpEF #OGlcNAcylation #EndothelialDysfunction #CardioResearch #MetabolicTherapeutics #CellMetabolism

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03:34

Cats, Dogs, and Clarity 🐕🐈💡: The Cognitive Perks of...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/09

🐾 New Research Alert! 🧠 Owning a dog or cat may do more than warm your heart — it could help preserve your mind! 🐶🐱 A large 18-year study across Europe found that pet owners experienced slower cognitive decline, especially in memory and verbal fluency. 🧪 No boost seen with fish or birds 🐠🐦, but fur friends = brain gains! 🔗 Let’s rethink aging — with tails, not pills. #HealthyAging #PetScience #CognitiveHealth #Longevity #BrainHealth 🧓💡

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03:14

🧪🛡️ Stroke Shield: How Tirofiban Tips the Scales

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/08

🧠✨ New Stroke Breakthrough! The ASSET-IT trial shows that early infusion of tirofiban after thrombolysis significantly boosts recovery in noncardioembolic stroke patients — with 65.9% achieving excellent outcomes at 90 days vs 54.9% with placebo 📈💉 ✅ Improved function ⚠️ Slightly higher bleeding risk 🌏 Study conducted across 38 centers in China 📚 Read the trial in NEJM (July 2025) #Stroke #Tirofiban #Neurology #RCT #PrecisionMedicine #Thrombolysis #CardiovascularResearch

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02:45

🧠 Trinity & Truth: The Theological Legacy of Boethius 📜

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/08

📚✨ Just explored Boethius: The Consolation of Philosophy — a timeless journey from despair to divine reason. Written in prison, this masterpiece blends Roman philosophy with Nicene Christian theology, standing firm against Arianism. 🕊️⚖️ 🎧 Listen now: Dr. Baliga’s Got Knowledge Doc Podkast #Boethius #Theology #FaithAndReason #Podcast 💡🎙️📜

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03:03

Exercise Without Exercise? Betaine’s Magic Revealed!...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/07

💡 New Study Alert! 🏃‍♂️🧪 Kidney-derived betaine mimics long-term exercise—blocking TBK1, reducing inflammation, and reversing aging markers. This multi-omics human + mouse study uncovers betaine as a precision geroprotector for those who can’t hit the gym. 📈 A leap toward exercise mimetics in aging science! #Geroprotection #PrecisionMedicine #ExerciseScience #Betaine 🧬🧓🔥

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03:07

🧪 Reset, Rewind, Rejuvenate: Chemical Reprogramming...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/07

🧬 Rewinding Cellular Time with Chemistry! 🧪 A groundbreaking study just showed that a two-chemical cocktail (2c) — Tranylcypromine + Repsox — can reverse aging markers in human cells and extend C. elegans lifespan by 42%! 🐛💥 Unlike gene-based reprogramming, this method is safer, scalable, and preserves cell identity. Think of it as “Yamanaka lite” — with big implications for aging and longevity science. 🧠💊 #Longevity #Epigenetics #Rejuvenation #Biotech #AgingResearch #Lifespan

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03:32

From ABI to Amputation: Navigating PAD with Precision

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/06

🚶‍♂️💔 Just recorded a podcast on Peripheral Artery Disease (PAD) – a silent threat affecting 200M+ people worldwide. We unpack the latest 2024 ACC/AHA guidelines: ✅ When to screen 💊 What therapies work 🦿 How to save limbs & lives Tune in to walk away smarter. 👣🎙️ #PAD #Cardiology #Guidelines #Prevention #LimbSalvage

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04:25

Osteoporosis Uncovered: Risk, Resilience, and...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/06

Just finished reviewing the latest JAMA 2025 article on osteoporosis by Morin et al. — a must-read for anyone managing bone health in aging adults! 📉 Despite advances, 70% of fractures occur in those without DXA-defined osteoporosis. 💊 Treatment isn’t just about T-scores — it’s about fracture risk, fall prevention, and smart sequencing of antiresorptive and anabolic therapies. 🏋️‍♀️ Plus, lifestyle matters: resistance training, calcium, vitamin D, and proactive screening save lives. 📈

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03:45

🧬 Targeting Aldosterone: A New Shot at Hypertension 🎯💥

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/05

🚨 New breakthrough in hypertension care! 💊 The Launch-HTN trial shows lorundrostat — a selective aldosterone synthase inhibitor — significantly lowers systolic BP in patients with uncontrolled or treatment-resistant hypertension. 📉 −16.9 mmHg vs −7.9 mmHg with placebo (P < .001) 🧪 Safe, well-tolerated, and effective across subgroups. A potential game-changer in aldosterone-targeted therapy! 🔄💥 #Hypertension #Cardiology #ClinicalTrials #PrecisionMedicine

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04:19

Diagnose, Personalize, Optimize: The 2025 Diabetes...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/05

Our latest podcast episode unpacks the 2025 JAMA Review on Type 2 Diabetes 🔬💊 We explore: ✅ New diagnostic strategies ✅ Why GLP-1s & SGLT2is are game-changers ✅ How lifestyle change can lead to remission ✅ Individualizing A1C goals in real-world care 🎙️ Episode Title: “Diagnose, Personalize, Optimize: The 2025 Diabetes Blueprint” 📈 Essential listening for clinicians, educators, and innovators in endocrine & cardiometabolic care. 👉 Tune in now and share with your network! #Type2Diabetes

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02:59

Early to Bed, Stronger Steps Ahead 💤💪👣”

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/04

How we sleep tonight shapes how we move tomorrow! 📉🏃‍♂️ In a large-scale wearable study (📱WHOOP & Fitbit data from >25,000 adults), researchers found: ✅ Sleeping earlier than usual boosts next-day physical activity ❌ Longer or later sleep = less movement 🔥 Max gains came from consistent sleep duration + early bedtime Let’s rethink our 💤 to power our 💥! 📣 Public health campaigns should promote sleep and exercise together—not in competition. 📄 PNAS, June 2025 | doi: 10.1073/pnas.2420846122

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07:32

Wrinkle, Rust, and Rewind: 17 Theories of Why We Age

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/04

🧬 Curious why we age? 🕰️ From DNA damage to developmental programs gone rogue, this new podcast episode dives deep into 17 theories of ageing — some classic, some controversial. 🔍 We explore wear-and-tear, free radicals, telomeres, mitochondria, stem cell exhaustion, and the rising stars of epigenetic drift and hyperfunction theory. 🎙️ Whether you’re a scientist, clinician, or just fascinated by the biology of time, tune in to uncover what really drives the ageing process—and what might one

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06:09

💥 Beyond the Block: Cracking the Code of Chest Pain 🔬❤️

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/03

Refractory Angina: Time to Rethink the Diagnosis 🫀💥 Chest pain that defies stents and statins? It may not be your typical obstructive CAD. This podcast unpacks the redefinition of refractory angina — spotlighting INOCA, CMD, vasospasm, and myocardial bridging 🔬⚙️ We explore PET, CMR, CFVR, and wire-based diagnostics 🔎 — and why a multidisciplinary Angina Heart Team is key to transforming care 👩‍⚕️👨‍⚕️🧠 🎧 Listen in as we chart a course from frustration to precision — because even stubborn

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03:46

Inflammaging: Myth, Marker, or Mismatch? 🧪❓🌐

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/03

🔬🌍 New insights from Nature Aging: Inflammaging isn’t universal! A fascinating cross-cultural study comparing Italy 🇮🇹, Singapore 🇸🇬, Bolivia 🇧🇴, and Malaysia 🇲🇾 shows that age-related inflammation—long considered a hallmark of aging—may actually be a product of industrialized environments. Populations like the Tsimane (Bolivia) and Orang Asli (Malaysian), despite high infection loads, show minimal correlation between cytokines and age-related disease. 📉 Conclusion: Inflammaging is

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03:54

🧠❤️ Predict. Prevent. Protect: AI’s Lifesaving Role...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/02

🚨 AI vs Sudden Cardiac Death in HCM 🫀🤖 Exciting new study published in Nature Cardiovascular Research showcases MAARS, a multimodal AI model that dramatically improves risk prediction for sudden arrhythmic death in hypertrophic cardiomyopathy patients. 📊 MAARS outperformed current guidelines with AUROC of 0.89 (internal) and 0.81 (external) 🧠 Integrated data: LGE-CMR 🧲, EHR 📋, and echo/CMR reports 💻 ⚖️ Demonstrated fairness across age and sex subgroups 🔍 Transparent predictions via

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04:26

💡 Personalized, Precise, Powerful: The Rise of Cancer...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/02

“Vax to the Future: Cancer Immunity Revolution 🧬💉” Cancer vaccines are no longer a promise — they’re a precision revolution. From HBV and HPV to cutting-edge mRNA-based neoantigen vaccines, we explore how tumor sequencing + AI + immune checkpoint inhibitors are reshaping oncology. 📈 Real data from trials in melanoma, ccRCC, and pancreatic cancer ⚔️ PD-1 inhibitors meet targeted T cells 🌍 A safer, scalable future for cancer care 🎧 Tune in to Got Knowledge Doc as we decode this

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02:58

🍬 Endothelium Under Attack: The...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/01

🚨 New Findings on Aspartame & Heart Health! 🍬🫀 A groundbreaking study in Cell Metabolism reveals how aspartame, a common artificial sweetener, may worsen atherosclerosis via an insulin-triggered inflammatory pathway involving the CX3CL1-CX3CR1 axis. 🧪 Key insights from mice and monkeys: – Aspartame spikes insulin via vagus nerve stimulation – Elevated insulin boosts CX3CL1 expression in endothelial cells – CX3CL1 recruits inflammatory monocytes ➡️ plaque growth & instability 🧬 Blocking

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02:57

Dr RR Baliga's Philosophical Discourses: Saint...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/01

Saint Augustine of Hippo (354–430 CE), a prominent theologian, philosopher, and bishop in Roman North Africa, profoundly influenced Western Christianity and philosophy. Known for works like Confessions, The City of God, and On Christian Doctrine, he developed doctrines on original sin, grace, just war, and ecclesiology. His thoughts shaped medieval theology, inspired Protestant Reformers, and continue to impact Christian teachings.

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03:27

Beats, Bytes, Brilliance 🫀💾🌟: The Rise of AI in...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/30

🚨 Just out in JAMA! 💡 PanEcho, a multitask AI model trained on over 1.2 million echo videos, can automate complete echocardiographic interpretation — from LVEF to valvular disease — with diagnostic AUCs up to 1.00 and MAE as low as 4.2%. 🌍 Validated across international cohorts, including point-of-care settings, this tool could redefine access, accuracy, and efficiency in cardiac imaging. 🫀🤖 A major leap toward AI-assisted cardiovascular diagnostics. 🔗 Read the study #AIinMedicine

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